Novel Targets and Pathways

• 3040 · PDF FOXM1 作为 NF1 相关恶性周围神经鞘瘤的药物靶点 FOXM1 as a drug target in NF1-associated malignant peripheral nerve sheath tumors Ellen M. Voigt, Quinn Hanigan, Joshua J. Lingo, Altay Koyas, Rebecca D. Dodd, Benjamin W. Darbro, Dragana Kopanja, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Dawn E. Quelle
• 3041 · PDF 选择性 PARP2 抑制剂通过破坏 PARP2-FOXA1 相互作用抑制前列腺癌中的雄激素受体信号 Selective PARP2 inhibitor disrupting PARP2-FOXA1 interaction to inhibit androgen receptor signaling in prostate cancer Fu Gui, Wenfei Hu, Qi Miao, Zhi Tan, Mingxing Teng, Adam S. Kibel, Wei Zhang, Li Jia
• 3042 · PDF 葫芦素 B 通过靶向 PPAT 抑制从头嘌呤生物合成从而遏制食管鳞状细胞癌生长 Inhibition of d e novo purine biosynthesis via PPAT targeting by cucurbitacin B restrains esophageal squamous cell carcinoma growth Mengqiu Song, Jing Guo, Huajie Jia, Jie Tian, Pan Li, Zigang Dong
• 3043 · PDF 用一种新型小分子调控 CKAP2 可产生优异的体外和体内抗肿瘤活性 CKAP2 modulation with a novel small molecule results in excellent in-vitro and in-vivo anti tumor activity Deepa M. Sridharan, Vignesh Viswanathan, Dmitry Kuchenov, Quynh Mai, Yerem Yeghiazarians, Kurosh Ameri
• 3044 · PDF PKMYT1抑制与CCNE1过表达具有合成致死关系，并与标准治疗化疗产生协同作用 PKMYT1 inhibition is synthetically lethal with CCNE1 overexpression and synergizes with standard of care chemotherapy Natalie Hill, Jeremy Fournier, Srijita Bhowmik, Jenny Zhu, Saranya Chandrasekar, Ester Fernandez-Salas, Samantha S. Hodge
• 3045 · PDF TM4SF20作为支架介导DDR1-IRS4信号通路以驱动PDAC转移，并代表一个可成药的治疗靶点 TM4SF20 scaffolds DDR1-IRS4 signaling to drive PDAC metastasis and represents a druggable therapeutic target Xinyue Liu, Weishuai Liu, Antao Chang, Jihui Hao
• 3046 · PDF 新型PDE10抑制剂ADT-030通过阻断RAS和beta-catenin信号传导并克服对RAS选择性抑制剂的耐药性，增强化疗和免疫治疗的疗效，展现出稳健而持久的抗肿瘤活性 Robust and durable antitumor activity of a novel PDE10 inhibitor, ADT-030, that enhances the efficacy of chemotherapy and immunotherapy by blocking RAS and beta-catenin signaling and overcoming resistance to RAS-selective inhibitors Gary A. Piazza, Dhana Sekhar Reddy Bandi, Veronica Ramirez Alcantara, Ganji Purnachandra Nagaraju, Junwei Wang, Sindhu Ramesh, Kristy Berry, Khalda Fadlalla, Elmar Nurmemmedov, Ivan Babic, Md Yeashin Gazi, Xi Chen, Jeremy B Foote, Adam B Keeton, Yulia Y. Maxuitenko, Donald Buchsbaum, Fokhrul Hossain, Gang Zhou, Bassel F. El-Rayes
• 3047 · PDF 一种NVL小分子抑制剂通过阻断核糖体生物合成抑制肿瘤生长 A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis Arin B. Aurora, Holly H. Guo, Ye Tao, Victor E. Cruz, Min Fang, VIshal Khivansara, Shanhai Xie, Ashley Leach, Divya Reddy, Johann Peterson, Jiwoong Kim, Noelle S. Williams, Jan P. Erzberger, Jef K. De Brabander, Deepak Nijhawan
• 3048 · PDF Nesuparib在BRCA野生型胰腺癌异种移植模型中增强吉西他滨与白蛋白结合型紫杉醇的抗肿瘤疗效 Nesuparib enhances anti-tumor efficacy with gemcitabine and nab-paclitaxel in BRCA wild type pancreatic cancer xenograft model Banyoon Cheon, Jung-young Shin, Geon Kang, Dae In Park, John Kim, Hyunju Cha
• 3049 · PDF Atamparib：首创PARP7抑制剂，用于NSCLC腺癌的单药治疗及与标准治疗联合 Atamparib: First-in-class PARP7 inhibitor for treatment of NSCLC adenocarcinoma in monotherapy and in combination with standards of care Genny Degani, Federica Carbone, Patrizia Banfi, Laura Gianellini, Nilla Avanzi, Elena Casale, Marina Fasolini, Laura Riva, Gianluca Papeo, Francesca Quartieri, Fabio Gasparri, Michael O. Hottiger, Claudia Perrera, Alessia Montagnoli
• 3050 · PDF RPT1G——一种新型双曲型NAMPT抑制剂，在体外和异种移植乳腺癌模型中与PARP抑制剂有效协同 RPT1G, a novel hyperbolic NAMPT inhibitor, effectively synergizes with PARP inhibitors in solid tumors in vitro and in a xenograft breast cancer model Michael Schelle, Min Wu, Francis Roushar, Banumathi Cole, Dennise A. De Jesús-Díaz, Gregory Thomas Crimmins
• 3051 · PDF 增强癌症（ca）靶向治疗（TT）中的配对：超越"既定"标准 Enhancing matchmaking in targeted therapy (TT) for cancer (ca): Beyond the ‘arranged' criteria Farah Mazahreh, Liyan Mazahreh, Ahmad Mazin Safar
• 3052 · PDF RK-582，一种tankyrase抑制剂，攻击携带短型APC突变且beta-catenin高表达的Wnt驱动型结直肠癌细胞 RK-582, a tankyrase inhibitor, attacks Wnt-driven colorectal cancer cells with short-type APC mutations and high beta-catenin expression Hiroyuki Seimiya, Mingjue Chen, Taichi Oishi, Yukiko Muramatsu, Manabu Takamatsu, Naomi Kawata, Ayane Nakamura, Saori Inaba, Satoshi Nagayama, Ryohei Katayama, Kensei Yamaguchi, Fumiyuki Shirai, Tetsuo Mashima
• 3053 · PDF MDM2拮抗剂ASTX295与Olaparib联合用作BRCA2突变、TP53野生型实体瘤的新型治疗方案 Combination of the MDM2 antagonist ASTX295 and Olaparib as a novel treatment option for BRCA2 mutant, TP53 wild-type solid tumors Antonio Morales, Joanna Obacz, Bryn Hardwick, Adam Jackson, Liam Davis, Zoe Haines, Patrick Herr, Paula Martinez Sanz, Violetta Serra, Judit Espana-Agusti, Gianni Chessari, Maria Ahn, John F. Lyons, Amy Emery, Sarah Holt, Stephen Shuttleworth, Barry R. Davies
• 3054 · PDF 抑制ARNT可抑制原代人肾癌细胞的生长 Inhibition of ARNT suppresses growth of primary human kidney cancer cells Shengchen Su, Yanping Wang, Yanchun Zhang, Patrick Tamukong, Hyung L. Kim
• 3055 · PDF 靶向MKK3/MYC蛋白-蛋白相互作用以克服MYC驱动型癌症的耐药性 Targeting the MKK3/MYC protein-protein interaction to overcome drug resistance in MYC-driven cancers Payton Fleming, Elsa Bildtsen, Zhen Chen, Eric J. Miller, Yuhong Du, Shi-Yong Sun, Haian Fu, Andrey A. Ivanov
• 3056 · PDF 己酸盐对三阴性乳腺癌致癌表型的抑制作用 Inhibition of oncogenic phenotypes by hexanoate in triple-negative breast cancer Nahara Yupe-Muñiz, Samira B.F. Abdullah-Vargas, Oscar A. Loperena-González, Ariana S. García- López, Gabriel Borges-Vélez, Josué Pérez-Santiago
• 3058 · PDF 一种首创的口服生物可利用小分子肿瘤抑制因子激活剂，用于治疗多种癌症 A first-in-class orally bioavailable small molecule tumor suppressor activator for the treatment of a wide range of cancers Hee-Sung Park, Chakrapani Subramanyam, Kyu-kwang Cho, Se Hee Hyun, Yeonjee Kahm
• 3059 · PDF 通过Lp-PLA2抑制靶向MYC驱动型骨肉瘤的代谢依赖性 Targeting metabolic dependencies in MYC-driven osteosarcoma through Lp-PLA2 inhibition Katherine Shelmidine, Juan Dou, Tajhal Patel, Jason Yustein
• 3060 · PDF 杠柳毒苷通过CTCF恢复HTR1E信号以抑制卵巢癌的增殖和播散 Periplocin restores HTR1E signaling by CTCF to inhibit proliferation and dissemination of ovarian cancer Rong Xiang, Haojie Chen, Yi Shi, Huimin Liu, Kejia Xu
• 3061 · PDF CS231295——一种新型AURKB偏向性多激酶抑制剂，在RB1缺陷型肿瘤中展现出合成致死效应及强效的颅内疗效 CS231295, a novel AURKB-biased multi-kinase inhibitor, demonstrates synthetic lethality in RB1-deficient tumors and potent intracranial efficacy You Zhou, Qianjiao Yang, Qinyi Xia, Yu Zhang, Zhijian Li, Desi Pan, Song Shan
• 3062 · PDF 抑制TRIM7可阻断RTK/RAS通路驱动的肿瘤增殖，且不依赖突变，并在KRASi耐药情境下有效 TRIM7 inhibition blocks RTK/RAS pathway driven tumor proliferation independent of mutation and in the setting of KRASi resistance Yuhui Chen, Marc Morra, Haru Kato, Kevin Li, Ulhas Bhatt, Kevin Gayler, Grace Elliott-Fromm, Nathan Oien, Julio Medina, Taylor H. Schreiber, George Fromm
• 3063 · PDF 丁酸盐的选择性细胞毒性凸显其作为靶向抗癌药物的潜力 Selective cytotoxicity of butyrate highlights its potential as a targeted anti-cancer agent Nahara Yupe-Muñiz, Josué Pérez-Santiago, Gabriel Borges-Vélez, Esther A. Peterson-Peguero, Ariana García-Lopez, Amanda Prats-Marrero, Samira B.F. Abdullah-Vargas
• 3064 · PDF 新型小分子CtBP抑制剂与DR5激动剂或BH3模拟物PROTAC的协同组合用于靶向化疗耐药性高级别浆液性卵巢癌 Synergistic combinations of novel small molecule CtBP inhibitors with DR5 agonists or BH3-mimetic PROTACs targeting chemoresistant high grade serous ovarian carcinoma Kranthi Kumar Chougoni, Nicholette St. Martin, Diana T. Dcona, Nari Kim, Boxiao Ding, Ronny I. Drapkin, Keith C. Ellis, Steven R. Grossman
• 3065 · PDF CK2抑制剂在患者来源的尤文肉瘤肺转移模型中的治疗疗效 Therapeutic efficacy of CK2 inhibitor in patient-derived lung metastatic model of Ewing sarcoma Muhammad Danial, Chandrika Gowda, Rajesh Rajaiah, Marudhu Pandiyan Shanmugam, Upendar Golla, Sholler Chloe, Jeremey Hengst, Abhinav Beeravally Nagulapally, Yasin Uzun, Hannah Valensi, Matthew Lanza, Giselle L. Saulnier Sholler
• 3066 · PDF 一类新型变构CDK8/19抑制剂通过同时抑制mTOR和c-MYC并激活p53介导的G2/M阻滞诱导合成致死 A novel class of allosteric CDK8/19 inhibitors induces synthetic lethality through concurrent mTOR and c-MYC suppression and activation of p53-mediated G2/M arrest Hui Chen, Zihan Xu, Erpei Wang, Jason Rivera, Judith Varner
• 3067 · PDF 短链脂肪酸抑制三阴性乳腺癌细胞的侵袭和克隆形成存活 Short-chain fatty acids suppress invasion and clonogenic survival in triple-negative breast cancer cells Amanda Prats-Marrero, Ariana S. García-López, Liah M. Román-Calderón, Samira B. F. Abdullah-Vargas, Gabriel Borges-Vélez, Esther Peterson-Peguero, Josué Pérez-Santiago
• 3068 · PDF 靶向鸟氨酸氨基转移酶作为肝细胞癌的有前景治疗策略 Targeting ornithine aminotransferase as a promising therapeutic strategy for hepatocellular carcinoma Wenan Qiang, Yi Yang, Tommy Ouyang, Vivian Chen, Alice Qiu, Richard B. Silverman
• 3069 · PDF ROS在阿米洛利衍生物诱导的三阴性乳腺癌细胞溶酶体依赖性细胞死亡中的作用 Involvement of ROS species in amiloride derivative-induced lysosome-dependent cell death in triple-negative breast cancer cells Noemi Castro, Michelle Hu, Anastasia Berg, Ruiwu Liu, KIT LAM, Kermit Carraway III

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