PO.CL05.12 · 临床研究
Redefining Targeted Therapy: Bispecific T-Cell Engagers and Antibody-Drug Conjugates 2
- 5388 5388 用双特异性抗体双重靶向CEACAM6和EGFR可诱导EGFR降解并克服抗EGFR耐药 Dual targeting of CEACAM6 and EGFR with a bispecific antibody induces EGFR degradation and overcomes anti-EGFR resistance Ming-Heng Wu, Chee Voon Yap, Yao-Tsung Tsai
- 5389 5389 CC312——一种新型CD19/CD3/CD28三特异性T细胞衔接器，可实现快速且深度的B细胞清除，在自身免疫性疾病中具有广泛的开发潜力 CC312, a novel CD19/CD3/CD28 tri-specific T cell engager, leads to rapid and deep B-cell depletion and has broad potential for development in autoimmune diseases Mingyuan Sun, Yingfeng Huang, Ruixia Zhang, Zhen Jing, Xiaofang Zhang, Yuchao Wei, Junyuan Qi
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- 5391 5391 一种多功能的 KY-HC-mouse™ 纳米抗体平台，可实现肿瘤锚定、条件性激活的 4-1BB 双特异性抗体 A versatile KY-HC-mouse™nanobody platform enabling tumor-anchored, conditionally active 4-1BB bispecific antibodies Xiaoting Liang, Siyu Li, Jie Xu, Hao Peng, Feng Hao, Jinying Ning
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- 5394 5394 新型多特异性 T 细胞衔接器利用亲合力高选择性地靶向 B-髓系混合表型急性白血病 Novel multispecific T cell engagers exploit avidity for highly selective targeting of B-myeloid mixed-phenotype acute leukemia Sophie Jamet, Huiyuan Zhang, Ray Ruff, Irene Chen, Sally Ditzler, Kiersten Tucker, Hailey Hentschel, Jessica Chantel Ramadhin, James M. Olson, Jason Price, Mignon L. Loh
- 5397 5397 一种新型抗 CD3×CD28×STEAP1 三特异性 T 细胞衔接器在前列腺癌中具有增强且持久的抗肿瘤反应 A novel anti-CD3×CD28×STEAP1 tri-specific T-cell engager with enhanced and durable antitumor responses in prostate cancer Ge Song, Aiying Xiong, Seng Zhu, Xuemei Tian, Xiaoling Yuan, Wanli Zhang, Wan-Jen Yang, Xiansong Xiong, Ling Ding, Haixiang Yu, Xiaoli Hou, Pingao Yan, Qingyu Wang, Xiao Zou, Chen Hu, Jijun Yuan
- 5399 5399 QLS2309，一种靶向 CD70 的三功能 NKp46/CD16a-NK 细胞衔接器，通过缓解对治疗性抗体依赖性细胞毒性的耐受来增强对急性髓系白血病的疗效 QLS2309, a trifunctional NKp46/CD16a-NK cell engager targeting CD70 enhances efficacy against acute myeloid leukemia via mitigating the refraction to therapeutic antibody-dependent cytotoxicity Liuqing Yang, Ruimei Li, Xiaoran Wu, Shuyong Zhao, Hua Ying, Weikang Tao
- 5400 5400 QLS2313，一种采用双靶向策略开发的 CD79b/CD20 三特异性 T 细胞衔接器，作为治疗 DLBCL 的新型疗法 QLS2313, a CD79b/CD20 tri-specific T cell engager with dual-targeting strategy developed as a new therapeutics for the treatment of DLBCL Ting Lu, Liuqing Yang, Fujia Yao, Dongdong Wu, Shuyong Zhao, Hua Ying, Weikang Tao
- 5401 5401 一种靶向 Nectin-4 和 HER2 的新型双特异性 ADC 在临床前模型中展现出优越且广泛的抗肿瘤疗效 A novel bispecific ADC targeting Nectin-4 and HER2 demonstrates superior and broad antitumor efficacy in preclinical models Jinxiu Hou, Tingting Gu, Chuan Chen, Chenpeng Su, Xiaoqian Chen, Dandan Liu, Jiyuan Tian, Zhihang Liu, Yongxin Shang, Rongmei Yan, Kezhen Ye, Liang Tian, Jian Peng, Zhenping Zhu
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- 5404 5404 肿瘤细胞靶向的granzyme B表现出直接的细胞毒性作用以及经多种明确蛋白介导的间接免疫原性细胞死亡 Tumor cell targeted granzyme B demonstrates direct cytotoxic action and indirect immunogenic cell death mediated through numerous defined proteins Khalid A. Mohamedali, Madhuri Wadehra, Lawrence H. Cheung, Michael G. Rosenblum
- 5405 5405 STX002：一种GPC3靶向抗体药物偶联物，在肝细胞癌临床前模型中具有强效且持久的抗肿瘤活性 STX002: A GPC3-targeted antibody-drug conjugate with potent and durable antitumor activity in preclinical models of hepatocellular carcinoma Deepak Rohila, Sameena Wani, Atul Tandon, Jianhua Zhao, Anindya Bagchi, Ashutosh Tiwari
- 5406 5406 一种新型AI工程化的双互补位DLL3/CD3 T细胞衔接器表现出强效的临床前疗效和良好的安全性特征 A novel AI-engineered biparatopic DLL3/CD3 T cell engager demonstrates potent preclinical efficacy and a promising safety profile Chuan Chen, Yue Wu, Chenpeng Su, Dandan Liu, Jiyuan Tian, Yujuan Li, Yongxin Shang, Xiaoqian Chen, Rongmei Yan, Liang Tian, Jian Peng, Zhenping Zhu
- 5407 5407 癌症中CAPRIN-1膜定位的机制及人源化抗CAPRIN-1抗体TRK-950的开发 Mechanism of CAPRIN-1 membrane localization in cancer and development of TRK-950, a humanized anti-CAPRIN-1 antibody Yoshitaka Minamida, Shoichi Ohno, Kazushi Tachibana, Ukei Wasai, Takayuki Fujita, Takashi Morimoto, Fumiyoshi Okano
