TCR and Autologous T Cell Therapies

• 5609 · PDF 机械动力学原理驱动的高特异性和高灵敏度下一代TCR的理性设计 Mechano-dynamic-principle-driven rational design of next-generation TCRs with high specificity and sensitivity Yushen Du, Wei Hu, Luying Liu, Suqiong Wang, Wei Chen
• 5610 · PDF 癌症反应性T细胞和新抗原特异性T细胞受体的表征 Characterization of cancer-reactive T cells and neoantigen-specific T cell receptors Wei Sun, Si Liu, Bo Yu, Zhehao Zhang, Philip Bradley, Marie Bleakley
• 5611 · PDF 过继性T细胞转移抑制淋巴细胞清除后内源性肿瘤特异性CD8⁺ T细胞的恢复 Adoptive T cell transfer suppresses endogenous tumor-specific CD8⁺ T cell recovery following lymphodepletion Rohan B. Chaudhari, Megan L. Burger
• 5612 · PDF 经纳米颗粒光热疗法改造的抗原特异性T细胞在免疫功能健全的卵巢癌小鼠模型中显示出抗肿瘤疗效 Antigen-specific T cells engineered with nanoparticle photothermal therapy demonstrate antitumor efficacy in an immunocompetent murine model of ovarian cancer Abigail V. Lee, Erin Grundy, Jose Colina, Elizabeth Sweeney, Rohan Fernandes, Nethaji Muniraj, Russell Y. Cruz, Katherine B. Chiappinelli
• 5613 · PDF 源自RenTCR的MAGEA1特异性TCR在体外和体内表现出优越的肽敏感性和强效抗肿瘤活性 RenTCR-derived MAGEA1-specific TCRs demonstrated superior peptide sensitivity and potent antitumor activity in vitro and in vivo Yi Yang, Yabo Zhang, Jiawei Yao
• 5614 · PDF 源自RenTCR的天然MAGE-A4特异性TCR在抗肿瘤疗效上优于亲和力增强型TCR RenTCR-derived natural MAGE-A4-specific TCRs outperformed affinity-enhanced TCRs in antitumor efficacy Yi Yang, Yong Wang, Yabo Zhang, Jiawei Yao
• 5615 · PDF ALK特异性TCR-T细胞在ALK阳性间变性大细胞淋巴瘤中显示出强效且特异的活性 ALK-specific TCR-T cells showed potent and specific activity in ALK-positive anaplastic large cell lymphoma Simone Piane, Carmen Mecca, Nirmala Tilija Pun, Ana Azambuja, Luca Alessandri, Phuc Bao Chi Nguyen, Elisa Bergaggio, Gabriele Saccu, Alessandro Gasparetto, Haley Ohlson, Claudia Voena, Marcos Simoes-Costa, Roberto Chiarle
• 5616 · PDF 武装肿瘤坏死因子-α的TCR-T和CAR-T细胞在无毒性的情况下为实体瘤提供优越的抗癌活性 Tumor necrosis factor-alpha armed TCR-T and CAR-T cells for solid tumors provide superior anticancer activity in the absence of toxicity Cole W. Peters, Miriam Valenzuela Cardenas, Moe Kawakami, Jaden Nguyen, Allison Flores, Andrew Dinh, Stephen Ma, Daniel G. Chen, Valerie Rezek, Scott Kitchen, Katie M. Campbell, Melissa Lechner, Theodore Scott Nowicki
• 5617 · PDF 靶向GPC2的人源化抗体Fab-TCR T细胞通过增强TCR信号传导和持续细胞毒性有效使神经母细胞瘤消退 Humanized antibody Fab-TCR T cells targeting GPC2 effectively regress neuroblastoma via enhanced TCR signaling and sustained cytotoxicity Mingyu Huo, Alex Quan, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho
• 5618 · PDF 来自噬菌体TCR文库的靶向KRASG12V和CTAG1B的TCR-T细胞抑制结直肠癌和食管癌肿瘤 KRASG12V- and CTAG1B-targeted TCR-T cells from phage TCR library suppress colorectal and esophageal tumors Obed Boadi Amissah, Wenfang Chen, Zhiyuan Li, Gloria Bora Kim
• 5619 · PDF 首创的间变性淋巴瘤激酶（ALK）特异性TCR-T细胞在ALK驱动的人类癌症中诱导强效且选择性的抗肿瘤免疫 First-in-class anaplastic lymphoma kinase (ALK)-specific TCR-T cells induce potent and selective antitumor immunity across ALK-driven human cancers Carmen Mecca, Simone Piane, Nirmala Tilija Pun, Ana Azambuja, Luca Alessandrí, Rafael Blasco, Chi Nguyen Puc Bao, Elisa Bergaggio, Gabriele Saccu, Alessandro Gasparetto, Haley Ohlson, David A. Barbie, Ellis L. Reinherz, Marcos Simoes-Costa, Roberto Chiarle
• 5620 · PDF 基于T细胞受体(TCR)的纤维板层型肝细胞癌(HCC)细胞疗法开发揭示TCR在CD4 T细胞分化中的作用 Development of T cell receptor (TCR) based cellular therapy for fibrolamellar HCC uncovers role of TCR in CD4 T cell differentiation Kayla J. Bendinelli, Allison M. Kirk, Marina Baretti, Abigail M. Gottschall, Heng-Chung Kung, Jeric Peter Hernandez, Waqar Arif, Julie Nauroth, Jennifer Durham, Christopher Thoburn, Amanda Huff, Neeha Zaidi, Alexei Hernandez, Hassan Jamaleddine, Timothy N. West, Justin McCallen, George Coukos, Alexandre Harari, Challice L. Bonifant, Elizabeth Jaffee, Won Jin Ho, Grégoire Altan-Bonnet, Paul G. Thomas, Mark Yarchoan
• 5621 5621 基于GPC3靶向hYP7抗体的gamma/delta TCR-T细胞疗法克服肝癌中的抗原突变和异质性 The GPC3-targeting hYP7 antibody-based gamma/delta TCR-T cell therapy for overcoming antigen mutation and heterogeneity in liver cancer Dan Li, Tianyuzhou Liang, Hsi-En Tsao, Zhijian Duan, Laura E. Hutchins, Madilyn Gaydos, Iris Yang, Elijah Edmondson, Xiaoshan Wang, Rui Zheng, Jing Zhou, Chin-Hsien (Emily) Tai, Jing Bian, Maggie Cam, Hongbing Zhang, Cheng Liu, Mitchell Ho
• 5622 · PDF 开发靶向KRAS G12D/HLA-A*11 pMHC的同种异体TCR模拟激活型gdT(TAG-T)细胞用于不可成药的KRAS突变癌症 Development of allogeneic TCR-mimic activating gdT (TAG-T) cells targeting KRAS G12D /HLA-A*11 pMHC for undruggable KRAS-mutated cancers Chia-Chun Chao, Hsin-Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Yi-Wen Jiang, K.S. Clifford Chao, Kevin Chih-Yang Huang
• 5623 · PDF 在PDX肉瘤模型中通过attIL12-TIL疗法消除肿瘤胶原以增强疗效的新机制 Novel mechanism for eliminating tumor collagens to boost efficacy by attIL12-TIL therapy in PDX sarcoma models Jiemiao Hu, Harjeet Singh, Yining Jin, Wendong Zhang, Jian Wang, Xueqing Xia, Neeta Somaiah, Richard Gorlick, Shulin Li
• 5624 5624 利用临床前模型增强肿瘤浸润淋巴细胞(TIL)疗法疗效的临床策略 Clinical strategies to enhance the efficacy of tumor-infiltrating lymphocyte (TIL) therapy using preclinical models Asraa Ahmed, Jonathan F. Khan, Sadna Budhu, Jedd D. Wolchok, Taha Merghoub
• 5625 · PDF T细胞耗竭的表观遗传重编程 Epigenetic reprogramming of T cell exhaustion Tsunghan Hsieh, Ruomin Xin, Enchong Zhao, Xiao Tian
• 5626 · PDF 联合表观遗传治疗揭示非经典新抗原以改善卵巢癌的过继T细胞疗法 Combination epigenetic therapy unmasks non-canonical neoantigens to improve adoptive T cell therapy in ovarian cancer Jose A. Colina, Katherine B. Chiappinelli, Erin E. Grundy, Conrad Russell Y. Cruz
• 5627 · PDF 间歇性环磷酰胺和长春瑞滨联合抗PD-1在TNBC小鼠模型中诱导可转移的T细胞介导的抗肿瘤免疫和长期记忆 Intermittent cyclophosphamide and vinorelbine combined with anti-PD-1 induce transferable T-cell-mediated antitumor immunity and long-term memory in TNBC mouse models Stefania Orecchioni, D'Ambrosio Lorenzo, Davide Lombardi, Anna Vaccari, Paola Nistico', Francesco Bertolini, Paolo Falvo

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