PO.TB10.02 · 肿瘤生物学
Metastasis and Organ-Specific Microenvironmental Evolution
- 6110 6110 Systemic inflammation induced by calprotectin (S100A8/S100A9 complex) triggers reactivation of dormant cells in mouse models of breast cancer Ahmet B. Caglayan, Ying Xin, Aysun Caglayan, Shruti Nagaraja, Deeksha Sharma, Cody Hager, Fulya Koksalar-Alkan, Hilmi K. Alkan, Monika Burness, Hasan Korkaya, Max S. Wicha
- 6111 6111 Opposite regulation of brain and lung metastases by endothelial FAK deletion Shoko Noda-Narita, Atsu Aiba
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- 6113 6113 ccRCC lung metastases harbor cancer associated fibroblast lymphocyte exclusion sites that form a confined TME as revealed by single cell and spatial multi-omics Yufei Wang, Jae-Won Cho, Yasmin Nabil Laimon, Wenxin Xu, Kun Huang, Aseman Bagheri Sheshdeh, Nithyassree Murugan, Hsien-Chi Yuan, Jon Wee, David Alexander Braun, Toni K. Choueiri, Catherine J. Wu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco
- 6114 6114 Integrated single-cell and spatial atlas of tumor-draining lymph nodes reveals metastasis-associated stromal and immune remodeling Enshuo Zhang, Lu Zhang, Haitang Yang, Feng Yao
- 6115 6115 Deciphering tumor microenvironment dynamics in tumorigenesis and lymph node metastasis of esophageal squamous cell carcinoma using single-cell and spatial transcriptomics Tae Hee Hong, Hansoll Na, Chung Lee, Young Ho Yang, Ha Eun Kim, Byung Jo Park, Min Hee Hong, Hye Ryun Kim, Hyun Ki Kim, Dae Joon Kim
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- 6117 6117 Fibroblast-derived extracellular vesicles promote organ-specific tumor growth and chemoresistance in pancreatic cancer liver metastasis via ptch2 downregulation Mahsa Pahlavanneshan, Weikun Xiao, Eileen Fung, Chae Young Eun, Chang-Il Hwang, Shannon Mumenthaler, Reginald Hill
- 6118 6118 Spatially resolved SEED (stromal-enriched metastatic decider) niches integrate tumor, stromal, and immune ecosystems to enable lymph node dissemination in LUAD Junghan Oh, Hoyeon Jeong, Yoon La Choi, Donggun Lee, Misook Lee
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- 6123 6123 TNBC-derived lipocalin-2 potentiates metastasis by inducing immunologic reprogramming of premetastatic and metastatic microenvironments Gabriela Ortiz-Soto, Joshua Gamez, Carolyn Rentz, Raynah Cheng, Francesca Sanchez, Abigail Terry, Peter Gray, Mary Lauren Benton, Jonathan Kelber
- 6124 6124 TIM3 + tumor associated M2 macrophages impair antitumor T cell immunity and promote gastric cancer progression and peritoneal metastasis Xiaodan Yao, Junsong Zhao, Yibo Fan, Yanting Zhang, Dipti Athavale, Curt Balch, Mikel Ghelfi, Anthony Pompetti, Jiankang Jin, Yong Ki Hong, Jamin Morrison, Madeline Torres, Francis Spitz, Generosa Grana, Shilpa S. Dhar, Linghua Wang, Jaffer A. Ajani, Shumei Song
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- 6126 6126 Multiomics integration unveils a shifted balance in the sphingosine-1 phosphate/ceramide rheostat fueled by macrophage immunosuppression in metastatic colorectal cancer Michelle M. Maurin, Siddabasave Gowda B. Gowda, Divyavani Gowda, Heiman Wang, Michael Nebozhyn, Ramani Soundararajan, Mckayla Carr, Punith M Sundaraswamy, Ashley Alden, Carolina Martinez, Robert David Bennett, Allen Chudzinski, Andreas Karachristos, Timothy M. Nywening, Paul M. Cavallaro, Matthew Linley Anderson, Robert J. Coffey, Michael Schell, Jorge Marcet, Richard Jacobson, Andrey Loboda, Ganesh V. Halade, Mingli Yang, Lance Pflieger, Warren Jackson Pledger, Shu-Ping Hui, Timothy J. Yeatman
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- 6131 6131 BDNF-TrkB.T1 receptor signaling modulate an immunosuppressive tumor microenvironment and epithelial-mesenchymal transition in gliomas Leyre Merino-Galan, Jin-Yih Low, Sergio Ortiz-Espinosa, Hawa L. Jagana, John M. Hemmenway, Ashmitha Rajendran, Mathew R. Hattaway, Taylor S. Jackson, Maryam Shabar, Noemi Reche-Ley, Sonali Arora, David Johnson, Daniel A. Kuppers, Patrick J. Paddision, Siobhan S. Pattwell
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- 6138 6138 Profiling the unique resident immune cell compartment in acral skin and its implications for acral melanoma tumor immunity Joshua K. H. Tay, Emilio Cortes-Sanchez, Amanda Jiang, Anastasia Prokofyeva, Robert Judson-Torres, Melissa Q. Reeves
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