PO.ET03.04 · 实验与分子治疗
Overcoming Chemotherapy Resistance
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3101 · PDF 针对铂耐药上皮性卵巢癌的新型多肽结合剂的鉴定与表征 Identification and characterization of novel peptide binders against platinum resistant epithelial ovarian cancer Pritha Ray, Sreyashi Nath, Pranita Uttamrao Patil, Parijat Das, Prasenjit Bhaumik
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3102 · PDF YB-1小分子抑制剂提高化疗治疗高级别浆液性卵巢癌的成功率 YB-1 small-molecule inhibitor improves chemotherapy success in treating high-grade serous ovarian carcinoma Dhanir Tailor, Fernando J. Garcia-Marques, Abel Bermudez, Wenqi Li, Annah Rolig, Chia-Feng Tsai, Tao Liu, Tanja Pejovic, Sharon Pitteri, Sanjay V. Malhotra
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3103 · PDF 空间蛋白质组学揭示血管系统和免疫调节以克服乳腺癌中的多柔比星耐药 Spatial proteomics reveals vasculature and immune modulation for overcoming doxorubicin resistance in breast cancer Gautami Gaidhani, Juraj Jakubik, Leoni Moldaner, Yishu Xu, Zuzana Tatarova
- 3104 3104 皮肤鳞状细胞癌高可塑性细胞状态对化疗和免疫检查点抑制剂治疗反应的表征 Characterization of high plasticity cell states in cutaneous squamous cell carcinoma in response to chemotherapy and immune checkpoint inhibitor treatments Ramin Farhad, Di Wu, Mark A. Taylor, Allan Balmain, Rosemary J. Akhurst
- 3105 3105 Malformin A1通过调节致癌信号通路逆转卵巢癌的顺铂耐药 MalforminA1 reverts cisplatin resistance by modulating oncogenic signaling pathways in ovarian cancer Yahya Tamimi, Aikou Okamoto, Ikram Burney
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3106 · PDF OC201和OC202e——一种AI驱动的药物组合,通过调节HIF-1alpha增强胰腺癌对FOLFIRINOX的敏感性 OC201 and OC202e, an AI-driven drug combination, enhance the susceptibility of pancreatic cancer to FOLFIRINOX by modulating HIF-1alpha Yongjin Kim, Sewon Kim, Dong Sub Jung, So Jung Sung, Yenny Kim, Ki Sung Song, Hyemin Won, Yi Rang Kim, Jihoon Kang
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3107 · PDF CWH43 成为一个与结直肠癌化疗耐药相关的新型治疗靶点 CWH43 emerges as a novel therapeutic target linked to chemoresistance in colorectal cancer Yu-Jia Chang, Chien-Yu Huang, Po-Li Wei, Cheng-Chin Lee
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3108 · PDF LEDGF/p75 通过调节 JAK/STAT 通路驱动 CML 的化疗耐药 LEDGF/p75 drives chemoresistance in CML via JAK/STAT pathway modulation Thatcher Akele, Cecilia Iglesias-Herrero, Frauke Christ, Zeger Debyser
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3109 · PDF 细胞外基质聚糖特征可预测卵巢癌的化疗反应 Extracellular matrix glycan signatures predict chemotherapy response in ovarian cancer Erica J. Peterson, Ryan J. Weiss, James D. Hampton, Ava R. S. Beaudin, Thomas M. Clausen, Joseph B. M. Turner, Amrita Basu, Bin Hu, Jennifer E. Koblenski, Nicholas P. Farrell, Larisa Litovchick
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3110 · PDF 用 EC359 靶向 LIF/LIFR 信号可克服卵巢癌化疗耐药并增强化疗疗效 Targeting LIF/LIFR signaling with EC359 overcomes chemoresistance and enhances chemotherapy efficacy in ovarian cancer Sonal R. Chaudhari, Baskaran Subramani, Gaurav Sharma, William Cole Arnold, Durga Meenakshi Panneerdoss, Edward R. Kost, Bindhu Santhamma, Hareesh B. Nair, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
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3111 · PDF 胰腺癌细胞在营养受限和化疗应激下上调 NAD+ 生成 Pancreatic cancer cells elevate NAD+production in response to nutrient limitation and chemotherapeutic stress Faith Nakazzi, Mehrdad Zarei, Mariana Lopes, Hallie J. Graor, William C. Beegan, Eric Gu, Sakineh Rezaei, Peder J. Lund, Jordan M. Winter
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3112 · PDF 靶向卵巢癌的化疗耐药 Targeting chemoresistance in ovarian cancer Dhanamjai Penta, Vishal Chandra, Lauren Dockery, Rajani Rai
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3113 · PDF 慢性 1 型干扰素暴露在高级别浆液性卵巢癌中表型模拟慢性顺铂暴露 Chronic type 1 interferon exposure phenocopies chronic cisplatin exposure in high grade serous ovarian cancer Ashlyn Conant, Kiera McGivney, Tise Suzuki, Sharon Asariah, Brigitte Vazquez, Jay Deng, HyeonJoo Cheon, Juli Unternaehrer
- 3115 3115 RTF2 通过促进相分离介导的同源重组修复驱动结直肠癌奥沙利铂耐药 RTF2 drives oxaliplatin resistance in colorectal cancer by promoting phase separation-mediated homologous recombination repair Yiran Bie, Chong Chen, Haiqin Jiang, Zhizhong Xiong, Bin Zhong, Haoyang Xv, Yufeng Chen, Lei Lian, Xiaojian Wu, Peishan Hu
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3116 · PDF CDK4/6 抑制通过抑制 TYMS 驱动的 R-loop 相关 DNA 损伤克服结直肠癌中的 5-FU 耐药 CDK4/6 inhibition overcomes 5-FU resistance by suppressing TYMS-driven R-loop-associated DNA damage in colorectal cancer Lingling Xu, jiabei zhu, Jinghua Sun, Man Li, Ajay Goel
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3117 · PDF 界定核仁应激在介导 DDB2 诱导的结直肠癌奥沙利铂耐药中的作用 Defining the role of nucleolar stress in mediating DDB2 induced oxaliplatin resistance in colorectal cancer Vinod Kumar, Dennis Hsu, Orlando D. Schärer, Matthew A. Schaich, Katherine E. Helfrich, Simon C. Watkins, Bennett Van Houten
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3118 · PDF 二氯乙酸重编程代谢并破坏 ROS 适应,减弱干性以逆转卵巢癌化疗耐药 Dichloroacetate reprograms metabolism and disrupts ROS adaptation, attenuating stemness to reverse chemoresistance in ovarian cancer Yen Thi Do, Seungmee Lee, Shin-Wha Lee, Eun Ji Nam, Jin-Young Kim, Sojin Shin, Ji Hae Seo
- 3119 3119 利用患者来源类器官建模结直肠癌的化疗持留 Modeling chemotherapy persistence in colorectal cancer using patient-derived organoids Yasmine Abouleila, Timo Voskuilen, Mayke Doorn, Roel Verkerk, Jasmin Pourfarzad, Joris Maas, Robert G. J. Vries, Sylvia F. Boj
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3120 · PDF 利用全基因组 CRISPR 筛选鉴定克服横纹肌肉瘤化疗耐药的合成致死靶点 Using genome wide CRISPR screening to identify synthetic lethal targets for overcoming chemoresistance in rhabdomyosarcoma Aqsa Mazhar, Qian Wang, Satyanarayana Gadde, Daenikka Ravindraraja, Belamy B. Cheung, Glenn Marshall
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3121 · PDF METTL7B 驱动的 m6A RNA 甲基化促进胰腺导管腺癌的吉西他滨耐药和肿瘤进展 METTL7B-driven m6A RNA methylation promotes gemcitabine resistance and tumor progression in pancreatic ductal adenocarcinoma Tung-Wei Hsu, Wan-Yu Wang, Yen-Hao Su, Chih-Ming Su, Po-Chen Tseng, Hsin-An Chen
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3122 · PDF 急性淋巴细胞白血病中与化疗反应相关的基因调控网络的整合多组学研究 Integrative multi-omic investigation of gene regulatory networks associated with chemotherapy response in acute lymphoblastic leukemia Kelly R. Barnett, Robert J. Mobley, Wenjian Yang, Landon Choi, Kami Chauncy, Kristine R. Crews, Samuel W. Brady, Jun J. Yang, Daniel Savic
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3123 · PDF 通过他汀类药物再利用进行代谢重编程:逆转 Warburg 效应并克服胰腺导管腺癌吉西他滨耐药的策略 Metabolic reprogramming via statin repurposing: A strategy to reverse the Warburg effect and overcome gemcitabine resistance in pancreatic ductal adenocarcinoma Takayuki Noma, Mitsuo Shimada, Ajay Goel
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3124 · PDF SRSF1协调剪接导向的双引擎葡萄糖代谢,驱动糖尿病相关胰腺癌的化疗耐药 SRSF1 orchestrates splicing-directed dual-engine glucose metabolism driving chemoresistance in diabetes-associated pancreatic cancer Zu-Wei Wang, Yi-Ting Chen, Jin-Peng Lu, Shun-Can Zhu, Hong-Yi Lin, Yin-Hao Chen, Hao-Xiang Zhang, Shi Chen
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3125 · PDF 化疗耐药胶质瘤细胞中糖基化基因的转录组分析 Transcriptomic analysis of glycosylation genes in chemotherapeutic-resistant glioma cells Vi P. Dang, Nicole S. Lav, Alan Y. L. Jiang, Jaclyn N. Hanamoto, Daniela A. Bota, Lisa A. Flanagan
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3127 · PDF 克服化疗耐药:通过减轻内质网应激恢复耐药DLBCL细胞的多柔比星敏感性和自然杀伤细胞免疫 Overcoming chemoresistance: Restoring doxorubicin sensitivity and natural killer cell immunity in resistant DLBCL cells through reduction of endoplasmic reticulum stress Yi-Cheng Lin, Chih-Chi Andrew Hu, Chih-Hang A. Tang, Chun-Yu Cheryl Chuang, Chiung-Tong Chen
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3128 · PDF IDH1抑制增强吉西他滨在胰腺导管腺癌中的疗效 IDH1 inhibition potentiates gemcitabine efficacy in pancreatic ductal adenocarcinoma Yuan Li, Wenhao Weng, Ajay Goel
- 3129 3129 VLX1570抑制蛋白酶体相关DUB以靶向UCHL5/USP14并增强顺铂在神经母细胞瘤中的疗效 Proteasome-associated DUB inhibition by VLX1570 targets UCHL5/USP14 and enhances cisplatin efficacy in neuroblastoma Yi Ju Kao, Kuan-Lin Kuo, Chen-Hsun Hsu, Shih-Ming Liao, Po-Ming Chow, Kuo-How Huang