PO.PS01.03 · 人群科学
压力如何深入体内：日常歧视、炎症与老年人癌症风险
How stress gets under the skin: Everyday discrimination, inflammation and cancer risk in older adults
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
癌症是一种主要影响老年人的毁灭性疾病，65岁以上的成年人占癌症相关死亡的70%和新诊断病例的60%以上。初步研究表明，黑人和西班牙裔/拉丁裔老年人被诊断为晚期癌症的风险更高，其癌症死亡率也高于其他种族/族裔群体的老年人。炎症是这些亚组中的一个此类风险因素，特别是通过日常歧视（EDD）等慢性应激源。测量这一应激通路的一种方法是通过炎症生物标志物，如C反应蛋白（CRP）和可溶性肿瘤坏死因子受体-1（sTNFR-1）。增进我们对EDD与炎症生物标志物在细分人群中交叉关系的理解，将有助于我们识别高风险群体，以改善诊断的及时性。我们检验了EDD是否与CRP和sTNFR-1水平升高相关，从而最终增加少数族裔人群的癌症风险。本研究纳入了2016年健康与退休研究静脉血生物标志物子样本（Health and Retirement Venus Blood Biomarker Subsample）中年龄在65-95岁的美国白人（n=3,187）、黑人（n=443）和西班牙裔/拉丁裔（n=375）老年人。结果显示，黑人老年人经历更多的EDD，其平均CRP[4.93 mg/L（0.41）]和sTNFR-1[1840.88 pg/mL（85.3）]水平高于白人[CRP=3.95 mg/L（0.16）；sTNFR-1=1807.21 pg/mL（20.7）]和西班牙裔/拉丁裔[CRP=4.50 mg/L（0.41）；sTNFR-1=1806.75 pg/mL（67.43）]老年人。OLS回归模型显示，报告更多EDD经历与更高的CRP水平相关（beta=0.23；p=0.03），特别是在黑人老年人中，但与更高的sTNFR-1水平无关。逻辑回归模型显示，在全样本中sTNFR-1（OR=1.00；p=0.04）显著增加被诊断为癌症的几率。研究结果表明，EDD经历可能通过CRP等炎症通路增加癌症风险。
查看英文原文 English abstract
Cancer is a devastating disease predominately affecting older adults, with adults 65+ accounting for 70% of cancer-related deaths and over 60% of new diagnoses. Preliminary studies show that Black and Hispanic/Latine older adults are at an increased risk of diagnosis of advanced staged cancers and experience higher mortality rates from cancer than older adults of other racial/ethnic groups. Inflammation is one such risk factors in these sub-groups, specifically through chronic stressors like everyday discrimination (EDD). One way to measure this stress pathway is via inflammatory biomarkers like C-Reactive Protein (CRP) and Soluble Tumor Necrosis Factor-1 (sTNFR-1). Improving our understanding of the intersection between EDD and inflammatory biomarkers in disaggregated populations will help us identify high-risk groups to improve timeliness and diagnosis. We examined whether EDD is associated with elevated CRP and sTRNFR-1 levels, ultimately increasing cancer risk for minoritized populations. This study included White (n=3,187), Black (n=443), and Hispanic/Latine (n=375) older adults in the U.S. who were 65-95 years old in the 2016 Health and Retirement Venus Blood Biomarker Subsample . Results show that Black older adults experience more EDD and have higher average CRP [(4.93 mg/L (0.41)] and sTNFR-1 [(1840.88 pg/mL (85.3)] levels than White [CRP= 3.95 mg/L (0.16) ; sTNFR-1= 1807.21 pg/mL (20.7)] and Hispanic/Latine [CRP=4.50 mg/L (0.41); sTNFR-1=1806.75 pg/mL (67.43)] older adults. OLS regression models show reporting more experiences of EDD is associated with higher CRP levels (beta;= 0.23; p=0.03), specifically in Black older adults, but is not associated with higher levels of sTNFR-1. Logistic regression models show sTNFR-1 (OR=1.00; p=0.04) significantly increases the odds of being diagnosed with cancer in the full sample. Findings suggest that experiences of EDD may increase cancer risk, via inflammatory pathways like CRP.
利益披露 Disclosure
C. Brown, None..
L. Brown, None.