Vaccine Platforms and Target Identification

• 4361 · PDF Single amino acid residue substitution to improve immunogenicity of HLA peptides targeting p53 neoantigen Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Zhenghui Wang, Lipeng Lai, Melvin Toh
• 4362 · PDF Mesenchymal stem cells delivering IL-33 oncolytic vaccinia virus enhance antitumor effects and overcome PD-1 inhibitor resistance in bladder cancerResistance in bladder cancer Yong Tang, Yingzhao Liu, Songlin Li, Wenjie Wang, Jiahu Wang, Qi Wang
• 4363 · PDF Viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity Emily Elizabeth Steffke, Laila Latifi, Taijun Hana, Ayaka Hara, Morgan Coombs, Jo Spurgeon, Caitlin Huguely, John Hancock, Brita Anderson, James McAuliffe, Vinnycius Pereira-Almeida, Amanda Wicki, Sara Abdel Malak, Laurine Noblecourt, Meili Zhang, Wei Zhang, Dionne Davis, Nicole Briceno, Hua Song, Chen Cam-El Makranz, Hideho Okada, Mark Gilbert, Carol Leung, Benoit Van den Eynde, Masaki Terabe
• 4364 · PDF Next-generation RNA vaccine modalities enable high-fidelity antigen discovery and T-cell immunogenicity screening Molly Chilton, Henry Leonard, Elsenoor Klaver, Olivier Reelfs, Lauren Schewitz-Bowers, James Corbett, Rebecca Roberts, Christopher Kirkham, Dan Rocca, Louise Brackenbury
• 4365 · PDF Pre-existing immunity boosts therapeutic efficacy of oncolytic influenza a virus in the presence and absence of neutralizing antibodies Gloria Dawodu, Soner Yildiz, Yonina Bykov, Vicent Tur Planells, Ethan Spodeck, Sara Cuadrado-Castaño, Adolfo Garcia-Sastre
• 4367 · PDF Strong therapeutic efficacy of oncolytic virus KLS-3021 in orthotopic head and neck cancer models regardless of PD-L1 expression via tumor microenvironment remodeling Sungmin Lee, Jinwon Seo, Kiwon Park, Joonsung Kim, Eunjin Lee, Jaeil Shin, Soon-Oh Hong, Sujeong Kim, Sun Jin Kim
• 4368 · PDF Vaccine targeting IGF1R induces neutralizing antibody and robust anti-tumor activity in a syngeneic mouse colon cancer model Kenneth Nansheng Lin, Melvin Toh, HONG WANG
• 4369 · PDF B7-H3 vaccine induces robust humoral and cellular immunity and inhibits tumor growth in mice Kenneth Nansheng Lin, Melvin Toh, HONG WANG
• 4370 · PDF TROP2-circular RNA vaccine and IL7 synergistically inhibit TROP2+ tumor growth in mouse models Zirong He, Yanan Li, Antong Li, Xiaoxuan Liu, Kenneth Nansheng Lin, Fan Yan Meng, Melvin Toh, Hong Wang
• 4371 · PDF Preclinical potential of gammadelta T cells in novel virus-like particle vaccines for triple-negative breast cancer Arnau Solé Casaramona, Anish Ghimire, Romano Josi, Sanjana Marar, Anita Ogriņa-Komarova, Simone De Brot, Chang Wang, David Wiggins, Wendao Liu, Sarat Kumar Kottarath, Martin F. Bachmann, Eva M. Sevick, Mona O. Mohsen
• 4372 · PDF Proteolysis-targeting vaccines, or PROTAX, for robust tumor combination immunotherapy Qiyan Wang, wenhua li, Shaomeng Wang, Guizhi Julian Zhu
• 4373 · PDF Rational design of immune-cell-homing macroporous hydrogels for enhanced dendritic cell recruitment and cancer vaccination Wenhao Xu, Hua Wang
• 4374 · PDF A novel RNA-LNP immunotherapy platform to drive anti-tumor efficacy in solid tumors Hailey R. Lee, Khalid Rashid, Tony Luu, Amanda Creech, Pu-Lin Teng, Emma Lieberman, Bridget Vause, Catherine Xie, Britney Trieu, Willy Hugo, Ting-Ting Wu, Norbert Pardi, Caius G. Radu
• 4375 · PDF Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model Na Wang, Lam Chow, Melvin Toh, Hong Wang
• 4376 · PDF Harnessing artificial intelligence to optimize neoantigen prediction and mRNA design for personalized cancer vaccine Yang Liu, Qingyi Mao, Wu Xinghan, Qiu Mantang
• 4377 · PDF High affinity receptor bio-selected novel oncolytic RNA virus, IVX055, demonstrates potent anti-tumor activity in human NSCLC, hepatocellular carcinoma and bladder cancer with potential for immunotherapeutic combinations Min Quah, Christine Lee, Rebecca Ingham, Oksana Zdanska, Darren Shafren
• 4378 · PDF Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Isabelle Miousse, Camila C. Simoes, Alexei Basnakian, Rangaswamy Govindarajan, Martin Cannon, Mitesh J. Borad, Bolni M Nagalo
• 4379 · PDF Enhanced cancer immunotherapy via sPD1-based DNA vaccination targeting epitope-focused TWIST1 antigen Zhiwu Tan, Mei Sum Chiu, Helen Xinyue Yu, Xiaoxiao Chang, Zhiwei Chen
• 4380 · PDF IRZ-01: A self-adjuvanted outer membrane vesicle vaccine targeting CEA and MUC1 for colorectal cancer immunotherapy Kevin Chen, Caleigh Fletcher, John Cowger, James E. Galen, Mayukh Das, Marcio Chedid
• 4381 · PDF Combination therapy with a HIF-1alpha/c-MET peptide vaccine and carboplatin reprograms the tumor microenvironment to overcome platinum resistance in an intraperitoneal metastasis model of high-grade serous ovarian carcinoma Soon Young Lim, JinHwa Hong, DongGeRaMi Moon, Hyeyeon Roh, Ju Won Kim, Ji Won Lee, Kyong Hwa Park
• 4382 · PDF Bridging in vitro screening to in vivo efficacy for cancer vaccines Hongyan Sun, Jialu Fan, Yujing Zhang, Yunlong Jiang, Huixin Yang, Xiang Gao
• 4383 · PDF Utilization of HBV-vaccinated immunity to suppress tumor progression via targeted delivery of HBsAg to CEA-positive colorectal cancer Chun-Chia Cheng, Zong-Lin Sie, Yung-Chin Hsiao, Ai-Sheng Ho, Chih‑Liang Wang, Cheng-Liang Peng, Chun‑I Wang, Hong-Zen Yeh, Jungshan Chang, Chun-Chao Chang
• 4384 · PDF Advancing novel vaccines: Preclinical evaluation in HLA-A2.1/HLA-DRB1*1.1 humanized mice Dana Emerson, Zhenlan Niu, Shuaiqiang Zhang, Xiaofei Zhou
• 4385 · PDF Engineering durable tumor immunity with a virus-tumor hybrid antigen dendritic cell vaccine Jin Muk Kang, Eun Hyang Han, Jin-kyu Choi, Seunghee Youm, Tej Pareek, Seong-Jin Kim, John Letterio, Seunghwan Lim
• 4386 · PDF Expanding the therapeutic potential of Bvax: A B-cell-based vaccine for solid tumors Hanxiao Wan, Joshua L. Katz, Yotam D. Hahn, Si Wang, Grace V. Jones, Alina R. Murphy, Rebecca Du, Jeffrey Bacha, Roger Stupp, Catalina Lee-Chang
• 4387 · PDF A clinical-adopted vaccine platform and new immunogenic epitopes combined against prostate cancer Elisa Marmocchi, Rubens Begaj, Marta Cantarelli, Davide Bressan, Nicole Annesi, Martina Cortese, Mattia Barbareschi, Giovanni Bertalot, Francesco Giuseppe Carbone, Alessandro Alaimo, Marianna Kruithof-de Julio, Nicola Ternette, Ugo Ala, Fulvio Chiacchiera, Guido Grandi, Andrea Lunardi
• 4388 · PDF Inducing memory humoral responses using multiple vaccines in PBMC humanized mice Destanie Rose, Ilian Radichev, Beau Parry, Leandro Salati D'Abronzo, Zahid Delwar, Jiwon Yang, Li-Chin Yao, James G. Keck
• 4389 · PDF Establishing a CTC-driven workflow for mRNA-transfected moDC production in personalized cancer immunotherapy Giovanna Manga Guimaraes, Nadia Bayou, Mara Serena Serafini, Eleonora Nicolò, Letizia Pontolillo, Brenno Pastò, Nassima Messali, Kiran Sahu, Paraskevi Giannakakou, Gabriela Coeli Menezes Evangelista, Olivier Elemento, Carolina Reduzzi, José Alexandre Barbuto, Massimo Cristofanilli

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