PO.IM02.03 · 免疫学
Microbiome, Inflammation, and Response to Immunotherapy in Cancer
- 2861 2861 肠道共生菌毛螺菌科（Lachnospiraceae）的比较基因组学及其与免疫检查点抑制剂癌症治疗应答的关联 Comparative genomics of gut commensal Lachnospiraceae and their associations with cancer treatment response with immune checkpoint inhibitors Shiva Jahanbakhshi, Amna Bibi, Rebecca Hoyd, Caroline Dravillas, Nyelia Williams, Shiqi Zhang, Aaditya Pallerla, Shankar Suman, Joseph Amann, Mounika Goruganthu, Tamio Okimoto, Yangyang Liu, Marisa A. Bittoni, Ni Shi, Alvin Anand, Bailey Conrad, Lane Nevers, Kristen Heitman, Maxine Webb, Elizabeth M. Grainger, Madison Grogan, Christian Quiles, Tong Chen, Carolyn J. Presley, Lang Li, Patrick Bradley, Yael Vodovotz, David P. Carbone, Steven K. Clinton, Jiangjiang Zhu, Daniel Spakowicz
- 2862 2862 膳食动物蛋白摄入与接受免疫检查点阻断（ICB）治疗的晚期尿路上皮癌（UC）和肾细胞癌（RCC）患者的无进展生存期（PFS） Dietary animal protein intake and progression-free survival (PFS) of patients (pts) with advanced urothelial cancer (UC) and renal cell carcinoma (RCC) on immune checkpoint blockade (ICB) Timothy B. Winslow, Ritesh Kotecha, Neha Ratna, David Gavrilov, Cihan Duzgol, Mahnoor Akhlaq, Min Yuen Teo, Ashley M. Regazzi, Samuel Funt, David H. Aggen, Scot Niglio, Maria Carlo, Daniel Lage, Neil Shah, Aditi Gupta, Darren F. Feldman, Martin H. Voss, Robert J. Motzer, Jonathan E. Rosenberg, Gopa Iyer, Brendan John Guercio
-
- 2864 2864 益生元纤维补充可减轻母体肥胖对子代肠道微生物组和乳腺肿瘤发生的影响 Prebiotic fiber supplementation mitigates the effects of maternal obesity on offspring's gut microbiome and mammary tumorigenesis Seema Yadav, Fabia Andrade, Melike Ozgul Onal, Sydney Shirk, Sercan Kenanogly, Christopher Staley, Leena Hilakivi-Clarke
- 2865 2865 结直肠癌浸润细菌促进具有抗肿瘤特性的细胞毒性淋巴细胞群增殖 Colorectal cancer-infiltrating bacteria promote the proliferation of cytotoxic lymphocyte populations endowed with antitumor properties Martina Villa, Julija Djordjevic, Elisa Sorrenti, Pedro Ventura, Davide Bressan, Antonino Cassotta, Caroline Junqueira, Fulvio Chiacchiera, Federica Sallusto, Dimitrios Christoforidis, Giandomenica Iezzi
- 2866 2866 宿主-微生物-表观遗传串扰：剖析微生物组、免疫失调和DNA甲基化在鳞状细胞癌中的作用 Host-microbe-epigenetic crosstalk: Dissecting the role of microbiome, immune dysregulation, and DNA methylation in squamous cell carcinoma Armando G. Licata, Cristina Gurizzan, Deborah Lenoci, Marta Lucchetta, Carlo Resteghini, Luigi Lorini, Rosalba Miceli, Paolo Bossi, Loris De Cecco
- 2867 2867 在异质性患者群体中T细胞炎症基因表达谱评分与肿瘤相关微生物组对结直肠癌死亡率的相互作用 Interaction between T-cell inflamed gene expression profile score and tumor-associated microbiome on colorectal cancer mortality in a heterogeneous patient population Claire Elizabeth Thomas, Hang Yin, Jeroen Huyghe, Nicole Catalina Lorona, Scott D. Labrie, Keith R. Curtis, Orsalem Kahsai, Sosun Nayemi, Ningxin Ma, Timothy Randolph, Conghui Qu, Sushma Thomas, Li Hsu, Amanda L. Koehne, Heather Green-Mantrana, Marc Matrana, James J. Tiesinga, William M. Grady, Diana Redwood, Christopher I. Li, Li Li, Riki (Ulrike) Peters, Jane C. Figueiredo, Timothy K. Thomas, Amanda I. Phipps, Meredith A. Hullar
- 2868 2868 MaaT013混合粪便微生物疗法改善胃肠道生理功能并控制炎症，从而在概念验证人源化小鼠研究中延缓GvHD MaaT013 pooled fecal microbiotherapy improves gastrointestinal physiology and controls inflammation which delays GvHD in a proof-of-concept humanized mouse study Julie Reygner, Margaux De Seilhac, Cyrielle Gasc, Emmanuel Prestat, Charlotte Petitjean, Sophie Declomesnil, Carole Schwintner, Nathalie Corvaia, Sheri Simmons, Ernst Holler, Robert R. Jenq, Bastien Laperrousaz
-
- 2870 2870 氨基酸代谢重编程驱动多拉菌素增强CD8⁺ T细胞免疫及肿瘤控制 Amino acid metabolic reprogramming drives doramectin-enhanced CD8⁺ T cell immunity and tumor control Sedigheh Taghinezhad-S, Amirhossein Mohseni, Vincenzo Casolaro, Zhongwei Lv, Dan Li
-
- 2874 2874 villin阳性胃祖细胞中PPARdelta过表达在小鼠中驱动胃肿瘤发生且独立于幽门螺杆菌感染 PPARdelta overexpression in villin-positive gastric progenitor cells drive gastric tumorigenesis independent of helicobacter infection in mice Daoyan Wei, Yi Liu, James C. Yao, Imad Shureiqi, Xiangsheng Zuo
- 2875 2875 Toll样受体4缺失在角质形成细胞中缺失一个Ikkalpha等位基因的小鼠中促进细菌负荷和皮肤肿瘤发生 Toll-like receptor 4 deletion promotes bacterial burden and cutaneous tumorigenesis in mice lacking one Ikkalpha allele in keratinocytes Deep Kumari Yadav, Amit Kumar Singh, Debra Tross, Yinling Hu
-
- 2879 2879 瘤内微生物群和宿主基因型协同塑造结直肠癌中中性粒细胞的抗肿瘤活性 Intra-tumoral microbiota and host genotype cooperatively shape neutrophil antitumor activity in colorectal cancer Elisa Sorrenti, Valeria Governa, Davide Bressan, Nicolo' Formaggio, Bianca Calì, Camilla Basso, Martina Villa, Giuseppe Sconocchia, Klaus-Peter Janssen, Milo Frattini, Fulvio Chiacchiera, Jean-Philippe Theurillat, Sara De Dosso, Luigi M. Terracciano, Lubor Borsig, Giulio C. Spagnoli, Dimitrios Christoforidis, Giandomenica Iezzi
-
- 2881 2881 白细胞介素-1以STAT1/STAT3依赖方式上调人胰腺癌细胞中双氧化酶2的表达和ROS生成 Interleukin-1 upregulates dual oxidase 2 expression and ROS production in human pancreatic cancer cells in a STAT1/STAT3-dependent manner David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky A. Diebold, Smitha Antony, Jennifer L. Meitzler, Goujian Jiang, Jiamo Lu, Krishnendu K. Roy, James H. Doroshow
-
- 2883 2883 不同的肠道微生物群落与黑色素瘤基线免疫特征、肿瘤特征和ICI预后的差异相关 Divergent gut microbial communities are linked to differences in baseline immune profiles, tumor features and ICI outcomes in melanoma Rebecca C. Simpson, Ines Pires Da Silva, Jayden Beckwith, Irene L. M. Reijers, Judith M. Versluis, Camelia Quek, Alexander M. Menzies, Gonzalez Maria, James S. Wilmott, Christian U. Blank, Richard A. Scolyer, Erin R. Shanahan, Georgina V. Long
-
- 2885 2885 内含子保留标志着一种髓系偏斜的免疫荒漠，并提名H. pylori阳性胃癌中ICI无应答的标志物 Intron retention marks a myeloid‑skewed immune desert and nominates an ICI nonresponse marker in H. pylori -positive gastric cancer Daisuke Takayanagi, Junya Kitadani, Masahiro Katsuda, Toshiyasu ojima, Keiji Hayata, Manabu Kawai, Sinichi Hashimoto, Kazuhiko Tagawa, Toru Sugino, Satoshi Wada, Hiroki Yamaue, Takuya Tsunoda
-
