PO.PS01.06 · 人群科学
膳食晚期糖基化终末产物与肺癌及慢性呼吸系统疾病的风险
Dietary advanced glycation end-products and risks of lung cancer and chronic respiratory diseases
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
背景：晚期糖基化终末产物（advanced glycation end-products, AGEs）可促进炎症和氧化应激，并参与多种慢性疾病的发生。膳食已被确认为外源性AGEs的主要来源。然而，关于膳食AGEs在呼吸系统相关疾病中作用的流行病学证据仍然稀缺。
方法：我们纳入了英国生物样本库（UK Biobank）的153,897名参与者，通过24小时膳食问卷收集其食物消费信息。我们估计了总AGEs的每日摄入量，包括N ε -(羧甲基)-赖氨酸（CML）、N ε -(1-羧乙基)-赖氨酸（CEL）和N δ -(5-氢-5-甲基-4-咪唑啉酮-2-基)-鸟氨酸（MG-H1），并将其归入17个食物组。采用多变量Cox比例风险模型估计总AGEs及不同食物来源AGEs与肺癌和慢性呼吸系统疾病的风险比（HR）及95%置信区间（CI）。
结果：在中位随访10.57年和10.81年后，分别确定了1,073例肺癌病例和19,584例慢性呼吸系统疾病病例。较高的总AGEs、CML、CEL和MG-H1摄入与较低的肺癌风险（主要为肺腺癌，HR Q5 vs. Q1：0.60-0.72）和慢性呼吸系统疾病风险（哮喘、COPD、IPF和肺炎，HR Q5 vs. Q1：0.67-0.91）相关。此外，肉类来源的AGEs与肺癌风险增加相关（HR Q5 vs. Q1=1.26，95% CI：1.04-1.53），而坚果来源的AGEs与肺癌风险降低相关（HR Q5 vs. Q1=0.69，95% CI：0.59-0.81）。饮料、肉类、马铃薯和甜食来源的AGEs使慢性呼吸系统疾病风险增加4%~10%（P趋势 <0.05），而谷物、蔬菜和水果、坚果及大多数其他食物来源的AGEs摄入增加则表现出对慢性呼吸系统疾病的保护趋势（P趋势 <0.05）。
结论：膳食AGEs暴露与肺癌和慢性呼吸系统疾病之间存在负相关。在评估AGEs对健康结局的影响时，需要强调不同食物来源AGEs的不同作用。
查看英文原文 English abstract
Background: Advanced glycation end-products (AGEs) can promote inflammation and oxidative stress, and are involved in the onset of various chronic diseases. Diet has been identified as a major source of exogenous AGEs. However, epidemiological evidence regarding the role of dietary AGEs in respiratory-related diseases remains scarce.
Methods: We included 153,897 participants from the UK Biobank, for whom food consumption information was collected via 24-hour dietary questionnaires. We estimated the daily intakes of total AGEs comprising N ε -(carboxymethyl)-lysine (CML), N ε -(1-carboxyethyl)-lysine (CEL), and N delta -(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), and categorized them into 17 food groups. Multivariable Cox proportional hazards models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of total and different food-derived AGEs with lung cancer and chronic respiratory diseases.
Results: After a median follow-up of 10.57 and 10.81 years, 1,073 cases of lung cancer and 19,584 cases of chronic respiratory disease were ascertained, respectively. Higher intakes of total AGEs, CML, CEL, and MG-H1 were associated with lower risks of lung cancer (mainly lung adenocarcinoma, HRs Q5 vs. Q1 : 0.60-0.72) and chronic respiratory diseases (asthma, COPD, IPF, and pneumonia, HRs Q5 vs. Q1 : 0.67-0.91). Additionally, meats-derived AGEs were related to an increased lung cancer risk (HR Q5 vs. Q1 =1.26, 95% CI: 1.04-1.53), whereas a reduced risk of lung cancer was associated with AGEs from nuts (HR Q5 vs. Q1 =0.69, 95% CI: 0.59-0.81). Beverages-, meats-, potatoes-, and sweets-derived AGEs increased the risk of chronic respiratory diseases by 4%~10% ( P trend <0.05), while increased intakes of AGEs from cereals, vegetables and fruits, nuts and most other foods presented a protective trend against chronic respiratory diseases ( P trend <0.05).
Conclusions: There existed an inverse association of dietary AGEs exposure with lung cancer and chronic respiratory diseases. The different role of AGEs by diverse food sources needs to be emphasized when assessing their impacts on health outcomes.
利益披露 Disclosure
A. Qin, None..
F. Liu, None..
Y. Peng, None..
P. Wang, None..
C. Si, None..
X. Wang, None..
J. Gong, None..
H. Zhou, None..
J. Gu, None..
M. Zhang, None..
F. Song, None.