Adoptive Cell Therapy 1

• 3699 · PDF “保存与扩增”流程：通过实现种子细胞的长期冷冻保存来提高自体肿瘤浸润淋巴细胞疗法可及性的关键里程碑 The "Preservation & Expansion" process: A key milestone for enhancing accessibility of autologous tumor-infiltrating lymphocyte therapy by enabling long-term cryopreservation of seed cells Zhou He, Xingming Ma, Feng Yin, Shanshan Liang, Wenjia Zhuang, Hui Yan, Huajun Jin
• 3700 · PDF 通过自分泌饲养信号改造iPSC来源的NK细胞以增强细胞毒功能 Engineering iPSC-derived NK cells with autocrine feeder signaling to enhance cytotoxic function Yi-Chen Sun, Zhi-Qian Lin, Chieh-Min Ｗang, Yun-Yi Yang, Yi-Ping Yang, Kai-Feng Hung
• 3701 · PDF CAR T细胞治疗在中枢神经系统淋巴瘤中的安全性和疗效：一项荟萃分析 Safety and efficacy of CAR T-cell therapy in CNS lymphoma: A meta-analysis Ahmad Shawabkeh, Muaath I. Alsufi, Homam AbuHashesh, Heba Khreisat, Zaid Muhanna, Salma Salman, Ahmad Obeid, Layan AlDaher, Jehad Yasin
• 3702 · PDF 地塞米松对体外及RRMM患者体内CAR-T细胞扩增无影响 No impact of dexamethasone on CAR-T cell expansion in vitro and in patients with RRMM Lelisa Gemta, Lawrence P. Andrews, Matthew J. Frigault, Binod Dhakal, Jacalyn Rosenblatt, Michael R. Bishop, Sigal Shachar, Jenny Mu
• 3703 · PDF 前哨淋巴结来源的CD45⁺细胞联合低剂量放疗和PD-1阻断作为头颈癌的新一代过继细胞疗法 Sentinel lymph node-derived CD45⁺ cells combined with low-dose radiotherapy and PD-1 blockade as a next-generation adoptive cell therapy in head and neck cancer Pardis Mohammadzadeh, Tomoya Kurokawa, Kelsey Decker, Peter Vo, Prakriti Sen, Riley N. Jones, Sayuri Miyauchi, Santiago Fassardi, Anais Zourelidis, Robert Saddawi-Konefka, Joseph A. Califano
• 3704 3704 使用基于仿生AeroCyte的人工抗原呈递细胞平台实现功能性CAR-T细胞的长期离体扩增 Long-term ex vivo expansion of functional CAR-T cells using the biomimetic AeroCyte-based artificial antigen-presenting cell platform Yu-Tsueng Liu, Mindy Yin, Guixin Shi
• 3705 · PDF 整合亲和力依赖性调控与CD5/TRAC敲除生成抗自相残杀且高细胞毒性的抗CD5 CAR-T细胞 Integration of affinity-dependent modulation and CD5/TRAC knockout generates fratricide-resistant and highly cytotoxic anti-CD5 CAR-T cells Seojeong Kim, Jeong Hoon Jeong, Jihyun Park, Youngho Lee, Hyung Cheol Kim, Hyoung Jin Kang, Matthew H. Porteus, Steven Feldman, Youngil Koh
• 3706 · PDF IL-2输注次数和产品不合格状态对黑色素瘤肿瘤浸润淋巴细胞治疗结局的影响 Impact of number of IL-2 infusions and product out of specification status on outcomes of tumor infiltrating lymphocyte therapy for melanoma Mohamed A. Aboelatta, Jeffrey E. Johnson, Jabra G. Zarka, Matyáš Benada, James W. Jakub, Roxana S. Dronca, Ruqin Chen, Mahesh Seetharam, Deepti Behl, Svetomir N. Markovic, Lisa A. Kottschade, Heather N. Montane, Matthew S. Block, Anastasios Dimou, Robert R. McWilliams, Paula Gill, Yi Lin, Arkadiusz Z. Dudek
• 3707 · PDF 通过PHOX2B衍生肽-HLA导向的CAR T细胞实现高危和难治性神经母细胞瘤的持久缓解：一项IND支持性研究 Durable remission of high-risk and refractory neuroblastoma by PHOX2B derived peptide-HLA directed CAR T cells: An IND enabling study Muzamil Y. Want, Richa Kapoor, David Groff, Keelan O’Reilly, Liron Grossmann, Alvin Farrel, Rebeca A. Ventura, Peiyao Li, Quinlen Marshall, Jenny pogoriler, Daniel Martinez, Matt Beasley, Ben Kiefel, Mark Yarmarkovich, John Maris
• 3708 · PDF 利用膜锚定工程化细胞因子激动剂改善抗肿瘤T细胞疗法 Improving antitumor T cell therapy with membrane-tethered engineered cytokine agonists Diana Gumber, Saul Priceman, Christine E. Brown, Leo D. Wang
• 3709 · PDF 一种同类首创的红细胞-抗PD-1偶联物克服泛实体瘤的免疫治疗耐药：一项I期试验 A first-in-class Erythrocyte-anti-PD-1 conjugate overcomes immunotherapy resistance across pan-solid tumors: A phase I trial Xiaoqian Nie, Liu Yang, Kurban Mattursun, Zheling Chen, Xiaofei Gao
• 3710 · PDF 改良并验证一种用于检测治疗性细胞中免疫屏蔽基因修饰的人源化小鼠模型 Adapting and validating a humanized mouse model for testing of immune-shielded genetic modifications in therapeutic cells Mino Yakoub, Katrin Ridders, Henning Jelten, Audrey Holtzinger, Matthias Austen, Claudia Wrzos
• 3711 · PDF 通过基于细胞表面标志物的分选富集CD8+和CD4+新抗原反应性肿瘤浸润淋巴细胞 Enriching CD8+ and CD4+ neoantigen-reactive tumor infiltrating lymphocytes by cell surface marker-based sorting Lisa M. Kenney, Nivedita Ratnam, Abraham A. Hakim, Juliette Rault-Wang, Steven A. Rosenberg, Frank J. Lowery
• 3712 · PDF 多效性氧化碳纳米酶通过氧化还原调节重编程CAR T细胞代谢以增强其持久性 Pleiotropic oxidized carbon nanozymes reprogram CAR T cell metabolism to enhance persistence through redox modulation Kevin Song, Yue Hu, Paul Derry, Thomas Kent, Xiaotong Song
• 3713 · PDF 用于评估HER2 CAR T细胞介导的癌细胞杀伤的荧光效力检测 Fluorescence potency assays for evaluating HER2 CAR T-cell-mediated killing in cancer cells Danny Flanigan, Nathalie Opdam - van de Laar, Denise Sullivan, DANIEL MILLARD, STACIE CHVATAL
• 3714 · PDF 通过免疫肽组学发现胎儿WNT相关抗原NKD1使HLA-A2+限制性TCR-T疗法治疗MSS mCRC成为可能 Immunopeptidomic discovery of fetal WNT-associated antigen NKD1 enables HLA-A2+ restricted TCR-T therapy for MSS mCRC Jaeyop Lee, Swara Patel, Iñaki Etxeberria, Elizabeth Benitez, Jura Pintar, Andres Rettig, Christopher Cowley, Stefanie Gerstberger, Kathleen Luckett, Asha Saxena, Zita Aretz, Tatyana Korontsvit, Zhuoning Li, Kevin Soares, Emmanouil Pappou, T. Peter Kingham, William Jarnagin, Philip B. Paty, Martin R. Weiser, Michael D’Angelica, Julio Garcia-Aguilar, Jinru Shia, Mara Monetti, Christopher A. Klebanoff, Karuna Ganesh, David A. Scheinberg
• 3715 · PDF 基于表观遗传和信号传导的工程化改造增强眼-脑淋巴瘤中的CAR-T细胞功能 Epigenetic and signaling-based engineering enhances CAR-T cell function in oculo-cerebral lymphoma Marion Alcantara, Jaime Fuentealba, Silvia Menegatti, Anne-Laure Privat, Lisseth Silva, Kyle Raymond, Daniel De Murat, Valentine Pottez Jouatte, Lamia Lamrani, Zélia Gouveia, Denis Malaise, Carole Soussain, Sebastian Amigorena
• 3716 · PDF 利用活化的自然杀伤细胞及抗肿瘤应答对肝细胞癌进行调节性免疫治疗 Regulatory immunotherapy utilizing activated natural killer cells and antitumor response for hepatocellular carcinoma Ola Sayed Ahmed, Refaat Gabre, Amr Iamail Abdelraouf, Hisham Imam, Maha Genhia
• 3717 · PDF 利用脂质纳米颗粒和环状RNA对小细胞肺癌进行DLL3靶向体内CAR-T治疗 DLL3-targeted in vivo CAR-T therapy of small cell lung cancer with lipid nanoparticles and circular RNA Yishan Ma, Jingsheng Cai, Yufei Xia, Xiaonan Huang, Mantang Qiu
• 3718 · PDF CAR检测试剂——引领CAR T分析技术的进步 CAR Detection Reagents - Pioneering advances in CAR T analytics Stephan Wilmes, Desiré Missing, Anja Brauchle, Nadine Borgelt, Johanna Müllers, Monika Winkels, Larissa Möckel, Michaela Niemöller, Dagmar Häußler-Kuballa, Franziska Antonia Bertram, Olga Goldbach, Dominik Poschen, Astrid Imann, Silvia Rüberg, Anijutta Appelshoffer, Fabio El Yassouri, Marsilius Mues, Volker Nölle, Andreas Bosio, Christian Dose, Anne Richter
• 3719 · PDF 从基因到临床：Mayo Clinic首个自主研发的BAFF-R CAR-T From gene to bedside: Mayo Clinic's first-in-house BAFF-R CAR-T Yan Luo, Shaohua Guo, Yaqing Qie, Martha E. Gadd, Tanya Hundal, Hemant S. Murthy, Mohamed A. Kharfan-Dabaja, Hong Qin
• 3720 · PDF Nectin-4靶向CAR-NK细胞对膀胱癌表现出强效抗肿瘤活性 Nectin-4-targeted CAR-NK cells exhibit potent antitumor activity against bladder cancer Mohammad Mousaei Ghasroldasht, Piyush K. Agarwal
• 3721 · PDF KSQ-001EX（一种SOCS1编辑的eTIL®治疗）的抗肿瘤功能和长期持久性，独立于IL-2共同给药 Anti-tumor function and long-term persistence of KSQ-001EX, a SOCS1-edited eTIL® therapy, independent of IL-2 co-administration Dipen Sangurdekar, Erica Tobin, Karrie Wong, Ashish Yeri, Alex Smashnov, Kelly Bowen, Giorgio Sarkis, Violetta Medik, Hsinyi Lu, Sevinj Isgandarova, Michelle Carrasco, Patricia Harris, Cara L. Haymaker, Micah Benson, Anna Truppel-Hartmann, Rodabe N. Amaria
• 3722 · PDF CD87靶向CAR-T治疗结直肠癌的临床前开发与评估 Preclinical development and evaluation of CD87-directed CART for colorectal cancer Andrea Feci, Trevor Baybutt, Robert Carlson, Emmett Grover, Jagmohan Singh, Ross Staudt, Miao Cao, Edoardo Manca, Jasmine Alvarez, Scott A. Waldman, Adam Snook
• 3723 · PDF 利用多模态2D和3D成像方法评估离体CAR-T细胞的细胞毒性和浸润 Evaluation of ex vivo CAR-T cell cytotoxicity and infiltration using multimodal 2-D and 3-D imaging approaches Catherine McManus, John G. Foulke, Meghan Sikes, Luping Chen, Hyeyoun Chang, Fang Tian
• 3724 · PDF 外源性IL-2给药可提升循环T细胞水平、持久性及异体UCART20x22在B细胞淋巴瘤小鼠模型中的治疗疗效 Exogenous IL-2 administration promotes circulating T-cell levels, persistence and therapeutic efficacy of allogeneic UCART20x22 in a B-cell lymphoma mouse model Shipra Das, Hana Cho, Marco Rotondi, Isabelle Chion-Sotinel, Margaux Sevin, Vivian Dai, Jean-Charles Epinat, Roman Galetto, Laurent Poirot, Adrian Kilcoyne
• 3725 · PDF 干细胞来源的异体抗CD19 CAR-iNKT细胞疗法GT719用于复发/难治性B细胞恶性肿瘤 Stem cell-derived allogeneic anti-CD19 CAR-iNKT cell therapy GT719 for relapsed/refractory B cell malignancies Dehui Zou, Wei Liu, Yan Yu, Huimin Liu, Yi Wang, Sisi Feng, Xiaona Xu, He Zhang, Ershao Zhang, Jiang Li, Jingman Wang, Jing Hao, Ning Wang, Huipin Zheng, Yin Cheng, Jun Cui, Jingwei Sun, Yarong Liu

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