PO.ET08.01 · 实验与分子治疗
Strategies to Enhance the Therapeutic Index of Radiotherapy
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- 4624 4624 还原型辅酶Q10（CoQ10）缓解盆腔放疗相关急性肠道毒性疗效的研究：一项随机、安慰剂对照、双盲比较研究 Investigation of the efficacy of reduced coenzyme Q10 (CoQ10) for alleviating acute intestinal toxicity associated with pelvic radiotherapy: A randomized, placebo-controlled, double-blind comparative study Satoshi Seno, Akifumi Kajiwara, Yasuyuki Shimizu, Kazuma Iwashita, Kana Kobayashi, Qin Qin, Qu Zhang, Hatamei Takabayashi, Kanako Suda, Hiroki Kawaguchi, Takeaki Ishihara, Daisuke Miyawaki, Sae Murakami, Yoshito Terai, Ryohei Sasaki
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- 4628 4628 线粒体丝氨酸/苏氨酸磷酸酶磷酸甘油酸变位酶5（PGAM5）是促进腹部放疗的新型靶点 Mitochondrial serine/threonine phosphatase, phosphoglycerate mutase 5 (PGAM5) is a novel target to promote abdominal radiotherapy Shujah Hamid Rehman, Rishi Man Chugh, Payel Bhanja, Stacey Krepel, Subhrajit Saha
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- 4630 4630 CD46靶向的双模态α粒子及细胞毒载荷负载抗体用于增强转移性去势抵抗性前列腺癌的治疗 CD46-targeted dual-modality alpha-particle and cytotoxic payload-loaded antibody for enhanced treatment of metastatic castration-resistant prostate cancer Anil Bidkar, Scott Bidlingmaier, Anju Wadhwa, Kondapa Naidu Bobba, Shubhankar Naik, Cheng Xue, Athira Raveendran, Megha Basak, Jonathan Chou, Rahul Aggarwal, Henry VanBrocklin, Youngho Seo, Bin Liu, Robert Flavell
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- 4633 4633 在LNCaP前列腺癌异种移植模型中对68Ga-PSMA、177Lu-PSMA治疗以及生物标志物指导的免疫治疗和DDR抑制剂联合方案的诊疗一体化评估 Theranostic evaluation of 68 Ga-PMSA, 177 Lu PSMA therapy, and biomarker guided immunotherapy and DDR inhibitor combinations in LNCaP prostate cancer xenografts Juliana Maynard, Anita Liu, Benedetta Arno, Tracy Hall, William Drewe, Kerry Shea, Andrzej Rutkowski, Grace Haydon, Tiffany-Jane Allen, Fiona Yau, Liviu Lucaciu, Mikaela Griffiths, Gayle Marshall
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- 4636 4636 解析放射敏感性确定MDM2为TP53野生型肺腺癌协同放射增敏的可靶向驱动因素 Deciphering radiation sensitivity identifies MDM2 as a targetable driver of synergistic radiosensitization in TP53 wild-type lung adenocarcinoma Chan Hoon Maeng, Jieon Hwang, Joong Bae Ahn, Sang Joon Shin
- 4637 4637 α粒子放疗联合抗CTLA-4协同克服放射抗性并在PDAC中诱导局部和全身抗肿瘤免疫 Alpha-particle radiotherapy combined with anti-CTLA-4 synergistically overcomes radioresistance and induces local and systemic antitumor immunity in PDAC Marco Reis, Poliana C. Marinello, Walison Augusto da Silva Brito, Scott Bright, Mark Wasley, Alexandre Rubinstein, Ronen Sega, Vered Bachar, Gabriel O. Sawakuchi
- 4638 4638 溶瘤单纯疱疹病毒M002通过减少G2/M期阻滞增强小鼠横纹肌肉瘤原位同种异体移植细胞的抗肿瘤放射应答 Oncolytic herpes simplex virus, M002, increases the antitumor radiation response by decreasing the G2/M arrest in murine rhabdomyosarcoma orthotopic allograft cells Maryam G. Shaikh, Nazia Nazam, Morgan L. Brown, Pranava Nande, Ali M. Eakes, Shamza Manzoor, Joel C. Opara, James M. Markert, Jamie M. Aye, Elizabeth A. Beierle
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- 4641 4641 高溶解度前药硼苯丙氨酸（L-BPA）二肽在中子照射治疗后展现显著肿瘤抑制作用并诱导癌症疫苗效应 Highly soluble prodrug boronophenylalanine (L-BPA) dipeptide, exhibits notable tumor suppression whilst inducing cancer vaccine effect post neutron irradiation treatment Samkeliso Dlamini, Michael Torgov, Arthur Raitano, Jason Quintana, Tioga Martin, Chunying Zhang, Maria Christina Malinao, Maki Ikeura, Linnette Capo, Karen Morrison, Robert Dorn, Kotaro Matsumoto, Aoi Komatsu, Yuya Higashi, Takushi Takata, Yoshinori Sakurai, Minoru Suzuki, Fuyuhiko Tamanoi, Kendall Morrison
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- 4643 4643 微卫星不稳定性作为结直肠癌放化疗敏感性的决定因素：整合临床、影像组学与三维类器官分析 Microsatellite instability as a determinant of chemoradiotherapy sensitivity in colorectal cancer: Integrated clinical, radiomic, and 3D organoid-based analyses Hyowon Hong, Shin Kim, Sang Jun Byun, Seong Kyu Baek, hyewon lee, sung wook bae
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- 4646 4646 验证一组表达成纤维细胞活化蛋白的细胞系来源异种移植模型作为靶向放射性配体治疗药物开发平台 Validation of a panel of fibroblast activation protein expressing cell line derived xenograft models as a platform for the development of targeted radioligand therapeutics Michael Batey, James Suchy, Taylor Hotz, Michael Milhollen, Kayla Duval, Jackson Chan, Karen Gelinas, Michael Bruce, Michelle Petrozzi, William Maccuaig, Neil Rollins, Jennifer Tavares, Erin Snay, Kyeara Mack-Henry, Soumya Ullas
- 4647 4647 用于评估靶向放射性配体疗法的、代表多种肿瘤适应症的细胞系来源异种移植模型组的开发与验证 Development and validation of a panel of cell line derived xenograft models representing multiple tumor indications for the evaluation of targeted radioligand therapeutics Michael Batey, James Suchy, Taylor Hotz, Michael Bruce, Jennifer Tavares, Erin Snay, Neil Rollins, Jackson Chan, Karen Gelinas, Kayla Duval, William Maccuaig, Michael Milhollen, Michelle Petrozzi, Kyeara Mack-Henry, Soumya Ullas
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