PO.PS01.04 · 人群科学
2016至2022年美国非裔美国人与白人宫颈癌按诊断时年龄和分期的5年相对生存率差异
Disparities in 5-year relative survival rates of cervical cancer by age and stage at diagnosis between African Americans and Whites, in the USA, from 2016 to 2022
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摘要 Abstract
中文摘要
背景：美国宫颈癌的总体五年相对生存率（RSR）约为67%，随诊断时分期显著变化。局限期宫颈癌的生存率较高，约为91%，而较晚期（区域或远处）的生存率较低，区域期为62%，远处期为19%。
目的：比较美国非裔美国人与白人宫颈癌RSR在诊断时年龄和分期方面的差异。
方法：使用2016至2022年SEER（监测、流行病学和最终结果）数据库的数据，我们分析了356名非裔美国人和4,612名白人宫颈癌患者。使用SEER*Stat软件按诊断时年龄和分期比较非裔美国人与白人的RSR。
结果：在局限期，15-44岁的白人RSR为97.1%（95% CI，95.5-98.2），持续高于非裔美国人，但45-54岁和55-64岁者除外，其RSR略高，分别为94.6%和91.6%（95% CI：77.0-98.8和65.2-98.2）。在区域期，白人总体生存较好，RSR为60.7%（95% CI，50.3-69.5）。例外是75岁及以上的非裔美国人，其RSR为56.2%（95% CI，0.2-94.9），高于同年龄组的白人。在远处期，15-44岁的非裔美国人与白人RSR均较低且相似，为31.5%（95% CI，19.8-30.1）。55-64岁和65-74岁的非裔美国人RSR较高，分别为22.6%和25.3%（95% CI：9.10-39.7和6.2-50.6），高于其白人对照。在75岁及以上者中，白人RSR较高（7.4%，95% CI：1.9-17.9）。对于分期不明的病例，15-44岁的白人RSR为91%（95% CI，73.5-97.2），再次高于非裔美国人。然而，45-54岁的非裔美国人RSR为67.3%（95% CI，5.1-94.9），高于同年龄组的白人。
讨论/结论：宫颈癌RSR在种族、年龄和分期方面存在显著差异。总体而言，非裔美国人的RSR低于白人，凸显了这两个群体间宫颈癌预后的持续性差异。
查看英文原文 English abstract
BACKGROUND: The overall five-year relative survival rates (RSRs) for cervical cancer in the USA are about 67%, varying significantly by stage at diagnosis. Localized cervical cancer has a higher survival rate, approximately 91%, while later stages (regional or distant) have lower rates, with the regional stage it is 62% and the distant stage it is 19%.
OBJECTIVE: To compare differences in cervical cancer RSRs by age and stage at diagnosis between African Americans and Whites in the U.S.
METHODS: Using data from the 2016 to 2022 SEER (Surveillance, Epidemiology, and End Results) database, we analyzed 356 African Americans and 4,612 Whites diagnosed with cervical cancer. RSRs compared African Americans and Whites by age and stage at diagnosis using SEER*Stat software.
RESULTS: At the localized stage, Whites aged 15-44 had an RSR of 97.1% (95% CI, 95.5-98.2), consistently higher than African Americans, except those aged 45-54 and 55-64, who had slightly higher RSRs at 94.6% and 91.6% (95% CIs: 77.0-98.8 and 65.2-98.2), respectively. At the regional stage, Whites had better survival overall, with an RSR of 60.7% (95% CI, 50.3-69.5). The exception was African Americans aged 75 and older, who had a higher RSR of 56.2% (95% CI, 0.2-94.9) than Whites in the same age group. At the distant stage, both African Americans and Whites aged 15-44 had similar lower RSRs of 31.5% (95% CI, 19.8-30.1). African Americans aged 55-64 and 65-74 had higher RSRs of 22.6% and 25.3% (95% CIs: 9.10-39.7 and 6.2-50.6) than their White counterparts. Among those aged 75 and older, Whites had a higher RSR (7.4%, 95% CI: 1.9-17.9). For cases with an unknown stage, Whites aged 15-44 had an RSR of 91% (95% CI, 73.5-97.2), again higher than African Americans. However, African Americans aged 45-54 had a higher RSR of 67.3% (95% CI, 5.1-94.9) compared to Whites in the same age group.
DISCUSSION/CONCLUSION: Significant disparities in cervical cancer RSRs exist by race, age, and stage. Overall, African Americans had lower RSRs than Whites, underscoring persistent disparities in cervical cancer outcomes among these two groups.
利益披露 Disclosure
M. Wilkerson, None..
J. Heath, None..
E. Abdalla, None.