PO.PS01.06 · 人群科学

乳腺癌幸存者的超加工食品摄入与炎症标志物

Ultra-processed food intake and inflammatory markers in breast cancer survivors

编号 5034 展板 7 时间 4/21 09:00–12:00 区域 Section 35 主讲 Minsu Cho, BS;MS

分会场 Diet, Alcohol, and Tobacco, and Other Lifestyle Factors

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作者与单位 Authors & Affiliations

Minsu Cho¹, Sihan Song², Zisun Kim³, Hyun Jo Youn⁴, Jihyoung Cho⁵, Jun Won Min⁶, Yoo Seok Kim⁷, Jihyoun Lee⁸, Seho Park⁹, Joon Jeong¹⁰, Jung Eun Lee¹

¹Department of Food and Nutrition, Seoul National University, Seoul, Korea, Republic of,²Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO,³Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea, Republic of,⁴Department of Surgery, Jeonbuk National University Medical School, Jeonju, Korea, Republic of,⁵Division of Breast and Thyroid Surgery, Department of Surgery, Koo Hospital, Daegu, Korea, Republic of,⁶Department of Surgery, College of Medicine, Dankook University, Cheonan, Korea, Republic of,⁷Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea, Republic of,⁸Department of Surgery, Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of,⁹Division of Breast Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of,¹⁰Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

摘要 Abstract

中文摘要

目的：本研究旨在考察韩国乳腺癌幸存者中超加工食品摄入与炎症标志物之间的关联。方法：共纳入641名乳腺癌幸存者。超加工食品摄入采用3天膳食记录或经过验证的食物频率问卷进行评估。测量了血浆中高敏C反应蛋白（hs-CRP）、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α及脂联素的水平。根据这五种生物标志物计算了复合炎症z评分。采用多变量逻辑回归和一般线性模型估计炎症标志物的比值比（OR）及最小二乘（LS）均值。结果：总超加工食品摄入总体上与炎症标志物无关联。然而，关联因诊断时的绝经状态、雌激素/孕激素受体（ER/PR）亚型及年龄而异。比较超加工食品摄入的极端四分位数，在诊断时为绝经前和绝经后的参与者中，复合炎症z评分升高的OR（95%置信区间，CI）分别为0.57（0.28，1.19）和3.10（1.20，8.00）（交互作用p<0.01）。在ER/PR阴性肿瘤者中，超加工食品摄入最低和最高四分位数的hs-CRP（mg/L）LS均值（95% CI）分别为0.28（0.16，0.51）和0.59（0.33，1.06）（趋势p=0.03），而在其他亚型者中相应值为0.41（0.31，0.53）和0.48（0.37，0.61）（趋势p=0.67）；交互作用未达到统计学意义（交互作用p=0.26）。对于脂联素降低，比较超加工食品摄入极端四分位数的OR（95% CI）在年龄<50岁者中为0.57（0.26，1.26），在年龄≥50岁者中为2.65（1.20，5.88）（交互作用p=0.03）。当我们考察超加工食品亚组的关联时，较高的包装及速食面摄入与hs-CRP升高相关。结论：在诊断时为绝经后、ER/PR阴性或年龄50岁及以上的韩国乳腺癌幸存者中，较高的超加工食品摄入与不良的炎症谱相关。在超加工食品亚组中，较高的包装及速食面摄入与更高的hs-CRP相关。致谢：本研究得到韩国国家研究基金会资助，由科学与信息通信技术部资助（2014R1A2A2A01007794、2019R1F1A1061017、2021R1F1A1062476及RS-2025-00560416）。

查看英文原文 English abstract

Objectives: This study aimed to examine the associations between ultra-processed food intake and inflammatory markers among Korean breast cancer survivors. Methods: A total of 641 breast cancer survivors were included. Ultra-processed food intake was assessed using 3-day dietary records or a validated food frequency questionnaire. Plasma levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6, interleukin-8, tumor necrosis factor-alpha, and adiponectin were measured. A composite inflammatory z-score was calculated from these five biomarkers. Multivariate logistic regression and general linear models were used to estimate odds ratios (ORs) and least-squares (LS) means for inflammatory markers. Results: Total ultra-processed food intake was not associated with inflammatory markers overall. However, the associations varied by menopausal status at diagnosis, estrogen/progesterone receptor (ER/PR) subtype, and age. Comparing extreme quartiles of ultra-processed food intake, ORs (95% confidence intervals, CIs) for an increased composite inflammatory z-score were 0.57 (0.28, 1.19) and 3.10 (1.20, 8.00) among participants who were premenopausal and postmenopausal at diagnosis, respectively ( p for interaction < 0.01). LS means (95% CIs) for hs-CRP (mg/L) in the lowest and highest quartiles of ultra-processed food intake were 0.28 (0.16, 0.51) and 0.59 (0.33, 1.06) among those with ER/PR-negative tumors ( p for trend = 0.03), whereas the corresponding values were 0.41 (0.31, 0.53) and 0.48 (0.37, 0.61) among those with other subtypes ( p for trend = 0.67); the interaction did not reach statistical significance ( p for interaction = 0.26). For reduced adiponectin, ORs (95% CIs) comparing extreme quartiles of ultra-processed food intake were 0.57 (0.26, 1.26) in those aged < 50 years and 2.65 (1.20, 5.88) in those aged ≥ 50 years ( p for interaction = 0.03). When we examined the associations of ultra-processed food subgroups, higher intake of packaged and instant noodles was associated with increased hs-CRP. Conclusions: Higher ultra-processed food intake was associated with unfavorable inflammatory profiles among Korean breast cancer survivors who were postmenopausal at diagnosis, ER/PR-negative, or aged 50 years and older. Among ultra-processed food subgroups, greater intake of packaged and instant noodles was associated with higher hs-CRP. Acknowledgements: This research was supported by the National Research Foundation of Korea grants, funded by the Ministry of Science and ICT (2014R1A2A2A01007794, 2019R1F1A1061017, 2021R1F1A1062476, and RS-2025-00560416).

利益披露 Disclosure

M. Cho, None.. S. Song, None.. Z. Kim, None.. H. Youn, None.. J. Cho, None.. J. Min, None.. Y. Kim, None.. J. Lee, None.. S. Park, None.. J. Jeong, None.. J. Lee, None.

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