Late-Breaking Research: Tumor Biology 3

• LB483 · PDF Benchmarking human tumor slices from gastrointestinal malignancies for precision cancer therapy Kevin Gulay, Rithika Medari, Isabella Ng, Jingjing Zou, Ethan Tabibzadeh, Elias Warren, Brian Wishart, Rebekah White, Herve Tiriac, Andrew Lowy, Jonathan Weitz
• LB484 · PDF Evaluation of immune-checkpoint inhibitor-induced pneumotoxicity using a patient-derived alveolar organoid and PBMC co-culture model Jaegyun Lim, Inhee Kim, Boram Song, Sooeun Oh
• LB485 · PDF Integrative analyses of cervical cancer and patient-derived organoids uncover signaling and metabolic circuits associated with therapy-resistant Rui Wang, Dalissa Negrón-Figueroa, Xiaogang Wu, Erica Lynn, Bo Jiang, Keiko Akagi, Jhoan Sebastian Gonzalez Diaz, Shae N. Jansen Aref, Barrett Craig Lawson, Timothy A. Harris, Maura L. Gillison, Lauren Colbert
• LB486 · PDF Origination and refinement of blood brain barrier spheroid model for glioblastoma therapy discovery Ryan Toedebusch, Christine Toedebusch, Randy Carney
• LB487 · PDF Patient-specific esophageal adenocarcinoma-on-a-chip: Modeling tumor-stromal-immune interactions and therapeutic response Manal Al Dow, Sanjima Pal, Cedric Julien, Anna Staravoitava, Ariane Brassard, Betty Giannias, Nick Bertos, Kim Ma, Lorenzo Ferri, Jonathan Cools Lartigue
• LB488 · PDF Organ-on-Chip: An in vitro model to study the efficacy and prediction of adjuvant therapy in lung cancer patient-derived cells Federico Dona, Nikolina Grkovic, Anna Rita Putignano, Luigi Terracciano, Debora Brascia, Emanuela Re Cecconi, Veronica Giudici, Paola Bossi, Charlotte NG, Giuseppe Marulli, Salvatore Piscuoglio
• LB489 · PDF A comparative analysis of paired normal, primary, and metastatic breast cancer organoids derived from core-needle biopsies Ying-Chih Chang, Jia-Yang Chen, Chia-Chun Liu, Yen-Jang Huang, Yung-Hao Lin, Kai-Yu Huang, King-Jen Chang, Yi-Chun Wu, Wen-Hung Kuo
• LB490 · PDF Preclinical evaluation of the nectin-4 antibody-drug conjugate MK-3120 (SKB410) in a panel of solid-tumor patient-derived xenograft models Evan Barry, Amy Beebe, Razvan Cristescu, Qingyun Yan, Mingmei Cai, Konstantin Dobrenkov, Gustave Hebert, Douglas Linn, Alan Northrup, Amir Vajdi, Brian Long
• LB491 · PDF PET imaging and response to amivantamab treatment of non-small cell lung cancer xenografts Mann Dangarwala, Aldred Mendez, Bernadette Marquez-Nostra
• LB492 · PDF Chromosome 17q genes BIRC5 , CDC6 , IGF2BP1 , and TK1 are oncogenic dependencies in MYCN -amplified neuroblastoma Wanqi Fang, Bo Cheng, Steven J. Pastor, Michael J. Zobel, Tania Porras, Hong-Wei Wu, Taneesh Kondapally, Chintan Parekh, Anestis Tsakaridis, Ivana Barbaric, Shahab Asgharzadeh, John M. Maris, Miller Huang
• LB493 · PDF A conserved enhancer locus in ecDNA and HSRs activates MYC transcription in group 3 medulloblastoma Jake D. Friske, Flore Cuisin, Paloma Guernalec, Hayden Malone, Stephanie Nance, Declan Bennett, Steven Burden, Ti-Cheng Chang, Hao Shi, Justin S. Williams, Virginia Valentine, Barbara Passaia, Bensheng Ju, Modupeore Adetunji, Paul Geeleher, Brian J. Abraham, Gang Wu, Chunliang Li, Martine F. Roussel
• LB494 · PDF Neuroblastoma phenotypic switching is blocked by FHD-286, a small molecule inhibitor of the SWI/SNF ATPases SMARCA2/4 Carly M. Sayers, Wendy Z. Fang, Jenna M. Lacy, Stefano Di Giulio, Xingyu Liu, Ming Sun, Zhihui Liu, Carol J. Thiele
• LB495 · PDF Amplified MYCN, GLI2 and mutant TP53 medulloblastoma are vulnerable to the translation inhibitor homoharringtonine Bo Cheng, Jamie Vu, Darren Finlay, Shujun Cheng, Theophilos Tzaridis, Maria Poblete, Soumik Saha, Till Milde, Qianqian Li, Martine F. Roussel, Kristiina Vuori, John R. Prensner, William A. Weiss, Robert J. Wechsler-Reya, Miller Huang
• LB496 · PDF Subtype-specific evolutionary constraints shape the genomic architecture of adult diffuse gliomas Thomas Veith, Yewon Kim, Sergio Chavez, Adriana Morales Miranda, Wen Luo, Weiyin Zhou, Tongwu Zhang
• LB497 · PDF Portraits of clonal landscape and mutational signature in primary tumors and matched lung metastatic model of osteosarcoma Sylvester Jusu, Wengdong Zhang, Qi Wang, Xingzhi Song, Zhang Zhongting, Zhaohui Xu, Yifei Wang, Xin Zhou, Michael Roth, Jonathan Gill, Douglas Harrison, Jing Wang, Jianhua Zhang, Richard Gorlick
• LB498 · PDF Transcriptional heterogeneity in hematopoietic stem cells prospectively predicts clonal fitness in aged microenvironments Marco De Dominici, Yang Liu, Kailiang Qian, Xunxuan Chen, Qiuyang Zhang, James S. Chavez, Travis Roeder, Ming Xu, Hideyuki Oguro, Eric Pietras, James DeGregori, Sheng Li

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