PO.CH01.07 · 化学
Computational, Technological, and Mechanistic Advances
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- 975 975 基于深度学习的逆转癌症相关转录表型的新型疗法的筛选与设计 Deep learning-based screening and design of novel therapeutics that reverse cancer-associated transcriptional phenotypes Jing Xing, Mingdian Tan, Dmitry Leshchiner, Mengying Sun, Shreya Paithankar, Rama Shankar, Erika Lisabeth, Bilal Aleiwi, Ruoqiao Chen, Matthew Giletto, Richard Neubig, Samuel So, Edmund Ellsworth, Mei-Sze Chua, Jiayu Zhou, Bin Chen
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- 986 986 具有独特蓝色荧光特性的SN-38甲硅烷基醚类似物通过拓扑异构酶I抑制表现出强效抗癌活性 Silyl ethers analogs of SN-38 with unique blue-fluorescent properties exhibit potent anti-cancer activity through topoisomerase I inhibition Sanika Vaidya, Ashley Mo, Alyssa Yee-Xin Chia, Katelyn Li, Shreya Somani, Isabella Lo, Lekhya Menta, Gary Johanning, Feng Wang-Johanning, Edward Njoo
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- 988 988 多异戊烯基磷酰酯抑制剂的合成、表征及对三阴性乳腺癌的生物学评价 Synthesis, characterization, and biological evaluation of polyisoprenylated phosphonyl ester inhibitors on triple-negative breast cancer Joshua Kofi Ablordeppey, Kweku Ofosu-Asante, Amarender Burra, Jahnissi Odoom, Desmond Kwakye, Nazarius S. Lamango
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- 992 992 一种基于内化增强肽的新型靶向蛋白降解平台，用于细胞表面蛋白的溶酶体降解 A novel targeted protein degradation platform based on internalization-enhancing peptide for lysosomal degradation of cell-surface proteins Dae Young Kim, Dahye Sim, Daeho Park, Yujin Park, Hee Young Kang, Hoil Choi
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- 1000 1000 功能化内酰胺的立体控制合成及其作为潜在抗三阴性乳腺癌药物的评价 Stereocontrolled synthesis and evaluation of functionalized lactams as potential anti-triple-negative breast cancer agents Leila Rahimian, Tolulope Omolekan, Ojasvi Dutta, Konstantin G. Kousoulas, Timothy K. Beng, Jean C. Chamcheu
- 1001 1001 靶向调控皮肤T细胞淋巴瘤中的F-actin：p38beta与p38gamma抑制剂的协同抑制 Targeting regulation of F-actin in cutaneous T-cell lymphoma: Synergistic inhibition of p38beta with p38gamma inhibitors Xu Hannah Zhang, Jack Hsiang, Markus Kalkum, Jun Wu, Steven T. Rosen
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- 1003 1003 通过GSH响应性互益前药靶向共递送gemcitabine和atRA，经氧化还原失衡和Pin1抑制增强细胞毒性 Targeted co-delivery of gemcitabine and atRA via a GSH-responsive mutual prodrug enhances cytotoxicity through redox imbalance and Pin1 inhibition Nanhee Song, Ilseob Kim, Chnagjin Lim, Dongwon Lee, Sun Il Choi, Yun-Hee Kim
