Humanized Mouse Models

• 3371 · PDF genO-BRGSF-HIS mice: A humanized mouse model for assessment of Treg-targeting therapies Gaëlle H. Martin, Florent Creusat, Siham Hedir, Amélie Marguier, Fabiane Sonego, Kader Thiam
• 3372 · PDF Predictive in vitro assays and PBMC donor banking: reducing variability in humanized mouse studies Matthias Bleisch, Philipp Meyer, Ina Rohleff, Eva Oswald, Anna Edinger, Julia B. Schueler
• 3373 · PDF Metabolism and carcinogenic potential of inorganic arsenic in humanized-liver mice Arpamas Vachiraarunwong, Shugo Suzuki, Masaki Fujioka, Runjie Guo, Guiyu Qiu, Yurina Kawamura, Ikue Noura, Anna Kakehashi, Hideki Wanibuchi, Min Gi
• 3374 · PDF In vivo evaluation of immune checkpoint inhibitors using PBMC-humanized NOG-ΔMHC mice engrafted with PDX tumors Asami Hanazawa, Seinosuke Sakai, Masayuki Komatsu, Chiyoko Nishime, Naohisa Ogo, Masami Suzuki, Jun-ichi Hata, Akira Asai, Taichi Yamamoto
• 3375 · PDF Novelapproaches fororthotopic tumor engraftment in humanized immune system mice Audrey Wetzel, Emilie Bayon, Anaïs Meynet-Cordonnier, Cecilia Mendez, Charline Boulout, Sebastien Tarbuyn, Dan Georgess
• 3376 · PDF Developing the next generation of customized human immune system mice for preclinical oncology Audrey Wetzel, Emilie Bayon, Sebastien Tabruyn, Dan Georgess
• 3378 · PDF Short telomeres limit braf V600E driven melanomagenesis in humanized telomere (HuT) mice Md Hazzaz Bin Kabir, Jiawei Liu, Fan Zhang, Kenneth I Porter, Gavin P. Robertson, Jiyue Zhu
• 3379 · PDF Small cell lung cancer humanized mouse models identifies unique T cell infiltration immune phenotypes in response to combination immune-radiation therapies. Bell Wu, Xiaozhuo Ran, Olivia Huang, Lifang Song, Vivek Phillip, Adrian Sacher, Ming Sound Tsao, Benjamin Lok
• 3380 · PDF Enhancing preclinical insights in immuno-oncology with humanized mice Caroline Mignard, Zoé Perin, Estelle Verronese, Damien France, Vincent Faugeroux, Marc Hillairet de Boisferon
• 3381 3381 ImmunoPET reveals tumor-associated macrophages in humanized MDA-MB-231 models Pin Yi Lee, Ayla Vaughn Embs, Catesby Mallard, Chloe La Prairie, Jonathan Mallard, Masakazu Kamata, Harriet M. Kluger, Ping Zhang, Bernadette V. Marquez-Nostra
• 3382 · PDF Characterization and preclinical efficacy of a CD3×CD20 bispecific T cell engager in a humanized PBMC mouse model Qikuan Chen, Longyun Zhang, Haixia Chen, Xiaowen Gong, Yanjie Chen, Mingqi Shao, Qi Zhu, Bobo Wang, Jingjing Zhu, Yinfei Yin
• 3383 · PDF Robust multiplex cytokine profiling in second-generation humanized NOG mice using a 41-plex humanized mouse immune panel: Cross-donor validation and implications for translational oncology studies Philip Dubé, Brooke Gilliam, Adam Bell, Nicholas Smith, Janell Richardson, Tina Raeber, Shane Curran, Monika Buczek
• 3384 · PDF Innovative preclinical mouse models support development of CD3/EPCAM-targeting T-cell engagers Jay Zhang, Linlin Wang, Xiaojing Quan, Xiaofei Zhou, Jing Guo
• 3385 · PDF Humanized mouse models 2.0 - Improved preclinical evaluation of novel immune cell therapies, check point inhibitors, and immune cell engagers by excluding false positive or negative results Maria Stecklum, Philip Dube, Ditte Olsen, Jens Hoffmann
• 3386 3386 MESHCAP (exogenous microbiota and humanized mice for lung cancer): Towards an innovative preclinical model for testing immunotherapies Pierre Montagne, Ulrich Jarry, Mathilde Harel, Laetitia Martinetti, Anna Le Mée, Charles Ricordel, Ahmad FAILI, Samer Kayal, Rémy Pedeux, Marwan Touati, Valentin Quiniou, Hang-Phuong Pham
• 3387 · PDF Enhancing the predictability of human pharmacokinetics for antibody-drug conjugates (ADCs) using human FcRn transgenic mice Xinhe Feng, Kefeng Gong, Weifang Wang, Xinhua Ding, Ludovic Bourre, Xiaolong Tu, Luke Yu
• 3388 · PDF One-stop solution for preclinical evaluation of bispecific T-cell engagers targeting STEAP1 Hongyan Sun, Yuqing Han, Fang Zhu, Yujing Zhang, Huixin Yang, Xiang Gao
• 3389 · PDF Preclinical models for evaluating bispecific antibodies targeting PD-1 and VEGF Hongyan Sun, Chenyang Liu, Yunlong Jiang, Yujing Zhang, Huixin Yang, Xiang Gao
• 3390 · PDF Enhanced human immune system engraftment in a novel triple-engineered NCG-hIL6-mTSLP-mFlt3-KOmouse model Hongyan Sun, Jun Xing, Shiying Guo, Yujing Zhang, Huixin Yang, Xiang Gao
• 3391 · PDF The humanized FcRn mouse model: A superior platform for predicting human PK of therapeutic antibodies Hongyan Sun, Yujing Zhang, Yuansheng Yi, Huixin Yang, Xiang Gao
• 3392 · PDF Development of novel NCG-hIL15 and hIL-2 mouse models for preclinical assessment of human NK cell function Hongyan Sun, Yinlian Zhang, Yunlong Jiang, Yujing Zhang, Huixin Yang, Xiang Gao

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