Vaccine Platforms and Target Identification

• 4361 · PDF 单氨基酸残基替换以改善靶向p53新抗原的HLA肽的免疫原性 Single amino acid residue substitution to improve immunogenicity of HLA peptides targeting p53 neoantigen Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Zhenghui Wang, Lipeng Lai, Melvin Toh
• 4362 · PDF 递送IL-33溶瘤痘苗病毒的间充质干细胞增强抗肿瘤作用并克服膀胱癌中的PD-1抑制剂耐药 Mesenchymal stem cells delivering IL-33 oncolytic vaccinia virus enhance antitumor effects and overcome PD-1 inhibitor resistance in bladder cancerResistance in bladder cancer Yong Tang, Yingzhao Liu, Songlin Li, Wenjie Wang, Jiahu Wang, Qi Wang
• 4363 · PDF 病毒载体疫苗诱导脑组织驻留记忆T细胞以驱动抗胶质母细胞瘤免疫 Viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity Emily Elizabeth Steffke, Laila Latifi, Taijun Hana, Ayaka Hara, Morgan Coombs, Jo Spurgeon, Caitlin Huguely, John Hancock, Brita Anderson, James McAuliffe, Vinnycius Pereira-Almeida, Amanda Wicki, Sara Abdel Malak, Laurine Noblecourt, Meili Zhang, Wei Zhang, Dionne Davis, Nicole Briceno, Hua Song, Chen Cam-El Makranz, Hideho Okada, Mark Gilbert, Carol Leung, Benoit Van den Eynde, Masaki Terabe
• 4364 · PDF 下一代RNA疫苗模态实现高保真抗原发现与T细胞免疫原性筛选 Next-generation RNA vaccine modalities enable high-fidelity antigen discovery and T-cell immunogenicity screening Molly Chilton, Henry Leonard, Elsenoor Klaver, Olivier Reelfs, Lauren Schewitz-Bowers, James Corbett, Rebecca Roberts, Christopher Kirkham, Dan Rocca, Louise Brackenbury
• 4365 · PDF 预存免疫在有或无中和抗体的情况下均可增强溶瘤甲型流感病毒的治疗效果 Pre-existing immunity boosts therapeutic efficacy of oncolytic influenza a virus in the presence and absence of neutralizing antibodies Gloria Dawodu, Soner Yildiz, Yonina Bykov, Vicent Tur Planells, Ethan Spodeck, Sara Cuadrado-Castaño, Adolfo Garcia-Sastre
• 4367 · PDF 溶瘤病毒KLS-3021通过重塑肿瘤微环境，在原位头颈癌模型中无论PD-L1表达如何均具有强效治疗作用 Strong therapeutic efficacy of oncolytic virus KLS-3021 in orthotopic head and neck cancer models regardless of PD-L1 expression via tumor microenvironment remodeling Sungmin Lee, Jinwon Seo, Kiwon Park, Joonsung Kim, Eunjin Lee, Jaeil Shin, Soon-Oh Hong, Sujeong Kim, Sun Jin Kim
• 4368 · PDF 靶向IGF1R的疫苗在同基因小鼠结肠癌模型中诱导中和抗体和强效抗肿瘤活性 Vaccine targeting IGF1R induces neutralizing antibody and robust anti-tumor activity in a syngeneic mouse colon cancer model Kenneth Nansheng Lin, Melvin Toh, HONG WANG
• 4369 · PDF B7-H3疫苗诱导强效体液和细胞免疫并抑制小鼠肿瘤生长 B7-H3 vaccine induces robust humoral and cellular immunity and inhibits tumor growth in mice Kenneth Nansheng Lin, Melvin Toh, HONG WANG
• 4370 · PDF TROP2环状RNA疫苗与IL7协同抑制TROP2+肿瘤在小鼠模型中的生长 TROP2-circular RNA vaccine and IL7 synergistically inhibit TROP2+ tumor growth in mouse models Zirong He, Yanan Li, Antong Li, Xiaoxuan Liu, Kenneth Nansheng Lin, Fan Yan Meng, Melvin Toh, Hong Wang
• 4371 · PDF gammadelta T细胞在用于三阴性乳腺癌的新型病毒样颗粒疫苗中的临床前潜力 Preclinical potential of gammadelta T cells in novel virus-like particle vaccines for triple-negative breast cancer Arnau Solé Casaramona, Anish Ghimire, Romano Josi, Sanjana Marar, Anita Ogriņa-Komarova, Simone De Brot, Chang Wang, David Wiggins, Wendao Liu, Sarat Kumar Kottarath, Martin F. Bachmann, Eva M. Sevick, Mona O. Mohsen
• 4372 · PDF 靶向蛋白降解疫苗（PROTAX）用于稳健的肿瘤联合免疫治疗 Proteolysis-targeting vaccines, or PROTAX, for robust tumor combination immunotherapy Qiyan Wang, wenhua li, Shaomeng Wang, Guizhi Julian Zhu
• 4373 · PDF 免疫细胞归巢型大孔水凝胶的理性设计，用于增强树突状细胞募集和肿瘤疫苗接种 Rational design of immune-cell-homing macroporous hydrogels for enhanced dendritic cell recruitment and cancer vaccination Wenhao Xu, Hua Wang
• 4374 · PDF 一种新型RNA-LNP免疫治疗平台，用于在实体瘤中驱动抗肿瘤疗效 A novel RNA-LNP immunotherapy platform to drive anti-tumor efficacy in solid tumors Hailey R. Lee, Khalid Rashid, Tony Luu, Amanda Creech, Pu-Lin Teng, Emma Lieberman, Bridget Vause, Catherine Xie, Britney Trieu, Willy Hugo, Ting-Ting Wu, Norbert Pardi, Caius G. Radu
• 4375 · PDF Claudin 6疫苗在同基因小鼠结肠癌模型中有效抑制肿瘤生长 Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model Na Wang, Lam Chow, Melvin Toh, Hong Wang
• 4376 · PDF 利用人工智能优化新抗原预测和mRNA设计以用于个性化肿瘤疫苗 Harnessing artificial intelligence to optimize neoantigen prediction and mRNA design for personalized cancer vaccine Yang Liu, Qingyi Mao, Wu Xinghan, Qiu Mantang
• 4377 · PDF 经高亲和力受体生物筛选的新型溶瘤RNA病毒IVX055在人NSCLC、肝细胞癌和膀胱癌中展现出强效抗肿瘤活性并具有免疫治疗联合的潜力 High affinity receptor bio-selected novel oncolytic RNA virus, IVX055, demonstrates potent anti-tumor activity in human NSCLC, hepatocellular carcinoma and bladder cancer with potential for immunotherapeutic combinations Min Quah, Christine Lee, Rebecca Ingham, Oksana Zdanska, Darren Shafren
• 4378 · PDF 减毒活MMR疫苗调节肿瘤免疫细胞浸润，并与标准治疗协同以延长临床前HCC模型的生存期 Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Isabelle Miousse, Camila C. Simoes, Alexei Basnakian, Rangaswamy Govindarajan, Martin Cannon, Mitesh J. Borad, Bolni M Nagalo
• 4379 · PDF 通过基于sPD1、靶向表位聚焦TWIST1抗原的DNA疫苗接种增强肿瘤免疫治疗 Enhanced cancer immunotherapy via sPD1-based DNA vaccination targeting epitope-focused TWIST1 antigen Zhiwu Tan, Mei Sum Chiu, Helen Xinyue Yu, Xiaoxiao Chang, Zhiwei Chen
• 4380 · PDF IRZ-01：一种靶向CEA和MUC1的自佐剂型外膜囊泡疫苗用于结直肠癌免疫治疗 IRZ-01: A self-adjuvanted outer membrane vesicle vaccine targeting CEA and MUC1 for colorectal cancer immunotherapy Kevin Chen, Caleigh Fletcher, John Cowger, James E. Galen, Mayukh Das, Marcio Chedid
• 4381 · PDF HIF-1alpha/c-MET肽疫苗联合卡铂重塑肿瘤微环境以克服高级别浆液性卵巢癌腹腔转移模型中的铂耐药 Combination therapy with a HIF-1alpha/c-MET peptide vaccine and carboplatin reprograms the tumor microenvironment to overcome platinum resistance in an intraperitoneal metastasis model of high-grade serous ovarian carcinoma Soon Young Lim, JinHwa Hong, DongGeRaMi Moon, Hyeyeon Roh, Ju Won Kim, Ji Won Lee, Kyong Hwa Park
• 4382 · PDF 衔接癌症疫苗的体外筛选与体内疗效 Bridging in vitro screening to in vivo efficacy for cancer vaccines Hongyan Sun, Jialu Fan, Yujing Zhang, Yunlong Jiang, Huixin Yang, Xiang Gao
• 4383 · PDF 利用HBV接种免疫通过将HBsAg靶向递送至CEA阳性结直肠癌以抑制肿瘤进展 Utilization of HBV-vaccinated immunity to suppress tumor progression via targeted delivery of HBsAg to CEA-positive colorectal cancer Chun-Chia Cheng, Zong-Lin Sie, Yung-Chin Hsiao, Ai-Sheng Ho, Chih‑Liang Wang, Cheng-Liang Peng, Chun‑I Wang, Hong-Zen Yeh, Jungshan Chang, Chun-Chao Chang
• 4384 · PDF 推进新型疫苗：在HLA-A2.1/HLA-DRB1*1.1人源化小鼠中的临床前评价 Advancing novel vaccines: Preclinical evaluation in HLA-A2.1/HLA-DRB1*1.1 humanized mice Dana Emerson, Zhenlan Niu, Shuaiqiang Zhang, Xiaofei Zhou
• 4385 · PDF 利用病毒-肿瘤杂合抗原树突状细胞疫苗构建持久的肿瘤免疫 Engineering durable tumor immunity with a virus-tumor hybrid antigen dendritic cell vaccine Jin Muk Kang, Eun Hyang Han, Jin-kyu Choi, Seunghee Youm, Tej Pareek, Seong-Jin Kim, John Letterio, Seunghwan Lim
• 4386 · PDF 扩展Bvax的治疗潜力：一种基于B细胞的实体瘤疫苗 Expanding the therapeutic potential of Bvax: A B-cell-based vaccine for solid tumors Hanxiao Wan, Joshua L. Katz, Yotam D. Hahn, Si Wang, Grace V. Jones, Alina R. Murphy, Rebecca Du, Jeffrey Bacha, Roger Stupp, Catalina Lee-Chang
• 4387 · PDF 一种临床采用的疫苗平台与新的免疫原性表位联合对抗前列腺癌 A clinical-adopted vaccine platform and new immunogenic epitopes combined against prostate cancer Elisa Marmocchi, Rubens Begaj, Marta Cantarelli, Davide Bressan, Nicole Annesi, Martina Cortese, Mattia Barbareschi, Giovanni Bertalot, Francesco Giuseppe Carbone, Alessandro Alaimo, Marianna Kruithof-de Julio, Nicola Ternette, Ugo Ala, Fulvio Chiacchiera, Guido Grandi, Andrea Lunardi
• 4388 · PDF 在PBMC人源化小鼠中使用多种疫苗诱导记忆性体液反应 Inducing memory humoral responses using multiple vaccines in PBMC humanized mice Destanie Rose, Ilian Radichev, Beau Parry, Leandro Salati D'Abronzo, Zahid Delwar, Jiwon Yang, Li-Chin Yao, James G. Keck
• 4389 · PDF 建立以CTC为驱动的工作流程用于个体化肿瘤免疫治疗中mRNA转染的moDC生产 Establishing a CTC-driven workflow for mRNA-transfected moDC production in personalized cancer immunotherapy Giovanna Manga Guimaraes, Nadia Bayou, Mara Serena Serafini, Eleonora Nicolò, Letizia Pontolillo, Brenno Pastò, Nassima Messali, Kiran Sahu, Paraskevi Giannakakou, Gabriela Coeli Menezes Evangelista, Olivier Elemento, Carolina Reduzzi, José Alexandre Barbuto, Massimo Cristofanilli

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