Antibody-Drug Conjugates and Linker Engineering 3

• 4423 · PDF 通过新一代位点特异性糖基偶联和双有效载荷灵活性推进ADC治疗药物的发展 Advancing ADC therapeutics with next-generation site-specific glycan conjugation and dual-payload flexibility Wei-Chien Tang, Yu-Hung Chen, Chih-Kang Chang, Ting-Wei Liu, Hung-Yi Lin, Wei-Jhen Huang, Chi-Huan Lu, Ren-Yu Hsu, Nan-Hsuan Wang, Ya-Chi Chen, Teng-Yi Huang
• 4424 · PDF 一种首创的抗整合素α/β ADC在难治性实体瘤中的临床前疗效 Preclinical efficacy of a first-in-class anti-Integrin alpha/beta ADC in hard-to-treat solid tumors Qinhong Ma, Daizong Li, Kewei Zhao, Mary Q. Xu, Mason Lu
• 4426 4426 新型肿瘤微环境（TME）激活的泛RASi和Topo1i双有效载荷连接子实现安全的广谱RAS抑制并克服Topo1i耐药 Novel tumor microenvironment (TME)-activated, pan-RASi and Topo1i dual-payload linker enables safe broad RAS inhibition and overcomes Topo1i resistance Zhengsong Gu, Cheng Liu, Yuan Liu
• 4427 · PDF CLIO-8221的开发：一种靶向HER2的多载荷ADC，用于克服ADC耐药 Development of CLIO-8221: A HER2-targeted multi-payload ADC to address ADC resistance Alyson Smith, Ben Ayers, Shalini Paliwal, Bhushan Dharmadhikari, Jerome Boyd-Kirkup
• 4430 · PDF WuXiTecan2：一种用于双载荷ADC发现的亲水性依沙替康连接子-载荷 WuXiTecan2: A hydrophilic exatecan linker-payload for dual-payload ADC discovery Hu Chen, Qirui Fan, Zili Xu, Xiaomei Li, Ding Wei, Lin Zhang, Chenghu Hu, Cindy Cheng, Marie Zhu
• 4431 · PDF ZW427：一种携带新型pan-RAS抑制剂载荷、靶向Ly6E的抗体药物偶联物，用于治疗RAS突变癌症 ZW427, a Ly6E-targeting antibody drug conjugate bearing a novel pan-RAS inhibitor payload for the treatment of RAS mutated cancers Dunja Urosev, Vidhi Khanna, Ambroise Wu, Jodi Wong, Saki Konomura, Elizabeth Porter, Matthew Bonderud, Victoria Harman-McKenna, Taixiang Wang, Linglan Fu, Diego Alonzo, Devika Sim, Adele Chan, Allysha Bissessur, Spencer Boisjoli, Michael Lee, Germanna Righetto, Jesse Leblanc, Raffaele Colombo, Graham Garnett, Jamie Rich, Stuart Barnscher
• 4432 · PDF LNF2105：一种采用特殊设计连接子和DXD类似物的新一代靶向nectin-4的ADC LNF2105, a next-generation nectin-4-targeted ADC with a specially designed linker and a DXD analogue Zhongsong Zhu, Shili Wang, Jinhua Xu, Fanliang Cheng, Yuqiang Zhu, Peibiao Zhang, Guimin Zhang, Lili Zhao, Zhenyu Li
• 4433 · PDF LM-364 TME的临床前评估：一种疗效可观且毒性降低的新一代抗Nectin4 ADC Preclinical evaluation of LM-364 TME : A next-generation anti-Nectin4 ADC with promising efficacy and reduced toxicity Lei Shi, Yun Zhang, Rongrong Huang, Xia Qin, Da Fei, Yuan Li, Wei Cao
• 4434 · PDF 靶向人乳腺癌和胃癌的C2LP-ADC与CLP2-ADC的体外和体内研究 In vitro and in vivo study of C 2 LP-ADC & CLP 2 -ADC targeting human breast and gastric cancer Xingquan Ma, Greg Liang, Weihua Shi, Bing Li, Shuwei Lu, Xinxin Yang, Qikuan Chen, Guilan Wang, Yao Ma
• 4435 · PDF 以新型连接子架构和载荷优化变革ADC开发 Transforming ADC development with novel linker architectures and payload optimization Gengcheng Jack Yang, Xudong Wei
• 4436 4436 Sutro的定点双载荷ADC：结合TOPO1i与DNA损伤应答抑制剂以增强疗效、克服耐药并改善安全性 Sutro's site-specific dual-payload ADCs combining TOPO1i and DNA damage response inhibitors to enhance efficacy, overcome resistance, and improve safety Krishna Bajjuri, Robert Yuan, Daniel Calarese, Rhoneil Pena, Ravi Singh, Young Park, Cuong Tran, Abigail Yu, Xiaofan Li, Guifen Xu, Yihong Zhou, Brian Vuillemenot, Werner Rubas, Genevive Hernandez, Alice Yam, Gang Yin, Hans-Peter Gerber
• 4437 · PDF 靶向组织因子(tissue factor)用于治疗实体瘤的抗体药物偶联物XNW28012的临床前开发 Preclinical development of XNW28012, an antibody drug conjugate targeting tissue factor for treatment of solid tumors Yonghan Hu, Zhe Zhang, Yuanbao Li, Liang Kong, Shihua Wang, Zhenwei Wu, Xiaocheng Hu, Ka Ruan, Wengui Wang, Guorong Li, Qifeng Shi, Haiyang Wei, Xiaojun Liu, Meijie Le, Jing Qiang
• 4438 · PDF 一种新型协同双载荷TROP2 ADC(CTPH-03)通过提高MTD带来更佳安全性 A novel synergistic dual-payload TROP2 ADC (CTPH-03) delivering enhanced safety by increased MTD Myeong Joo Kim, Soyeon Lim, Dahyun Kim, Han ah Kim, Jaebeom Park, Eunseok Choi, Da wo Jeong, Ji Eun Choi, Young Sang Kim, Seung Chan Kim, Hyo Jin Kang, Chang-Sun Lee
• 4439 · PDF HWK-007的临床前评估：一种采用新型生物偶联及连接子-载荷技术的新一代PTK7靶向ADC Preclinical assessment of HWK-007, a next-generation, PTK7-targeting ADC with novel bioconjugation and linker-payload technology Kathy S. Keegan, Shihe Hou, Ashwini B. Pai, Enrico Bellomo, Erik Kratzer, Victor Peykov, Bryan Ball, Xia Wang, Qingling Lu, Lei Wu, Jijie Gu, David J. Lennon, David Dornan
• 4440 4440 HWK-206的临床前评估：一种采用新型生物偶联及连接子-载荷技术的新一代双互补位SEZ6靶向ADC Preclinical assessment of HWK-206, a next-generation, biparatopic, SEZ6-targeting ADC with novel bioconjugation and linker-payload technology Kathy S. Keegan, Shihe Hou, Ashwini B. Pai, Enrico Bellomo, Erik Kratzer, Victor Peykov, Bryan Ball, Lei Wu, Mengmeng Sun, Lu Jiang, Jijie Gu, David J. Lennon, David Dornan
• 4441 · PDF 新型LIV1抗体药物偶联物的临床前表征 Preclinical characterization of novel LIV1 antibody drug conjugates Fei Teng, Huanhuan Guo, Xinlai Yao, Lizhi Qin, Lei Shi, Xu Lin, Yi Gu, Xueming Qian
• 4442 · PDF 利用拓扑异构酶I ADC靶向ITGB4：在结直肠癌和头颈癌中的临床前抗肿瘤活性 Targeting ITGB4 with a topoisomerase I ADC: Preclinical antitumor activity in colorectal and head and neck cancers Mi Young Cha, Hyunuk Kim, Hyunkyung Yu, Youngeun Ha, Kitae Park, Seungmin Byun, Bu-Nam Jeon, Mira Kim, Gyeongyeon Kim, Sangmoo Park, Wuhwui An, Suah Choi, Yura Kang, Hansoo Park
• 4443 · PDF GENA-104 ADC的临床前开发：一种靶向CNTN4、基于exatecan的新型抗体药物偶联物，用于实体瘤 Preclinical development of GENA-104 ADC, an exatecan-based novel antibody-drug conjugate targeting CNTN4, for solid tumors Mi Young Cha, Hyunkyung Yu, Hyunuk Kim, Kitae Park, Youngeun Ha, Seungmin Byun, Jiyeong Lee, Mira Kim, Bu-Nam Jeon, Soojung Moon, Gyeongyeon Kim, Gyeong-Jin Cheon, Hansoo Park
• 4444 · PDF 整合素α-2(ITGA2)是一种新型且非常适合的抗体药物偶联物(ADC)靶点 Integrin alpha-2 (ITGA2) is a novel and well-suited antibody-drug conjugate (ADC) target Sophie Colombo, Vincent Martin, Aurélie Courtin, Sylvain Roqueviere, Lou-Amélia Revellin, Benjamin Beaufils, Catherine C. L. Wong, Pei Han, Wei Li, Yu Song, Qing Zhou, Feng He, Chuanying Xu, Weihong Nian, Mary Jane Hinrichs, Elisabetta Leo
• 4445 · PDF 多样化ADC新型载荷的综合筛选与评估平台 Diverse ADC novel payloads, comprehensive screening and evaluation platform Ying Meng, Qian Wang, Min Kang, Xuan Qiao, Chanrui Wang, Yixiao Zhao, Jiangtao Lin, Jiamei Zhao, Li Li, Tiejun Bing
• 4447 4447 用于在三维系统中评估抗体偶联药物的新一代分子工具 Next generation molecular tools for evaluating antibody drug conjugates in 3D systems Jayanth Surya Narayanan Shankara Narayanan, Ryan Holly
• 4448 · PDF 在评估ADC候选物时，三维肿瘤类器官相较于二维细胞更能预测体内抗癌药理学 3D-tumor organoid, over 2D-cell, is more predictive of in vivo anti-cancer pharmacology in assessing ADC candidates Tao Yang, Jun Zhou, Hang Ke, Jessie Jingjing Wang, Jiawen Gao, Qing Li, Jinxi Wang, Feiyu Peng, Cen Chen, Lei Zhang, Faming Zhang, Henry Li
• 4449 · PDF 功能性类器官筛选揭示TROP2 ADC的靶点依赖性和旁观者杀伤效应 Functional organoid screening uncovers target dependency and bystander killing in TROP2 ADCs Jialei Sun, Marten Hornsveld, Lenno Krenning, Dorrith Verstegen, Peng Han, Zhongman Sun, Caitlyn Hulsebosch, Dione Blok, Peter van Schaik, Mali He, Huike Ju, Yi Sun, Mariusz Madej, Hester Bange, Jun Zhou, Peng Wang, Ludovic Bourre, Marrit Putker

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