Late-Breaking Research: Tumor Biology 1

• LB226 · PDF Age-dependent matrisome remodeling in young breast adipose tissue identifies a potential mechanism of tumor aggressiveness Mackenzie Hawes, Khudeja Salim, Nicole Cullen, Katherine Herbert, Delia Carlino, Bruce Bunnell, Bridgette Collins-Burow, Van Barnes, Jorge Belgodere, Matthew Burow, Elizabeth Martin
• LB227 LB227 Adipokine adipsin promotes breast cancer progression by inducing adipocyte maturation Yohei Shimono, Behnoush Khaledian, Masahiro Mizuno, Jumpei Yoshida, Kazutsune Yamagata, Takuya Kato, Lisa Thibes, Satoru Ishihara, Fujiko Sueishi, Yuko Kijima, Motoshi Suzuki, Kenji Kawada, Naoya Asai
• LB228 · PDF DPYSL2 mediates extracellular vesicle-driven reprogramming of the glioblastoma tumor microenvironment Marissa Russo, Emily Norton, Weiwei Wang, Shreyartha Mukherjee, Daniel Wickland, TuKiet Lam, Hugo Guerrero-Cazares
• LB229 · PDF Single-cell and spatially resolved transcriptomics identifies clinically targetable myeloid niches in fibrolamellar carcinoma Jason Carter, Andreas Stephanou, Sheela R. Damle, Kristin E. Goodsell, Lindsay K. Dickerson, Heidi L. Kenerson, Xiuyun Jiang, Raymond S. Yeung, Ian N. Crispe, Praveen Sethupathy, Venu Pillarisetty
• LB230 · PDF A prospective immunological analysis of head and neck squamous cell carcinoma in humans Tarralyn Y. Clark, Erin Connolly, Jeromy Dooyema, Nabil Saba, Shlomo Koyfman, Haydn Kissick, Nicole C. Schmitt, Christine Lee-Poturalski, Timothy Chan, David Yu, Zachary S. Buchwald
• LB231 · PDF Intra-pancreatic adipocytes promote pancreatic cancer progression by inhibiting tumor immunity Chengcheng Wang, Xinpeng Yin, Yupei Zhao
• LB232 LB232 BRCA1 deficiency programs a microglia-supported ferroptosis-resistant niche in breast cancer brain metastasis Rami Khoury, Kathrin Laue, Giuseppe Longobardi, Shahar Greenberg, Jean J. Zhao, Uri Ben-David, Ronit Satchi-Fainaro
• LB233 · PDF Protein engineering of selective MMP-9 inhibitors reveals a therapeutic strategy for triple-negative breast cancer Alireza Shoari, Alexandra Hockla, Mathew A. Coban, Ella E. Aitchison, Alexandra M. Dimesa, Evette S. Radisky
• LB234 · PDF Cabozantinib remodels the pancreatic tumor microenvironment to potentiate immunotherapy Jayati Chakrabarti, Saptarshi Mallick, Xi Sun, Ugonna Ezuma-Igwe, Abigail G. Branch, Jiang Wang, Sangmin Kim, Rohan Kanakamedala, Syed A. Ahmad, Davendra Sohal, Rachna Shroff, Yana Zavros
• LB235 · PDF Elucidating the impact of the immune microenvironment on the evolutionary dynamics of early-stage ovarian clear cell carcinoma YuYi Huang, Yen-Chun Chen, Pei-Chi Cheng, Ko-Chen Chen, Alice Hsiang-Kuo Yang, Hsien-Neng Huang, Ruby Yun-Ju Huang, Lin-Hung Wei, Wei-Ting Hung
• LB237 · PDF High-resolution spatial transcriptomics identifies unique spatial programs in lung adenocarcinoma from never smokers Wei Zhao, Aaron Rozeboom, Phuc H. Hoang, Tam-Anh Tran, Maria Teresa Landi
• LB238 · PDF Spatial transcriptomics identifies distinct molecular and immune pathways in endometrial cancer in African American women Danyelle Hill, Yuxin Jin, Javier Arias-Stella, Joseph Carlson, David Craig, Rania Bassiouni, John Carpten
• LB239 · PDF Spatial programs of cancer-associated and normal fibroblasts diverges with mismatch repair status in colorectal cancer Debanjan Barua, Tze Guan Tan, Shu Wen Samantha Ho, Michael T. Wong, Iain B. H. Tan, Jennifer H. Yearley, Su-Yang Liu
• LB240 · PDF Cross-validated spatial architecture of tissue-resident memory T-cells predicts recurrence pattern in nasopharyngeal carcinoma Ngar-Woon (Yvonne) Kam, Pak Hei, Syrus Lai, Cho Yiu Lau, Wei Dai, Dora Lai Wan Kwong, Victor Ho Fun Lee
• LB241 · PDF Development of breast adipose-cancer co-culture model to decipher the impact of lipid heterogeneity on triple-negative breast cancer Khudeja Salim, Elnaz Sheikh, Jorge A. Belgodere, Bridgette M. Collins Burow, Van H. Barnes, Manas R. Gartia, Matthew E. Burow, Elizabeth C. Martin
• LB243 · PDF Targeting eRNA-producing super-enhancers converts undruggable regulatory hubs into therapeutic targets in cancer-associated fibroblasts So-Young Yeo, Keun-Woo Lee, Insuk Sohn, In Gu Do, Hyung Ook Kim, Jae Woo Kwon
• LB244 · PDF Osteosclerosis is associated to low anaplastic histological patterns in prostate cancer bone metastasis Felipe Eltit Guersetti, Bita Mojtahedzadeh, Dennis Xie, Sara Koohbor, Eva Corey, Michael E. Haffner, Colm Morrissey, Michael E. Cox
• LB245 · PDF Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy Sonal Srivastava, John J. Powers, Jay H. Mehta, Sadegh Marban, Ryunosuke Nozaki, Laxmi Swetha Karanam, Jacob Torrez, Harish S. Bharambe, Farhoud Faraji, Ritu Chaudhary, Pino Bordignon, Jacqueline Giliberti, Robbert J. C. Slebos, Joseph O. Johnson, Chandler Gantenbee, Xiaofei Song, Marco Cassano, Jose A. Guevara-Patino, Duy T. Nguyen, Alexander R. A. Anderson, Mitsuo Yamauchi, Jeffery West, J. Silvio Gutkind, Christine H. Chung, Antonio L. Amelio
• LB246 · PDF Neoadjuvant androgen signaling inhibition promotes the emergence of mixed basal/club-like cancer identity cells in prostate cancer tumors Antti Kiviaho, Thomas Cecchetto, Sini K. Eerola, Mazlina Ismail, Charles T.A. Parker, Alexander Giesen, Anni Perämäki, Sini Hakkola, Jasper van Goubergen, Steven Joniau, Tapio Visakorpi, Mikael Marttinen, Kirsi J. Rautajoki, Frank Claessens, Gerhardt Attard, Alfonso Urbanucci, Matti Nykter
• LB248 LB248 Development of organotypic patient-derived ovarian cancer model for therapy testing Iris Schilt, Sander de Ruiter, Masato Ohbuchi, Marjolein Vermeer, Johnny Suijker, Aleksandra Olczyk, Thomas Olivier, Orsola Mocellin, Paul Vulto, Jos Joore, Henriëtte Lanz, Bart Kramer, Karla Queiroz, Shinsuke Oshima, Ryuichi Moriya

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