PO.PS01.05 · 人群科学
多样化亚洲人群中外周T细胞淋巴瘤的亚型特异性模式
Subtype-specific patterns of peripheral T-cell lymphoma in diverse Asian populations
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
外周T细胞淋巴瘤（PTCL）是一类罕见、侵袭性的非霍奇金T细胞淋巴瘤，预后不良。黑人个体的发病率高于白人个体，但对于特定亚洲人群的发病率知之甚少。我们基于美国2000年人口普查的年龄分布，获取了亚洲亚人群中非特指型外周T细胞淋巴瘤（PTCL-NOS，ICD-O-3：9702）、血管免疫母细胞性T细胞淋巴瘤（AITL，9705）和间变性大细胞淋巴瘤（ALCL，9714）的平均年度年龄调整发病率（AAIR）/10万人，此外还计算了以非西班牙裔白人（NHW）为参照组、比较各种族/族裔群体的率比（RR）。数据来自监测、流行病学和最终结果（SEER）9登记处（1990-2014）。合并亚型分析显示亚裔-太平洋岛民整体与NHW之间无显著差异（RR 0.94；p=0.0976），但SEER中的分层分析显示出显著差异。东南亚人的发病率最高，其次是菲律宾人，而中国人的发病率最低（表1）。按亚型，东南亚人的PTCL-NOS发病率最高（0.72/10万，RR=2.40，p=0.002，基于21例病例），其次是菲律宾人（0.45/10万，RR=1.49，p<0.001）。菲律宾人（p=0.0004）和越南人（p=0.05）的AITL发病率（0.18/10万）均高于NHW（0.1/10万），RR=1.73。NHW的ALCL发病率最高（0.23/10万）。与NHW相比，中国人、日本人和韩国人的ALCL发病率显著较低（RR=0.45-0.57，p<0.01）。这些发现凸显了亚洲亚群之间不同的亚型特异性PTCL风险模式。鉴于病例数较少，结果应谨慎解读。在PTCL亚组中对亚洲亚群进行细分仍然至关重要，以识别高风险群体并提高预后准确性。
表1. 按种族/族裔群体的PTCL的AAIR和RR。AAIR/10万 95% CI N 率比 95% CI P值 非西班牙裔白人 0.63 0.62, 0.65 6,778 1.0
中国人 0.50 0.43, 0.59 171 0.80 0.68, 0.93 0.0031 日本人 0.60 0.51, 0.71 141 0.96 0.80, 1.13 0.6544 菲律宾人 0.80 0.71, 0.91 260 1.27 1.12, 1.44 0.0004 韩国人 0.51 0.39, 0.65 64 0.80 0.61, 1.03 0.0932 越南人 0.73 0.58, 0.92 87 1.16 0.91, 1.45 0.2260 太平洋岛民 0.73 0.54, 0.96 54 1.16 0.86, 1.52 0.3385 东南亚人 0.94 0.59, 1.41 28 1.49 0.94, 2.23 0.0882
查看英文原文 English abstract
Peripheral T-cell lymphomas (PTCLs) are rare, aggressive non-Hodgkin T-cell lymphomas with a poor prognosis. Black individuals have a higher incidence compared to White individuals, but little is known about incidence rates for specific Asian populations. We obtained average annual age-adjusted incidence rates (AAIR)/100,000 based on the age distribution for the US 2000 Census for PTCL-not otherwise specified (ICD-O-3: 9702), angioimmunoblastic T-cell lymphoma (AITL, 9705), and anaplastic large cell lymphoma (ALCL, 9714) within Asian subpopulations, in addition to rate ratios(RR) comparing racial/ethnic groups with non-Hispanic whites (NHW) as a reference group. Data was obtained from the Surveillance, Epidemiology, and End Results (SEER) 9 registry (1990-2014). The combined-subtype analysis showed no significant difference between Asian-Pacific Islanders overall and NHW (RR 0.94; p=0.0976), but stratified analysis in SEER showed striking differences. Southeast Asians had the highest incidence rates, followed by Filipinos, while Chinese had the lowest incidence rates (Table 1). By subtype, Southeast Asians had the highest incidence rates of PTCL-NOS (0.72/100,000, RR= 2.40, p=0.002, based on 21 cases), followed by Filipinos (0.45/100,000, RR=1.49, p<0.001). Both Filipinos (p=0.0004) and Vietnamese (p=0.05) had higher incidence rates of AITL (0.18/100,000) compared to NHW (0.1/100,000) with RR=1.73. NHW had the highest incidence rates of ALCL (0.23/100,000). Compared to NHW, Chinese, Japanese, and Koreans showed significantly lower ALCL rates (RRs = 0.45-0.57, p < 0.01). These findings highlight distinct subtype-specific PTCL risk patterns across Asian subgroups. Given the low case counts, results should be interpreted cautiously. Disaggregation of Asian subgroups in PTCL subgroups remains essential to identify high-risk groups and improve prognostic accuracy.
Table 1. AAIR and RR for PTCL by racial/ethnic group. AAIR/100,000 95% CI N Rate Ratio 95% CI P-value Non-Hispanic Whites 0.63 0.62. 0.65 6,778 1.0
Chinese 0.50 0.43, 0.59 171 0.80 0.68, 0.93 0.0031 Japanese 0.60 0.51, 0.71 141 0.96 0.80, 1.13 0.6544 Filipino 0.80 0.71, 0.91 260 1.27 1.12, 1.44 0.0004 Korean 0.51 0.39, 0.65 64 0.80 0.61, 1.03 0.0932 Vietnamese 0.73 0.58, 0.92 87 1.16 0.91, 1.45 0.2260 Pacific Islander 0.73 0.54, 0.96 54 1.16 0.86, 1.52 0.3385 SE Asian 0.94 0.59, 1.41 28 1.49 0.94, 2.23 0.0882
利益披露 Disclosure
X. Kuang, None..
M. P. Bernstein, None..
N. Foley, None..
L. Pinter-Brown, None..
M. S. Lim, None..
W. Cozen, None.