Pediatric Cancer Genomics and Epigenomics

• 3486 · PDF 阐明ecDNA在儿童髓母细胞瘤治疗耐药和免疫逃逸中的作用 Elucidating the role of ecDNA in treatment resistance and immune evasion within pediatric medulloblastoma Meenakshi Singhal, Joy Ku, Kun Wang, Rohit Bhargava
• 3488 · PDF 通过整合分子与形态学数据推进儿童癌症（PeCan）知识库上的儿童肿瘤亚型分类 Advancing pediatric tumor subtype classification on the pediatric cancer (PeCan) knowledge base by integrating molecular and morphology data Stephanie Sandor, Delaram Rahbarinia, Yuan Feng, Ramzi Alsallaq, Van L. Nguyen, Daniel K. Putnam, David Finkelstein, Jinman Park, Bo Wang, Jobin Sunny, Jian Wang, Sue Qiu, Michael Edmonson, Robert Greenhalgh, Meghann Kirk, Ira Baranova, Stephen V. Rice, Abbas Shirinifard, Hoaran Chen, Ali F. Pour, Clay McLeod, Lu Wang, Jeffery Klco, Brent Orr, Michael Dyer, Xiang Chen, Xiaotu Ma, Michael Rusch, Jinghui Zhang
• 3489 · PDF EWSR1::WT1融合癌蛋白与雄激素受体塑造促结缔组织增生性小圆细胞肿瘤的生物学特性 EWSR1::WT1 fusion oncoprotein and the androgen receptor shape the biology of desmoplastic small round cell tumors Danh Truong, Emre Arslan, Veena Kochat, Jiaqian Fan, Diana Shamsutdinova, Davis Ingram, Kevin Murgas, Clement Agyemang, Roberto Cardenas-Zuniga, Asmaa G. Ahmed, Justin Magrath, Alexander Lazar, Najat Daw Bitar, Sean B. Lee, Andrea Hayes-Dixon, Kunal Rai, Joseph A. Ludwig
• 3490 · PDF 儿童癌症患者来源异种移植模型中染色体外DNA的保留与克隆行为 Preservation and clonal behavior of extrachromosomal DNA in patient-derived xenograft models of childhood cancers Rishaan Kenkre, Jon D. Larson, Owen Chapman, Jens Luebeck, Yan Yeun Lo, Paul Megan, Wenshu Zhang, Vineet Bafna, Robert Wechsler-Reya, Lukas Chavez
• 3491 · PDF B细胞急性淋巴细胞白血病中RAB5B GTP酶表达的表观遗传调控 Epigenetic regulation of the RAB5B GTPase expression in B-cell acute lymphoblastic leukemia Katarina Dovat, Yali Ding, Daniel Bogush, Rabab Husain, Ryan Chingakham, Dhimant Desai, Sinisa Dovat
• 3492 · PDF 靶向ALKBH5介导的ChREBP信号通路损害髓母细胞瘤中癌症干细胞代谢和肿瘤生长 Targeting ALKBH5 mediated ChREBP signaling impairs cancer stem cell metabolism and tumor growth in medulloblastoma Panneerdoss Subbarayalu, Daisy Medina, Prabhakar Pitta Venkata, Shahad Abdulsahib, Saif Nirzhor, Santosh Timilsina, Deepika Singh, Phat Do, Desiree Denman, Krishna Priya Evani, Dhiya Billa, Meera Nair, Esha Reddy, Yogesh Gupta, Peter Houghton, Yidong Chen, Suryavathi Viswanadhapalli, Gangadhara R. Sareddy, Andrew Brenner, Ratna K. Vadlamudi, Manjeet Rao
• 3493 3493 超快速全基因组测序助力儿童癌症的个性化治疗 UltraFast whole genome sequencing enables personalized treatments in childhood cancers Aditi Vedi, Jamie Trotman, Joao Dias, Martina Mijuskovic, Sera Choi, Laura Kingham, Rachel Moore, Sarah M. Leiter, Rowena Guermech, Amanda Semerene, Aviva Grisby, Sophie Wool, Victoria Joslin, Zoya Kingsbury, Mark Ross, David Bentley, Sam Behjati, Sean Humphray, Patrick Tarpey, David Rowitch
• 3494 · PDF 多层菊形团胚胎性脑肿瘤的表观遗传图谱与基因调控 Epigenetic landscape and gene regulation in embryonal brain tumors with multilayered rosettes Shanzheng Wang, Sander Lambo, Monika Mauermann, Phylicia Stathi, Robert Autry, Natalie Jäger, Stefan M. Pfister, Marcel Kool
• 3495 · PDF MYC诱导的免疫肽组特征分析 Characterizing the MYC-induced immunopeptidome Jack Faulkner, Anwesha Dasgupta, John R. Prensner
• 3496 · PDF CBFA2T3-GLIS2的表观遗传重编程揭示高危儿童AML中可成药的DNA甲基化轴脆弱性 Epigenetic repurposing by CBFA2T3-GLIS2 reveals a druggable DNA methylation axis in high-risk pediatric AML vulnerability in pediatric AML Samrat Roy Choudhury, Arundhati Chavan, Rhonda E. Ries, Giselle Almeida Gonzalez, Soheil Meshinchi, Jason E. Farrar
• 3497 · PDF 超罕见儿童恶性横纹肌样瘤基因组图谱的综合分析 Comprehensive analysis of genomic landscape of ultra-rare pediatric malignant rhabdoid tumors Elizabeth Rasmussen, Elena Mironova, Dias Kurmashev, Kendra Maaß, Stefanie Volz, Zhao Lai, Stefan M. Pfister, Yidong Chen, Raushan Kurmasheva
• 3498 · PDF 通过更新的细胞类型注释、CNV推断和可视化工具提升单细胞儿童癌症图谱的实用性 Improving the utility of the single-cell pediatric cancer atlas through updated cell type annotations, CNV inference, and visualization tools Allegra G. Hawkins, Joshua A. Shapiro, Stephanie J. Spielman, David S. Mejia, Deepashree Venkatesh Prasad, Nozomi Ichihara, Arkadii Yakovets, Avrohom M. Gottlieb, Kurt G. Wheeler, Chanté J. Bethell, Steven M. Foltz, Jennifer O'Malley, Casey S. Greene, Jaclyn N. Taroni
• 3499 · PDF BRD9在滑膜肉瘤中作为GBAF的负性调控因子发挥作用 BRD9 functions as a negative regulator of GBAF in synovial sarcoma Jinxiu Li, Mary Nelson, Li Li, Xiaobo Xia, Christine Stephan, Katarzyna Modzelewska, Gary Yu, Iain Mulford, Honnappa Srinivas, Xinyi Ge, Sarah McCollum, Ewin R Jones, Yixuan Guo, Xi Chen, Thomas Zoller, Gregory Hollingworth, Ensar Halilovic, Tinya J. Abrams, Edmund Harrington, Sofia Gkountela, Giorgio Galli, Hans Voshol, Nathalie Carte, Jason Thomas, Xiaoyang Zhang, David Lum, Martin Hirst, Jeffery Yap, William Forrester, Bradley R. Cairns, Kevin Bruce Jones
• 3500 · PDF 协同靶向EP300/CBP和EYA共激活因子瓦解横纹肌肉瘤核心调控环路 Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit Annika Gustafson, Stephanie Nance, Berkley Gryder, Noha A. Shendy, Lars Wick, Grace McKay-Corkum, K. Elaine Ritter, Stephen Connor Purdy, Arthur R. Wolin, Sheera R. Rosenbaum, Sabateeshan Mathavarajah, Nickerson A. Demelfi, Yueyang Wang, Yang Zhang, Mark W. W. Zimmerman, Anoop M. Kavirayani, John Hardin, Alexander LaVeck, Xiang Wang, Neekesh V. Dharia, Andrew Hong, Guillaume Kugener, Jesse S. Boehm, Jennifer Roth, Javed Khan, Francisca Vasquez, Kristin B. Artinger, Rui Zhao, David M. Langenau, Jun Qi, Kimberly Stegmaier, Heide L. Ford, Adam D. Durbin, Brian J. Abraham
• 3501 · PDF 尤因肉瘤中的关键依赖性：PAX7在从头微卫星增强子处减弱EWS::FLI1活性以维持肿瘤发生 A critical dependency in Ewing sarcoma: PAX7 attenuates EWS::FLI1 activity at de novo microsatellite enhancers to maintain oncogenesis Caroline Fraser, Alex Belt, Andrew McFadden, Ian Davis
• 3502 · PDF 组蛋白3赖氨酸9三甲基化的缺失驱动高危儿童髓母细胞瘤复发 Loss of histone 3 lysine 9 trimethylation drives recurrence in high-risk pediatric medulloblastoma John DeSisto, Andrew M. Donson, Bethany Veo, Rajeev Vibhakar
• 3503 · PDF Y染色体拷贝数的体细胞改变与神经母细胞瘤的临床和分子特征相关 Somatic changes in Y chromosome copy number are associated with clinical and molecular features in neuroblastoma Teodoro Rivera-Wills, Preshita Dave, Esther Rheinbay
• 3504 · PDF 光神霉素类似物捕获EWS-FLI1转录复合物、驱逐ETV6并使尤因肉瘤中的致癌凝聚体功能失效 Mithramycin analogues trap the EWS-FLI1 transcriptional complex, evict ETV6, and disable oncogenic condensate function in Ewing sarcoma Srijan Acharya, Rajesh Yetirajam, Yasuda Kazuto, Suhas Bhosale, Jurgen Rohr, Markos Leggas
• 3505 · PDF 儿童癌症幸存者中饮食质量与治疗相关心脏毒性的DNA甲基化特征 DNA methylation signatures of diet quality and treatment-related cardiotoxicity in childhood cancer survivors Yoonji Kim, Xiaoxi Meng, Kwangyeon Oh, Tuo Lan, Tiffany Eulalio, Heather L. Mulder, John B. Easton, Jinghui Zhang, Emily Walker, Geoffrey A. Neale, Deo Kumar Srivastava, Min Ni, I-Chan Huang, Stephanie B. Dixon, Gregory T. Armstrong, Melissa M. Hudson, Kirsten K. Ness, Yikyung Park, Zhaoming Wang

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