Gene and Vector-Based Therapy

• 258 · PDF Preclinical study of nucleic acid therapeutics targeting the Warburg effect Keita Matsumoto, Hirokatsu Hayashi, Seito Fujibayashi, Noriki Mitsui, Takeshi Horaguchi, Yuji Hatanaka, Ryoma Yokoi, Ayana Yokoyama, Chika Mizutani, Masashi Kuno, Masahiro Fukada, Ryuichi Asai, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Yoshihiro Tanaka, Nobuhisa Matsuhashi
• 259 · PDF Targeted STEAP2 knockdown with self-delivering antisense oligonucleotide reduces cancer malignant behavior Nagesh K. Panchal, Araceli Bernal, Brittany Michelle Barre, Francisco Cigarroa, LuZhe Sun
• 260 · PDF EpCAM-CD3 bispecific antibody-encoding mRNA delivered by lung targeted lipid nanoparticles suppresses orthotopic lung tumor growth Dong Wang, Gang Liu, Yuhe Han, Maorong Fu, Tingting Li, Xiangnan Qiang, Shunchuan Zhang, Zhixiang Zhang, Letian Kuai
• 261 · PDF A mRNA-encoded trispecific CD19xBCMAxCD3 T cell engager to treat cancer and autoimmunity Beibei Cao, Bingxu Zhang, Shuting Yao, Qiang Zhang, Shanshan Zhou, Lun Zhang, Lei Li, Chenxing Ni, Jianqi Zhang, Ya Zhou, Xiaoyun Ma, Xiaoju Zhang, Hongya Han, Wei Xu
• 262 · PDF Leveraging cancer-activated gene expression and cGAS-STING activation for efficient tumor killing via a DNA-LNP delivery platform Moataz Reda, Evan Bishop, Priyanka Balasubrahmanyam, Blaine McCarthy, Sushil Lathwal, Robby Chandra, Audrey Smith, Xiao Wu, Jesse Simons, Kim Tran, Ajda Rojc, Jayalakshmi Ramani, Suyog Shaha, Dang Dang, David Rosen, Badri Ananthanarayanan, Nadege Morisot, David Suhy
• 263 · PDF Towards personalized cancer vaccines: LNP-mediated delivery of multi-epitope mRNA extends survival in aggressive melanoma cancer model Jay Paquette, Gayatri Namala, Leanna Yee, Sams MA Sadat, Ruchi Sharma, Darius Menezes, Pierrot Harvie, Nikita Jain, Zhengyu Chen, Malathi Anantha, Tony Wu, Vicente Lacap, Richard Jiang, Vinay Mayya, Sijo Chemmannur, Avisek Deyati, Anitha Thomas
• 264 · PDF A novel gene therapy approach for treating breast cancer through the overexpression of mutant estrogen receptor Seung-hwan Jeong, Seokbong Hong, Hyeong Dong Yuk, Cheol Kwak
• 265 · PDF Engineering robust AAV vectors: Addressing ITR instability for effective cancer gene therapy Crystal Richardson, Sofija Markovic, Cassandra Koole, Andrea O’Hara, Sumit Kumar
• 266 · PDF Redtail: A dual-programmable virotherapy platform for systemic tumor targeting and localized gene delivery Yunyi Kang, Duong H. Nguyen, Stephanie Songco, Trevor Smith, David Nguyen, Yan Pang, Lina Schulte, Hongli Zhang, Sinje Tigges, Fabian Kortum, Daniela Kleinholz, Susan Tamraz, Ivelina Minev, Evan Cassavaugh, Travis Clifton, Thomas Herrmann, Barbara Hartl, Antonio F. Santidrian
• 268 · PDF Engineering a novel epithelial-tropic pseudovirus platform for targeted gene therapy to carcinomas Kendall Wesley Knechtel, Daniel Pelaez
• 269 · PDF Functionalization of virus-like particles for improved in vivo immune cell engineering Frances Rocamora, Matthew S. Kim, Barbara S. Perez, Vivian Le, Trinidad Kellemen, Enaaya Mahmood, Dan Kaufman
• 270 · PDF pIR-a new antibiotic free plasmid production platform for non-viral DNA delivery Dan Zhao, Yifei Wang, Junhao Wang, Zak D. Carden, Perry Ayn Mayson Maza, Dana Rae Cyril-Ramirez, Yong Li
• 271 · PDF IL-7-secreting Salmonella synergizes with PD-L1 blockade to induce durable antitumor immune memory Minju Han
• 272 · PDF Attenuated Salmonella secreting IFN-beta via the flagellar secretion system enhances antitumor immunity and therapeutic efficacy Kim Eunji
• 273 · PDF High-avidity reversible engager proteins efficiently redirect the entry of intravenously delivered lentiviral vectors, simplifying the direct in vivo delivery of CAR-T cell therapy Gopal Naik Nenavath, Nandakumar Packiriswamy, Diana Gataulin, Md Sharif Hasan, Tatenda Kadungure, Harshitha Anantharama, Pragati Jain, Kyle Gromer, Karina Krotova, Miriam Eisenstein, Gideon Schreiber, Patrycja Lech, Luis Blancas Mejia, Colin Caine, Thipparat Suwanmanee, Luke Breigenzer, Darren Phung, Tim Carey, Hamid Salimi, Emma Buck, Christian Kinney, Luke Russell, Kah-Whye Peng, Stephen J Russell, Menachem Rubinstein
• 274 274 Overcoming recombination in semi-replicating retroviral vectors: A novel double suicide gene therapy for glioblastoma Soojin Kim, Moonkyung Kang, Yeon-Soo Kim
• 275 · PDF Bioluminescent tools for quantification of in vivo CAR‑T delivery systems Julia K. Gilden, Pete Stecha, Rich Moravec, Jun Wang, Rod Flemming, Jim Harnett, Steven Edenson, Kristin Riching, Jamison Grailer, Mei Cong
• 276 · PDF Anti-tumor activity in humanized xenograft models and B-cell aplasia in non-human primates with a novel CD3-directed in vivo gene-modifying CAR (GCAR) lentivector encoding chimeric antigen receptors and a cellular fitness-enhancing co-stimulatory protein Michael Betts, Matilda Mostrom, Ewa A. Jaruga-Killeen, Frederic Vigant, Anirban Kunda, Michelle Andraza, Cody Gowan, Iryna Oliinyk, Gregory Wade, Gregory Schreiber, Carter Bir, Jason P. Dufour, Robert V. Blair, Nicholas J. Maness, H. Michael Shepard, Gregory Ian Frost
• 277 · PDF IMV102, an in vivo BCMA-targeting CAR-T therapy, achieves durable tumor control in multiple myeloma models Yantao Li, Shuangshuang Zhang, Xiaojiang Fan, Zhenggang Jiang, Ruidong Hao, Minmin Sun
• 278 · PDF In vivo adenine base editing of STK11 Q37* reprograms tumor for radiosensitizing effect Jiazhuo Yan, Yihan Xu, Qingxiao Fang, Jinpu Yu, Zhiyong Yuan
• 279 · PDF Completion of IND-enabling studies for NRT-YHD_001, a macrophage checkpoint inhibitor in liver cancer Suk Woo Nam, In Seop Yoon, Sang Yean Kim, Minjeong Na, Jin Woong Ha, Soyoung Jeon, Hyunmin Lee, Seo Hyeon Mun, Chang Won Park

在会议检索中浏览本分会场