AACR Project GENIE: Genomic Characterization

• 4096 · PDF 泛儿科基因调控网络分析揭示儿科实体瘤中可成药的依赖性 A pan-pediatric gene-regulatory network analysis reveals druggable dependencies across pediatric solid tumors Daniel Lee, Abid A. Reza, Syed A. Bukhari, Jun S. Wei, Hsein-Chao Chou, Xinyu Wen, Andrew S. Brohl, Javed Khan
• 4097 · PDF cBioPortal：癌症基因组学平台 cBioPortal for cancer genomics Ino de Bruijn, Tali Mazor, Gaofei Zhao, Manda Wilson, Avery Wang, Floris Vleugels, Pim van Nierop, Henk-Jan van den Ham, S. Onur Sumer, Jessica Singh, Baby A. Satravada, Oleguer Plantalech, Angelica Ochoa, Zain-ul-Abideen Nasir, Ramyasree Madupuri, Pieter Lukasse, Aaron Lisman, James Lindsay, Xiang Li, Bryan Lai, Ritika Kundra, Priti Kumari, Sowmiyaa Kumar, Tim Kuijpers, James Ko, Zeynep Karagöz, Karthik Kalletla, Prasanna K Jagannathan, Jason Hwee, Guizela Huelsz Prince, Charles Haynes, Benjamin Gross, Zhaoyuan Fu, Ruslan Forostianov, Calla Chennault, Rima AlHamad, Ugur Dogrusoz, Allison Heath, Adam C. Resnick, Trevor J. Pugh, Chris Sander, Jianjiong Gao, Nikolaus Schultz, Ethan Cerami
• 4099 · PDF 10,000 例韩国泛癌患者的基因组与临床全景揭示预后和治疗反应的分子决定因素：K-MASTER 项目 Genomic and clinical landscape of 10,000 Korean pan-cancer patients reveals molecular determinants of prognosis and therapeutic response: K-MASTER program Ji Yoon Lee, Jisoo Hong, Kyong Hwa Park, Soohyeon Lee, Jwa Hoon Kim, Ju Won Kim, Ji Won Lee, Yonghwa Choi, Doyoon Kim, Yoonji Kim, Woo Young Jang, Jiwon Kim, You Jin Song, Dayoung Lee, Hyeonmin Jeong, Wooseok Lee, Yoon Ji Choi, Jason K. Sa
• 4100 · PDF 用于肿瘤基因组解读的大语言模型 Large language models for tumor genomic interpretation Jennifer Yu, Madison Darmofal, Michele Waters, January Choy, Thinh N. Tran, Chenlian Fu, Leah Morales, Kaicheng U, Ross L. Levine, Nikolaus Schultz, Michael F. Berger, Quaid Morris, Justin Jee
• 4102 · PDF EGFR 突变亚型改变了 TP53 功能缺失对肺癌脑转移和生存的临床影响 EGFR mutation subtype modifies the clinical impact of TP53 functional loss on brain metastasis and survival in lung cancer Lexi Li, Yiye Wong, Nathan Yan, J. Nicholas Bodor, Yunyun Zhou
• 4103 · PDF BRAF 改变型恶性肿瘤中的动态共突变模式及治疗意义：来自 AACR Project GENIE 的证据 Dynamic co-mutation patterns and therapeutic implications in BRAF-altered malignancies: Evidence from AACR Project GENIE Mohamed M. Khamis, Vivek Subbiah, Mohamed Gouda
• 4104 · PDF AACR GENIE 数据库中皮肤附属器癌的基因组全景：对精准癌症医学的意义 The genomic landscape of skin adnexal carcinomas in the AACR GENIE database: Implications for precision cancer medicine Valbert Oliveira Costa Filho, Mariana Macambira Noronha, Pedro Robson Costa Passos, Carlos Diego Holanda Lopes, Giuseppe G. F. Leite, Carlos Wagner de Souza Wanderley, Sam D. Saibil, Danielle Calheiros Campelo Maia, Erick F. Saldanha
• 4105 · PDF 结直肠癌、胰腺癌、小肠癌和肛门癌中不同的年龄相关基因组全景：对来自 AACR Project GENIE v18.0 的 34,000 例肿瘤的泛胃肠道分析 Distinct age associated genomic landscapes in colorectal, pancreatic, small bowel, and anal cancers: A pan gastrointestinal analysis of 34,000 tumors from AACR Project GENIE v18.0 Ahmed Abdelhakeem, Nency Ganatra, Dina Elantably, Tayo Adeoye, Nayef H. Abdel-Razeq, Mosalem M. Osama, Hani M. Babiker
• 4106 · PDF AACR Project GENIE 中 101,240 例肿瘤样本的同源重组修复（HRR）基因改变的泛癌富集：对肿瘤不可知性 PARP 抑制剂扩展应用的意义 Pan cancer enrichment of homologous recombination repair (HRR) gene alterations in 101,240 tumor samples from AACR Project GENIE: Implications for tumor-agnostic PARP inhibitor expansion Ahmed Abdelhakeem, Nency Ganatra, Dina Elantably, Tayo Adeoye, Nayef H. Abdel-Razeq, Osama M. Mosalem, Hani M. Babiker
• 4107 · PDF AACR Project GENIE 生物制药协作组（BPC）非小细胞肺癌（NSCLC）队列中与早期治疗中断相关的因素 Factors associated with early treatment discontinuation in the AACR Project GENIE Biopharma Collaborative (BPC) non-small cell lung cancer (NSCLC) cohort Dany Hamze, Sanjay Mishra, Aleenah Mohsin, Sarah Minuit, Ece Gamsiz Uzun, Jeremy L. Warner
• 4109 · PDF IDH1/2 突变的泛癌种全景，聚焦非小细胞肺癌：来自 AACR GENIE 登记数据库的见解 Pan-cancer landscape of IDH1/2 mutations with a focus on non-small cell lung cancer: Insights from the AACR GENIE Registry Zhaohui L. Arter, Cathleen Park, Misako Nagasaka, Sai-Hong I. Ou
• 4110 · PDF 通过整合登记数据库与 GENIE 分析揭示化生性乳腺癌的基因组易感性与临床行为 Genomic vulnerabilities and clinical behavior of metaplastic breast cancer through integrated registry and GENIE analysis Ahmed Shatta, Diego F. Chamorro, Blessie Elizabeth Nelson, Bora Lim
• 4111 · PDF 社区集水人群中结直肠癌的综合多组学表征 Comprehensive multi-omics characterization of colorectal cancer in a community catchment population Brigette Waldrup, Francisco Carranza, Yuxin Jin, Yonatan Amzaleg, Mackenzie Postel, David W. Craig, John D. Carpten, Boudoir Salhia, Charite N. Ricker, Julie O. Culver, Carmen E. Chavez, Mariana C. Stern, Lourdes Baezconde-Garbanati, Heinz-Josef Lenz, Enrique I. Velazquez-Villarreal
• 4112 · PDF 多形性胶质母细胞瘤中 NTRK 错义突变的识别：来自 AACR Project GENIE 及结构-功能分析的见解 Identification of NTRK missense mutations in glioblastoma multiforme: Insights from AACR Project GENIE and structural-functional analyses Jehad A. Yasin, Muaath I. Alsufi, Ahmad Shawabkeh, Abdallah Al-Ramadi, Mohammad Alghaniem, Layan AlDaher, Reger Mikaeel
• 4113 · PDF 早发性头颈部鳞状细胞癌中独特的临床、分子及多组学生物标志物 Distinct clinical, molecular and multi-omics biomarkers in early-onset head and neck squamous cell carcinoma Joab O. Odera, Rong Jiang, Morgan C. Byrd, Oyomoare L. Osazuwa-Peters, Nosa Osazuwa-Peters
• 4114 · PDF 基于人群的人乳头瘤病毒感染与宫颈癌发病率、驱动突变及总生存的模式 Population-based patterns of human papillomavirus infections and cervical cancer incidence, driver mutations and overall survival S. Ahmed Hussain, Chunqiao Tian, Christopher Tarney, Thomas Beltran, Pouya Javadian, Ryan McLaughlin, Paulette Mhawech-Fauceglia, Doris M. Benbrook, Sean Cronin, Zachary Kopelman, Colin Sitler, Leslie M. Randall, John Chan, Daniel Kapp, Chad A. Hamilton, Charles A. Leath, Christina Washington, Kathleen Moore, Kristen Bunch, Nicholas Bateman, Thomas P. Conrads, G. Larry Maxwell, Kathleen M. Darcy
• 4116 · PDF 慢性淋巴细胞白血病及 Richter 转化在患者一生中的克隆演化轨迹 Clonal trajectories of chronic lymphocytic leukemia and Richter transformation over the patients' lifespan Ian Márquez-López, Aleix Real, Núria Russiñol, Nicholas Williams, Romina Royo, Markus van Roosmalen, Heribert Playa-Albinyana, Juan Antonio Piñeyroa, Melika Bashiri, Pablo Mozas, Armando López-Guillermo, Julio Delgado, Dolors Colomer, Ruben van Boxtel, Jyoti Nangalia, Elias Campo, Ferran Nadeu

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