海报库PosterKeep
PO.MCB10.02 · 分子与细胞生物学

从拉丁美洲患者中鉴定与乳腺癌预后相关的lncRNA

Identification of lncRNAs associated with breast cancer prognosis from Latina America patients

海报缩略图：从拉丁美洲患者中鉴定与乳腺癌预后相关的lncRNA
编号 5896 展板 3 时间 4/21 02:00–05:00 区域 Section 20 主讲 Maria Nagai
分会场 Functional Roles of Noncoding RNAs in Cancer Progression, Metabolism, and Therapy Response
查看 PDF 下载 PDF 🔒 查看 / 下载完整 PDF 需登录并开通下载套餐 · 查看套餐 / 开通 AACR 官方页面

作者与单位 Authors & Affiliations

Xinhui Wang1, Marcio L. Acencio1, Flavia Rotea Mangone2, Roger Chammas3, Dirce Maria Carraro4, Andrea S. Llera5, Eliana Abdelhay6, Nora Artagaveytia7, Adrián Daneri-Navarro8, Bettina Müller8, Osvaldo L. Podhajcer9, Carlos Velazquez10, Maria A. Nagai3

1Luxembourg Centre for Systems Biomedicine,University of Luxembourg, Luxembourg, Luxembourg,2Inst. do Cancer do Estado de São Paulo (ICESP), São Paulo, Brazil,3Center for Translational Research in Oncology, University of São Paulo, São Paulo, Brazil,4A.C. Camargo Cancer Center - Brazil, São Paulo, Brazil,5Leloir Institute Foundation, Buenos Aires, Argentina,6Bone Marrow Transplantation Unit, Instituto Nacional de Câncer, Rio de Janeiro, Brazil,7Hospital de Clínicas, Facultad de Medicina Universidad de la República, Montevideo, Uruguay, Montevideo, Uruguay,8Universidad de Guadalajara, Guadalajara, Mexico,9Head, Gene Therapy Laboratory, Fundacion Institute Leloir, Ciudad de Buenos Aires, Argentina,10Universidad de Sonora, Hermosillo, Mexico

摘要 Abstract

中文摘要
乳腺癌（BC）是全球女性癌症相关死亡的最常见原因，被视为一个公共卫生问题。许多功能研究表明，长链非编码RNA（lncRNA）在基因表达调控中发挥不同作用，充当表观遗传因子。越来越多的证据表明，lncRNA调节多种生物学过程，其表达改变与包括BC在内的癌症的发生和进展相关。在此，为鉴定与乳腺癌相关的lncRNA，我们对LACRN MPBCS项目（拉丁美洲癌症研究网络——乳腺癌分子特征研究）中1,071例符合条件患者肿瘤的表达数据进行了重新分析。使用标准化数据，我们比较了三阴性乳腺癌（TNBC；170例）与非TNBC肿瘤（782例）的表达谱。基于|log2FC| > 1和FDR < 0.05的标准，使用DESeq2 R包共鉴定出59个差异表达lncRNA（DElncRNA）。在Kaplan-Meier生存分析中，我们鉴定出影响无病生存和/或总生存的DElncRNA，其中TNBC中有8个，非TNBC患者中有26个。此外，我们使用多变量Cox比例风险模型评估生存的独立预测因子。其中两个DElncRNA，VLDLR-AS1和PART1，是TNBC患者的独立预后标志物；七个，LINC00239、FAM30A、LINC00842、LINC01315、EGOT、LY6E-DT和SLC25A21-AS1，是非TNBC患者的独立预后标志物。我们的研究鉴定出多个可能参与肿瘤进展并可作为BC候选生物标志物的lncRNA。
查看英文原文 English abstract
Breast cancer (BC) is the most common cause of female cancer-related death worldwide and is considered a public health problem. Many functional studies have shown that long noncoding RNAs (lncRNAs) play different roles in gene expression regulation, acting as epigenetic factors. Accumulating evidence indicates that lncRNAs modulate diverse biological processes, and their altered expression is associated with the development and progression of cancer, including BC. Here, aiming to identify lncRNAs associated with breast cancer, we performed a re-analysis of the expression data from 1,071 tumors of eligible patients in the project LACRN MPBCS (Latin American Cancer Research-Network - Molecular Profile of Breast Cancer Study). Using normalized data, we compared the expression profiles of triple-negative breast cancer (TNBC; 170 cases) and non-TNBC tumors (782 cases). A total of 59 differentially expressed lncRNAs (DElncRNAs) could be identified based on the criteria of |log2FC| > 1 and FDR < 0.05, using the DESeq2 R package. In the Kaplan-Meier survival analysis, we identified DElncRNAs that affect disease-free survival and/or overall survival, with 8 in TNBC and 26 in non-TNBC patients. Further, we used multivariate Cox proportional-hazards models to evaluate independent predictors of survival. Two of those DElncRNAs, VLDLR-AS1 and PART1, were independent prognostic markers for TNBC patients, and seven, LINC00239, FAM30A, LINC00842, LINC01315, EGOT, LY6E-DT, and SLC25A21-AS1, were independent prognostic markers for non-TNBC patients. Our study identifies several lncRNAs that might participate in tumor progression and may serve as candidate biomarkers for BC.
利益披露 Disclosure
X. Wang, None.. M. L. Acencio, None.. F. R. Mangone, None.. R. Chammas, None.. D. M. Carraro, None.. E. Abdelhay, None.. N. Artagaveytia, None.. A. Daneri-Navarro, None.. B. Müller, None.. O. L. Podhajcer, None.. C. Velazquez, None.. M. A. Nagai, None.

← 返回 AACR 2026 检索