Oncogenic Pathways and Cancer Immunity

• 5558 · PDF KRT6A在头颈部鳞状细胞癌中介导免疫排斥和抗PD-1耐药 KRT6A mediates immune exclusion and anti-PD-1 resistance in head and neck squamous cell carcinoma Yi-Che Wu, Muh-Hwa Yang
• 5559 · PDF 驱动头颈部鳞状细胞癌神经周围侵犯的空间神经免疫串扰 Spatial neuroimmune crosstalk driving perineural invasion in head and neck squamous cell carcinoma Riya Chhabra, Alfred Kao, Suravi Bajaj, Reena Ding, Daniel John, Wei Tse Li, Jessica Y. Wang-Rodriguez, Weg M. Ongkeko
• 5560 · PDF KRAS G12D抑制可刺激抗原提呈并增强胰腺癌中基于mRNA的免疫治疗 KRAS G12D inhibition stimulates antigen presentation and potentiates mRNA-based immunotherapy in pancreatic cancer Amanda Creech, Hailey Lee, Khalid Rashid, Tony Luu, Emma Lieberman, Michael Srienc, Alykhan Premji, Ahmad Kassem, Luyi Li, James Wohlschlegel, Timothy Donahue, Norbert Pardi, Caius Radu
• 5561 · PDF 靶向LILRB1/HLA-G轴的LILRB1抗体：支持首次人体试验的临床前疗效、药代动力学与安全性 LILRB1 antibody targeting the LILRB1/HLA-G axis: Preclinical efficacy, pharmacokinetics, and safety supporting first-in-human trials Han Byoul Kim, Seok-Joo Kim, Younghoon Kim, Junhaeng Cho, Minsoon Kim, JungA Kim, Suji Hong, Heehang Kim, Shin-Young Kang, Kyungna Ko, Jun-Gyu Park, Hyungjin Cho, Jeeyeon Roh, Young Dok Son, Wooseok Ko
• 5562 · PDF 拮抗β-Catenin/BCL9相互作用可抑制多形核髓源性抑制细胞的生成与维持 Antagonism of beta-Catenin/BCL9 interaction suppresses polymorphonuclear myeloid-derived suppressor cell generation and maintenance Claudio Scuoppo, Julia Diehl, Rick Ramirez, Barry J. Kappel, Abi Vainstein-Haras, Jim A. Rotolo
• 5563 · PDF 长链非编码RNA网络作为三阴性乳腺癌中细胞毒性免疫细胞耗竭的新型主调控因子 Long noncoding RNAs networks as novel master regulators of cytotoxic immune cell exhaustion in triple-negative breast cancer Raquel Sanchez, Eduardo E. Chaib Lozano, Barbara Yang, Shrikanth S. Gadad, Enrique I. Ramos
• 5564 · PDF 神经酰胺与前列腺素信号之间的串扰介导了对免疫检查点阻断的耐药 Crosstalk between ceramide and prostaglandin signaling mediates resistance to immune checkpoint blockade Wyatt O. Wofford, Elif Percin, Han G. Lee, Odai Darawshi, Bryan Granger, Lucy Mulligan, Natalia V. Oleinik, Mohamed F. Kassir, Chase Walton, Paramita Chakraborty, Stefano Berto, Raymond N. DuBois, Shikhar Mehrotra, Besim Ogretmen
• 5565 5565 C118S介导的KRAS G12D突变氧化还原调节重编程免疫代谢以抑制肥胖驱动的胰腺肿瘤发生 C118S-mediated redox modulation of KRASG12D mutation reprograms immunometabolism to suppress obesity-driven pancreatic tumorigenesis Zahid Rafiq, Weiqin Lu
• 5566 · PDF 分子进化揭示卵巢癌中低患病率的驱动突变、突变协同作用及相关的免疫动态 Molecular evolution reveals low-prevalence driver mutations, mutational synergies, and associated immune dynamics in ovarian cancer Julia McAdams, Nic Fisk
• 5567 · PDF 联合治疗促进对KRAS-G12C抑制剂耐药细胞的免疫介导旁观者杀伤 Combination therapies promote immune-mediated bystander killing of KRAS-G12C inhibitor resistant cells Mona Tomaschko, KangBo Ng, Christopher Moore, Claire E. Pillsbury, Sareena Rana, James Campbell, Saptaparna Mukherjee, Ania Mikolajczak, Panayiotis Anastasiou, Andrea de Castro, Alicia Alonso de la Vega, Sophie de Carné Trécesson, Nathan W. Goehring, Miriam Molina-Arcas, Julian Downward
• 5568 · PDF PRTN3 通过蛋白水解切割 CXCL9 抑制 KRAS 突变型肺腺癌中细胞毒性免疫细胞的活化及抗肿瘤免疫 PRTN3 suppresses cytotoxic immune-cell activation and antitumoral immunity through proteolytic cleavage of CXCL9 in KRAS mutant lung adenocarcinoma Rong Xiang, Yi Liu, Yunping Luo
• 5570 · PDF 尿路上皮癌中肿瘤相关白细胞增多的多组学解析鉴定出 IL13RA2 为关键驱动因素 Multi-omics dissection of tumor-related leukocytosis in urothelial carcinoma identifies IL13RA2 as a key driver Harvey Yu-Li Su, Shih-Yu Huang, Chung-Wen Kuo, Chang-Ting Lin, Yi-Hua Chen, Ming-Chun Kuo, Hsuan-Ying Huang, Chih-Yen Chien
• 5571 · PDF 动态转录重塑和功能适应驱动淋巴瘤的恶性进展 Dynamic transcriptional remodeling and functional adaptation drive malignant progression in lymphoma Bandish Kapadia, Anirban Roychodhury, Forum Kayastha, Won Sok Lee, Nahid Nanaji, Jolene windle, Ronald B. Gartenhaus
• 5572 · PDF 通过人类血管肉瘤与犬血管肉瘤的比较基因组分析揭示驱动突变和致癌通路改变的保守性 Conservation of driver mutations and oncogenic pathway alterations revealed through a comparative genomic analysis of human angiosarcoma and canine hemangiosarcoma Lucas Rodrigues, Garrett Harvey, Gerald Post, Benjamin Lewis, Abigail Hull, Aubrey O'Grady, Lindsay Lambert, Christina Lopes, Thaddeus Allen
• 5573 · PDF 新型 ASPORIN/CRABP2 轴驱动从腺癌到神经内分泌样前列腺癌的细胞状态可塑性 Novel ASPORIN/CRABP2 axis drives cell-state plasticity from adenocarcinoma to neuroendocrine-like prostate cancer Parthasarathy Seshacharyulu, Shobhit Lall, Sushanta Halder, Sakthivel Muniyan, Zahraa Wajih Alsafwani, Ramakanth Chirravuri-Venkata, Moorthy P. Ponnusamy, Surinder K. Batra
• 5574 · PDF KMT2C 和 KMT2D 在调节子宫内膜癌肿瘤免疫微环境中的作用 Role of KMT2C and KMT2D in modulating tumor immune microenvironment of endometrial cancer Sanjeev Ganesh, Swornalata Pukhrambam, Juveria Ali, Savannah Hughes, Heather Marie Gibson, Michael Wilson
• 5575 · PDF 通过靶向癌细胞中失调的 EZH2-RKIP 轴抑制免疫逃逸 Inhibition of immune evasion via targeting the dysregulated EZH2-RKIP axis in cancer cells Ryan McWhorter, Talia Festekedjian, Benjamin Bonavida
• 5576 · PDF 三突变型星形细胞瘤中依赖 BRD 和 EHMT 的免疫抑制性转录组 BRD- and EHMT-dependent immunosuppressive transcriptome in triple-mutant Astrocytoma Qingzhu Gao, Leyi Xie, Gengchen Cai, Sophie Sall, Bachchu Lal, Lopez-Bertoni Hernando, John Laterra, Yunqing Li
• 5577 · PDF 抑制LSD1可重塑肿瘤微环境以增强HNSCC中的抗PD1免疫治疗 LSD1 inhibition remodels the tumor microenvironment to enhance anti-PD1 immunotherapy in HNSCC Amit Kumar Chakraborty, Chumki Choudhury, Rajnikant Raut, Manish V. Bais
• 5578 · PDF 卵巢癌中转座元件的调控与表达 Regulation and expression of transposable elements in ovarian cancer Reddick Russell Walker, Kevin Nestler, Melissa Hadley, Katherine B. Chiappinelli

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