PO.TB04.04 · 肿瘤生物学
In Vivo Models 2: Genetically Engineered Mouse Models, PDXs, Syngeneic Models
- 6055 6055 靶向CEP55作为一种普遍的致癌依赖性：在转化型临床前癌症模型中整合空间多组学与靶向治疗 Targeting CEP55 as a universal oncogenic dependency: Integrating spatial multi-omics and targeted therapy across translational preclinical cancer models Behnam Rashidieh, Pirjo Apaja, Quan Nguyen, Nigel McMillan, Kum Kum Khanna
- 6056 6056 缺失必需即刻早期反式激活因子RTA/ORF50的KSHV基因组在转基因小鼠中诱导血管肉瘤 The KSHV genome, devoid of the essential immediate early transactivator RTAORF50, induces angiosarcoma in transgenic mice Dirk P. Dittmer, Kyle Shifflett, Eason B. Anthony, Su Huanjuan, Zhigang Zhang, Blossom Damania
- 6057 6057 IKZF1 N159Y部分串联重复突变体驱动染色质重塑、B细胞发育缺陷和白血病起始 The IKZF1 N159Y partial tandem duplication mutant drives chromatin remodeling, B-cell developmental defects and leukemia initiation Ruth W. Wang'ondu, Devanand Bondage, Qiong Zhang, Yiming Wu, Baranda Hansen, Chun Shik Park, Prady Baviskar, Emily Backhaus-Wagner, Ilaria Iacobucci, Surbhi Sona, Huiyun Wu, Qingsong Gao, Wojciech Rosikiewicz, Beisi Xu, Hongjian Jin, Ti-Cheng Chang, Stanley Pounds, Laura Janke, Trevor Cunningham, Kristine R. Crews, Jun J. Yang, Shondra Pruett-Miller, Charles G. Mullighan
- 6058 6058 抑癌基因失活塑造EGFR突变型肺腺癌进展的格局及其治疗意义 Tumor suppressor gene inactivation shapes the landscape of EGFR-mutant lung adenocarcinoma progression with therapeutic implications Mariana Do Carmo, Matthew Martin, Michael Rosen, Lily Blair, Anna Tribe, Keita Maemura, Giorgia Foggetti, Francisco Exposito, Zeynep Ugur, Lafia Sebastian, Vy Tran, Ian Lai, Alyna Katti, Ian Winters, Dmitri A. Petrov, Nicolas Floc'h, Monte M. Winslow, Katerina A. Politi
- 6059 6059 在NF1失活型黑色素瘤的新型人源和小鼠模型中，垂直靶向MAPK通路是实现肿瘤消退所必需的 Vertical MAPK pathway targeting is required for tumor regression in novel human and mouse models of NF1-inactivated melanoma Olvania-Danyca Hilaire, Alexis M. Jones, Moriah H. Nissan, Sebastien Monette, Jordan Eichholz, Cailian Liu, Xia Yang, Ayana Sawai-Frantz, Elisa de Stanchina, Taha Merghoub, Neal Rosen, David B. Solit, Aphrothiti J. Hanrahan
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- 6061 6061 利用NCI患者来源模型库开发胰腺癌和结肠癌患者来源异种移植（PDX）肿瘤微阵列（TMA） Development of pancreatic and colon patient-derived xenograft (PDX) tumor microarrays (TMAs) from the NCI patient derived models repository Cindy R. Timme, Lindsay Dutko, Sayak Ghatak, Ting-Chia Chang, Alice P. Chen, Li Chen, Biswajit Das, Tara Grinnage-Pulley, Shahanawaz Jiwani, Kaci Paulus, Chris A. Karlovich, Sergio Alcoser, Yvonne Evrard, Melinda G. Hollinghead, James H. Doroshow
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- 6065 6065 解码KRAS信号强度：胰腺癌肿瘤侵袭性和对RAS抑制反应的关键驱动因素 Decoding KRAS signaling intensity: A key driver of tumor aggressiveness and response to RAS inhibition in pancreatic cancer Mehrnaz Salehi, Sara Raji, Mohammadreza Ranjouri, Fengming Chen, Ashley Fletcher, Peter J. Allen, Zahra Kabiri
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- 6073 6073 代表初治、化疗和靶向治疗耐药患者群体的一组EGFR突变肺癌XPDX模型的建立与表征 Establishment and characterization of a panel of EGFR-mutant lung XPDX models representing naïve, chemotherapy, and targeted therapy-resistant patient populations Christopher Nelson, Mia Lopez, Amy Fredrickson, Alyssa Simonson, Natalia Baños Herraiz, Shaquille Johnson, Ian Sturgill, Guillermo Sanz Martin, Jim Lund, Jennifer Garcia, Kyriakos P. Papadopoulos, Victor Moreno Garcia, Chris Takimoto, Michael J. Wick
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- 6077 6077 一种与SCLC患者生存改善相关的天然抗体应答可在SCLC小鼠模型中被主动诱导并显著改善生存 A natural antibody response associated with improved survival of SCLC patients can be actively induced in a SCLC mouse model and leads to significantly improved survival Diego Alejandro Velarde, Joseph Valdes, Chunli Yan, Sarah Elmalh, Hannah Lee, Daniel James Mullen, Angie Moreno, Matthew A. Gladstone, JONATHAN CASTILLO, Crystal N. Marconett, Nicky Nie, Ming Li, W. Martin Kast, Ite A. Offringa
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- 6081 6081 用于研究TME并评估抗癌药物的肺癌原位移植模型的开发及其临床前研究应用 Development of a lung cancer orthotopic transplantation model for investigating the TME and evaluating anticancer agents for preclinical studies Chiyoko Nishime, Eiko Nishinaka, Hitomi Satou, Toshio Imai, Masayuki Komatsu, Misa Mochizuki, Taichi Yamamoto, Masami Suzuki
- 6082 6082 IFNalpha通过诱导蛋白质翻译使中性粒细胞极化为粒细胞型MDSC IFNalpha polarizes granulocytic MDSCs from neutrophils by inducing protein translation Juanita L. Merchant, Lin Ding
- 6083 6083 基于颈内动脉注射、不破坏血脑屏障的脑转移模型用于临床前药物评价 Intracarotid injection-based brain metastasis models without disrupting the blood-brain barrier for preclinical drug evaluation Arianna Bandini, Gojko Bijelic, Melanie Heisler, Pia Norz, Philipp Metzger, Cynthia Obodozie, Holger Weber
