Late-Breaking Research: Molecular/Cellular Biology and Genetics 2

• LB276 · PDF Exposing a vulnerability to mTOR inhibition in triple negative breast cancer by targeting NIMA related kinase 2 (NEK2) Mary Vincent, Kristen Weber-Bonk, Daniella Obidi, Ananya Jain, Darcie Seachrist, Ruth Keri
• LB277 · PDF The p53-Reprimo-Hippo-YAP-p73 pathway: An extrinsic apoptosis mechanism for tumor suppression Rieko Ohki
• LB278 · PDF Pancreatic cancer affects entosis by regulating the cytoskeleton through mechanical stress Chengcheng Wang, Chenxue Yin, Yupei Zhao
• LB279 · PDF Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity Yvonne T. Kschonsak
• LB280 · PDF PDIA4-NF-κB signaling mediates soluble E-cadherin-driven inflammatory breast cancer progression Xiaoding Hu, Kiros Haddish Tesfamariam, Isabella L. Rizzo, Emilly S. Villodre, Lan Thi Hanh Phi, Juhee Song, Yun Gong, Savitri Krishnamurthy, Wendy A. Woodward, Bisrat G. Debeb
• LB281 · PDF Loss of ERK pulsatility drives transformation of colonic organoids through collapse of Akt-mediated signaling insulation Lauren Riede, Alex Borowiec, Woody March-Steinman, Jayati Chakrabarti, Sohini Mallick, Curtis Thorne, Andrew Paek, Kelvin Pond
• LB282 · PDF STIP1 drives metabolic reprogramming in esophageal squamous cell carcinoma via AHCY-LDHA Axis Guoguo Jin, Yanming Song
• LB283 LB283 Oncogenic WNT/beta-catenin signaling reduces MAPK signaling to suppress broad gene expression and promote colorectal cancer progression Andrew E. Evans, Ariana A. Entezari, Adi Caspi, Jasmine A. Alvarez, Adam E. Snook, Scott A. Waldman
• LB284 LB284 Platelet-derived TGF-beta initiates a neutrophil HIF-1alpha/NETs positive feedback loop driving osteosarcoma intratumoral hypoxia and lung metastasis Qianyu Shi, Tao Ji
• LB285 · PDF RASH3D19 mediates RAS pathway activation and adaptive resistance to KRAS targeting drugs in cancer Warapen Treekitkarnmongkol, Hiroshi Katayama, Deivendran Sankaran, Mei-Chee Tai, Sanchita Rauth, Hanxiao Chen, Tristian Nguyen, Kieko Hara, Fredrik I. Thege, Moorthy P. Ponnusamy, Surinder K. Batra, Huamin Wang, Ignacio I. Wistuba, Thomas D. Schmittgen, John V. Heymach, Scott Kopetz, Tony Hu, Wantong Yao, Anirban Maitra, Subrata Sen
• LB286 · PDF Keap1 loss promotes cancer stemness and anti-PD-1 resistance in head and neck cancer Khandoker Ifaz Ahmed, Qu Deng, Xue Xiong, Savallya Boyini, Yash Shah, Zhibin Cui
• LB287 · PDF Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance Masahiro Wakita, Eiji Hara
• LB288 · PDF KDM4A mediated chromatin remodeling promotes tumor progression and immune modulation in malignant pleural mesothelioma SrinivasVinod Saladi, Harshini Vemula, Martin Sattler
• LB289 · PDF RNA-binding protein NF90 mediates Polycomb-independent transactivation by EZH2 to promote cancer growth Yuan Wang, Liu Peng, Xiaodong Lu, Jonathan Zhao, Jindan Yu
• LB290 · PDF AR-V7 utilizes a noncanonical nuclear localization signal to sustain androgen-independent nuclear import and signaling Urko del Castillo, Naira E. Abou-Ghali, Colin Burdette, Michelle Naidoo, Kiran Kumari Sahu, Paul Zumbo, Jacob Geri, Paraskevi Giannakakou
• LB291 · PDF Investigating translation inhibition for the treatment of transcription inhibitor resistant Group 3 medulloblastoma Soumik Saha, Kelly Cai, Sangita Pal, Pratiti Bandopadhayay, John Robert Prensner
• LB293 · PDF Cystine restriction enhances CD8+ CAR-T potency by promoting OXPHOS via GCN2-eIF2alpha-SLC1A5 axis Xiaoxue Pan, Yuhang Yin, Pengyuan Wang, Shanwen Chen
• LB294 LB294 Vhl-/-Tsc1-/- mice rapidly develop clear cell renal cell carcinoma with pronounced metabolic and redox reprogramming that necessitates NRF2 signaling Xiaoqing (Cathy) Cheng, Jianing Xu, Omran Abu Aboud, Ying-Bei Chen, Ed Reznik, Toshinao Oyama, Satish Tickoo, Emily H. Cheng, Robert H. Weiss, James J. Hsieh
• LB295 LB295 Cancer beyond mutations: Developmental programs of nutrient acquisition influence oncogenic competence in YAP-driven liver cancer Mikaela M. K. Wong, Kieran F. Harvey, Kristin K. Brown, Andrew G. Cox
• LB296 · PDF RNA structure-targeted inhibition suppresses glioblastoma growth in human cerebral organoids Maria-Ancuta Jurj, Michael A. Attathikhun, Sanjay Kumar Singh, Meng Chen, Venkata Narayana Vidadala, Frederick Lang, Gabriele Varani, George A. Calin

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