Late-Breaking Research: Molecular/Cellular Biology and Genetics 2

• LB276 · PDF 通过靶向 NIMA 相关激酶 2（NEK2）暴露三阴性乳腺癌对 mTOR 抑制的脆弱性 Exposing a vulnerability to mTOR inhibition in triple negative breast cancer by targeting NIMA related kinase 2 (NEK2) Mary Vincent, Kristen Weber-Bonk, Daniella Obidi, Ananya Jain, Darcie Seachrist, Ruth Keri
• LB277 · PDF p53-Reprimo-Hippo-YAP-p73 通路：一种用于肿瘤抑制的外源性凋亡机制 The p53-Reprimo-Hippo-YAP-p73 pathway: An extrinsic apoptosis mechanism for tumor suppression Rieko Ohki
• LB278 · PDF 胰腺癌通过机械应力调控细胞骨架影响入胞现象（entosis） Pancreatic cancer affects entosis by regulating the cytoskeleton through mechanical stress Chengcheng Wang, Chenxue Yin, Yupei Zhao
• LB279 · PDF 肿瘤靶向双特异性抗体在最大限度降低毒性的同时有效抑制致癌通路 Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity Yvonne T. Kschonsak
• LB280 · PDF PDIA4-NF-κB 信号介导可溶性 E-cadherin 驱动的炎性乳腺癌进展 PDIA4-NF-κB signaling mediates soluble E-cadherin-driven inflammatory breast cancer progression Xiaoding Hu, Kiros Haddish Tesfamariam, Isabella L. Rizzo, Emilly S. Villodre, Lan Thi Hanh Phi, Juhee Song, Yun Gong, Savitri Krishnamurthy, Wendy A. Woodward, Bisrat G. Debeb
• LB281 · PDF ERK 脉冲性丧失通过 Akt 介导的信号绝缘崩溃驱动结肠类器官转化 Loss of ERK pulsatility drives transformation of colonic organoids through collapse of Akt-mediated signaling insulation Lauren Riede, Alex Borowiec, Woody March-Steinman, Jayati Chakrabarti, Sohini Mallick, Curtis Thorne, Andrew Paek, Kelvin Pond
• LB282 · PDF STIP1 通过 AHCY-LDHA 轴驱动食管鳞状细胞癌的代谢重编程 STIP1 drives metabolic reprogramming in esophageal squamous cell carcinoma via AHCY-LDHA Axis Guoguo Jin, Yanming Song
• LB283 LB283 致癌性WNT/beta-catenin信号通过降低MAPK信号来抑制广泛的基因表达并促进结直肠癌进展 Oncogenic WNT/beta-catenin signaling reduces MAPK signaling to suppress broad gene expression and promote colorectal cancer progression Andrew E. Evans, Ariana A. Entezari, Adi Caspi, Jasmine A. Alvarez, Adam E. Snook, Scott A. Waldman
• LB284 LB284 血小板来源的TGF-beta启动中性粒细胞HIF-1alpha/NETs正反馈环路，驱动骨肉瘤瘤内缺氧和肺转移 Platelet-derived TGF-beta initiates a neutrophil HIF-1alpha/NETs positive feedback loop driving osteosarcoma intratumoral hypoxia and lung metastasis Qianyu Shi, Tao Ji
• LB285 · PDF RASH3D19介导RAS通路激活及癌症对KRAS靶向药物的适应性耐药 RASH3D19 mediates RAS pathway activation and adaptive resistance to KRAS targeting drugs in cancer Warapen Treekitkarnmongkol, Hiroshi Katayama, Deivendran Sankaran, Mei-Chee Tai, Sanchita Rauth, Hanxiao Chen, Tristian Nguyen, Kieko Hara, Fredrik I. Thege, Moorthy P. Ponnusamy, Surinder K. Batra, Huamin Wang, Ignacio I. Wistuba, Thomas D. Schmittgen, John V. Heymach, Scott Kopetz, Tony Hu, Wantong Yao, Anirban Maitra, Subrata Sen
• LB286 · PDF Keap1缺失促进头颈癌的癌症干性和抗PD-1耐药 Keap1 loss promotes cancer stemness and anti-PD-1 resistance in head and neck cancer Khandoker Ifaz Ahmed, Qu Deng, Xue Xiong, Savallya Boyini, Yash Shah, Zhibin Cui
• LB287 · PDF 衰老细胞裂解药物的比较分析揭示了疗效与耐药的线粒体决定因素 Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance Masahiro Wakita, Eiji Hara
• LB288 · PDF KDM4A介导的染色质重塑促进恶性胸膜间皮瘤的肿瘤进展和免疫调节 KDM4A mediated chromatin remodeling promotes tumor progression and immune modulation in malignant pleural mesothelioma SrinivasVinod Saladi, Harshini Vemula, Martin Sattler
• LB289 · PDF RNA结合蛋白NF90介导EZH2的非Polycomb依赖性转录激活以促进癌症生长 RNA-binding protein NF90 mediates Polycomb-independent transactivation by EZH2 to promote cancer growth Yuan Wang, Liu Peng, Xiaodong Lu, Jonathan Zhao, Jindan Yu
• LB290 · PDF AR-V7利用非经典核定位信号维持不依赖雄激素的核输入和信号传导 AR-V7 utilizes a noncanonical nuclear localization signal to sustain androgen-independent nuclear import and signaling Urko del Castillo, Naira E. Abou-Ghali, Colin Burdette, Michelle Naidoo, Kiran Kumari Sahu, Paul Zumbo, Jacob Geri, Paraskevi Giannakakou
• LB291 · PDF 探索翻译抑制用于治疗转录抑制剂耐药的3组髓母细胞瘤 Investigating translation inhibition for the treatment of transcription inhibitor resistant Group 3 medulloblastoma Soumik Saha, Kelly Cai, Sangita Pal, Pratiti Bandopadhayay, John Robert Prensner
• LB293 · PDF 胱氨酸限制通过GCN2-eIF2alpha-SLC1A5轴促进OXPHOS从而增强CD8+ CAR-T的效力 Cystine restriction enhances CD8+ CAR-T potency by promoting OXPHOS via GCN2-eIF2alpha-SLC1A5 axis Xiaoxue Pan, Yuhang Yin, Pengyuan Wang, Shanwen Chen
• LB294 LB294 Vhl-/-Tsc1-/-小鼠迅速发展出伴有显著代谢和氧化还原重编程的透明细胞肾细胞癌，且该重编程需要NRF2信号 Vhl-/-Tsc1-/- mice rapidly develop clear cell renal cell carcinoma with pronounced metabolic and redox reprogramming that necessitates NRF2 signaling Xiaoqing (Cathy) Cheng, Jianing Xu, Omran Abu Aboud, Ying-Bei Chen, Ed Reznik, Toshinao Oyama, Satish Tickoo, Emily H. Cheng, Robert H. Weiss, James J. Hsieh
• LB295 LB295 超越突变的癌症：营养获取的发育程序影响YAP驱动肝癌的致癌胜任性 Cancer beyond mutations: Developmental programs of nutrient acquisition influence oncogenic competence in YAP-driven liver cancer Mikaela M. K. Wong, Kieran F. Harvey, Kristin K. Brown, Andrew G. Cox
• LB296 · PDF 靶向RNA结构的抑制在人脑类器官中抑制胶质母细胞瘤生长 RNA structure-targeted inhibition suppresses glioblastoma growth in human cerebral organoids Maria-Ancuta Jurj, Michael A. Attathikhun, Sanjay Kumar Singh, Meng Chen, Venkata Narayana Vidadala, Frederick Lang, Gabriele Varani, George A. Calin

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