PO.PS01.02 · 人群科学
基于人群登记的21世纪前二十年匈牙利早发实体癌发病率
Incidence of early-onset solid cancers in Hungary in the first two decades of the 21 st century based on a population-based registry
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摘要 Abstract
中文摘要
背景：相对较年轻年龄（<50岁）新发现的恶性肿瘤具有极大的科学意义。既往研究发现这些早发癌症的发病率呈全球性上升，尽管其模式因癌症类型而异。然而，匈牙利数据的分析尚未发表。
方法：匈牙利国家癌症登记处（HNCR）负责匈牙利癌症患者的数据收集。其运作基于人群、符合国际标准并覆盖全国。依据国际疾病及相关健康问题统计分类第10次修订版，从HNCR数据库中提取新发现的癌症病例。该查询聚焦于20至49岁的患者以及2001至2019年的时期。除绝对病例数外，还分析了年龄标准化值（参照：2013年欧洲标准人口）。采用Spearman相关检验以识别性别和疾病特异性趋势。
结果：在研究期间，早发癌症的发病率在男性中呈下降，而在女性中未变化。值得注意的是，与新发现癌症病例总数相比，早发癌症的比例在两性中均呈下降趋势。按癌症类型分类显示，在较年轻年龄中女性乳腺癌和子宫体癌的发病率升高，而宫颈癌呈下降——后者的趋势超过了普通人群。结直肠癌的发病率在女性中未变化，但在男性中下降。烟草相关的肺癌和头颈部区域的发病率下降。
结论：与纳入全球趋势的分析相比，匈牙利早发癌症的情况似乎更为复杂。一方面，过去几年的举措如引入HPV疫苗接种和吸烟限制，使相关癌症数量下降。另一方面，需要识别导致增长类型癌症（如乳腺癌）的新机制。
查看英文原文 English abstract
Background: Newly discovered malignancies at a relatively younger age (<50) are of great scientific interest. Previous studies found that the incidence of these early-onset cancers showed a global increase, although the pattern varied by cancer type. However, analysis of the Hungarian data has not yet been published.
Methods: The Hungarian National Cancer Registry (HNCR) is responsible for data collection of the Hungarian cancer patients. Its operation is population-based in accordance with international standards and covers the entire country. Based on the 10 th Revision of International Statistical Classification of Diseases and Related Health Problems, newly discovered cancer cases were extracted from the HNCR's database. The query focused on patients between the ages of 20 and 49 and period from 2001 to 2019. Next to absolute case numbers, age-standardized values were also analyzed (reference: European Standard Population 2013). Spearman's correlation test was performed to identify gender- and disease-specific trends.
Results: During the studied period, the incidence of early-onset cancers showed decrease among males, while it did not change among females. It should be noted that compared to the total number of newly discovered cancer cases, the proportion of early-onset cancers showed decreasing trend in both genders. Categorization by cancer type revealed that among younger age the incidence of female breast and uterine corpus cancer elevated, while cervical cancer showed a decrease - the latter trend exceeded that of the general population. The incidence of colorectal cancer did not change among females, but decreased among males. The incidence of tobacco-related lung cancer and head and neck region decreased.
Conclusion: Compared to analyses enrolled global trends, the Hungarian situation of early-onset cancers seemed to be more complex. On one hand, activities in the past few years such as introduction of HPV vaccination and restrictions on smoking resulted a decrease in the number of related cancers. On the other hand, new mechanisms underlying the increasing types of cancers (e.g. breast cancer) need to be identified.
利益披露 Disclosure
I. Kenessey, None..
A. Wéber, None..
M. Dobozi, None..
I. Szatmári, None..
P. Parrag, None..
P. Nagy, None..
M. Dank, None.