PO.TB10.17 · 肿瘤生物学
Therapeutic Modulation of the Tumor Microenvironment: New Targets and Approaches 1
- 3508 3508 以抑制层粘连蛋白-411 的多功能纳米药物治疗胶质母细胞瘤可激活局部免疫应答、提高小鼠生存并揭示 AI 筛选的免疫分子通路 Glioblastoma treatment with multifunctional nanodrug inhibiting laminin-411 activates local immune response, increases survival of mice and reveals AI-selected immune molecular pathways Alexander V. Ljubimov, Rameshwar Patil, Vladimir A. Ljubimov, Hui Ding, Yizhou Wang, Sarah Song, Andrei A. Kramerov, Oksana Chepurna, Vanessa Borges, Jessica Dos Santos, Eggehard Holler, Julia Y. Ljubimova, Keith L. Black
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- 3510 3510 高剂量 FcRH5xCD3 T 细胞衔接双特异性抗体（TCB）在体外克服多发性骨髓瘤中 Treg 介导的抑制 High-dose FcRH5xCD3 T-cell-engaging bispecific antibody (TCB) overcomes Treg-mediated suppression in-vitro in multiple myeloma Kai Lu, Darya Khantakova, Rin Nakamura, Kerstin Trunzer, Hyun Yong Jin, Elizabeth Punnoose, Elizabeth Germino, Katerina Hatzi
- 3511 3511 重编程肿瘤微环境以阻止转移：Akos 靶向实体瘤中的转移性癌症相关成纤维细胞 Reprogramming the tumor microenviroment to halt metastasis: Akos targets metastatic cancer-associated fibroblast in solid tumors Valentina Cerda I, Benjamin Prieto, Muriel Nuñez, Daniela Barrera, Alexis Salas, Patricia Garcia, Enrique Brandan, Javier Cerda-Infante
- 3512 3512 高精度碳离子放疗引发有效的原位肿瘤疫苗接种和持久的抗肿瘤免疫 High-precision carbon ion radiotherapy elicits effective in-situ tumor vaccination and durable antitumor immunity Sarah Meister, Matilde Recusani, Maximilian Knoll, Ralph Sinn, Aoife Gahlawat, Jennifer Furkel, Michael Breckwoldt, Dirk Jäger, Jürgen Debus, Amir Abdollahi
- 3513 3513 新型 lncRNA SEAL1——泛癌 myCAF 细胞状态的关键调控因子，决定预后和免疫治疗反应——是实体癌一个有前景的新治疗靶点 The novel lncRNA SEAL1 - key regulator of the pan-cancer myCAF cell state dictating prognosis ans immunotherapy response - is a promising new therapeutic target for solid cancers Emely Möller, Baroj Abdulkarim, Venkatesh Kancherla, Soumitra Ghosh, Sanne Schrevens, René Dreos, Kristen Gentry, Claire Roberts, Marco Mina, Rudi Micheletti, G. Paolo Dotto, Daniel Blessing, Samir Ounzain
- 3514 3514 组蛋白去乙酰化酶 9（HDAC9）通过调节肿瘤-中性粒细胞相互作用介导晚期肝细胞癌的治疗抵抗 Histone deacetylase 9 (HDAC9) mediates therapy resistance by regulating tumor-neutrophil interaction in advanced hepatocellular carcinoma Yunong Xie, Minghe Zhang, Linglin Liu, Yimiao He, Jiahuan Cai, Clive Yik-Sham Chung, Leung Hoi Wing, Terence Kin-Wah Lee, Stephanie Ma, Ka-Fai To, Jingying Zhou, Carol Man Carol Tong
- 3515 3515 调控胰液中ENPP1-STING的交互作用以重塑胰腺癌的肿瘤免疫格局 Modulating pancreatic juice ENPP1-STING crosstalk to reprogram the tumor immune landscape in pancreatic cancer Sadaaki Nishimura, Jun Tauchi, Ryota Tanaka, Shigeaki Kurihara, Masahiko Kinoshita, Kohei Nishio, HIroji Shinkawa, Takeaki Ishizawa
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- 3521 3521 在患者来源的癌症类器官中研究GSK5764227抗体-药物偶联物的作用机制和旁观者效应 Studying the mechanism of action and bystander effect of the GSK5764227 antibody-drug conjugate in patient-derived cancer organoids Maria Fankhaenel, Priya Narayanan, Halh Al-Serori, Veronika Yankova, Mint Htun, Elias Sulaiman, Barbara Seller, Irina Piven, Lena Wedeken, Anna Pasto, Tony NG
- 3522 3522 维生素D（骨化三醇）增强前列腺癌细胞系中CB2介导的抗肿瘤反应：分子机制与治疗潜力 Vitamin D (calcitriol) potentiates CB2-mediated anti-tumor responses in prostate cancer cell lines: Molecular mechanisms and therapeutic potential William B. Speed, Cimona Vaughn Hinton, Nakea Pennant
- 3523 3523 抗原提呈性癌相关成纤维细胞和间皮细胞在结直肠癌中的免疫学作用 Immunological roles of antigen-presenting cancer-associated fibroblasts and mesothelial cells in colorectal cancer Yasuhiro Fukui, Hiroaki Kasashima, Yukina Kusunoki, Nobuhiro Naito, Zizhou Wang, Iguru Omori, Yuki Seki, Kenji Kuroda, Yuichirou Miki, Mami Yoshii, Tatsurou Tamura, Masatsune Shibutani, Takahiro Toyokawa, Masakazu Yashiro, Yuki Nakanishi, Naoko Ohtani, Kiyoshi Maeda
- 3524 3524 在患者来源的肿瘤外植体（PDEs）中探索GSK5764227抗体-药物偶联物的靶向及非靶向（旁观者）效应 Exploring both targeted and untargeted (bystander) effects of GSK5764227 antibody‑drug conjugate in patient‑derived tumor explants (PDEs) Debayan Mukherjee, Jenny Wade, Morgan Heycock, Mint Htun, Benjamin Miller, Zeinab Mokhtari, Diana Munera, Anna Pasto, Paul Barber, Tony NG, Sue Griffin
