PO.TB10.05 · 肿瘤生物学
Aging and Host Determinants of Tumor Progression: The Macroenvironmental Axis
- 2071 2071 Aging impairs NK-cell surveillance to promote metastatic outgrowth in breast cancer Pulkit Datt, Jhon Pasamonte, Kelly Coutant, Anastasiia Burtseva, Mitchell Fane
- 2072 2072 Role of the aging on the ᵧdelta T-cells in metastatic cutaneous melanoma progression Kelly Coutant, Christopher Price, Jhon Pasamonte, Pulkit Datt, Mitchell Fane
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- 2074 2074 Adenosine-driven inflammatory reprogramming of aged cancer-associated fibroblasts promotes immune suppression in pancreatic ductal adenocarcinoma Shuncang Zhu, Jinpeng Lu, Ziyi Tu, Hongyi Lin, Yinhao Chen, Yiting Chen, Haoxiang Zhang, Zuwei Wang, Shi Chen
- 2075 2075 Lactate-driven cholesterol reprogramming induces fibroblast senescence and immune suppression in aged pancreatic cancer Ziyi Tu, Jinpeng Lu, Shuncang Zhu, Hong-yi Lin, Yi-ting Chen, Yinhao Chen, Haoxiang Zhang, Zu-Wei Wang, Shi Chen
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- 2078 2078 Aging promotes liver and lung melanoma metastasis via tissue-infiltrating Tregs Anastasiia Burtseva, Kelly Coutant, Jhon Pasamonte, Christopher Price, Mitchell Fane
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- 2080 2080 Aged-induced increases in IL-11 leads to immune escape and PD-1 resistance in melanoma through myeloid cell polarization Michael F. Emmons, Chao Zhang, ethan vallebuona, Richard L. Bennett, Manali Phadke, Jonathan D. Licht, Keiran Smalley
- 2081 2081 Age of host impact on epigenetics in tumors derived from early or late onset Hispanic colorectal cancer patients Lesly Torres-Gonzalez, Shivani Soni, Zeyi Yang, Ben Y. Tew, Jae H. Lo, Pooja Mittal, Unnati H. Shah, Michela Bartolini, Steve Soto Trujillo, Yitzher Goretsky, Sandra Algaze, Wu Zhang, David W. Craig, John D. Carpten, Salhia Bodour, Heinz-Josef Lenz
- 2082 2082 Multiplex immunofluorescence reveals compartment-specific immune cell correlations associated with age and immunotherapy response in ovarian carcinoma Kathy Kwock, Okan Gültekin, Hanim I. Ozkizilkaya, Lynda D. Roman, William Dean Wallace, Tirzah Petta, Joseph W. Carlson
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- 2084 2084 Angiotensin-II-induced chronic hypertension reprograms the antitumor-immune-response in pancreatic ductal adenocarcinoma Benjamin Wolf, Heena Kumra, Ryo Morisue, Karim El-marouk, Igor L. Gomes-Santos, Rieke Schleinhege, Tsion H. Tale, Marc Charabati, Sonu Subudhi, Dai Fukumura, Rakesh K. Jain
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- 2091 2091 Progesterone promotes immunosuppression in murine mammary tumors by modulating CD4 T cell viability and helper functions, promoting T cell apoptosis and a shift from inflammatory to anti-inflammatory cytokine profiles Amanda Glen Heard
- 2092 2092 Single-cell RNA sequencing reveals ancestry-associated molecular and cellular immunosuppressive features in non-small cell lung cancer Liang Liu, Pengbo Zhang, Enzo Palma, Ashley Ballard, Lance Miller, Gregory Hawkins, Cristina M. Furdui, Edward Levine, Alberto de Hoyos, Wencheng Li, Fang-Chi Hsu, Ralph D'Agostino, David Foureau, Wei Zhang
- 2093 2093 Elucidating the mechanistic connection between the elevated occurrence of EGFR mutation in Hispanic/Latinx lung adenocarcinoma patients Jonathan Castillo, William D. Wallace, Leonidas Arvanitis, Dan Raz, Crystal N. Marconett
- 2094 2094 Investigating the influence of genetic background on TNBC-T cell interactions in TNBC organoids and co-cultures Batoul Farran, Moses Kamita, Shuk Mei Wong, Sylvester Antwi, Valerie Ofori Aboah, Harriet Larrious-Lartey, Jessica Jessica Bensenhaver, Ali Haythem, Walker Eleonor, Foster Amponsah, Josephine Nsafu., Rose Dampson, Patrick Kafui Akapko, Evelyn Jiage
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