PO.MCB03.01 · 分子与细胞生物学
RAS/MAPK Signaling, KRAS Targeting, and Adaptive Resistance
- 5976 5976 单分子水平上RAS-RAF信号的时空调控 Spatiotemporal control of RAS-RAF signaling at the single-molecule level Rodrigo E. Cáceres-Gutiérrez, Rebika Shreshta, Jean Castillo-Badillo, Vanessa Wall, Scott Eury, Katie Powell, William Burgan, Min Hong, Peter Frank, Dwight V. Nissley, Frank McCormick, Thomas Turbyville
- 5977 5977 抑制mTOR通过一个新的AKT启动的反馈环激活EGFR-MAPK网络，促进适应性耐药 mTOR inhibition activates the EGFR-MAPK network by a novel AKT-initiated feedback loop promoting adaptive resistance Keiichi Koshizuka, Hiroki Izumi, Tomohiko Ishikawa, Kuniaki Sato, Jean-Philippe Coppe, J. Silvio Gutkind
- 5978 5978 SPR2015是一种高效且选择性的KRAS G12D（ON）抑制剂，在临床前模型中作为单药对结直肠癌表现出良好的药代动力学特性和显著的抗肿瘤疗效 SPR2015, a highly potent and selective KRAS G12D (on) inhibitor, exhibits favorable pharmacokinetic behavior and significant anti-tumor efficacy against colorectal cancer as monotherapy in preclinical models Yi Qian, Zirong Zhang, Zhifei Fu, Kai Zhou, Meibi Dai, Shuqin Liu, Yang Zhang, Tao Hu
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- 5980 5980 AUBE00：一种新型环肽泛KRAS抑制剂，靶向包括KRAS突变癌症和野生型结直肠癌在内的KRAS激活型癌症 AUBE00: A novel cyclic peptide pan-KRAS inhibitor targeting KRAS-activated cancers including KRAS-mutant cancers and wild-type colorectal cancer Kana Takei, Mayuki Ueda, Toshiaki Tsunenari, Ai Shinoda, Munehiro Yuki, Hitoshi Sase, Saki Michisaka, Yukako Tachibana, Masami Hasegawa, Toshihiko Fujii, Shino Kuramoto, Miho Nagayasu, Mengxuan Gao, Kazuhiro Ohara, Keisuke Oki, Mikito Owa, Seiya Hirai, Haon Futamata, Takuya Torizawa, Hatsuo Kawada, Mirai Kage, Mikimasa Tanada, Takuya Shiraishi, Hitoshi Iikura, Takehisa Kitazawa, Hiroshi Tanaka
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- 5986 5986 敲除AKT1抑制PTEN缺失诱导的肝内胆管癌但不抑制小鼠肝细胞癌的发生 Deletion of AKT1 inhibits PTEN-loss induced intrahepatic cholangiocarcinoma but not hepatocellular carcinoma development in mice Ielyzaveta Slarve, Yining Ding, Yushan Wang, Zifei Xu, Lina He, Bangyan L. Stiles
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- 5997 5997 基于网络的图谱揭示了导致 KRAS G12C 肺癌 Sotorasib 耐药的机制驱动因素和可靶向枢纽 Network based mapping reveals mechanistic drivers and targetable hubs contributing to Sotorasib resistance in KRAS G12C lung cancer Atish Ranjan Mohanty, Baiyi Quan, Dana Do, Ting-Yu Wang, Tsui-Fen Chou, Prakash Kulkarni, Ravi Salgia
