Natural Products

• 3642 · PDF 辣椒素纳米颗粒使人肺鳞状细胞癌对紫杉醇的生长抑制活性增敏 Capsaicin-nanoparticles sensitize human squamous cell lung cancer towards the growth-inhibitory activity of paclitaxel Amanda M. Sugrue, Kushal J. Modi, Reagan S. Light, Kaitlyn B. Conley, Sarah L. Miles, Piyali Dasgupta
• 3643 · PDF 放线菌素D与白藜芦醇联合可对消化呼吸道癌产生协同抗癌活性 The combination of actinomycin D and resveratrol induces synergistic anticancer activities against aerodigestive tract cancers Raji M. Lukmon, Jihan F. Amin, A.R.M. Ruhul Amin
• 3644 · PDF 色霉素A2通过整合的自噬和凋亡程序破坏白血病细胞活力 Chromomycin A2 disrupts leukemia cell viability via integrated autophagic and apoptotic programs Keli Lima, Emilly O. Vieira, Rita C. Cavaglieri, Frederico L. Nogueira, Glaucia M. Machado-Santelli, Leticia V. Costa-Lotufo, Eduardo M. Rego, João A. Machado-Neto
• 3646 · PDF 橄榄苦苷和石榴酸对MCF-7细胞毒性的差异机制及氧化应激与过氧化物还原酶抗氧化剂的作用 Differential mechanisms of MCF-7 cytotoxicity by oleuropein and punicic acid and the role of oxidative stress and peroxiredoxin antioxidants Samantha Diiorio, Braden Quitmeyer, Shelley A. Phelan
• 3647 3647 将最优合成的槲皮素类似物与BRAF抑制剂联合作为治疗黑色素瘤的新型协同方法 Combining optimally synthesized quercetin analogs with BRAF inhibitors as a novel synergistic approach to treat melanoma Ahlam Armaly, Paige Toran, Victoria Del Gaizo Moore
• 3648 · PDF 木犀草素抑制DNA甲基转移酶1和alpha 6-整合素基因表达以抑制西非血统患者乳腺癌细胞的增殖和干性 Luteolin inhibits DNA methyltransferase 1 and alpha 6-integrin gene expression to suppress proliferation and stemness in breast cancer cells from patients of West African ancestry Michael H. Hall, Mya St. Louis, Ozichi Amobi, John Olanrewaju, Shawneee Angeloni, Ubaldo Soto, Eileen Brantley
• 3649 · PDF 天然产物高通量筛选发现核糖体生物合成抑制剂 High-throughput screening of natural products discovers inhibitors of ribosome biogenesis Garrett Kimble, Michael Buszczak, Mark J. Henderson, Vincent Tagliabracci, Monagna Jarajapu, Bruce Posner, Barry R. O'Keefe, Sara Sanders
• 3650 · PDF 评估雷公藤红素在异基因造血干细胞移植后小鼠急性移植物抗宿主病中的免疫调节作用 Evaluating the immunomodulatory role of celastrol in murine acute graft versus host disease after allogeneic hematopoietic stem cell transplantation Tara Chand Yadav, Yogamaya Divakar Prabhu, Vasantharaja Raguraman, Shanid Mohiyuddin, Venkatesh Rajamanickam, Ibrahim Mohammed, Deepthi Rao, Gerhard C. Hildebrandt, Senthilnathan Palaniyandi
• 3651 · PDF 鼠尾草酸在NSCLC细胞中诱导ROS并激活ASK1信号通路 Carnosic acid induces ROS and activates ASK1 signalling in NSCLC cells Eric J. O'Neill, Evangelia Tsiani
• 3652 · PDF 百里醌通过改变新型circRNA和miRNA抑制胰腺导管腺癌的生长 Thymoquinone blocks pancreatic ductal adenocarcinoma growth by altering novel circRNAs and miRNAs Bin Bao, Irfana Muqbil, Md Hafiz Uddin, Yang Shi, Yin Wan, Adeeb Aboukameel, Ramzi M. Mohammad
• 3653 · PDF 针对5-脂氧合酶(5-LOX)和mPGES1促炎靶点的天然产物文库筛选以用于CRC阻断 Screening of natural products library against 5-lipoxygenase (5-LOX) and mPGES1 proinflammatory targets for CRC interception Krishnendu Goswami, Nataliya Smith, Ravi Manjhi, Gopal Pathuri, Brandon Somerville, Yurong Song, Venkateshwar Madka, Kajal Biswas, Altaf Mohammed, Robert H. Shoemaker, Matthew J. Hart, Chinthalapally V. Rao
• 3654 3654 来源于黑豆的植物外泌体用于对抗胰腺癌和结肠癌细胞 Plant-derived exosomes from black soybeans for combatting pancreatic and colon cancer cells Zhangzhu Ruixian, Makiko Nakahana, Yasuyuki Shimizu, Mohammed Salah, Hiroaki Akasaka, Hiroki Kawaguchi, Tomoya Ishida, Qin Qin, Qu Zhang, Takeaki Ishihara, Daisuke Miyawaki, Ryohei Sasaki
• 3655 · PDF 一种生物活性大麻来源提取物REPYR-SC1对前列腺癌的剂量依赖性抗增殖活性 Dose-dependent anti-proliferative activity of a bioactive hemp-derived extract REPYR-SC1 against prostate cancer Joel Costoya, Joaquin J. Jimenez
• 3656 · PDF 穿心莲内酯的A环类似物抑制wnt1信号并在乳腺癌和结直肠癌模型中表现出强效抗癌活性 A-ring analogs of Andrographolide inhibit wnt1 signaling and exhibit potent anticancer activity in breast and colorectal cancer models Rushika Raval, Selina Xi, Ruirui Liu, Abigail Yee, Aileen Pak, Edward Njoo, Gary Johanning, Feng Wang-Johanning
• 3657 · PDF 用于体外和体内治疗实体瘤的海葱苷A糖基类似物的临床前发现 Preclinical discovery of proscillaridin A glycan analogs for the in vitro and in vivo treatment of solid tumors Shreya Somani, Lekhya Menta, Gary Johanning, Feng Wang-Johanning, Edward Njoo
• 3658 · PDF 鬼臼毒素的C-4类似物抑制微管蛋白聚合:用于发现癌症抗有丝分裂疗法的可推广平台 C-4 analogs of podophyllotoxin inhibit tubulin polymerization: A generalizable platform for the discovery of antimitotic therapeutics for cancer Shreya Somani, Stella Yang, Lekhya Menta, Yining Xie, Anna Gribok, Evy Hsen, Edward Njoo, Gary Johanning, Feng Wang-Johanning
• 3659 · PDF 槲皮素在多种人类癌细胞系中对内源性膜结合TRAIL的异质性表达及癌症选择性调控 Heterogeneous expression and cancer-selective regulation of endogenous membrane TRAIL by quercetin across various human cancer cell lines Erin Marie Thorpe, Candece L. Gladson, Michael Kalafatis, Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, OH
• 3660 · PDF 网络药理学揭示穿心莲联合乳铁蛋白治疗胰腺癌的功能成分与分子机制 Network pharmacology reveals functional components and molecular mechanisms of andrographis combined with lactoferrin in pancreatic cancer treatment Yuan Li, Wenhao Weng, Ajay Goel
• 3661 · PDF 发现红厚壳（Spondias mombin）黄酮类化合物芦丁作为一种新型DNA甲基转移酶1抑制剂及治疗西非血统患者三阴性乳腺癌的潜在药物 Discovery of Spondias mombin flavonoid rutin as a novel DNA methyltransferase 1 inhibitor and potential agent to treat triple negative breast cancer in patients of West African ancestry Afees John Olanrewaju, Elyssa Fraser, Joseph Enya, Leviticus Arietarhire, Ezekiel Olugbogi, Toluwanimi Afolabi, Oladimeji Soremekun, Michael Hall, Ozichi Amobi, Victor Chinedu, John Khalaf, Jonathan De Anda, Shawnee Angeloni, Ubaldo Soto, Eileen J. Brantley
• 3662 · PDF 天然化合物的活性谱分析鉴定出在亲本和耐药淋巴瘤模型中均具活性的强效化学型 Activity profiling of natural compounds identifies potent chemotypes active in parental and drug-resistant lymphoma models Filippo Spriano, Francesca Ghirga, Deborah Quaglio, Mattia Mori, Alberto J. Arribas, Bruno Botta, Francesco Bertoni
• 3663 · PDF B细胞淋巴瘤中的抗增殖筛选：加纳药用植物及其植物化学关联 Antiproliferative screening in B cell lymphoma: Ghanaian medicinal plants and their phytochemical correlates Filippo Spriano, Alberto J. Arribas, Alberto Furlan, Johnson Nketiah, Barbara Z. Anibea, Andrea Cavalli, Afua A. Mensah, Dorcas Osei-Safo, Francesco Bertoni
• 3664 · PDF 一种新型四味中药复方抑制三阴性乳腺癌的转移 A novel 4-herb traditional Chinese medicine formula inhibits metastasis of triple-negative breast cancer Longling Wang, Julia K.M. Lee, Judy Y.W. Chan, Zhong Zuo, Kenneth K.W. To
• 3665 · PDF 来源于橄榄叶的酚类化合物橄榄苦苷在MDA-MB-231乳腺癌细胞中发挥细胞毒性并诱导过氧化物还原酶 Oleuropein, a phenolic compound from olive leaves, exerts cytotoxicity and peroxiredoxin induction in MDA-MB-231 breast cancer cells Giovanna Kalin, Adam Vaz, Shelley A. Phelan
• 3666 · PDF 咖啡二萜类化合物咖啡醇乙酸酯和咖啡豆醇对紫杉烷耐药性及神经内分泌性前列腺癌细胞的抗肿瘤作用 Antitumor effects of coffee diterpenes, kahweol acetate and cafestol, on taxane-resistant and neuroendocrine prostate cancer cells Tomohiro Hori, Hiroaki Iwamoto, Taiki Kamjima, Hiroshi Kano, Makino Tomoyuki, Renato Naito, Hiroshi Yaegashi, Kazuyoshi Shigehara, Takahiro Nohara, Kouji Izumi, Atsushi Mizokami
• 3667 · PDF 新橙皮苷二氢查耳酮：一种新型的天然铁死亡抑制剂 Neohesperidin dihydrochalcone: A novel natural inhibitor of ferroptosis Bomi Han, Yi-Xi Gong, Seonghye Son, Eui Man Jeong
• 3668 3668 利用海马齿（Carpobrotus edulis）甲醇提取物靶向凋亡机制以抑制胰腺癌生长 Targeting apoptotic machinery using methanolic extracts of Carpobrotus edulis to suppress pancreatic cancer growth Lesetja Motadi, Ronald Makalapetlo
• 3669 · PDF 橄榄苦苷通过直接抑制 PKA 和 ERK 介导的周转下调黑色素瘤中的 MITF Oleuropein downregulates MITF via direct PKA inhibition and ERK-mediated turnover in melanoma Ingyu Lee, Jihye Kim, Yi-Xi Gong, Eui Man Jeong
• 3670 · PDF β-内酰胺——天然产物的结构类似物——作为抗胰腺癌药物：一项初步研究 Beta-lactams, structural mimics of natural products, as anti-pancreatic cancer agents: A pilot study Debasish Bandyopadhyay, Tushar Debnath, Attrayo Mukherjee, Jonathan Rock, Omar Espino, Vivek Kumar Kashyap, Subhash C. Chauhan

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