Gene and Vector-Based Therapy

• 258 · PDF 靶向Warburg效应的核酸疗法临床前研究 Preclinical study of nucleic acid therapeutics targeting the Warburg effect Keita Matsumoto, Hirokatsu Hayashi, Seito Fujibayashi, Noriki Mitsui, Takeshi Horaguchi, Yuji Hatanaka, Ryoma Yokoi, Ayana Yokoyama, Chika Mizutani, Masashi Kuno, Masahiro Fukada, Ryuichi Asai, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Yoshihiro Tanaka, Nobuhisa Matsuhashi
• 259 · PDF 利用自递送反义寡核苷酸靶向敲低STEAP2可降低癌症恶性行为 Targeted STEAP2 knockdown with self-delivering antisense oligonucleotide reduces cancer malignant behavior Nagesh K. Panchal, Araceli Bernal, Brittany Michelle Barre, Francisco Cigarroa, LuZhe Sun
• 260 · PDF 由肺靶向脂质纳米颗粒递送的编码EpCAM-CD3双特异性抗体的mRNA可抑制原位肺肿瘤生长 EpCAM-CD3 bispecific antibody-encoding mRNA delivered by lung targeted lipid nanoparticles suppresses orthotopic lung tumor growth Dong Wang, Gang Liu, Yuhe Han, Maorong Fu, Tingting Li, Xiangnan Qiang, Shunchuan Zhang, Zhixiang Zhang, Letian Kuai
• 261 · PDF 一种用于治疗癌症和自身免疫病的mRNA编码三特异性CD19xBCMAxCD3 T细胞衔接器 A mRNA-encoded trispecific CD19xBCMAxCD3 T cell engager to treat cancer and autoimmunity Beibei Cao, Bingxu Zhang, Shuting Yao, Qiang Zhang, Shanshan Zhou, Lun Zhang, Lei Li, Chenxing Ni, Jianqi Zhang, Ya Zhou, Xiaoyun Ma, Xiaoju Zhang, Hongya Han, Wei Xu
• 262 · PDF 通过DNA-LNP递送平台利用癌症激活的基因表达和cGAS-STING激活实现高效肿瘤杀伤 Leveraging cancer-activated gene expression and cGAS-STING activation for efficient tumor killing via a DNA-LNP delivery platform Moataz Reda, Evan Bishop, Priyanka Balasubrahmanyam, Blaine McCarthy, Sushil Lathwal, Robby Chandra, Audrey Smith, Xiao Wu, Jesse Simons, Kim Tran, Ajda Rojc, Jayalakshmi Ramani, Suyog Shaha, Dang Dang, David Rosen, Badri Ananthanarayanan, Nadege Morisot, David Suhy
• 263 · PDF 迈向个性化癌症疫苗:LNP介导的多表位mRNA递送可延长侵袭性黑色素瘤模型的生存期 Towards personalized cancer vaccines: LNP-mediated delivery of multi-epitope mRNA extends survival in aggressive melanoma cancer model Jay Paquette, Gayatri Namala, Leanna Yee, Sams MA Sadat, Ruchi Sharma, Darius Menezes, Pierrot Harvie, Nikita Jain, Zhengyu Chen, Malathi Anantha, Tony Wu, Vicente Lacap, Richard Jiang, Vinay Mayya, Sijo Chemmannur, Avisek Deyati, Anitha Thomas
• 264 · PDF 一种通过过表达突变型雌激素受体治疗乳腺癌的新型基因治疗策略 A novel gene therapy approach for treating breast cancer through the overexpression of mutant estrogen receptor Seung-hwan Jeong, Seokbong Hong, Hyeong Dong Yuk, Cheol Kwak
• 265 · PDF 构建稳健的AAV载体：解决ITR不稳定性以实现有效的癌症基因治疗 Engineering robust AAV vectors: Addressing ITR instability for effective cancer gene therapy Crystal Richardson, Sofija Markovic, Cassandra Koole, Andrea O’Hara, Sumit Kumar
• 266 · PDF Redtail：一种用于全身肿瘤靶向和局部基因递送的双可编程病毒疗法平台 Redtail: A dual-programmable virotherapy platform for systemic tumor targeting and localized gene delivery Yunyi Kang, Duong H. Nguyen, Stephanie Songco, Trevor Smith, David Nguyen, Yan Pang, Lina Schulte, Hongli Zhang, Sinje Tigges, Fabian Kortum, Daniela Kleinholz, Susan Tamraz, Ivelina Minev, Evan Cassavaugh, Travis Clifton, Thomas Herrmann, Barbara Hartl, Antonio F. Santidrian
• 268 · PDF 构建一种新型上皮嗜性假病毒平台用于对癌的靶向基因治疗 Engineering a novel epithelial-tropic pseudovirus platform for targeted gene therapy to carcinomas Kendall Wesley Knechtel, Daniel Pelaez
• 269 · PDF 病毒样颗粒的功能化以改进体内免疫细胞工程 Functionalization of virus-like particles for improved in vivo immune cell engineering Frances Rocamora, Matthew S. Kim, Barbara S. Perez, Vivian Le, Trinidad Kellemen, Enaaya Mahmood, Dan Kaufman
• 270 · PDF pIR——一种用于非病毒DNA递送的新型无抗生素质粒生产平台 pIR-a new antibiotic free plasmid production platform for non-viral DNA delivery Dan Zhao, Yifei Wang, Junhao Wang, Zak D. Carden, Perry Ayn Mayson Maza, Dana Rae Cyril-Ramirez, Yong Li
• 271 · PDF 分泌IL-7的Salmonella与PD-L1阻断协同诱导持久的抗肿瘤免疫记忆 IL-7-secreting Salmonella synergizes with PD-L1 blockade to induce durable antitumor immune memory Minju Han
• 272 · PDF 通过鞭毛分泌系统分泌IFN-β的减毒Salmonella增强抗肿瘤免疫和治疗疗效 Attenuated Salmonella secreting IFN-beta via the flagellar secretion system enhances antitumor immunity and therapeutic efficacy Kim Eunji
• 273 · PDF 高亲合力可逆连接蛋白高效重定向静脉给药的慢病毒载体的进入过程，简化CAR-T细胞疗法的直接体内递送 High-avidity reversible engager proteins efficiently redirect the entry of intravenously delivered lentiviral vectors, simplifying the direct in vivo delivery of CAR-T cell therapy Gopal Naik Nenavath, Nandakumar Packiriswamy, Diana Gataulin, Md Sharif Hasan, Tatenda Kadungure, Harshitha Anantharama, Pragati Jain, Kyle Gromer, Karina Krotova, Miriam Eisenstein, Gideon Schreiber, Patrycja Lech, Luis Blancas Mejia, Colin Caine, Thipparat Suwanmanee, Luke Breigenzer, Darren Phung, Tim Carey, Hamid Salimi, Emma Buck, Christian Kinney, Luke Russell, Kah-Whye Peng, Stephen J Russell, Menachem Rubinstein
• 274 274 克服半复制型逆转录病毒载体中的重组：一种用于胶质母细胞瘤的新型双自杀基因疗法 Overcoming recombination in semi-replicating retroviral vectors: A novel double suicide gene therapy for glioblastoma Soojin Kim, Moonkyung Kang, Yeon-Soo Kim
• 275 · PDF 用于定量体内CAR-T递送系统的生物发光工具 Bioluminescent tools for quantification of in vivo CAR‑T delivery systems Julia K. Gilden, Pete Stecha, Rich Moravec, Jun Wang, Rod Flemming, Jim Harnett, Steven Edenson, Kristin Riching, Jamison Grailer, Mei Cong
• 276 · PDF 一种新型CD3导向的体内基因修饰CAR（GCAR）慢病毒载体（编码嵌合抗原受体及增强细胞适合度的共刺激蛋白）在人源化异种移植模型中的抗肿瘤活性及在非人灵长类动物中的B细胞发育不全 Anti-tumor activity in humanized xenograft models and B-cell aplasia in non-human primates with a novel CD3-directed in vivo gene-modifying CAR (GCAR) lentivector encoding chimeric antigen receptors and a cellular fitness-enhancing co-stimulatory protein Michael Betts, Matilda Mostrom, Ewa A. Jaruga-Killeen, Frederic Vigant, Anirban Kunda, Michelle Andraza, Cody Gowan, Iryna Oliinyk, Gregory Wade, Gregory Schreiber, Carter Bir, Jason P. Dufour, Robert V. Blair, Nicholas J. Maness, H. Michael Shepard, Gregory Ian Frost
• 277 · PDF IMV102，一种体内BCMA靶向CAR-T疗法，在多发性骨髓瘤模型中实现持久的肿瘤控制 IMV102, an in vivo BCMA-targeting CAR-T therapy, achieves durable tumor control in multiple myeloma models Yantao Li, Shuangshuang Zhang, Xiaojiang Fan, Zhenggang Jiang, Ruidong Hao, Minmin Sun
• 278 · PDF 体内腺嘌呤碱基编辑STK11 Q37*重编程肿瘤以产生放射增敏效应 In vivo adenine base editing of STK11 Q37* reprograms tumor for radiosensitizing effect Jiazhuo Yan, Yihan Xu, Qingxiao Fang, Jinpu Yu, Zhiyong Yuan
• 279 · PDF NRT-YHD_001（一种用于肝癌的巨噬细胞检查点抑制剂）IND申报支持研究的完成 Completion of IND-enabling studies for NRT-YHD_001, a macrophage checkpoint inhibitor in liver cancer Suk Woo Nam, In Seop Yoon, Sang Yean Kim, Minjeong Na, Jin Woong Ha, Soyoung Jeon, Hyunmin Lee, Seo Hyeon Mun, Chang Won Park

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