Humanized Mouse Models

• 3371 · PDF genO-BRGSF-HIS小鼠：一种用于评估Treg靶向疗法的人源化小鼠模型 genO-BRGSF-HIS mice: A humanized mouse model for assessment of Treg-targeting therapies Gaëlle H. Martin, Florent Creusat, Siham Hedir, Amélie Marguier, Fabiane Sonego, Kader Thiam
• 3372 · PDF 预测性体外实验与PBMC供者库：降低人源化小鼠研究中的变异性 Predictive in vitro assays and PBMC donor banking: reducing variability in humanized mouse studies Matthias Bleisch, Philipp Meyer, Ina Rohleff, Eva Oswald, Anna Edinger, Julia B. Schueler
• 3373 · PDF 无机砷在人源化肝脏小鼠中的代谢及致癌潜能 Metabolism and carcinogenic potential of inorganic arsenic in humanized-liver mice Arpamas Vachiraarunwong, Shugo Suzuki, Masaki Fujioka, Runjie Guo, Guiyu Qiu, Yurina Kawamura, Ikue Noura, Anna Kakehashi, Hideki Wanibuchi, Min Gi
• 3374 · PDF 使用移植PDX肿瘤的PBMC人源化NOG-ΔMHC小鼠对免疫检查点抑制剂进行体内评估 In vivo evaluation of immune checkpoint inhibitors using PBMC-humanized NOG-ΔMHC mice engrafted with PDX tumors Asami Hanazawa, Seinosuke Sakai, Masayuki Komatsu, Chiyoko Nishime, Naohisa Ogo, Masami Suzuki, Jun-ichi Hata, Akira Asai, Taichi Yamamoto
• 3375 · PDF 人源化免疫系统小鼠中原位肿瘤移植的新方法 Novelapproaches fororthotopic tumor engraftment in humanized immune system mice Audrey Wetzel, Emilie Bayon, Anaïs Meynet-Cordonnier, Cecilia Mendez, Charline Boulout, Sebastien Tarbuyn, Dan Georgess
• 3376 · PDF 开发下一代用于临床前肿瘤学的定制化人类免疫系统小鼠 Developing the next generation of customized human immune system mice for preclinical oncology Audrey Wetzel, Emilie Bayon, Sebastien Tabruyn, Dan Georgess
• 3378 · PDF 短端粒在人源化端粒（HuT）小鼠中限制Braf V600E驱动的黑色素瘤发生 Short telomeres limit braf V600E driven melanomagenesis in humanized telomere (HuT) mice Md Hazzaz Bin Kabir, Jiawei Liu, Fan Zhang, Kenneth I Porter, Gavin P. Robertson, Jiyue Zhu
• 3379 · PDF 小细胞肺癌人源化小鼠模型识别出对免疫-放射联合治疗反应中独特的T细胞浸润免疫表型 Small cell lung cancer humanized mouse models identifies unique T cell infiltration immune phenotypes in response to combination immune-radiation therapies. Bell Wu, Xiaozhuo Ran, Olivia Huang, Lifang Song, Vivek Phillip, Adrian Sacher, Ming Sound Tsao, Benjamin Lok
• 3380 · PDF 利用人源化小鼠增强免疫肿瘤学中的临床前见解 Enhancing preclinical insights in immuno-oncology with humanized mice Caroline Mignard, Zoé Perin, Estelle Verronese, Damien France, Vincent Faugeroux, Marc Hillairet de Boisferon
• 3381 3381 ImmunoPET揭示人源化MDA-MB-231模型中的肿瘤相关巨噬细胞 ImmunoPET reveals tumor-associated macrophages in humanized MDA-MB-231 models Pin Yi Lee, Ayla Vaughn Embs, Catesby Mallard, Chloe La Prairie, Jonathan Mallard, Masakazu Kamata, Harriet M. Kluger, Ping Zhang, Bernadette V. Marquez-Nostra
• 3382 · PDF 一种CD3×CD20双特异性T细胞衔接器在人源化PBMC小鼠模型中的表征及临床前疗效 Characterization and preclinical efficacy of a CD3×CD20 bispecific T cell engager in a humanized PBMC mouse model Qikuan Chen, Longyun Zhang, Haixia Chen, Xiaowen Gong, Yanjie Chen, Mingqi Shao, Qi Zhu, Bobo Wang, Jingjing Zhu, Yinfei Yin
• 3383 · PDF 利用41重人源化小鼠免疫检测板对第二代人源化NOG小鼠进行稳健的多重细胞因子分析：跨供体验证及对转化肿瘤学研究的意义 Robust multiplex cytokine profiling in second-generation humanized NOG mice using a 41-plex humanized mouse immune panel: Cross-donor validation and implications for translational oncology studies Philip Dubé, Brooke Gilliam, Adam Bell, Nicholas Smith, Janell Richardson, Tina Raeber, Shane Curran, Monika Buczek
• 3384 · PDF 创新性临床前小鼠模型支持靶向CD3/EPCAM的T细胞衔接器的开发 Innovative preclinical mouse models support development of CD3/EPCAM-targeting T-cell engagers Jay Zhang, Linlin Wang, Xiaojing Quan, Xiaofei Zhou, Jing Guo
• 3385 · PDF 人源化小鼠模型2.0——通过排除假阳性或假阴性结果改善对新型免疫细胞疗法、检查点抑制剂和免疫细胞衔接器的临床前评估 Humanized mouse models 2.0 - Improved preclinical evaluation of novel immune cell therapies, check point inhibitors, and immune cell engagers by excluding false positive or negative results Maria Stecklum, Philip Dube, Ditte Olsen, Jens Hoffmann
• 3386 3386 MESHCAP（用于肺癌的外源性微生物组和人源化小鼠）：迈向用于测试免疫疗法的创新性临床前模型 MESHCAP (exogenous microbiota and humanized mice for lung cancer): Towards an innovative preclinical model for testing immunotherapies Pierre Montagne, Ulrich Jarry, Mathilde Harel, Laetitia Martinetti, Anna Le Mée, Charles Ricordel, Ahmad FAILI, Samer Kayal, Rémy Pedeux, Marwan Touati, Valentin Quiniou, Hang-Phuong Pham
• 3387 · PDF 利用人FcRn转基因小鼠增强抗体药物偶联物（ADCs）人类药代动力学的可预测性 Enhancing the predictability of human pharmacokinetics for antibody-drug conjugates (ADCs) using human FcRn transgenic mice Xinhe Feng, Kefeng Gong, Weifang Wang, Xinhua Ding, Ludovic Bourre, Xiaolong Tu, Luke Yu
• 3388 · PDF 靶向STEAP1的双特异性T细胞衔接器临床前评估的一站式解决方案 One-stop solution for preclinical evaluation of bispecific T-cell engagers targeting STEAP1 Hongyan Sun, Yuqing Han, Fang Zhu, Yujing Zhang, Huixin Yang, Xiang Gao
• 3389 · PDF 评估靶向PD-1和VEGF双特异性抗体的临床前模型 Preclinical models for evaluating bispecific antibodies targeting PD-1 and VEGF Hongyan Sun, Chenyang Liu, Yunlong Jiang, Yujing Zhang, Huixin Yang, Xiang Gao
• 3390 · PDF 新型三重工程化 NCG-hIL6-mTSLP-mFlt3-KO 小鼠模型中人类免疫系统的植入增强 Enhanced human immune system engraftment in a novel triple-engineered NCG-hIL6-mTSLP-mFlt3-KOmouse model Hongyan Sun, Jun Xing, Shiying Guo, Yujing Zhang, Huixin Yang, Xiang Gao
• 3391 · PDF 人源化 FcRn 小鼠模型:预测治疗性抗体人类 PK 的卓越平台 The humanized FcRn mouse model: A superior platform for predicting human PK of therapeutic antibodies Hongyan Sun, Yujing Zhang, Yuansheng Yi, Huixin Yang, Xiang Gao
• 3392 · PDF 用于人类 NK 细胞功能临床前评估的新型 NCG-hIL15 和 hIL-2 小鼠模型的开发 Development of novel NCG-hIL15 and hIL-2 mouse models for preclinical assessment of human NK cell function Hongyan Sun, Yinlian Zhang, Yunlong Jiang, Yujing Zhang, Huixin Yang, Xiang Gao

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