PO.CL04.01 · 临床研究

加勒比地区的衰老与癌症：COVID-19期间老年人群的发病率和死亡率趋势——来自马提尼克岛2008-2022年的基于人群的分析

Aging and cancer in the Caribbean: Incidence and mortality trends among older adults during Covid-19: Population-based analysis from Martinique, 2008-2022

编号 2467 展板 8 时间 4/20 09:00–12:00 区域 Section 41 主讲 Adrian Puello Guerrero, MD;MPH;PhD

分会场 Cancer and Aging: Implications for Outcomes

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作者与单位 Authors & Affiliations

Adrian Puello¹, Murielle Beaubrun-Renard², Jonathan Macni², Stephen Ulric-Gervaise², Manon Boullard², Mylene Vestris², Aimee Pierre-Louis², Sophia Hl George³, Moustapha Drame⁴, Clarisse Joachim¹

¹Registre General des Cancers de la Martinique, Pôle de Cancérologie-Hématologie-Urologie, CHU Martinique & EpiCliV Research Unit, Faculty of Medicine, University of the French West Indies, Fort de France, France,²Registre General des Cancers de la Martinique, Pôle de Cancérologie-Hématologie-Urologie, CHU Martinique, Fort de France, France,³Department of Obstetrics, Gynaecology and Reproductive Sciences, Miller School of Medicine, University of Miami, Miami, FL,⁴EpiCliV Research Unit, Faculty of Medicine, University of the French West Indies, Fort de France, France

摘要 Abstract

中文摘要

背景：前列腺癌、乳腺癌、胃癌、结直肠癌、肺癌和血液系统癌症是加勒比地区老年人群的一项区域性公共卫生负担。我们分析了马提尼克岛老年人群15年间的发病率和死亡率趋势，包括COVID-19时期，以描述癌症负担、筛查和治疗的变化。方法：我们利用马提尼克岛基于人群的癌症登记处开展了一项基于人群的队列研究（2008-2022年）。患者选择基于所有登记的居民，不论国籍。采用Segi/WHO年龄标准化发病率和死亡率（ASR），使用世界标准人口计算，并计算≥65岁患者按肿瘤部位和性别的年度百分比变化（APC）及95% CI。结果：我们记录了15,400例新发癌症；其中9,913例（64.4%）发生于男性。年龄标准化发病率（每10万人ASR）从2008-2012年的847.80（95% CI：801.80-893.90）到2018-2022年的862.10（821.2-903.0），表明总体稳定并从早期到后期略有上升。前列腺癌死亡率下降；女性乳腺癌发病率上升而死亡率稳定；结直肠癌发病率稳定而死亡率有所波动；胃癌发病率和男性肺癌死亡率下降。结论：在十五年间，马提尼克岛老年人群的癌症负担模式与加勒比地区和全球观察结果一致，但在幅度和时间上因部位和性别而异，反映了筛查强度的变化、新型疗法以及COVID-19的干扰。这些发现支持为老年人制定量身定制的癌症控制策略，强调公平获得诊断和治疗，以及针对服务中断的韧性规划。未来研究应纳入社会经济和合并症因素。

查看英文原文 English abstract

Background: Prostate, breast, stomach, colon-rectum, lung, and hematologic cancers represent a regional public health burden among older adults in the Caribbean. We analyzed 15-year trends in incidence and mortality among older adults in Martinique, including the COVID-19 period, to describe changes in cancer burden, screening and treatment. Methods: We conducted a population-based cohort study (2008-2022) from the population-based cancer registry of Martinique. Patient selection on all registered residents irrespective of nationality. Segi/WHO age-standardized incidence and mortality rates (ASR) were calculated using the world standard population and Annual Percent Change (APC) in patients ≥65 years, by tumor site and sex with 95% CI. Results: We recorded 15,400 incident cancers; 9,913 (64.4%) occurred in men. An indicating overall stability with a slight increase from the first to the later periods in age-standardized incidence rates (ASR per 100,000) were 847.80 (95% CI: 801.80-893.90) in 2008-2012 to 862.10 (821.2-903.0) in 2018-2022. Prostate cancer mortality declined; rising female breast cancer incidence with stable mortality; stable colorectal cancer incidence with varying mortality; and declines in stomach cancer incidence and male lung cancer mortality. Conclusions: Over fifteen years, cancer burden among older adults in Martinique patterns were consistent with Caribbean and global observations, with differences in magnitude and timing by site and sex, reflecting changing screening intensity, new therapeutics, and COVID-19 disruptions. These findings support tailored cancer control strategies for older adults, emphasizing equitable access to diagnostics and treatment, and resilience planning for service interruptions. Future research should integrate socioeconomic and comorbidity factors.

利益披露 Disclosure

A. Puello, None.. M. Beaubrun-Renard, None.. J. Macni, None.. S. Ulric-Gervaise, None.. M. Boullard, None.. M. Vestris, None.. A. Pierre-Louis, None.. S. H. George, None.. M. Drame, None.. C. Joachim, None.

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