Immunomodulatory Agents and Interventions

• 7773 · PDF 头颈部鳞状细胞癌进展后继续免疫检查点抑制剂治疗：一项多中心研究 Continuation of immune checkpoint inhibitor therapy after progression in head and neck squamous cell carcinoma: A multicenter study Hyun Ae Jung, Young Kim, Ross Merkin, Thomas Roberts, Manisha Patel, Boram Park, Jinyong Kim, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Lori J. Wirth, Jong Chul Park
• 7774 · PDF 用溶瘤病毒阻断细胞-ECM相互作用可抑制肿瘤STING激活并诱导抗肿瘤免疫 Blockade of cell-ECM interaction with an oncolytic virus suppresses tumoral STING activation while inducing antitumor immunity Upasana Sahu, Matthew Mullarkey, Kimberly Rivera Caraballo, Sergie Bombin, Adam Chadli, Ravindra Kolhe, James M. Markert, Bangxing Hong, Balveen Kaur
• 7775 · PDF TGFbetaR2xPD-1双特异性抗体INCA33890在MSS转移性结直肠癌（mCRC）患者中的药效学生物标志物 Pharmacodynamic biomarkers of TGFbetaR2xPD-1 bispecific antibody INCA33890 in patients with MSS metastatic colorectal cancer (mCRC) Michelle Kinder, Rui Hong, Chifei Sun, Yunlan Fang, Michael Smith, Cynthia Timmers, Chiara Greggio, Jordi Rodon Ahnert
• 7776 · PDF 一种含胞外多糖的酸奶可保留CCR6+CD4+T细胞：Th7R，并可能增强肺癌患者的免疫治疗应答 An exopolysaccharide-containing yogurt preserves CCR6 + CD4 + T Cells: Th7R, and may enhance immunotherapy responses in lung cancer patients Hiroshi Kagamu, Ayako Shiono, Hisao Imai, Atsuto Mouri, Ou Yamaguchi, Kosuke Hashimoto, Shota Takei, Hirotaka Kawanabe-Matsuda, Kyoichi Kaira
• 7777 · PDF 利用多功能纳米衔接器在人源化肾癌中直接体内激活并功能重编程人TILs Direct in vivo activation and functional reprogramming of human TILs using a multifunctional nanoengager in humanized renal carcinoma Man Wang, Lifu Ruan, Xin Wen, Tian Zhang, Andrew Z. Wang
• 7778 · PDF GS24-B047：一种整合共刺激信号、具有潜在同类最佳（best-in-class）性能的DLL3靶向T细胞衔接器，用于治疗小细胞肺癌 GS24-B047, a potential best-in-class DLL3-targeting T-cell engager with integrated costimulatory signal, for the treatment of small cell lung cancer Zeng Qi, Fu Li, Zhiyu Cui, Hongmei Xie, Sijia Liu, Dechen Cao, Liang Xu, Yihui Lin, Lishan Kang, Siqin Wang, Lei Jin, John L. Xu
• 7779 · PDF 一种可调节的白介素-18（IL-18）平台，经工程化设计以完全逃逸诱饵受体IL-18结合蛋白（IL-18BP） A tunable interleukin-18 (IL-18) platform engineered for complete escape from the decoy receptor IL-18 binding protein (IL-18BP) Haiming Huang, Wencong Peng, Ruohan Zhu, Quanxiao Li, Liwen Ji, Yao Lu, Dong Wei, Yanling Wu, Tianlei Ying
• 7781 · PDF 患者来源的肿瘤-免疫类器官捕捉功能与机制界面，用于预测结直肠癌患者对标准疗法和免疫疗法的应答 Patient derived tumor-immune organoids capture the functional and mechanistic interface in predicting response to standard therapeutics and immunotherapeutics in colorectal cancer patients Suman Dutta, Debarpan Mitra, Manoranjan Jha, Rimi Mukherjee, Juluri Srinivas, Kadambari Dixit, Krishanu Dey, Aswin Pandit, Sindu Pilli, Chandra C. Ghosh, Amjad Hussain, Gnaneswar Atturu, Ram Shankar Upadhayaya, Pradip K Majumder, Biswanath Majumder
• 7782 · PDF Cbl-b-Notch1轴阻断剂重塑免疫抑制性肿瘤，驱动细胞毒性与抗血管生成免疫应答 Cbl-b-Notch1 axis blockers rewire immunosuppressive tumors to drive cytotoxic and anti-angiogenic immune responses Zhi Huang, Mairah Khan, Laura Naldi, Brionna King, Luis Del Valle, Silvana Leit, Beth Browning, Christine Loh, Lucio Miele, Giulia Monticone
• 7783 · PDF 胶原结合型IL-12重塑免疫抑制性微环境并改善复发性胶质母细胞瘤的生存 Collagen-binding IL-12 remodels immunosuppresive microenvironment and improves survival in recurrent glioblastoma Opeyemi Iwaloye, Jun Takei, Lewis Barr, Ken Furudate, Koichi Sasaki, Haruka Ichie, Shunsuke Tsuzuki, Jun Ishihara, Satoru Osuka
• 7784 · PDF 靶向PRMT7通过促进MHC-I表达激发抗AML免疫 Targeting PRMT7 elicits anti-AML immunity by promoting MHC-I expression Shuaishuai Ge, Kaixiu Luo, Lei Zhang, Meng Liu, Xin He, Guohua Wu, Yang Li, Yadav P. Umesh, Haojie Dong, Shengli Xue, Jian Jin, Ling Li
• 7785 · PDF 空间分析揭示HPV相关HNSCC中肿瘤及淋巴结微环境的表观遗传和免疫治疗驱动的重塑 Spatial profiling reveals epigenetic and immunotherapy-driven remodeling of the tumor and lymph node microenvironment in HPV-associated HNSCC Takeshi Ito, Alexander Ladenheim, Hans Zhao, Ernest Hidalgo Cedeno, Benjamin Judson, Saral Mehra, Ansley Roche, Zafar Sayed, Avanti Verma, Natalia Isaeva, Wendell Yarbrough, Aarti Bhatia, Barbara Burtness, Michael Chiorazzi
• 7786 7786 用于新型癌症免疫疗法的靶向、条件性激活的干扰素、白介素和CD8 T细胞衔接器 Targeted, conditionally active interferons, interleukins and CD8 T cell engagers for novel cancer immunotherapies Lennart Zabeau, Anje Cauwels, Leander Huyghe, Silvie Taveirne, Joris Wauman, Alexander Van Parys, Jared E. Lopes, Erik Depla, Niko Kley
• 7787 · PDF 表型定制的预防性免疫调节使高危患者在发生严重irAEs后能够安全地再次使用免疫检查点抑制剂 Phenotype-tailored prophylactic immunomodulation enables safe immune checkpoint inhibitor rechallenge after severe irAEs in high-risk patients Lucrezia Mencarelli, Pierre Van Mol, Douglas Daoudlarian, Sofiya Latifyan, Nuria Alfonso Mederos, Hasna Bouchaab, Matteo Torsello, Antonia Stamatiou, Nicolas Etienne, Karim Abdelhamid, Nabila Ferahta, Athina Stravodimou, Keyvan Shabafrouz, Solange Peters, Michel Obeid
• 7788 · PDF Daiad-2/15：一种条件性激活、靶向、超强效的IL-2/IL-15免疫激动剂在体内安全且有效 Daiad-2/15: A conditionally active, targeted, hyperpotent IL-2/IL-15 immune agonist is safe and effective in vivo Anu Jayabalu, Mark E. Branum, Jonathan G. Drachman, Alexander Astrakhan
• 7790 · PDF 多肽递送的低剂量IL-2重编程胰腺癌免疫以改善生存 Peptide-delivered low dose IL-2 reprograms pancreatic cancer immunity to improve survival In Hwan Park, Shawn Abeynaike, Ashley Martinez, Jonathan Cho, Daisuke Nishizaki, Gregory P. Botta
• 7791 · PDF 抑制PAI-1可减轻硬皮病样慢性移植物抗宿主病小鼠模型的炎症反应 PAI-1 inhibition attenuates the inflammatory response in a murine model of sclerodermatous chronic graft-versus-host disease Sahra Gabure, Yogamaya Divakar Prabhu, Vasantharaja Raguraman, Shanid Mohiyuddin, Yan Ji, William Fay, Senthilnathan Palaniyandi, Gerhard Hildebrandt
• 7792 7792 PIK3CA激活突变重塑肿瘤微环境以促进鳞状细胞癌的免疫逃逸 PIK3CA activating mutation reshapes the tumor microenvironment to promote immune evasion in squamous cell carcinoma Sydney Fisher, Benjamin Nicholson, Weijie Guo, Yuxuan Phoenix Miao
• 7793 · PDF 通过生物电磁重编程肿瘤-免疫代谢以选择性摧毁NSCLC Bioelectromagnetic reprogramming of tumor-immune metabolism to selectively destroy NSCLC Sunny Huang, Jennifer Petssche, Danielle Foster, Charles Searby, Val Sheffield, Douglas R. Spitz, Calvin Carter
• 7794 7794 当应激扩散：可传播的ER应激作为PDAC免疫重塑的驱动因素 When stress spreads: Transmissible ER stress as a driver of immune remodeling in PDAC Naveen Chintala Ramulu, Shreya Pokharel, Nishanthini Pirashanna, Basel Abuaita, Joseph Francis

在会议检索中浏览本分会场