PO.CL12.03 · 临床研究
Epigenetics, Cytogenetics, and Clinical Molecular Genetics
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- 5282 5282 使用CLK抑制剂破坏剪接在恶性横纹肌样瘤临床前模型中显示活性 Splicing disruption using a CLK inhibitor shows activity in malignant rhabdoid tumor pre-clinical models Clemence Basse, Pawel Sobczuk, Andrea Gazzo, Tom Zhang, Marissa Mattar, Inna Khodos, Elisa De Stanchina, Romel Somwar, Neerav N. Shukla, Marc Ladanyi
- 5283 5283 基于云的计算框架用于儿童急性淋巴细胞白血病的个体化基因组分析：一项全国性多中心真实世界临床研究 Cloud-based computational framework for individualized genomic analysis in pediatric acute lymphoblastic leukemia: A nationwide multi-center real-world clinical study Han Wang, Jiaoyang Cai, Jie Yu, Shaoyan Hu, Yongjun Fang, Ju Gao, Jian Li, Hua Jiang, Xiuli Ju, Sixi Liu, Wenyong Kuang, Runming Jin, Liangchun Yang, Xuedong Wu, Xiaowen Zhai, Qun Hu, Hui Jiang, Ningling Wang, Chi Kong Li, Lirong Sun, Jiao Jin, Chun Li, Changda Liang, Yan Dai, Kaili Pan, Hao Xiong, Ching-Hon Pui, Shuhong Shen, Yu Liu
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- 5287 5287 遗传性癌症中的亲本来源感知基因组分析：仅使用先证者的血液样本识别家族中处于风险的一方 Parent-of-Origin-Aware genomic analysis in hereditary cancer: identifying the side of the family at risk using only the proband's blood sample Lilian Cordova, Vahid Akbari, Tiffany Leung, Kieran O’Neill, Katherine Dixon, Alexandra Roston, Eugene Cheung, Chuyi Zheng, Millicent Sharman, Alshanee Sharma, Steve Bilobram, Yaoqing Shen, Janine Senz, Yanni Wang, Daniel Chan, Alexandra Fok, Jennifer Nuk, Quang Hong, Robin Coope, Eric Chuah, Simon Chan, Hyun-Wu Lee, Yongjun Zhao, Miruna Bala, Karen Mungall, Andrew Mungall, Richard Moore, Nur Diana Binte Ishak, Siao Ting Chong, Ee Ling Chew, Ashley McDonald, Anna Martinez, Gregory Kelly, Rosella Delgado, Caitlin Orr, Joanne Yuen Yie Ngeow, Kara N. Maxwell, Stephen B. Gruber, Dean Regier, Alice Virani, Louis Lefebvre, Fabio Feldman, Marco Marra, Sophie Sun, Stephen Yip, Peter Lansdorp, Steven John Jones, Kasmintan Schrader
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- 5292 5292 表观遗传调节剂romidepsin和mithramycin A在高温条件下重激活肿瘤抑制程序并抑制结直肠腹膜转移中的c-MYC Epigenetic modulators romidepsin and mithramycin A reactivate tumor-suppressive programs and suppress c-MYC under hyperthermic conditions in colorectal peritoneal metastasis Yazid Ghanem, Gena Topper, Sahil Jethi, Jessica Collier, Marlena Buonasorte, Yong Ki Hong, Weam Othman Elbezanti
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- 5295 5295 胰腺癌中DNA甲基化介导的表观遗传基因改变的整合鉴定与功能研究 Integrative identification and functional interrogation of DNA methylation-mediated epigenetic gene alterations in pancreatic cancer Sanghee Nam, Galam Leem, Seungmin Bang
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- 5298 5298 基因组及临床因素对早期阶段表观遗传治疗疗效反应的影响：来自两家主要I期研究中心的国际队列 Impact of genomic and clinical factors on therapeutic response to arly‑phase epigenetic therapies: An international cohort from two major phase I units Manuel Pedregal, Harold Nathan Tan, Mercedes Avedillo, Ignacio Mahillo, Ester Garcia, Bernard Gaston Doger de Spéville, Miriam Dorta, Jordi Rodon Ahnert, Victor Moreno Garcia
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