Late-Breaking Research: Tumor Biology 3

• LB483 · PDF 用于精准癌症治疗的胃肠道恶性肿瘤人源肿瘤切片基准评估 Benchmarking human tumor slices from gastrointestinal malignancies for precision cancer therapy Kevin Gulay, Rithika Medari, Isabella Ng, Jingjing Zou, Ethan Tabibzadeh, Elias Warren, Brian Wishart, Rebekah White, Herve Tiriac, Andrew Lowy, Jonathan Weitz
• LB484 · PDF 利用患者来源肺泡类器官与PBMC共培养模型评估免疫检查点抑制剂诱导的肺毒性 Evaluation of immune-checkpoint inhibitor-induced pneumotoxicity using a patient-derived alveolar organoid and PBMC co-culture model Jaegyun Lim, Inhee Kim, Boram Song, Sooeun Oh
• LB485 · PDF 宫颈癌及患者来源类器官的整合分析揭示与治疗耐药相关的信号和代谢环路 Integrative analyses of cervical cancer and patient-derived organoids uncover signaling and metabolic circuits associated with therapy-resistant Rui Wang, Dalissa Negrón-Figueroa, Xiaogang Wu, Erica Lynn, Bo Jiang, Keiko Akagi, Jhoan Sebastian Gonzalez Diaz, Shae N. Jansen Aref, Barrett Craig Lawson, Timothy A. Harris, Maura L. Gillison, Lauren Colbert
• LB486 · PDF 用于胶质母细胞瘤治疗发现的血脑屏障球体模型的建立与优化 Origination and refinement of blood brain barrier spheroid model for glioblastoma therapy discovery Ryan Toedebusch, Christine Toedebusch, Randy Carney
• LB487 · PDF 患者特异性食管腺癌芯片：建模肿瘤-基质-免疫相互作用与治疗反应 Patient-specific esophageal adenocarcinoma-on-a-chip: Modeling tumor-stromal-immune interactions and therapeutic response Manal Al Dow, Sanjima Pal, Cedric Julien, Anna Staravoitava, Ariane Brassard, Betty Giannias, Nick Bertos, Kim Ma, Lorenzo Ferri, Jonathan Cools Lartigue
• LB488 · PDF 器官芯片：一种研究肺癌患者来源细胞辅助治疗疗效与预测的体外模型 Organ-on-Chip: An in vitro model to study the efficacy and prediction of adjuvant therapy in lung cancer patient-derived cells Federico Dona, Nikolina Grkovic, Anna Rita Putignano, Luigi Terracciano, Debora Brascia, Emanuela Re Cecconi, Veronica Giudici, Paola Bossi, Charlotte NG, Giuseppe Marulli, Salvatore Piscuoglio
• LB489 · PDF 源自空芯针活检的配对正常、原发和转移性乳腺癌类器官的比较分析 A comparative analysis of paired normal, primary, and metastatic breast cancer organoids derived from core-needle biopsies Ying-Chih Chang, Jia-Yang Chen, Chia-Chun Liu, Yen-Jang Huang, Yung-Hao Lin, Kai-Yu Huang, King-Jen Chang, Yi-Chun Wu, Wen-Hung Kuo
• LB490 · PDF nectin-4抗体药物偶联物MK-3120（SKB410）在一组实体瘤患者来源异种移植模型中的临床前评估 Preclinical evaluation of the nectin-4 antibody-drug conjugate MK-3120 (SKB410) in a panel of solid-tumor patient-derived xenograft models Evan Barry, Amy Beebe, Razvan Cristescu, Qingyun Yan, Mingmei Cai, Konstantin Dobrenkov, Gustave Hebert, Douglas Linn, Alan Northrup, Amir Vajdi, Brian Long
• LB491 · PDF 非小细胞肺癌异种移植瘤对amivantamab治疗的PET显像及应答 PET imaging and response to amivantamab treatment of non-small cell lung cancer xenografts Mann Dangarwala, Aldred Mendez, Bernadette Marquez-Nostra
• LB492 · PDF 17号染色体长臂基因BIRC5、CDC6、IGF2BP1和TK1是MYCN扩增型神经母细胞瘤的致癌依赖性 Chromosome 17q genes BIRC5 , CDC6 , IGF2BP1 , and TK1 are oncogenic dependencies in MYCN -amplified neuroblastoma Wanqi Fang, Bo Cheng, Steven J. Pastor, Michael J. Zobel, Tania Porras, Hong-Wei Wu, Taneesh Kondapally, Chintan Parekh, Anestis Tsakaridis, Ivana Barbaric, Shahab Asgharzadeh, John M. Maris, Miller Huang
• LB493 · PDF ecDNA和HSR中一个保守的增强子位点激活3组髓母细胞瘤中的MYC转录 A conserved enhancer locus in ecDNA and HSRs activates MYC transcription in group 3 medulloblastoma Jake D. Friske, Flore Cuisin, Paloma Guernalec, Hayden Malone, Stephanie Nance, Declan Bennett, Steven Burden, Ti-Cheng Chang, Hao Shi, Justin S. Williams, Virginia Valentine, Barbara Passaia, Bensheng Ju, Modupeore Adetunji, Paul Geeleher, Brian J. Abraham, Gang Wu, Chunliang Li, Martine F. Roussel
• LB494 · PDF SWI/SNF ATP酶SMARCA2/4的小分子抑制剂FHD-286阻断神经母细胞瘤的表型转换 Neuroblastoma phenotypic switching is blocked by FHD-286, a small molecule inhibitor of the SWI/SNF ATPases SMARCA2/4 Carly M. Sayers, Wendy Z. Fang, Jenna M. Lacy, Stefano Di Giulio, Xingyu Liu, Ming Sun, Zhihui Liu, Carol J. Thiele
• LB495 · PDF MYCN、GLI2扩增及TP53突变的髓母细胞瘤对翻译抑制剂高三尖杉酯碱敏感 Amplified MYCN, GLI2 and mutant TP53 medulloblastoma are vulnerable to the translation inhibitor homoharringtonine Bo Cheng, Jamie Vu, Darren Finlay, Shujun Cheng, Theophilos Tzaridis, Maria Poblete, Soumik Saha, Till Milde, Qianqian Li, Martine F. Roussel, Kristiina Vuori, John R. Prensner, William A. Weiss, Robert J. Wechsler-Reya, Miller Huang
• LB496 · PDF 亚型特异性进化约束塑造成人弥漫性胶质瘤的基因组结构 Subtype-specific evolutionary constraints shape the genomic architecture of adult diffuse gliomas Thomas Veith, Yewon Kim, Sergio Chavez, Adriana Morales Miranda, Wen Luo, Weiyin Zhou, Tongwu Zhang
• LB497 · PDF 骨肉瘤原发肿瘤及配对肺转移模型中克隆图谱和突变特征的描绘 Portraits of clonal landscape and mutational signature in primary tumors and matched lung metastatic model of osteosarcoma Sylvester Jusu, Wengdong Zhang, Qi Wang, Xingzhi Song, Zhang Zhongting, Zhaohui Xu, Yifei Wang, Xin Zhou, Michael Roth, Jonathan Gill, Douglas Harrison, Jing Wang, Jianhua Zhang, Richard Gorlick
• LB498 · PDF 造血干细胞的转录异质性可前瞻性预测衰老微环境中的克隆适应性 Transcriptional heterogeneity in hematopoietic stem cells prospectively predicts clonal fitness in aged microenvironments Marco De Dominici, Yang Liu, Kailiang Qian, Xunxuan Chen, Qiuyang Zhang, James S. Chavez, Travis Roeder, Ming Xu, Hideyuki Oguro, Eric Pietras, James DeGregori, Sheng Li

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