PO.PS01.06 · 人群科学
睡眠时长和质量与肥胖相关癌症的关联：来自健康检查者研究的结果
The association of sleep duration and quality with obesity-related cancers: Results from the health examinees study
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摘要 Abstract
中文摘要
本研究旨在调查大规模韩国人群中自我报告的睡眠时长和质量与肥胖相关癌症风险的关联。这项前瞻性队列研究利用了来自健康检查者-Gem（HEXA-G）队列的数据，该队列由年龄≥40岁的成年人组成。本研究共纳入126,866名提供了睡眠时长和质量信息的参与者。睡眠时长在基线时自我报告，并分类为<6小时、6-<8小时和≥8小时。睡眠质量通过四个独立问题评估，包括非恢复性睡眠、日间疲劳、入睡困难和夜间焦虑。癌症病例通过韩国国家癌症中心韩国中央癌症登记处的国家癌症登记数据识别。本研究采用国际癌症研究机构定义的肥胖相关癌症。使用Cox比例风险模型估计风险比（HR）和95%置信区间（CI），随访从入组年龄两年后开始，持续至首次癌症诊断、失访或研究结束（2018年12月31日）。在中位7.3年（范围，年）的随访期间，记录了7,284例全部位癌症新发病例，包括4,113例肥胖相关癌症病例。长睡眠时长（≥8小时）与肥胖相关癌症显著相关（1.08；1.01-1.16），与全部位癌症呈边缘性相关（1.05；1.00-1.11），与非肥胖相关癌症无关。与报告各睡眠质量成分为“完全没有”的参与者相比，报告非恢复性睡眠“有时”（1.08；1.01-1.16）或“大多数时候”（1.11；1.01-1.22）的参与者显示出更高的肥胖相关癌症风险；报告入睡困难“有时”与肥胖相关癌症风险相关（1.08；1.01-1.16），而日间疲劳和夜间焦虑未显示出显著关联。报告睡眠≥8小时伴非恢复性睡眠（“有时”）增加了全部位癌症（1.10；1.01-1.20）和肥胖相关癌症风险（1.24；1.11-1.39）。报告睡眠≥8小时伴日间疲劳增加了全部位癌症（1.18；1.06-1.31）和肥胖相关癌症风险（1.19；1.04-1.37）。报告睡眠≥8小时伴入睡困难增加了全部位癌症（1.16；1.04-1.30）和肥胖相关癌症风险（1.26；1.13-1.41）。长睡眠时长与肥胖相关癌症风险显著相关。长睡眠时长合并非恢复性睡眠、日间疲劳、入睡困难或夜间焦虑与全部位和肥胖相关癌症风险呈正相关，但与非肥胖相关癌症无关。
查看英文原文 English abstract
This study aims to investigate the associations of self-reported sleep duration and quality with obesity-related cancer risk in a large-scale Korean population. This prospective cohort study utilized data from the Health Examinees-Gem (HEXA-G) cohort, comprising adults aged ≥40 years. A total of 126,866 participants who provided information on both sleep duration and quality were included in the present study. Sleep duration was self-reported at baseline and categorized into <6 hours, 6-<8 hours, and ≥8 hours. Sleep quality was assessed using four independent questions, including nonrestorative sleep, daytime fatigue, difficulty in initiating sleep, and nighttime anxiety. Cancer cases were identified through national cancer registration data from the Korea Central Cancer Registry of the Korea National Cancer Center. This study adopted obesity-related cancers, defined by the International Agency for Research on Cancer. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with follow-up beginning two years after the age at enrollment and continuing until the first cancer diagnosis, loss to follow-up, or the end of the study (December 31, 2018). During the median follow-up period of 7.3 years (range, years), 7,284 incident all-site cancer cases, including 4,113 obesity-related cancer cases, were documented. Long sleep duration (≥8 h) was significantly associated with obesity-related cancer (1.08; 1.01-1.16), marginally associated with all-site cancer (1.05; 1.00-1.11), and not associated with non-obesity-related cancer. Compared with participants reporting each sleep quality component “not at all,” those reporting nonrestorative sleep “sometimes” (1.08; 1.01-1.16) or “most of the time” (1.11; 1.01-1.22) showed higher obesity-related cancer risk; those reporting initiation difficulty “sometimes” was associated with obesity-related cancer risk (1.08; 1.01-1.16), whereas daytime fatigue and nighttime anxiety showed no significant associations. Reporting sleep ≥8 h with nonrestorative sleep (“sometimes”) increased all-site cancer (1.10; 1.01-1.20) and obesity-related cancer risk (1.24; 1.11-1.39). Reporting sleep ≥8 h with daytime fatigue increased all-site cancer (1.18; 1.06-1.31) and obesity-related cancer risk (1.19; 1.04-1.37). Reporting sleep ≥8 h with initiation difficulty increased all-site cancer (1.16; 1.04-1.30) and obesity-related cancer risk (1.26; 1.13-1.41). Long sleep duration was significantly associated with obesity-related cancer risk. Long sleep duration combined with nonrestorative sleep, daytime fatigue, initiation difficulties, or nighttime anxiety had positive associations with all-site and obesity-related cancer risks, but not with non-obesity-related cancers.
利益披露 Disclosure
S. Cho, None..
S. Min, None..
H. Lee, None..
S. Lee, None..
D. Kang, None.