PO.PR01.01 · 预防研究
波多黎各健康相关风险因素与癌症结局的地理空间制图：来自波多黎各生物样本库的数据
Geospatial mapping of health-linked risk factors and cancer outcomes in Puerto Rico: Data from the Puerto Rico BioBank
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
波多黎各生物样本库（PRBB）由庞塞健康科学大学（Ponce Health Sciences University）与莫菲特癌症中心（Moffitt Cancer Center）合作建立，并得到美国国家癌症研究所（National Cancer Institute）的支持，是波多黎各首个以癌症为核心的集中化生物样本库。其设计目的是收集、储存和分配来自全岛癌症确诊个体的注释完善的生物标本及相关临床数据。PRBB通过提供与人口统计学、诊断和地理数据关联的高质量生物标本来支持转化研究。截至2025年，该生物样本库已累计纳入超过5,000名参与者。本研究的目的是描述PRBB的现有结构和内容，并强调其整合数据集如何能够对健康相关因素（如合并症、就诊地理距离、社会人口学因素和诊断）进行制图。自2019年以来，PRBB已通过波多黎各南部学术附属医院和诊所纳入2,550名癌症确诊个体。所有参与者均同意在诊断时收集组织样本、临床信息和邮政编码。数据集包括临床病理变量、合并症、治疗路径和人口统计学变量。生物标本和数据的收集、处理和储存均遵循符合国家生物样本库最佳实践的标准化方案，并在机构IRB批准的程序下进行管理。采用描述性统计进行统计分析。使用R统计软件2025.09.1+401版本进行分析。初步分析显示，超过50%的PRBB参与者居住在距庞塞（Ponce，中部各市镇患者进行诊断和专科护理的主要地点）30公里以上，通常单程需往返45-90分钟以获得服务。社会人口学数据进一步显示，35%的参与者仅完成8-12年级学业。大多数参与者报告家庭年收入低于40,000美元（83%），37%享有公共保险。此外，73%有癌症家族史，29%报告当前或既往有烟草使用史。PRBB作为一个稳健且不断扩展的研究平台，用于调查影响全岛癌症结局的区域特异性因素。通过将生物标本与临床、地理和社会人口学数据整合，PRBB能够识别与诊断分期、护理可及性和治疗差异相关的空间模式。这一基础设施支持未来旨在改善早期检测、指导移动筛查计划以及为解决波多黎各癌症负担进行资源规划的研究。
查看英文原文 English abstract
The Puerto Rico BioBank (PRBB), established through a partnership between the Ponce Health Sciences University and the Moffitt Cancer Center with support from the National Cancer Institute, was the first centralized cancer-focused biorepository in Puerto Rico. It was designed to collect, store, and distribute well-annotated biological specimens and associated clinical data from individuals diagnosed with cancer across the island. The PRBB supports translational research by providing high-quality biospecimens linked to demographic, diagnostic, and geographic data. As of 2025, the biobank has accrued over 5,000 participants. The aim of this study is to describe the current structure and contents of the PRBB and highlight how its integrated dataset enables the mapping of health-linked factors such as comorbidities, geographic distance to care, sociodemographic factors, and diagnosis.Since 2019, the PRBB has enrolled 2,550 individuals diagnosed with cancer through academic-affiliated hospitals and clinics in southern Puerto Rico. All participants provided consent for the collection of tissue samples, clinical information, and zip code at the time of diagnosis. The dataset includes clinico-pathological variables, comorbidities, treatment pathways, and demographic variables. Biospecimens and data are collected, processed, and stored under standardized protocols consistent with national biobanking best practices and managed under institutional IRB-approved procedures. Statistical analysis was conducted using descriptive statistics. Analysis was performed using R statistical software version 2025.09.1+401.Preliminary analysis shows that over 50% of PRBB participants live more than 30 km from Ponce, the primary site for diagnostic and specialty care for patients from the central municipalities often traveling 45-90 minutes each way for services. Sociodemographic data further reveal that 35% of participants have only completed grades 8-12. Most participants report household annual incomes under $40,000 (83%), and 37% are publicly insured. Additionally, 73% have a family history of cancer and 29% report current or past tobacco use.The PRBB serves as a robust and expanding research platform for investigating region-specific factors that influence cancer outcomes across the island. By integrating biospecimens with clinical, geographic, and sociodemographic data, the PRBB enables the identification of spatial patterns related to stage at diagnosis, access to care, and treatment variability. This infrastructure supports future studies aimed at improving early detection, guiding mobile screening initiatives, and informing resource planning to address cancer burden in Puerto Rico.
利益披露 Disclosure
J. A. Oliveras Torres, None.