PO.ET02.04 · 实验与分子治疗
Antibody-Drug Conjugates and Linker Engineering 4
- 5631 5631 TCX-201：一种靶向特定肿瘤相关碳水化合物抗原（TACA）的新型ADC，在实体瘤模型中具有优异的临床前疗效、PK和安全性特征 TCX-201, a novel ADC targeting a specific tumor-associated carbohydrate antigen (TACA) with excellent preclinical efficacy, PK and safety profile in solid tumor models Matthias Ocker, Francesco Muraca, Stephan Grunwald, Wiebke Winkler, Karla E. G. Soto, Carolin Lange, Jean Engela, Peter Sondermann
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- 5633 5633 YB-811：一种靶向肿瘤选择性人神经元五聚体蛋白受体的新型抗体药物偶联物，在实验性肿瘤模型中显示出显著疗效 YB-811, a novel antibody drug conjugate targeting the tumor-selective human neuronal pentraxin receptor shows pronounced efficacy in experimental tumor models Peter Schiemann, Michel Janicot, Gunther Wennemuth, Mykola Lyndin
- 5634 5634 KY102：一种携带拓扑异构酶1抑制剂载荷的新型Glypican 3靶向纳米抗体药物偶联物，在肝细胞癌模型中展现出引人注目的临床前活性 KY102, a novel Glypican 3-targeting nanobody drug conjugate bearing a topoisomerase 1 inhibitor payload demonstrates compelling preclinical activity in hepatocellular carcinoma models Haikun Shi
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- 5637 5637 一种用于治疗实体瘤的新型EGFR和B7H3双靶向抗体偶联药物（ADC） A novel EGFR and B7H3 dual-targeted antibody-drug conjugate (ADC) for the treatment of solid tumors Mingkun Zhang, Xuguo Zhu, Jun Wang, Jing Zhao
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- 5639 5639 HDP-103，一种靶向PSMA的基于鹅膏蕈碱的ADC，即使在PSMA表达异质、难以治疗的患者来源异种移植模型中也具有疗效 HDP-103, a PSMA targeting amanitin-based ADC, is efficacious even in difficult to treat patient derived xenograft models with heterogenous PSMA expression Kristin Decker, Christian Orlik, Irina Dranova, Anikó Palfi, Torsten Hechler, Andreas Pahl, Michael Kulke
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- 5641 5641 BCG037，一种首创的抗人ALPP/ALPG治疗性ADC，在胰腺癌和胃癌PDX模型中抑制肿瘤生长 BCG037, a first-in-class anti-human ALPP/ALPG therapeutic ADC that inhibits tumor growth in pancreatic cancer and gastric cancer PDX models Yong Xie, Peiran Li, Ying Zhu, Yanan Guo
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- 5643 5643 RC118 ADC的临床前表征及其相对于其他抗CLDN18.2抗体的差异性结合模式鉴定 Preclinical characterization of RC118 ADC and identification of its differential binding pattern relative to other anti-CLDN18.2 antibodies Lili Wang, Xiaoping Zhang, Mingyang Li, Xiao Wang, Yidan Xu, Xiaoli He, Shengle Ji, Shuya Ji, Shifu Wang, Yinghao Xin, Fanxue Bu, Yuelei Shen, Jianmin Fang, Yuanhao Li
- 5644 5644 DA-3501 (AT-211)：一种位点特异性CLDN18.2靶向抗体偶联药物(ADC)的免疫介导抗肿瘤活性评价及联合免疫治疗潜力 DA-3501 (AT-211): Evaluation of immune-mediated antitumor activity and combination immunotherapy potential of a site-specific CLDN18.2-targeting antibody-drug conjugate (ADC) Kyoung-Ho Pyo, Seong-Hyun Park, Dongsop Lee, Haneol Kim, Younggyu Kong, Younggeun Lee, Hojin Yeom, Sowon Aum, Sun Hee Park, Huijo Oh, Cheyeon Kim, Hyeonseok Jin, Hyeonseok Jin, Aera Lee, Hojeong Hong, Ju Hwan Kim, Hyungseok Choi, Mi-Kyung Kim, Taedong Han
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- 5647 5647 GS24-B057，一种潜在同类最佳的Nectin-4和Trop-2双靶向双特异性ADC，用于治疗尿路上皮癌及其他实体瘤 GS24-B057, a potential best-in-class Nectin-4- and Trop-2-directed bispecific ADC, for the treatment of urothelial carcinoma and other solid tumors Meihan Li, Fu Li, Qiuru Che, Xiaojing Huang, Dongxia Chu, Qiyang Zhang, Nan Li, Qingjuan Ma, Weiming He, Wenqiang Zhai, Yihui Lin, Xiaozhen Wang, Fanglong Yang, Siqing Wang, Lei Jin, John L. Xu
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- 5651 5651 LUA005的临床前开发：一种差异化的二价EGFR/cMET双特异性ADC，展现出强大的抗癌疗效和更宽的治疗窗 Preclinical development of LUA005: A differentiated bivalent EGFR/cMET bispecific ADC displays strong anti-cancer efficacy and a wider therapeutic window Lei Han, Ken Qin, Ying huang, Xi Xiao, Zhebin Zhang, Wei Wang, Wei Zheng, Hai Wu, Xiaoshuang Yan, Dongdong Wu, Shuyong Zhao, Ling Zhang, Yang Yang, Hua Ying, Weikang Tao
- 5652 5652 新型CDH17/cMET双特异性ADC药物LUA011的临床前开发：抗肿瘤疗效增强且胃肠道毒性减轻 Preclinical development of LUA011, a novel CDH17/cMET bispecific ADC with enhanced antitumor efficacy and mitigated gastrointestinal toxicity Guoyin Huang, Ken Qin, Man Wu, Lei Han, Ying Huang, Wei Zheng, Xiaoshuang Yan, luchan deng, Hai Wu, Wenshu Huang, Shuyong Zhao, Ling Zhang, Yang Yang, Hua Ying, Weikang Tao
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- 5656 5656 新型pre|CISION®技术化合物的表征与转化开发：在FAP裂解后向肿瘤微环境递送互补的双载荷 Characterization and translational development of novel pre|CISION® technology compounds delivering complementary dual payloads to the tumor microenvironment following FAP cleavage Victoria Juskaite, Tom Clough, Ellen Watts, Iva Zlatareva, Folake Orafidiya, Hanna Buist, Alexa Kennedy, Jannah Jeon, Greg Billenness, Douglas Sammon, Sophie Brown, Curtis Rink, Ruairidh Edwards, Vidicha Chunilal, Manuel Pinto, Dave Liebowitz, Francis Wilson, Michelle Morrow, David Jones
- 5657 5657 一种通过消除肿瘤微环境中的免疫抑制来治疗实体瘤的新型双特异性ADC A novel bispecific ADC to treat solid tumors by removing immunosuppression in the tumor microenvironment Shiva Bhowmik, William Brady
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