PO.TB04.04 · 肿瘤生物学
In Vivo Models 2: Genetically Engineered Mouse Models, PDXs, Syngeneic Models
- 6055 6055 Targeting CEP55 as a universal oncogenic dependency: Integrating spatial multi-omics and targeted therapy across translational preclinical cancer models Behnam Rashidieh, Pirjo Apaja, Quan Nguyen, Nigel McMillan, Kum Kum Khanna
- 6056 6056 The KSHV genome, devoid of the essential immediate early transactivator RTAORF50, induces angiosarcoma in transgenic mice Dirk P. Dittmer, Kyle Shifflett, Eason B. Anthony, Su Huanjuan, Zhigang Zhang, Blossom Damania
- 6057 6057 The IKZF1 N159Y partial tandem duplication mutant drives chromatin remodeling, B-cell developmental defects and leukemia initiation Ruth W. Wang'ondu, Devanand Bondage, Qiong Zhang, Yiming Wu, Baranda Hansen, Chun Shik Park, Prady Baviskar, Emily Backhaus-Wagner, Ilaria Iacobucci, Surbhi Sona, Huiyun Wu, Qingsong Gao, Wojciech Rosikiewicz, Beisi Xu, Hongjian Jin, Ti-Cheng Chang, Stanley Pounds, Laura Janke, Trevor Cunningham, Kristine R. Crews, Jun J. Yang, Shondra Pruett-Miller, Charles G. Mullighan
- 6058 6058 Tumor suppressor gene inactivation shapes the landscape of EGFR-mutant lung adenocarcinoma progression with therapeutic implications Mariana Do Carmo, Matthew Martin, Michael Rosen, Lily Blair, Anna Tribe, Keita Maemura, Giorgia Foggetti, Francisco Exposito, Zeynep Ugur, Lafia Sebastian, Vy Tran, Ian Lai, Alyna Katti, Ian Winters, Dmitri A. Petrov, Nicolas Floc'h, Monte M. Winslow, Katerina A. Politi
- 6059 6059 Vertical MAPK pathway targeting is required for tumor regression in novel human and mouse models of NF1-inactivated melanoma Olvania-Danyca Hilaire, Alexis M. Jones, Moriah H. Nissan, Sebastien Monette, Jordan Eichholz, Cailian Liu, Xia Yang, Ayana Sawai-Frantz, Elisa de Stanchina, Taha Merghoub, Neal Rosen, David B. Solit, Aphrothiti J. Hanrahan
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- 6061 6061 Development of pancreatic and colon patient-derived xenograft (PDX) tumor microarrays (TMAs) from the NCI patient derived models repository Cindy R. Timme, Lindsay Dutko, Sayak Ghatak, Ting-Chia Chang, Alice P. Chen, Li Chen, Biswajit Das, Tara Grinnage-Pulley, Shahanawaz Jiwani, Kaci Paulus, Chris A. Karlovich, Sergio Alcoser, Yvonne Evrard, Melinda G. Hollinghead, James H. Doroshow
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- 6065 6065 Decoding KRAS signaling intensity: A key driver of tumor aggressiveness and response to RAS inhibition in pancreatic cancer Mehrnaz Salehi, Sara Raji, Mohammadreza Ranjouri, Fengming Chen, Ashley Fletcher, Peter J. Allen, Zahra Kabiri
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- 6073 6073 Establishment and characterization of a panel of EGFR-mutant lung XPDX models representing naïve, chemotherapy, and targeted therapy-resistant patient populations Christopher Nelson, Mia Lopez, Amy Fredrickson, Alyssa Simonson, Natalia Baños Herraiz, Shaquille Johnson, Ian Sturgill, Guillermo Sanz Martin, Jim Lund, Jennifer Garcia, Kyriakos P. Papadopoulos, Victor Moreno Garcia, Chris Takimoto, Michael J. Wick
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- 6077 6077 A natural antibody response associated with improved survival of SCLC patients can be actively induced in a SCLC mouse model and leads to significantly improved survival Diego Alejandro Velarde, Joseph Valdes, Chunli Yan, Sarah Elmalh, Hannah Lee, Daniel James Mullen, Angie Moreno, Matthew A. Gladstone, JONATHAN CASTILLO, Crystal N. Marconett, Nicky Nie, Ming Li, W. Martin Kast, Ite A. Offringa
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- 6081 6081 Development of a lung cancer orthotopic transplantation model for investigating the TME and evaluating anticancer agents for preclinical studies Chiyoko Nishime, Eiko Nishinaka, Hitomi Satou, Toshio Imai, Masayuki Komatsu, Misa Mochizuki, Taichi Yamamoto, Masami Suzuki
- 6082 6082 IFNalpha polarizes granulocytic MDSCs from neutrophils by inducing protein translation Juanita L. Merchant, Lin Ding
- 6083 6083 Intracarotid injection-based brain metastasis models without disrupting the blood-brain barrier for preclinical drug evaluation Arianna Bandini, Gojko Bijelic, Melanie Heisler, Pia Norz, Philipp Metzger, Cynthia Obodozie, Holger Weber
