PO.ET02.14 · 实验与分子治疗
Tumor Microenvironment, Multispecifics, and Immunomodulation
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- 5836 5836 在肺癌小鼠模型中肿瘤电场治疗（TTFields）联合抗VEGFR和多西他赛治疗增强抗肿瘤活性 Augmented antitumor activity of Tumor Treating Fields (TTFields) with anti-VEGFR and docetaxel treatment in a lung cancer mouse model Helena Mumblat, Yara Eid Mutlak, Yuval Shmueli, Ruslana Militsin, Catherine Tempel-Brami, Shay Cahal, Alexandra Volodin, Sara Jacobovitch, Martin Gabay, Itai Tzchori, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti
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- 5840 5840 开发载米诺环素微粒与可注射藻酸盐支架复合物以延长释放用于治疗胶质母细胞瘤 The development of minocycline-loaded microparticles and injectable alginate scaffolds composites to prolong release for the treatment of glioblastoma Florestella Rivera, Dorina A. Madrid, Samantha C. Davila, Serenade Trevino, Jorge L. De Leon, Sebastian Flores, Sue Anne Chew
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- 5842 5842 KRAS通路抑制与脂质体伊立替康联合治疗增强肿瘤消退、减轻促结缔组织增生并增加胰腺导管腺癌中的T细胞浸润 Combined KRAS pathway inhibition and liposomal irinotecan treatment enhances tumor regression, attenuates desmoplasia, and augments T cell infiltration in pancreatic ductal adenocarcinoma Hari Krishnareddy Rachamala, Fang Wei, Debabrata Mukhopadhyay, Hani M. Babiker
- 5843 5843 超越活力：PRISM条形码标记癌细胞系混合物的治疗后单细胞和空间转录组分析 Beyond viability: Post treatment single cell and spatial transcriptomic profiling in mixtures of PRISM barcoded cancer cell lines Laura Doherty, Ashish B. George, Mustafa Kocak, Paul Lund, Andrew Kohlway, Andrew Boddicker, Ben Song, Carlos Ruiz Perez, Bryan Lajoie, Catarina D. Campbell, Matthew G. Rees, Jennifer A. Roth
- 5844 5844 使用CT7439新型抑制转录性细胞周期蛋白依赖性激酶CDK12/13作为CDK12上调结直肠癌的治疗 Novel inhibition of transcriptional cyclin-dependent kinases, CDK12/13, using CT7439 as a treatment for colorectal cancer with CDK12 upregulation Jason A. Somarelli, Wylie Katherine Watlington, Divya Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu
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- 5846 5846 AVA6103是一种FAP激活的pre|CISION®肽-药物偶联物，在肿瘤微环境中持续释放exatecan并具有强效抗肿瘤活性 AVA6103 is a FAP-enabled pre|CISION ® peptide-drug conjugate delivering sustained release of exatecan in the tumor microenvironment with potent antitumor activity Curtis Rink, Tom Clough, Ellen Watts, Folake Orafidiya, Marine Houée, Sophie Brown, Victoria Juskaite, Gezim Lahu, Ruairidh Edwards, Karen Campbell, Dave Liebowitz, David Jones, Francis Wilson, Michelle Morrow
- 5848 5848 ADT-030靶向磷酸二酯酶10A通过抑制癌细胞和髓源性抑制细胞中的RAS-MAPK信号传导使肿瘤免疫微环境正常化 Targeting phosphodiesterase 10A by ADT-030 normalizes the tumor immune microenvironment by inhibiting RAS-MAPK signaling in both cancer cells and myeloid-derived suppressor cells Gazi Md Yeashin, Ogacheko David Okoko, Yan Ye, Xin Wang, Khalda Fadlalla, Adam Keeton, Yulia Maxuitenko, Xi Chen, Lynn Hedrick, Huidong Shi, Gary A. Piazza, Gang Zhou
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- 5851 5851 （共同轻链抗体+纳米抗体）×多基质免疫平台助力抗肿瘤多特异性抗体药物的开发 (Common-light-chain-antibody+nano-body) × multi-matrix-immunization platform facilitates the development of antitumor multispecific antibody drugs Yi Gu, Xinde Liu, Peng Li, Feng He, Feng Hao, JInying Ning
- 5852 5852 一种新型靶向CD33和TRAIL-R2的双特异性抗体用于治疗复发/难治性急性髓系白血病 A novel CD33 and TRAIL-R2 targeting bispecific antibody to treat relapsed/refractory acute myeloid leukemia Shiva Bhowmik, William Brady, Kaitlyn Ko, Sheng Cai, William Grossman, Naval Daver, Jonathan Gerber, Herbert Kim Lyerly
- 5853 5853 靶向MUC1和MUC4上肿瘤特异性Tn糖表位的双特异性和双互补位抗体实现上皮性肿瘤广泛而选择性的靶点覆盖 Bispecific and biparatopic antibodies targeting tumor-specific Tn-glycoepitopes on MUC1 and MUC4 enable broad, selective tumor coverage in epithelial cancers Nisha Shrestha, Boris Klebanov, Aaron C. Groen, Constantine Theodoropulos, Hans H. Wandall
- 5855 5855 NECTIN4×PD-L1双特异性抗体药物偶联物整合检查点阻断与靶向细胞毒性用于尿路上皮癌和肺鳞状细胞癌 NECTIN4×PD-L1 bispecific antibody-drug conjugate integrating checkpoint blockade and targeted cytotoxicity for urothelial carcinoma and lung squamous cell carcinoma Kyoung-Ho Pyo, Seong-Hyun Park, Dongsop Lee, Haneol Kim, Younggyu Kong, Younggeun Lee, Hojin Yeom, Sowon Aum, Sun Hee Park, Huijo Oh, Cheyeon Kim, Hyeonseok Jin, Aera Lee, Hojeong Hong, Ju Hwan Kim, Hyungseok Choi, Mi-Kyung Kim, Taedong Han
- 5856 5856 Hanjugator喜树碱平台：高效、低毒设计最大化抗体功能并递送潜在的同类最佳EGFR/cMet双特异性抗体药物偶联物 Hanjugator camptothecin platform: Effective, low-toxicity design maximizing antibody functionality and delivering potential best-in-class EGFR/cMet bispecific antibody-drug conjugate Rui Liu, Ge Song, Yushi Chi, Lingli Zhang, Fan Yang, Junjie Zhang, Boqi Gu, Chencheng Han, Xiayan Zhang, Wan-jen Yang, Xiaomu Cheng, Xiaoling Yuan, Yi Zhang, Zhiliang Lv, Qian Zou, Huixin Yan, Chen Hu, Jijun Yuan
- 5857 5857 LBL-054 TDC：一种首创的CDH17靶向T细胞衔接器药物偶联物用于治疗CDH17阳性胃肠道肿瘤 LBL-054 TDC: A first-in-class CDH17 targeted T cell engager drug conjugate for the treatment of CDH17-positive gastrointestinal cancer Yang Ye, Yurong Qin, Xingxing Fang, Xiaoya Liu, Tingting Li, Chengze Ni, Peng Zhang, Chao Chu, Mi Ye, Huan Lin, Wanting Wang, Guojin Wu, Jianming Sun, Hui Yuwen, Yuanzhi Lv, Jing Guan, Min Chen, Yue Zhao, Jordan Zhu, Charles Cai, Xiao Huang, Xiaoqiang Kang, Hong Ling
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