PO.ET02.12 · 实验与分子治疗
Novel Therapeutics and Drug Targets 2
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3073 · PDF Dickkopf1作为高度侵袭性乳腺癌的潜在治疗靶点 Dickkopf1 as a potential therapeutic target in highly aggressive breast cancers Mohd Mughees, Jian Wang, Wendy A. Woodward, Megumi Kai, MDACC IBC Team, Sharon H. Giordano, Chandra Bartholomeusz
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3074 · PDF 一种首创的ER应激调节剂选择性诱导STK11/TP53缺陷型癌细胞的调节性细胞死亡 A first-in-class ER stress modulator selectively induces regulated cell death of STK11/TP53-deficient cancer cells Ying-Jie Wang, Xiaobing Zhang, Wei Jia, Bo Kang, Zhao Xu, Mingxing Yin, Hongban Zhong
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3075 · PDF FGFR2b是肝内胆管癌中一个高度普遍且可成药的细胞表面靶点 FGFR2b is a highly prevalent and actionable cell surface target in intrahepatic cholangiocarcinoma Nakul M. Shah, Beatriz Alvarado-Hernandez, Xinyue Chen, Quentin Kimana, Felicity Namayanja, Wei Lu, Khaja B Khan, Juan Gallegos, Sangeeta Goswami, Lawrence N. Kwong, Luisa M. Solis Soto, Milind M. Javle, Sachet A. Shukla
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3076 · PDF 用于治疗食管腺癌的SIX1特异性PROTAC的开发 Development of a SIX1-specific PROTAC for the treatment of esophageal adenocarcinoma Asad Faili, Vic Scharfenberger, Ellen Weber, Samaneh Heydarzadeh, Reinhard Buettner, Tristan Lerbs
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3077 · PDF 一种新型MMP靶向肽通过降低MSI1活性抑制胶质母细胞瘤转移 A novel MMP-targeting peptide suppresses glioblastoma metastasis by reducing MSI1 activity Xian Liu, Liang-Ting Lin
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3078 · PDF 靶向TGFBR2的非经典neddylation修饰抑制口腔鳞状细胞癌的转移潜能 Targeting the non-canonical neddylation of TGRBR2 suppresses the metastatic potentials of oral squamous cell carcinoma Yuan-Feng Lin
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3079 · PDF 发现一种具有抗肿瘤活性的新型共价异双功能硫氧还蛋白还原酶抑制剂 Discovery of a novel, covalent and heterobifunctional thioredoxin reductase inhibitor with antitumor activity Yanyan Han, Nicholas Blazanin, Sasi Kotagiri, Md Qudratullah, Xiaobing Liang, Yonathan Lissanu
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3080 · PDF CPL976H-MMAE的位点特异性偶联实现对PD-L1和AXL稳定而选择性的双重靶向 Site-specific conjugation of CPL976H-MMAE enables stable and selective dual targeting of PD-L1 and AXL Delfina Popiel, Filip Mitula, Anna Jablonska, Krzysztof Lacek, Natalia Czerwinska, Tomasz Kornatowski, Magdalena Langowska, Sylwia Wieczorek, Bartosz Wiernicki, Damian Kolakowski, Adam Zmyslowski, Tomasz Banach, Joanna Deshayes, Michal Mroczkiewicz, Marcin Zagozda, Joanna Hucz-Kalitowska, Emilia Mroz, Malgorzata Choros, Maciej Wieczorek, Olga Abramczyk
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3081 · PDF IAG933抑制TEAD作为胆管癌的一种新型治疗策略 TEAD inhibition by IAG933 as a novel therapeutic strategy for cholangiocarcinoma Hidemi Nishi, Erik Jessen, Danielle M. Carlson, Amro M. Abdelrahman, Enis H. Ozmert, J. Pedro Fincatto Safi, Brandon A. Wilbanks, Shelby K. Yee, Jack W. Sample, Nathan W. Werneburg, Rory L. Smoot
- 3082 3082 一种新型iNOS抑制剂作为炎性乳腺癌的靶向治疗策略 A novel iNOS inhibitor as a targeted therapeutic approach for inflammatory breast cancer Karina Ortega Martinez, Maria Florencia Chervo, Feng Li, Jenying Deng, Liliana Guzman-Rojas, Wei Qian, Jianying Zhou, Recep Bayraktar, Aireana Phillips, Ivonne Uzair, Mailin Li, Aijun Zhang, Spencer Hankins, Dale Hamilton, Zhonglin Liu, Christopher Lincoln, Christoforos Thomas, Jenny C. Chang
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3083 · PDF YT-DP:一种基于糖偶联的双载荷ADC平台 YT-DP: A glyco-conjugation-based dual-payloads ADC platform Yi Yang, Zhentao Song, Rui Yu, Jiangping Hu, Zhouyang Qian, Xinyue He, Guoli Yang, Ji Chen, Juntao Yu
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3084 · PDF 基于网络的肿瘤检查点反转药物发现:靶向胰腺导管腺癌细胞状态与巨噬细胞重编程 Network-based discovery of tumor-checkpoint inverter drugs targeting pancreatic ductal adenocarcinoma cell states and macrophage reprogramming Yining Chen, Alvaro Curiel-Garcia, Alex Piacentini, Zhouzerui Liu, Tim Olsen, Richard Yau, Praveer Sharma, Liz Murray, Gaetano Viscido, Ken Olive, Andrea Califano
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3085 · PDF 小分子JKYN-1抑制DNA修复蛋白RAD51的分子表征 Molecular characterization of inhibition of the DNA repair protein RAD51 by the small molecule JKYN-1 Peter Ferguson, Mark Vincent, Yousef Najajreh, Morgan Black, Sweta Sharma Saha, Melissa Thomas, Olivier Lord, Stephen Ritter, Jean-Yves Masson, Brian Shilton, James Koropatnick
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3086 · PDF ART1作为EGFR突变型肺癌中一种免疫调节治疗靶点 ART1 as an immune modulating therapeutic target in EGFR-mutated lung cancer Mimansa ., Rajika Jindani, Mukherjee Sumit, Jorge Quintero, Naresh Regmi, Grace Ha, Justin Olivera, Justin Rosario, Melissa Tracy, Brendan Mullaley, Victor Gray, Erik Wennerberg, Lindsay M. LaFave, Brendon Stiles
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3087 · PDF 靶向AURKA和TRIP13利用有丝分裂脆弱性并增强Rb缺陷型免疫健全肺癌模型中的抗肿瘤免疫 Targeting AURKA and TRIP13 exploits mitotic vulnerability and enhances antitumor immunity in Rb-deficient immunocompetent lung cancer models Soma Ghosh, Jennifer L. Anderson, Andrew G. Sikora, Faye M. Johnson
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3088 · PDF 靶向NONO作为转移性去势抵抗性前列腺癌(mCRPC)的治疗策略 Targeting NONO as a therapeutic strategy for metastatic castration-resistant prostate cancer (mCRPC) Brian McEllin, Gaelle Mercenne, Daniele Canzani, Gavin Hirst, Lindsay Pino, Alexander Joel Federation
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3089 · PDF 一种激活整合应激反应的新型天冬酰胺合成酶抑制剂的表征 Characterization of a novel inhibitor of asparagine synthetase that activates the integrated stress response Nicholas T. Walda, Lucciano A. Pearce, Nigel Richards, Wen Zhu, Yuichiro Takagi, Ronald C. Wek, Kirk A. Staschke
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3090 · PDF 抑制 VRK1 利用旁系同源基因合成致死效应选择性靶向 VRK2 缺陷的癌细胞 VRK1 inhibition leverages paralog synthetic lethality to selectively target VRK2-deficient cancer cells Kiera M. Vassallo, Kevin M. Cottrell, Katarzyna B. Handing, Mu-Sen Liu, Alvin Lu, Alice Tsai, Maria Dam Ferdinez, Patrick McCarren, Sirimas Sudsakorn, Jannik N. Andersen, Kimberly J. Briggs
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3091 · PDF 通过多样化的临床前策略探索 HLA-G 靶向疗法的抗肿瘤潜力 Exploring the anti-tumor potential of HLA-G-targeted therapeutics through diverse preclinical approaches Hyeonju Kang, Inyoung Lee, Sungyeon Park, Yoo jin Kim, Kyueun Cho, Hongjai Lee, Yiyoung Choi, Jiyeon Hong, Chihye Park, Chungmin Lee, Gyongsik Ha
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3092 · PDF 表皮调节素与双调蛋白作为结直肠癌的双重靶点 Epiregulin and amphiregulin as dual targets in colorectal cancer Cara Biddle-Guernsey, Joan Jacob, Zhengdong Liang, Kendra S. Carmon
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3093 · PDF SLC25A28 是核苷酸切除修复缺陷型癌症中的合成致死靶点 SLC25A28 is a synthetic lethal target in nucleotide excision repair-deficient cancer Nan Yang, Vijai Joseph, Lisa Hoeg, Xuechun Bai, Sizhi Gao, Ouathek Ouerfelli, David B. Solit, Jian Carrot-Zhang, Gopa Iyer, Daniel Durocher, Kent W. Mouw, Kenneth Offit, Steven M. Lipkin
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3094 · PDF 靶向 TUBB2B:利用三阴性乳腺癌的脑转移易感性 Targeting TUBB2B: Exploiting brain metastatic vulnerabilities in triple-negative breast cancer Qingling He, Jianyang Hu, Gary M. Tse, Julia Y. Tsang, Pui-Chi Lo, C Geoffrey Lau, Y Rebecca Chin
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3095 · PDF 优化药物载体上靶向分子的密度以改善细胞摄取 Optimizing targeting molecule density on drug carriers to improve cellular uptake Maria Lambros, Manjot Kaur
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3096 · PDF 水飞蓟宾通过调节 JAK1/STAT3 信号通路和抑制 MMP 水平在三阴性乳腺癌细胞中的抗癌作用 The anti-cancer effects of silibinin through the modulation of JAK1/STAT3 signaling and inhibition of MMPs levels in triple-negative breast cancer cells Shubham D. Mishra, Patricia Mendonca, Sukhmandeep Kaur, Karam F. a. Soliman
- 3097 3097 MBS309(一种 PD-1 靶向且 alpha 偏向的 IL-2)的临床前表征,展示出强效抗肿瘤活性和良好的安全性特征 Preclinical characterization of MBS309, a PD-1-targeted and alpha-biased IL-2, demonstrating robust anti-tumor activity and a favorable safety profile Jiangmei Li, Guangzhong Lin, Lunfeng Zhang, Shuo Huang, Shuang Qing, Feng Li, Mingze Sun, Hong Chen
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3098 · PDF RAD51抑制剂JKYN-1的发现及其在非小细胞肺癌临床前模型中抗癌活性的表征 Discovery of the RAD51 inhibitor JKYN-1 and characterization of its anticancer activity in preclinical models of non-small cell lung cancer Yifan Yu, Morgan Black, Nikolina Radulovich, Peter Ferguson, James Koropatnick, Ming Sound Tsao, Mark D. Vincent, Geoffrey Liu, Samir H. Barghout
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3099 · PDF 以ECI830选择性抑制CDK2:临床前表征、疗效,以及由生物标志物和基因特征分析支持的靶向机制 Selective CDK2 inhibition with ECI830: preclinical characterization, efficacy, and on-target mechanism supported by biomarker and gene signature analysis Ophelia Maertens, Bradley French, Eric Fang, Imad Hanna, Ying Huang, Sajan Joseph, Fallon Lin, Neil Umbreit, Anna Uvarova, Vivek Rauniyar, Samuel Ho