Tumor Microenvironment Modulators

• 7926 · PDF 新型口服高选择性PTPN2/1抑制剂（ZE00-0388）的疗效、体内安全性及PK/PD研究 Efficacy, in vivo safety, and PK/PD studies for novel, oral, highly selective PTPN2/1 inhibitor (ZE00-0388) Alexei Pushechnikov, Ruben Karapetian, Stepan Mochalov, Sanja Baumann Tomovska, Nikolay Savchuk, Iain Dukes, Ruben Abagyan
• 7927 · PDF 受SPRED2调控的外泌体通过激活IL6/STAT3信号重塑肿瘤微环境 Exosomes, regulated by SPRED2, reshape tumor microenvironment via activating IL6/ STAT3 signaling Tong Gao, Akihiro Matsukawa
• 7928 · PDF 快速进展的青年发病舌癌的免疫微环境模式：一项病例系列分析 Immune microenvironmental patterns in rapidly progressive young-onset tongue cancer: A case series analysis Alisa Kimura, Takahiro Tsujikawa, Shota Sugaya, Yuna van der Aar, Koichi Yoshizawa, Sumiyo Saburi, Shigeyuki Mukudai, Hikaru Nagao, Aki Tamura, Nana Sakurai, Aya Miyagawa-Hayashino, Hiroshi Ogi, Saya Shibata, Eiichi Konishi, Kyoko Itoh, Shigeru Hirano
• 7929 · PDF DDR2-CAR巨噬细胞重编程肿瘤微环境并使血管正常化以增强抗肿瘤免疫 DDR2-CAR macrophages reprogram the tumor microenvironment and normalize vasculature to potentiate antitumor immunity Dandan WANG
• 7930 · PDF 内脏脂肪与年龄的交互作用对人类乳腺肿瘤微环境的塑造 Interaction of visceral adiposity and age in shaping the human breast tumor microenvironment Anlan Cao, Sophia Fuller, Jorge Gómez Tejeda Zañudo, Wendy Y. Chen, Deborah A. Dillon, Sandra S. McAllister, Rinath M. Jeselsohn, Bette J. Caan, Adrienne L. Castillo, Elizabeth M. C. Feliciano
• 7931 · PDF 肛门直肠黏膜黑色素瘤中独特的微生物群组成与免疫检查点抑制耐药相关 Distinct microbiota composition in anorectal mucosal melanoma is associated with resistance to immune checkpoint inhibition Pritika Parmar, Morgan MacBeth, Mallory Karr, Nichole Nusbacher, Stacey M. Bagby, Phaedra Whitty, Kylie Michel, Richard P. Tobin, Martin McCarter, Theresa Medina, Catherine Lozupone, William A. Robinson, Kasey Couts
• 7932 · PDF FL115：一种为最大限度降低癌症免疫治疗安全风险而理性设计的新型IL-15超级激动剂 FL115, a novel IL-15 superagonist rationally designed to minimize safety risks for cancer immunotherapy Quanxiao Li, Yaping Cheng, Dong Wei, Qiang Gao, Yanling Wu, Tianlei Ying
• 7933 · PDF 细胞外囊泡介导的皮质醇诱导miR-143-3p从巨噬细胞转移促进血管生成 Extracellular vesicle-mediated transfer of cortisol-induced miR-143-3p from macrophages promotes angiogenesis Amod Sharma, Sarabjeet Kour Sudan, Ajay P. Singh, Seema Singh
• 7934 · PDF IL-24工程化间充质干细胞作为重塑非小细胞肺癌肿瘤微环境的新型治疗策略 IL-24 engineered mesenchymal stem cells as a novel therapeutic strategy to remodel the tumor microenvironment in non-small cell lung cancer Yuting Zhang, Yuxuan Zhang, Sai Fung Yeung, Chi-Hang Wong, Tsz Tung Kwong, Connie Wun Chun Hui, Stephen Kwok-Wing Tsui, Tony S. Mok, Desheng Liang, Molly Siu Ching Li
• 7935 · PDF 多模式免疫治疗重塑肝细胞癌的肿瘤微环境：一项II期试验的整合空间与转录组学分析 Multimodal immunotherapy remodels the tumor microenvironment in hepatocellular carcinoma: Integrative spatial and transcriptomic profiling from a Phase II trial Lionel Aurelien Kankeu Fonkoua, Christopher L. Hallemeier, Basim Salem, Arina Tkachuk, Kaitlynn McCay, Panwen Wang, Ying Li, Thomas D. Atwell, Krishan R. Jethwa, Caitlin Conboy, Nguyen H. Tran, Leslie A. Washburn, Melody Wu, Chen Wu, Andre De Menezes Silva Corraes, Rondell P. Graham, Jose Caetano Villasboas, Kevin Regan, Zuoyi Shao, Rayaan Kamal, Nathan R. Foster, Haidong Dong, Sean Park, Yi Lin, Lewis R. Roberts
• 7936 · PDF 表观遗传重编程基质-上皮串扰以改善胰腺导管腺癌的免疫治疗反应 Epigenetic reprogramming of stromal-epithelial crosstalk to improve immunotherapy response in pancreatic ductal adenocarcinoma Celia Martín-Otal, Daire Hanna, Kairbaan Hodivala-Dilke, Angus J. M. Cameron, Oliver Pearce, David Propper
• 7937 · PDF 推进同类最佳的交叉特异性LILRB1/LILRB2抗体IOMX-0675进入实体瘤临床开发 Advancing the best-in-class cross-specific LILRB1/LILRB2 antibody IOMX-0675 into clinical development for solid tumors Ana Ogrinc Wagner, Kristina Heinig, Christina Hartl, Marisa Stebegg-Wagner, Michail Maraslis, Carmen Ginzel, Thomas Jaquin, Bettina Langer, Alina Huth, Tiantom Jarutat, Alexander N. Marziale, Stefan Bissinger
• 7938 · PDF 胰腺癌中一种新型lncRNA的鉴定：通过Wnt通路调控促进恶性进展 Identification of a novel lncRNA in pancreatic cancer: Contribution to malignancy through Wnt pathway regulation Isshin Narumoto, Keiko Shinjo, Yutaka Kondo, Shu Hirako
• 7939 · PDF 应激诱导的失巢凋亡抵抗触发子宫平滑肌瘤细胞的类恶性表型 Stress-induced anoikis-resistance triggers malignant-like phenotypes in uterine leiomyoma cells Roseli da Silva Soares, Edmund C. Baracat, Katia C. Carvalho
• 7940 · PDF TNX-1700在非人灵长类动物及人FcRn/血清白蛋白转基因小鼠中的药代动力学 Pharmacokinetics of TNX-1700 in non-human primates and human FcRn/serum albumin transgenic mice Mayanka Awasthi, Jennifer Cho, Nelson Martinez, Bernd Meibohm, Seth Lederman, Christopher Cooper, Sina Bavari, Bruce L. Daugherty
• 7941 · PDF Sphk1-B细胞轴作为癌症中可靶向的免疫调节通路 The Sphk1-B cell axis as a targetable immunoregulatory pathway in cancer Mona Singh, Prachi Gupta, Arezou Rahimi, Sunila Pradeep
• 7942 · PDF TAE226将免疫冷的头颈部肿瘤重编程为免疫热，增强免疫治疗疗效 TAE226 reprograms immune-cold head and neck tumors to immune-hot, augmenting immunotherapy efficacy Atish Ranjan Mohanty, Dana Do, Sharad S. Singhal, Haiqing Li, Sravani Ramisetty, Raju Pillai, Sultatna Shoukath, Prakash Kulkarni, Ellie G. Maghami, Ravi Salgia, Erminia Massarelli
• 7943 · PDF TP53突变重塑子宫内膜癌的免疫微环境 TP53 mutation reshapes the immune microenvironment in endometrial cancer Konrad Snioch, Mahima Rasquinha, Dmitriy Zamarin
• 7944 · PDF 从诊断到RCHOP复发的纵向弥漫性大B细胞淋巴瘤（DLBCL）病例中肿瘤免疫微环境（TME）的动态变化 Tumor immune micro-environment (TME) dynamics in longitudinal diffuse large B-cell lymphoma (DLBCL) cases from diagnosis to RCHOP relapse Raoul Santiago, Raquel Aloyz, Stéphanie Bianco, Svetlana Dmitrienko, Nathalie Johnson, Andreas I. Papadakis, Naciba Benlimame, Cynthia Guilbert, Alan Spatz, François E. Mercier, Madelyne Abraham, Laura Hilton, David W. Scott, Koren K. Mann, Sarit Assouline
• 7945 · PDF 全基因组倍增诱导染色体不稳定性，塑造肿瘤-免疫微环境并损害非小细胞肺癌对免疫检查点抑制剂的反应 Whole-genome doubling induces chromosomal instability to shape the tumor-immune microenvironment and impair the response to immune checkpoint inhibitors in non-small cell lung cancer Cheolyong Joe, Jinyong Kim, Hyemin Kim, Junsu Choe, Miran Jang, Eunjoo Oh, Naeun Lee, Subin Kim, Sehhoon Park, Hyun Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Joo Kyung Park, Se-Hoon Lee
• 7946 · PDF 一种高选择性ITK抑制剂的发现：其在体外和体内均能促进Th1分化并缓解T细胞耗竭 Identification of a highly selective ITK inhibitor which promotes Th1 differentiation and alleviates T cell exhaustion in vitro and in vivo Lei Jiang, Zhiyong Yu, Xin Cheng, Baoying Cheng, Yuyao Zhang, Wenwen Zhao, Youxi Chen, Feng Zhou
• 7947 · PDF miR-150在乳腺癌中协调免疫激活和淋巴细胞迁移 miR-150 orchestrates immune activation and lymphocyte trafficking in breast cancer Masanori Oshi, Rongrong Wu, Colin J. Rog, Li Yan, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
• 7948 · PDF 靶向UFMylation通路以促进乳腺癌的免疫治疗应答 Targeting the UFMylation pathway to promote immunotherapy response of breast cancers Ciara J. Miller, Jackson P. Riffee, Danielle R. Cook, Timothy D. Martin
• 7949 · PDF 药理学性抑制wtIDH1可重塑PDAC免疫格局并改善检查点阻断疗效 Pharmacologic wtIDH1 inhibition remodels the PDAC immune landscape and improves checkpoint blockade efficacy Priyashree Sunita, Shakti Pattanayak, Mehdad Zarei, Omid Hajihassani, Goutam dey, Hallie Graor, Sami Abul-Khoudoud, Faith Nakazzi, Jordan M Winter
• 7950 · PDF 靶向OSM-OSMR信号轴以重编程肿瘤微环境并克服胰腺癌中的免疫抑制 Targeting the OSM-OSMR signaling axis to reprogram the tumor microenvironment and overcome immune suppression in pancreatic cancer Yuan Sui, Tony Hunter
• 7951 · PDF 卵巢肿瘤FAK抑制释放omega-3脂肪酸，刺激GATA6腹膜巨噬细胞产生CXCL13，增强TIGIT免疫治疗 Ovarian tumor FAK inhibition releases omega-3 fatty acids stimulating GATA6 peritoneal macrophage CXCL13 production augmenting TIGIT immunotherapy Xiao Lei Chen, Kevin M. Tharp, Marjaana Ojalill, Duygu Ozmadenci, Antonia Boyer, Terrance J. Hannen, Christine Lawson, Hyojae J. Lee, Marvin Xia, Elise Tahon, Yichi Zhang, Cray Minor, Safir U. Khan, Colin C. Anderson, Travis Nemkov, Michael Rose, Monica V. Estrada, Alfredo A. Molinolo, Elias Warren, Patrick Penalosa, Ramez N. Eskander, Michael T. McHale, Shizhen E. Wang, Denise C. Connolly, Kathleen M. Fisch, Dwayne G. Stupack, David D. Schlaepfer
• 7952 · PDF 整合组织和分泌组分析鉴定出腹膜癌病中一种IL-6/IL-8主导的免疫表型 Integrated tissue and secretome profiling identifies an IL-6/IL-8-dominant immune phenotype in peritoneal carcinomatosis Christopher Sherry, Neda Dadgar, Zuqiang Liu, Yong Fan, Hyun Young Park, Ali Zaidi, Paige Mirsky, Oleksii Kucherenko, Albert Donnenberg, David L. Bartlett, Vera S. Donnenberg, Patrick Wagner
• 7953 · PDF 工程化分泌IL7/IL15的iPSC来源间充质基质细胞将免疫抑制性肿瘤微环境（TME）转变为免疫激活性TME并增强抗肿瘤免疫 Engineered IL7/IL15 secreting iPSC-derived mesenchymal stromal cells convert the immunosuppressive into immune-activated tumor microenvironments (TME) and potentiate antitumor immunity Michael Andreeff, Sandeep Singh, Andrea Bedoy, Muharrem Muftuoglu, Li Li, Vivek Anand, Dipmoy Nath, Lauren Ostermann, Ivo Vletic, Christopher D. Pacheco, Mahesh Basyal, Taeyun Kim, Kyle M. Garland, Matthew Angel, Sanjeev Luther, Robert Pierce, Christopher B. Rohde

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