PO.TB10.02 · 肿瘤生物学
Metastasis and Organ-Specific Microenvironmental Evolution
- 6110 6110 钙卫蛋白（S100A8/S100A9 复合物）诱导的全身性炎症在乳腺癌小鼠模型中触发休眠细胞的再激活 Systemic inflammation induced by calprotectin (S100A8/S100A9 complex) triggers reactivation of dormant cells in mouse models of breast cancer Ahmet B. Caglayan, Ying Xin, Aysun Caglayan, Shruti Nagaraja, Deeksha Sharma, Cody Hager, Fulya Koksalar-Alkan, Hilmi K. Alkan, Monika Burness, Hasan Korkaya, Max S. Wicha
- 6111 6111 内皮 FAK 缺失对脑转移和肺转移的相反调控 Opposite regulation of brain and lung metastases by endothelial FAK deletion Shoko Noda-Narita, Atsu Aiba
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- 6113 6113 单细胞与空间多组学揭示ccRCC肺转移灶中存在癌相关成纤维细胞淋巴细胞排斥位点，形成受限的TME ccRCC lung metastases harbor cancer associated fibroblast lymphocyte exclusion sites that form a confined TME as revealed by single cell and spatial multi-omics Yufei Wang, Jae-Won Cho, Yasmin Nabil Laimon, Wenxin Xu, Kun Huang, Aseman Bagheri Sheshdeh, Nithyassree Murugan, Hsien-Chi Yuan, Jon Wee, David Alexander Braun, Toni K. Choueiri, Catherine J. Wu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco
- 6114 6114 肿瘤引流淋巴结的单细胞与空间整合图谱揭示转移相关的基质与免疫重塑 Integrated single-cell and spatial atlas of tumor-draining lymph nodes reveals metastasis-associated stromal and immune remodeling Enshuo Zhang, Lu Zhang, Haitang Yang, Feng Yao
- 6115 6115 利用单细胞与空间转录组学解析食管鳞状细胞癌肿瘤发生和淋巴结转移中的肿瘤微环境动态 Deciphering tumor microenvironment dynamics in tumorigenesis and lymph node metastasis of esophageal squamous cell carcinoma using single-cell and spatial transcriptomics Tae Hee Hong, Hansoll Na, Chung Lee, Young Ho Yang, Ha Eun Kim, Byung Jo Park, Min Hee Hong, Hye Ryun Kim, Hyun Ki Kim, Dae Joon Kim
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- 6117 6117 成纤维细胞来源的细胞外囊泡通过下调ptch2促进胰腺癌肝转移中器官特异性的肿瘤生长和化疗耐药 Fibroblast-derived extracellular vesicles promote organ-specific tumor growth and chemoresistance in pancreatic cancer liver metastasis via ptch2 downregulation Mahsa Pahlavanneshan, Weikun Xiao, Eileen Fung, Chae Young Eun, Chang-Il Hwang, Shannon Mumenthaler, Reginald Hill
- 6118 6118 空间解析的SEED（基质富集转移决定者）生态位整合肿瘤、基质和免疫生态系统以促成LUAD的淋巴结播散 Spatially resolved SEED (stromal-enriched metastatic decider) niches integrate tumor, stromal, and immune ecosystems to enable lymph node dissemination in LUAD Junghan Oh, Hoyeon Jeong, Yoon La Choi, Donggun Lee, Misook Lee
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- 6123 6123 TNBC 来源的 lipocalin-2 通过诱导转移前和转移微环境的免疫学重编程增强转移 TNBC-derived lipocalin-2 potentiates metastasis by inducing immunologic reprogramming of premetastatic and metastatic microenvironments Gabriela Ortiz-Soto, Joshua Gamez, Carolyn Rentz, Raynah Cheng, Francesca Sanchez, Abigail Terry, Peter Gray, Mary Lauren Benton, Jonathan Kelber
- 6124 6124 TIM3+ 肿瘤相关 M2 巨噬细胞损害抗肿瘤 T 细胞免疫并促进胃癌进展和腹膜转移 TIM3 + tumor associated M2 macrophages impair antitumor T cell immunity and promote gastric cancer progression and peritoneal metastasis Xiaodan Yao, Junsong Zhao, Yibo Fan, Yanting Zhang, Dipti Athavale, Curt Balch, Mikel Ghelfi, Anthony Pompetti, Jiankang Jin, Yong Ki Hong, Jamin Morrison, Madeline Torres, Francis Spitz, Generosa Grana, Shilpa S. Dhar, Linghua Wang, Jaffer A. Ajani, Shumei Song
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- 6126 6126 多组学整合揭示转移性结直肠癌中由巨噬细胞免疫抑制驱动的鞘氨醇-1-磷酸/神经酰胺变阻器失衡 Multiomics integration unveils a shifted balance in the sphingosine-1 phosphate/ceramide rheostat fueled by macrophage immunosuppression in metastatic colorectal cancer Michelle M. Maurin, Siddabasave Gowda B. Gowda, Divyavani Gowda, Heiman Wang, Michael Nebozhyn, Ramani Soundararajan, Mckayla Carr, Punith M Sundaraswamy, Ashley Alden, Carolina Martinez, Robert David Bennett, Allen Chudzinski, Andreas Karachristos, Timothy M. Nywening, Paul M. Cavallaro, Matthew Linley Anderson, Robert J. Coffey, Michael Schell, Jorge Marcet, Richard Jacobson, Andrey Loboda, Ganesh V. Halade, Mingli Yang, Lance Pflieger, Warren Jackson Pledger, Shu-Ping Hui, Timothy J. Yeatman
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- 6131 6131 BDNF-TrkB.T1 受体信号调节胶质瘤中的免疫抑制性肿瘤微环境和上皮-间质转化 BDNF-TrkB.T1 receptor signaling modulate an immunosuppressive tumor microenvironment and epithelial-mesenchymal transition in gliomas Leyre Merino-Galan, Jin-Yih Low, Sergio Ortiz-Espinosa, Hawa L. Jagana, John M. Hemmenway, Ashmitha Rajendran, Mathew R. Hattaway, Taylor S. Jackson, Maryam Shabar, Noemi Reche-Ley, Sonali Arora, David Johnson, Daniel A. Kuppers, Patrick J. Paddision, Siobhan S. Pattwell
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- 6138 6138 表征肢端皮肤中独特的驻留免疫细胞区室及其对肢端黑色素瘤肿瘤免疫的意义 Profiling the unique resident immune cell compartment in acral skin and its implications for acral melanoma tumor immunity Joshua K. H. Tay, Emilio Cortes-Sanchez, Amanda Jiang, Anastasia Prokofyeva, Robert Judson-Torres, Melissa Q. Reeves
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