PO.CL05.04 · 临床研究
Immune Checkpoint Blockade
- 6535 6535 通过PD-L1配体-Ir(III)配合物偶联物增强NSCLC对anti-PD-1-PD-L1治疗的敏感性 Enhancing NSCLC susceptibility to anti-PD-1 - PD-L1 therapy trough PD-L1 ligand-Ir(III) complex conjugates Valentina Pagliara, Giulia Assoni, Giovanna Polcaro, Luigi Liguori, Pierfausto Seneci, Francesco Saverio Di Leva, Vincenzo Maria D’Amore, Cristina R. Ferrone, Stefano Pepe, Luciana Marinelli, Daniela Arosio, Francesco Sabbatino
-
6536 · PDF 一种新型多模态PD-L1xVEGF-ADC HX116可能成为泛实体瘤的新型强效候选治疗药物 A novel multi-modal PD-L1xVEGF-ADC, HX116, could be a new potent candidate treatment for pan-solid tumors Hang Ke, Tao Yang, Feiyu Peng, Jialin Li, Cen Chen, Lei Zhang, Faming Zhang, Henry Li
-
6537 · PDF 肿瘤IDO1通过抑制T细胞募集和效应功能驱动对过继细胞转移的耐药 Tumor IDO1 drives resistance to adoptive cell transfer by suppressing T cell recruitment and effector function Mamadou Alpha Bah, Rachana Maniyar, Jonathan F. Khan, Anais Assouvie, Sadna Budhu, Parwiz Abrahimi, Inna Serganova, Gabrielle A. Rizzuto, Taha Merghoub, Jedd D. Wolchok
-
6538 · PDF 一种通过Shp2凝聚介导PD-1介导T细胞抑制的相分离机制 A phase-separation mechanism underlying PD-1-mediated T-cell inhibition via Shp2 condensation Takeya Masubuchi, George Wen, Xiaoxian Song, Haian Shao, Enfu Hui
-
6539 · PDF 大型泛癌症队列中多系统免疫相关不良事件的特征与预测因素:一项回顾性分析 Characteristics and predictors of multi-system immune-related adverse events in a large pan-cancer cohort: A retrospective analysis Julia G. Contini, Min Jung Koh, Charmi Trivedi, Mackenzie Adams, Jacqueline J. Chu, Sapana R. Gupta, Curtis Petruzzelli, Kanika Malani, Rebecca Steuer, Sandeep Jain, William Park, May Min, Matthew J. Hadfield
-
6540 · PDF 剖析Adam17内宿主遗传变异所致肿瘤免疫检查点阻断耐药的机制 Dissecting mechanisms of tumor immune checkpoint blockade resistance due to host genetic variation within Adam17 James P. Heiserman, Darren Li, Ons Mamai, Tanuja Desai, Rosemary J. Akhurst, Szu-Ying Chen
-
6541 · PDF 首剂检查点抑制剂的给药时间影响肝细胞癌的临床结局和免疫应答 Time-of-day of first checkpoint inhibitor dose influences clinical outcomes and immune responses in hepatocellular carcinoma Howard L. Li, Soren Charmsaz, Benjamin J. Reisman, Franshisca Hayek, Madelena Brancati, James M. Leatherman, Carlotta Pazzi, Royce P. Lee, Xiyu Zhao, Eric Christenson, Waqar Arif, Jeric P. Hernandez, Caroline Ellis, Nicole E. Gross, Christopher Thoburn, G Scott Chandler, Rajat Mohindra, Sanjay Bansal, Laura Tang, Aditi Guha, Chi V. Dang, Neeha Zaidi, Elizabeth M. Jaffee, Daniel A. Laheru, Daniel J. Zabransky, Marina Baretti, Won Jin Ho, Mark Yarchoan, Mari Nakazawa
-
6542 · PDF 靶向ITGB3逆转终末期T细胞耗竭以增强食管鳞状细胞癌的治疗疗效 Targeting ITGB3 reverses terminal T cell exhaustion to enhance therapeutic efficacy in esophageal squamous cell carcinoma Beilei Liu, Xin-Yuan Guan, Bowen Yao, Hongyu Zhou, Licheng Tan, Jiayi Huang, Shuang Zhang
-
6543 · PDF NTX1088首次实现DNAM1的临床恢复,定义了一条全新的免疫肿瘤学轴 NTX1088 demonstrates the first-ever clinical restoration of DNAM1, defining a novel immune-oncology axis Anas Atieh, Alon Vitenshtein, Akram Obiedat, Simona Chechik, Rivki Cashman, Guy Cinamon, Keren Paz, Yaron Daniely, Paola Kučan Brlić, Tihana Lenac Roviš, Lea Hiršl, marija mazor, ema bellulovich, Stipan Jonjic, Ofer Mandelboim, Pini Tsukerman
-
6544 · PDF 肾移植受者中的免疫检查点抑制剂治疗:抗肿瘤活性与移植物排斥风险的真实世界结局 Immune checkpoint inhibitor therapy in kidney transplant recipients: Real-world outcomes of antitumor activity and graft rejection risk Ali Rezazadeh Roudkoli, Elena Barbir, Shahin Kavousi, Mohamed A. Aboelatta, Claudia-Denise Haivas, Byron H. Smith, Aleksandra Kukla, Arkadiusz Z. Dudek
-
6545 · PDF 表征ATF6激活驱动的改善ICB疗效的机制 Characterizing ATF6 activation-driven mechanisms improving ICB efficacy Sanjay Adhikary, Jacob Edmondson, Daniel Fil, Duah H. Alkam, Megan R. Reed, Billie Heflin, Katherine Bronson, Sydnye Shuttlewoth, Katherine F. Wallis, Nathan Avaritt, Sean Taverna, Brian S. Koss, Alan Tackett
-
6546 · PDF 超越密度:拓扑感知的空间指标预测免疫治疗结局 Beyond density: Topography-aware spatial metrics predict immunotherapy outcomes Artur Mezheyeuski, Neda Hekmati, Ina Hrynchyk, Amanda Lindberg, Jakob Friedrich, Johanna Mattsson, Miklos Gulyas, Klas Kärre, Johan Isaksson, Carina Strell, Patrick Micke
-
6547 · PDF tremelimumab联合durvalumab(MEDI4736)(T300+D)治疗合并Child-Pugh-B肝硬化的晚期肝细胞癌的II期单臂研究(STRIDE in CP-B) Phase II single arm study of tremelimumab and durvalumab (MEDI4736) (T300+D) in advanced hepatocellular carcinomas with Child-Pugh-B cirrhosis (STRIDE in CP-B) Sukeshi Patel Arora, Lorena Fuentes, James Denno, Jennifer Moseley, Brittany M. Altermatt, Elizabeth Diaz, Joshua Ray Smith, Joel Michalek, Lei Zheng
-
6548 · PDF 用于模拟免疫疗法肿瘤清除与正常组织免疫损伤的人多器官微生理系统 A human multiorgan microphysiological system for modeling immunotherapies tumor clearance and normal tissue immune injury John Collins, Henry C. Wong, Alyssa J. Villegas, Johar Kohana, Harpreet S. Saluja
-
6549 · PDF 整合功能性生物特征与同细胞空间多组学以预测头颈癌联合检查点治疗的协同获益 Integrating functional biosignatures and same-cell spatial multiomics to predict synergistic benefit of combination checkpoint therapy in head and neck cancer Yi Cui, Moumita Nath, Michael Emilio Patrick, Claire Williams, Daniel McGuire, Jobin K. Paul, Kowshik Jaganathan, Biswajit Das, Mohit Malhotra, Shanshan He, Joseph M. Beechem, Satish Sankaran
-
6550 · PDF 全人源拮抗性抗BTLA单克隆抗体的体外表征 In vitro characterization of fully human antagonistic anti-BTLA monoclonal antibodies Bruce L. Daugherty, Hsunhui Yang, Subhra Mahapatra, Yadong Yu, Christine L. Hsieh, Brian A. Zabel, Seth Lederman
-
6551 · PDF 米非司酮介导的激素受体阳性乳腺肿瘤中PD-L1表达的诱导 Mifepristone-mediated induction of PD-L1 expression in hormone receptor positive breast tumors Mariana Salatino, Magali Berton, Joaquin Merlo, Andres M. Elia, Tomas Dalotto Moreno, Claudia Lanari, Gabriel Rabinovich
-
6552 · PDF PD-1治疗无应答者在黑色素瘤中共享一个OXPHOS与神经元样耐药联合程序 Nonresponders to PD-1 therapy share a combined OXPHOS and neuronal-like resistance program in melanoma Otília Menyhart, Janos Tibor Fekete, Balazs Gyorffy
- 6553 6553 HMGB1作为预测小细胞肺癌免疫治疗疗效生物标志物的综合分析 A comprehensive analysis of HMGB1 as a biomarker for predicting immunotherapy efficacy in small cell lung cancer Bohui Zhao, Chaoqi Zhang, Peng Wu, Dongyu Li, Xuanyu Gu, Hengjia Tu, Nan Sun, Jie He
-
6554 · PDF 一种双特异性TROP2/PDL1抗体药物偶联物展现出增强的抗肿瘤活性和良好的安全性特征 A bispecific TROP2/PDL1 antibody-drug conjugate demonstrates enhanced antitumor activity and favorable safety profile Chuan Chen, Yue Wu, Chenpeng Su, Dandan Liu, Jiyuan Tian, Yujuan Li, Yongxin Shang, Xiaoqian Chen, Rongmei Yan, Liang Tian, Jian Peng, Zhenping Zhu
-
6555 · PDF Nelmastobart阻断BTN1A1增强顺铂诱导的NSCLC肿瘤抑制 BTN1A1 blockade with Nelmastobart potentiates cisplatin-induced tumor suppression in NSCLC Seung-Hoon Lee, Jong-Su Park, Young-Seung Kim, Chunai Wu, Bong-Ki Hong, Andrew H. Park, Stephen S. Yoo
-
6556 · PDF VISTA在转移性黑色素瘤肺部肿瘤微环境中的作用 The role of VISTA in the lung tumor microenvironment of metastatic melanoma Carly M. Fielder, Qianni Hu, Hyundong Yoon, Raymond Zhang, Anjali Raman, Megan L. Tigue, Chi Yan, Vivian L. Weiss, Douglas B. Johnson, Jin Chen, Tae Kon Kim
-
6557 · PDF 联合PARP抑制和免疫检查点阻断通过促进三级淋巴结构形成引发抗肿瘤免疫反应,在BRCA1、BRCA2缺陷型与CHEK2、ATM缺陷型乳腺癌中带来差异化改善的生存 Combined PARP inhibition and immune checkpoint blockade elicit differentially improved survival in BRCA1, BRCA2 vs CHEK2, ATM deficient breast cancer by promoting an anti-tumor immune response through tertiary lymphoid structure formation Sibapriya Chaudhuri, Alberto Emata, Scott Thomas, Pamela N. Munster
-
6558 · PDF 急性髓系白血病中免疫检查点调控的硒依赖性调节 Selenium dependent regulation of immune checkpoint control in acute myeloid leukemia Deborpita Sarkar, Fenghua Qian, Robert F. Paulson, K.Sandeep Prabhu
-
6559 · PDF 研究B7-H7介导的NK细胞活性激活的转录组特征 Investigating the transcriptomic signature of B7-H7-mediated activation of NK cell activity Michael Gomez, Deepthi Chowbene, Nahuel Perrot, Nikolaos Kalavros, Shuoshuo Wang, Antonella Arruda de amaral, David F. McDermott, Gordon J. Freeman, Ioannis S. Vlachos, Kathleen M. Mahoney
- 6560 6560 靶向适应度监视恢复T细胞免疫并使实体瘤对免疫检查点抑制剂敏感 Targeting fitness surveillance restores T-cell immunity and sensitizes solid tumors to immune checkpoint inhibitors Amit Kumar, Antonio Palma, Praveen Bhoopathi, Esha Madan, Rajan Gogna
-
6561 · PDF B7-H3/PD-L1双特异性ADC的合理设计:将检查点阻断与靶向细胞毒性相结合以提高抗肿瘤疗效 Rational design of a B7-H3/PD-L1 bsADC combining checkpoint blockade with targeted cytotoxicity for improved antitumor efficacy Zhangyi Song, Jie Chen, Huifang Zong, Zhen Li, Shusheng Wang, Jianwei Zhu, Xiaodong Xiao
-
6562 · PDF 识别致癌基因依赖性非小细胞肺癌亚组对免疫检查点抑制剂的脆弱性。 Identifying vulnerabilities to immune checkpoint inhibitors of oncogene-addicted non-small cell lung cancer subgroups. Inés Díaz-Cano, José Gracia, Patricia Cozar, Belén Revuelta, Nuria Carrizo, Laura García-Redondo, Joan Russo, Rita Manzano, Jose Garrido-Mesa, Daniel Meraviglia-Crivelli, Juan Dubrot, Luis Paz-Ares, Itziar Otano
-
6563 · PDF 胃食管癌围手术期化学免疫治疗后免疫检查点阻断(ICB)再挑战应答的免疫和临床决定因素 Immune and clinical determinants of response to immune checkpoint blockade (ICB) rechallenge after perioperative chemoImmunotherapy in gastroesophageal cancer Jeremy M. Tchack, Samuel L. Cytryn, Steven B. Maron, Patrick Evans, Jessica Posada, Geoffrey Y. Ku, Jessica Yang, Ryan B. Sugarman, Ping Gu, Laura H. Tang, Amitabh Srivastava, Vivian E. Strong, Daniela Molena, Yelena Yuriy Janjigian
-
6564 · PDF 转移性黑色素瘤对新辅助免疫检查点阻断应答的空间解析免疫学标志 Spatially resolved immunologic hallmarks of response to neoadjuvant immune checkpoint blockade in metastatic melanoma Zichao Liu, Xiaofei (Sophia) Song, Jodi A. Balasi, Wei-Shen Chen, Jiang He, Justin He, Jonathan Nguyen, Carlos M. Morán-Segura, Joseph O. Johnson, Chaomei Zhang, Jane L. Messina, Zena Sayegh, Douglas C. Marchion, Sean J. Yoder, Vernon K. Sondak, Jeffrey H. Chuang, Pei-Ling Chen