Late-Breaking Research: Tumor Biology 1

• LB226 · PDF 年轻乳腺脂肪组织中年龄依赖性的基质体重塑揭示肿瘤侵袭性的潜在机制 Age-dependent matrisome remodeling in young breast adipose tissue identifies a potential mechanism of tumor aggressiveness Mackenzie Hawes, Khudeja Salim, Nicole Cullen, Katherine Herbert, Delia Carlino, Bruce Bunnell, Bridgette Collins-Burow, Van Barnes, Jorge Belgodere, Matthew Burow, Elizabeth Martin
• LB227 LB227 脂肪因子 adipsin 通过诱导脂肪细胞成熟促进乳腺癌进展 Adipokine adipsin promotes breast cancer progression by inducing adipocyte maturation Yohei Shimono, Behnoush Khaledian, Masahiro Mizuno, Jumpei Yoshida, Kazutsune Yamagata, Takuya Kato, Lisa Thibes, Satoru Ishihara, Fujiko Sueishi, Yuko Kijima, Motoshi Suzuki, Kenji Kawada, Naoya Asai
• LB228 · PDF DPYSL2 介导细胞外囊泡驱动的胶质母细胞瘤肿瘤微环境重编程 DPYSL2 mediates extracellular vesicle-driven reprogramming of the glioblastoma tumor microenvironment Marissa Russo, Emily Norton, Weiwei Wang, Shreyartha Mukherjee, Daniel Wickland, TuKiet Lam, Hugo Guerrero-Cazares
• LB229 · PDF 单细胞和空间分辨转录组学鉴定纤维板层型癌中临床可靶向的髓系龛 Single-cell and spatially resolved transcriptomics identifies clinically targetable myeloid niches in fibrolamellar carcinoma Jason Carter, Andreas Stephanou, Sheela R. Damle, Kristin E. Goodsell, Lindsay K. Dickerson, Heidi L. Kenerson, Xiuyun Jiang, Raymond S. Yeung, Ian N. Crispe, Praveen Sethupathy, Venu Pillarisetty
• LB230 · PDF 人类头颈部鳞状细胞癌的前瞻性免疫学分析 A prospective immunological analysis of head and neck squamous cell carcinoma in humans Tarralyn Y. Clark, Erin Connolly, Jeromy Dooyema, Nabil Saba, Shlomo Koyfman, Haydn Kissick, Nicole C. Schmitt, Christine Lee-Poturalski, Timothy Chan, David Yu, Zachary S. Buchwald
• LB231 · PDF 胰腺内脂肪细胞通过抑制肿瘤免疫促进胰腺癌进展 Intra-pancreatic adipocytes promote pancreatic cancer progression by inhibiting tumor immunity Chengcheng Wang, Xinpeng Yin, Yupei Zhao
• LB232 LB232 BRCA1缺失在乳腺癌脑转移中编程一个小胶质细胞支持的铁死亡抵抗龛 BRCA1 deficiency programs a microglia-supported ferroptosis-resistant niche in breast cancer brain metastasis Rami Khoury, Kathrin Laue, Giuseppe Longobardi, Shahar Greenberg, Jean J. Zhao, Uri Ben-David, Ronit Satchi-Fainaro
• LB233 · PDF 选择性MMP-9抑制剂的蛋白工程揭示三阴性乳腺癌的治疗策略 Protein engineering of selective MMP-9 inhibitors reveals a therapeutic strategy for triple-negative breast cancer Alireza Shoari, Alexandra Hockla, Mathew A. Coban, Ella E. Aitchison, Alexandra M. Dimesa, Evette S. Radisky
• LB234 · PDF 卡博替尼重塑胰腺肿瘤微环境以增强免疫治疗 Cabozantinib remodels the pancreatic tumor microenvironment to potentiate immunotherapy Jayati Chakrabarti, Saptarshi Mallick, Xi Sun, Ugonna Ezuma-Igwe, Abigail G. Branch, Jiang Wang, Sangmin Kim, Rohan Kanakamedala, Syed A. Ahmad, Davendra Sohal, Rachna Shroff, Yana Zavros
• LB235 · PDF 阐明免疫微环境对早期卵巢透明细胞癌进化动态的影响 Elucidating the impact of the immune microenvironment on the evolutionary dynamics of early-stage ovarian clear cell carcinoma YuYi Huang, Yen-Chun Chen, Pei-Chi Cheng, Ko-Chen Chen, Alice Hsiang-Kuo Yang, Hsien-Neng Huang, Ruby Yun-Ju Huang, Lin-Hung Wei, Wei-Ting Hung
• LB237 · PDF 高分辨率空间转录组学鉴定从不吸烟者肺腺癌中独特的空间程序 High-resolution spatial transcriptomics identifies unique spatial programs in lung adenocarcinoma from never smokers Wei Zhao, Aaron Rozeboom, Phuc H. Hoang, Tam-Anh Tran, Maria Teresa Landi
• LB238 · PDF 空间转录组学鉴定非裔美国女性子宫内膜癌中独特的分子和免疫通路 Spatial transcriptomics identifies distinct molecular and immune pathways in endometrial cancer in African American women Danyelle Hill, Yuxin Jin, Javier Arias-Stella, Joseph Carlson, David Craig, Rania Bassiouni, John Carpten
• LB239 · PDF 结直肠癌中癌相关成纤维细胞与正常成纤维细胞的空间程序随错配修复状态而分化 Spatial programs of cancer-associated and normal fibroblasts diverges with mismatch repair status in colorectal cancer Debanjan Barua, Tze Guan Tan, Shu Wen Samantha Ho, Michael T. Wong, Iain B. H. Tan, Jennifer H. Yearley, Su-Yang Liu
• LB240 · PDF 组织驻留记忆T细胞的交叉验证空间结构可预测鼻咽癌的复发模式 Cross-validated spatial architecture of tissue-resident memory T-cells predicts recurrence pattern in nasopharyngeal carcinoma Ngar-Woon (Yvonne) Kam, Pak Hei, Syrus Lai, Cho Yiu Lau, Wei Dai, Dora Lai Wan Kwong, Victor Ho Fun Lee
• LB241 · PDF 构建乳腺脂肪-癌共培养模型以解析脂质异质性对三阴性乳腺癌的影响 Development of breast adipose-cancer co-culture model to decipher the impact of lipid heterogeneity on triple-negative breast cancer Khudeja Salim, Elnaz Sheikh, Jorge A. Belgodere, Bridgette M. Collins Burow, Van H. Barnes, Manas R. Gartia, Matthew E. Burow, Elizabeth C. Martin
• LB243 · PDF 靶向产生eRNA的超级增强子可将不可成药的调控枢纽转化为癌相关成纤维细胞中的治疗靶点 Targeting eRNA-producing super-enhancers converts undruggable regulatory hubs into therapeutic targets in cancer-associated fibroblasts So-Young Yeo, Keun-Woo Lee, Insuk Sohn, In Gu Do, Hyung Ook Kim, Jae Woo Kwon
• LB244 · PDF 骨硬化与前列腺癌骨转移中低度间变性组织学模式相关 Osteosclerosis is associated to low anaplastic histological patterns in prostate cancer bone metastasis Felipe Eltit Guersetti, Bita Mojtahedzadeh, Dennis Xie, Sara Koohbor, Eva Corey, Michael E. Haffner, Colm Morrissey, Michael E. Cox
• LB245 · PDF 胶原重塑促进ADGRG1+ CD8+ T细胞中一种GPCR介导的机械感觉免疫检查点并作为免疫治疗应答的空间生物标志物 Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy Sonal Srivastava, John J. Powers, Jay H. Mehta, Sadegh Marban, Ryunosuke Nozaki, Laxmi Swetha Karanam, Jacob Torrez, Harish S. Bharambe, Farhoud Faraji, Ritu Chaudhary, Pino Bordignon, Jacqueline Giliberti, Robbert J. C. Slebos, Joseph O. Johnson, Chandler Gantenbee, Xiaofei Song, Marco Cassano, Jose A. Guevara-Patino, Duy T. Nguyen, Alexander R. A. Anderson, Mitsuo Yamauchi, Jeffery West, J. Silvio Gutkind, Christine H. Chung, Antonio L. Amelio
• LB246 · PDF 新辅助雄激素信号抑制促进前列腺癌肿瘤中混合型基底/club样癌身份细胞的出现 Neoadjuvant androgen signaling inhibition promotes the emergence of mixed basal/club-like cancer identity cells in prostate cancer tumors Antti Kiviaho, Thomas Cecchetto, Sini K. Eerola, Mazlina Ismail, Charles T.A. Parker, Alexander Giesen, Anni Perämäki, Sini Hakkola, Jasper van Goubergen, Steven Joniau, Tapio Visakorpi, Mikael Marttinen, Kirsi J. Rautajoki, Frank Claessens, Gerhardt Attard, Alfonso Urbanucci, Matti Nykter
• LB248 LB248 开发用于疗法测试的器官型患者来源卵巢癌模型 Development of organotypic patient-derived ovarian cancer model for therapy testing Iris Schilt, Sander de Ruiter, Masato Ohbuchi, Marjolein Vermeer, Johnny Suijker, Aleksandra Olczyk, Thomas Olivier, Orsola Mocellin, Paul Vulto, Jos Joore, Henriëtte Lanz, Bart Kramer, Karla Queiroz, Shinsuke Oshima, Ryuichi Moriya

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