PO.CL01.05 · 临床研究
Biomarkers Predictive of Therapeutic Benefit 5
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5235 · PDF 利用多模态AI和液体活检基因组输入对sotorasib敏感性进行真实世界预测和生物学特征分析 Real world prediction and biological characterization of sotorasib sensitivity using multimodal AI and liquid biopsy genomic inputs Maayan Baron, Felicia Kuperwaser, Sepideh Foroutan, Sunil Kumar, Dillon Tracy, Kevin Freisen, Brandon Funkhouser, Zong Miao, Nathaniel Tann, Fahad Khan, Sean Klei, Jordan Wolinsky, Taylor Wood, Jean Michel Rouly, Nick Lee, Ripple Khera, Anshu Jain, Jeff Sherman, Emily A. Vucic
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5236 · PDF cadonilimab联合regorafenib作为晚期肝细胞癌二线或后线治疗的最新探索性生物标志物分析:确定Bola3为潜在预测性生物标志物 Updated exploratory biomarker analysis of cadonilimab plus regorafenib as second-line or later therapy in advanced hepatocellular carcinoma: Identification of Bola3 as a potential predictive biomarker Yang Liu, Jin Zhang, Qi Qi, Dandan Wu, Linze Xu, Yueguo Li, Huikai Li
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5237 · PDF claudin-3(CLDN3)和B7-H3(CD276)的显著共表达可作为神经内分泌癌靶向治疗的潜在生物标志物 The significant co-expression of claudin-3(CLDN3) and B7-H3(CD276) as a potential biomarker for targeted therapy in neuroendocrine carcinomas Ji-Hye Nam, Ju-Yeon Kim, Jae Choi, Minjung Sung, Jae Hwan Kang, Hobin Yang, Yoon-la Choi, Young Kee Shin
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5238 · PDF 指导EGFR突变型NSCLC患者EGFR-TKI后续治疗策略的临床生物标志物回顾性研究 Retrospective study for clinical biomarkers to guide post-EGFR-TKI treatment strategies in EGFR-mutant NSCLC Tadaaki Yamada, Kenji Morimoto, Naoki Furuya, Hisashi Tanaka, Akihiro Yoshimura, Tomohiro Oba, Makoto Hibino, Takahito Fukuda, Yasuhiro Goto, Akira Nakao, Shinsuke Ogusu, Yuta Okazaki, Taishi Harada, Takayo Ota, Ken Masubuchi, Tae Hata, Koji Mikami, Shoki Matsumoto, Ryoichi Honda, Koji Date, Yusuke Chihara, Koichi Takayama
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5239 · PDF DT-9081已完成的I期研究中的生物标志物动态:晚期实体瘤中离体细胞因子刺激、尿PGEM及肿瘤生物标志物的分析 Biomarker dynamics in the completed phase I study of DT-9081: An analysis of ex vivo cytokine stimulation, urinary PGEM, and tumoral biomarkers in advanced solid tumors Thomas Maurin, Lola Lecru, Antoine Mousson, Orphée Blanchard, Malaury Schappler, Christophe Le Tourneau, Zahra Castel-Ajgal, Jean-Pascal Machiels, Rachel Galot, Nuria Kotecki, Christiane Jungels, Jean-Pierre Delord, Iphigenie Korakis, Camille Dietsch, Luc Baron, Maria Jesus Garcia Léon, Edith Steinberg, Katia Saulnier, Samira El-Farouk, Calire Jouffroy-Zeller, Anne Quesnel, Carolina Duarte, Abdelkrim Taamma, Anne-Laure Blayo, Thibaut Brugat, Nathalie Lenne, Jean-Marie Cuillerot, Stephan Schann
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5240 · PDF CXCL10/11和CCL19双重显色检测法可补充非小细胞肺癌中的PD-L1免疫组织化学 A CXCL10/11 and CCL19 duplex chromogenic assay complements PD-L1 immunohistochemistry in non-small cell lung cancer Alexander L. Tang, Liad Elmelech, William L. Tang, Maxwell Spurrell, Maria Ganci, Yiwen He, Catherine B. Meador, Christopher S. Nabel, Jessica J. Lin, Mari Mino-Kenudson, Nir Hacohen, Justin F. Gainor, Jonathan H. Chen
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5241 · PDF 利用微滴数字PCR检测急性髓系白血病中的个性化融合可测量残留病 Personalized fusion measurable residual disease detection in acute myeloid leukemia using droplet digital PCR Asra Noor, Xiaojuan Cao, Maggie J. Cox, Francesca Ferraro, David H. Spencer, Stephen T. Oh, Grant A. Challen, Andrew L. Young
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5242 · PDF APG-157治疗头颈癌可下调HPV 16与NF-κB并上调gigaxonin及免疫标志物:一项2A期临床研究 Down regulation of HPV 16 and NF-ΚB and upregulation of gigaxonin and immune markers in APG-157 treated head and neck cancer: A phase 2A clinical investigation Saroj K. Basak, Bhavani Shankara Gowda, Manasvini Kala, Jin Zhong, Trent Su, Daniel Sanghoon Shin, Marilene B. Wang, Eri S. Srivatsan
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5243 · PDF 外周LAG-3+CD8+ T细胞的特征分析:一类与免疫治疗耐药相关的免疫细胞群 Profiling of peripheral LAG-3+CD8+ T cells: An immune cell population associated with immunotherapy resistance Ariel Kogan Zajdman, Cory A. Brennick, Kayla J. Foster, Sydney A. Riddick, Tatiana Shcheglova, Matthew Adamow, Jasme Lee, Ronglai Shen, Katherine S. Panageas, Xiyu Peng, Margaret K. Callahan
- 5244 5244 基因组HLA I类等位基因失衡削弱晚期非小细胞肺癌的持久免疫治疗应答 Genomic HLA class I allelic imbalance undermines enduring immunotherapy response in advanced non small cell lung cancer Yiting Dong#, Shun Wang#, Wenbin Li*, Zhijie Wang*, Jie Wang*
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5246 · PDF NSCLC的免疫分析与可靶向生物标志物:迈向基于CKI的联合方案的合理设计 Immune profiling and targetable biomarkers in NSCLC: Toward rational design of CKI-based combinations Rania Gaspo, Alexandra Jean, Renaud Burrer, Jérôme Sallette, Amanda Finan-Marchi, Marie Gérus-Durand
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5247 · PDF 整合免疫组化用于NSCLC生物标志物检测:迈向精准治疗的一步 Integrating immunohistochemistry for biomarker detection in NSCLC: A step toward precision therapy Rania Gaspo, Renaud Burrer, Jérôme Sallette, Amanda Finan-Marchi, Marie Gérus-Durand
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5248 · PDF 单细胞多组学揭示TP53与表观遗传基因共突变驱动CAR-T治疗后B-ALL的髓系转化 Single-cell multi-omics reveals co-mutation of TP53 and epigenetic gene driving myeloid transformation in B-ALL following CAR-T therapy Shuang Zhao, Yanjing Tang, Meng Su, Bowen Cui, Rongrong Fan, Han Wang, Liu Yang, Lixia Ding, Ronghua Wang, Huiying Sun, Ying Zhong, Qiaoqiao Shi, Yuxuan Guo, Lili Song, Xinyu Wan, Tianyi Wang, Jing Yang, Benshang Li, Yu Liu
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5249 · PDF 纵向液体活检鉴定头颈部鳞状细胞癌免疫检查点阻断应答的早期预测性生物标志物 Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma Robert Saddawi-Konefka, Binbin Wang, Lauren M. Clubb, Cynthia Tang, Di Wu, Sumit Mukherjee, Sahil Sahni, Saugato Rahman Dhruba, Sumeet Patiyal, Chi-Ping Day, Parth Anil Desai, Clint Tanner Allen, Kun Wang, J. Silvio Gutkind, Eytan Ruppin
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5250 · PDF 基于CTC的生物标志物检测方法开发与工作流程优化,用于预测HR+/HER2-乳腺癌对CDK4/6抑制剂的应答 Method development and workflow optimization of a CTC-based biomarker assay to predict response to CDK4/6 inhibitors in HR+/HER2- breast cancer Mantasha Tabassum, Shivaani Suresh Kanna, Wangjia Cao, Suneel Kumar, Mothaffar F. Rimawi, George Miles, Meghana Trivedi
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5251 · PDF 利用NGS精确刻画代谢组学状态,揭示ccRCC对TKIs应答的新潜在生物标志物 Precise description of metabolomic states using NGS uncover new potential biomarkers of response to TKIs in ccRCC Alina Tarasova, Stanislav Kurpe, Andrey Kravets, Nikita Kotlov
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5252 · PDF 利用全面基因组分析的计算建模预测早期NSCLC的化学免疫治疗获益 Computational modeling of comprehensive genomic profiling to predict chemo-immunotherapy benefit in early stage NSCLC Prashant Nair, Kishor Promod, Ansu Kumar, Swati Khandelwal, Ambreen Ambreen, Susheel George, Mamatha Patil, Deepak Lala, Ashokraja Bala, Veena Balakrishnan, Shweta Kapoor, Drew Watson, James Wingrove, Tejas Patil
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5253 · PDF 帕博利珠单抗治疗复发性胶质瘤中无进展生存的分子相关因素 Molecular correlates of progression-free survival in recurrent gliomas treated with pembrolizumab Shameel Shafqat, Muhammad Asad Maqbool, Hussam Al Kateb, Terry C. Burns, Jian L. Campian, Shannon P. Fortin Ensign, Evanthia Galanis, Julie E. Hammack, Cristaine M. Ida, Mitch L. Klebig, Timothy J. Kaufmann, Autumn C. Moon, Maciej M. Mrugala, Bryan J. Neth, Alyx B. Porter, Michael W. Ruff, Ugur T. Sener, Wendy J. Sherman, Joon H. Uhm, Rachael A. Vaubel, Sani H. Kizilbash
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5254 · PDF PSG拷贝数扩增与女性肺腺癌患者不良生存相关 Copy number amplification of PSG is associated with poor survival in female lung adenocarcinoma patients Jung Hun Oh, Yingjie Zhu, Himangi Srivastava, Leyla Ebrahimpour, Rena Elkin, Larry Norton, Nadeem Riaz, Joseph O. Deasy
- 5255 5255 KRAS亚型可能改变胰腺癌对免疫治疗的不良应答:来自早期临床试验的证据 KRAS subtype may modify the poor immunotherapy response in pancreatic cancer: Evidence from early phase trials Dilsa Mizrak Kaya, Yangruijue Ma, Tarik Demir, Aparna Kalyan, Sheetal Kircher, Mary Mulcahy, Al B. Benson III, Ruohui Chen, Devalingam Mahalingam
- 5256 5256 NME1、CXCL12、VDR、DNMT1、CAV1、IL27和IL33多态性与孟加拉国女性乳腺癌易感性的关联:一项病例对照与计算机模拟研究 Association of NME1, CXCL12, VDR, DNMT1, CAV1, IL27, and IL33 polymorphisms with breast cancer susceptibility in Bangladeshi women: A case-control and in silico study Mohammad Safiqul Islam, Md Abdul Barek
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5257 · PDF 装甲型TIL GT201在晚期实体瘤中诱导强效的肿瘤特异性TCR扩增和持久的抗肿瘤应答 Armored TIL GT201 induces potent tumor-specific TCR expansion and durable antitumor responses in advanced solid tumor Pin Wang, Rong Zhou, Yong Han, Zhengxiang Han, Weijia Fang, Kai Chen, Youguo Chen, Liqing Ma, Lili Lu, Derun Shen, Jiahui Jin, Yiyang Tan, Ke Liu, Zhenjiang Liu, Jingman Wang, Zhao Xu, Jingwei Sun, Jun Cui, Jing Yu, Yue He, Yarong Liu
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5258 · PDF 通过循环肿瘤DNA监测非小细胞肺癌免疫治疗期间的分子应答 Monitoring of molecular response during immunotherapy by circulating tumor DNA in non-small cell lung cancer Johanna Svensson, Maria Yhr, Per Torstensson, Levent Akyürek, Andreas Hallqvist, Sukanya Raghavan, Anna Rohlin
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5260 · PDF DNMT3A突变的肿瘤浸润性克隆性造血可预测晚期非小细胞肺癌对免疫检查点抑制剂的应答 DNMT3A -mutated tumor-infiltrating clonal hematopoiesis predicts immune checkpoint inhibitor response in advanced non-small cell lung cancer Geun-Ho Park, Cheolyong Joe, Hyemin Kim, Eunjoo Oh, Naeun Lee, Subin Kim, Junsu Choe, Jinyong Kim, Sehhoon Park, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Joo Kyung Park, Se-Hoon Lee
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5261 · PDF 以肿瘤指导的系列血浆二代测序作为指导免疫治疗停药的新疗效指标 Serial plasma tumor-informed next generation sequencing as a new efficacy metric to guide immunotherapy treatment discontinuation Meghan J. Mooradian, Aleigha Lawless, Julianne Czapla, Amaya Gasco, Patrick Boyle, Merrida Childress, Ryan J. Sullivan