Immunotherapies in Pediatric Cancers

• 7798 · PDF CURE AI对胚胎性和腺泡状横纹肌肉瘤免疫治疗获益的预测 Embryonal and alveolar rhabdomyosarcoma immunotherapy treatment benefit prediction by CURE AI Amit Weiss, Ofir Landau, Tzvi Lederer, Gregory Koushnir, Radesh P. Nattamai Malli, Tal Shor, Daniel Khankin, Vitalay Fomin, Neil Pfister
• 7801 · PDF DLL3靶向CAR-T细胞在神经母细胞瘤中的临床前疗效 Preclinical efficacy of DLL3 targeted CAR T cells in neuroblastoma Salvatore M. Aspromonte, Tamar Feinberg, Ali Cihan, Samantha Brosius, Armaan H. Siddiquee, Dylan Domenico, Daoqi You, Shakeel Modak, Kevin J. Curran, Andrew L. Kung, Anthony Daniyan, Filemon Dela Cruz
• 7802 · PDF cGAS-STING通路激动剂联合免疫检查点抑制剂增强化疗在小鼠骨肉瘤模型中的疗效 cGAS-STING pathway agonist plus immune checkpoint inhibitor augments chemotherapy effectiveness in murine osteosarcoma models Mayra L. Mendiola, Michele Doucet, Erin E. Resch, Brian H. Ladle
• 7805 · PDF 针对神经母细胞瘤（NB）和尤因肉瘤（EWS）的GFRA2靶向抗体药物偶联物的开发 Development of a GFRA2-targeting antibody drug conjugate for neuroblastoma (NB), and Ewing sarcoma (EWS) Amber K. Hamilton, Seungmin Shin, Raphael D. Lopez, Nicholas Hartnett, Alexander B. Radaoui, Maggie Hines, Maria Evancho, Rebecca S. Kaufman, Khushbu Patel, Karina L. Conkrite, Dan Martinez, Brian Mooney, Michelle E. Keyel, Elissa Levine, Alberto D. Guerra, Jarrett Lindsay, Yael P. Mosse, Jennifer Pogoriler, Gregg Morin, Poul H. Sorensen, Patrick J. Grohar, Benjamin A. Garcia, C. Patrick Reynolds, Wei Li, Sharon J. Diskin, John M. Maris
• 7806 · PDF CAR预激降低TCR激活阈值以增强对低亲和力肿瘤抗原的识别 CAR priming lowers TCR activation threshold to enhance recognition of low affinity tumor antigens Chu-Hsuan Chiu, Leo D. Wang
• 7808 · PDF AZD0754（一种显性负性TGFβRII装甲型STEAP2 CAR-T细胞疗法）在尤因肉瘤异种移植模型中的疗效 Efficacy of AZD0754, a dominant-negative TGFbetaRII-armored STEAP2 CAR T-cell therapy, in Ewing sarcoma xenograft models Peter Zanvit, Brianna Janocha, Shannon Breen, Christine Fazenbaker, Jessica Pezold, Lihe Zhang, David Clark, Nicolas Giraldo, Ryan Golden, Jonathan Fitzgerald, Mark Cobbold, Gordon Moody, Emily Bosco
• 7809 · PDF 表位编码mRNA-LNP疫苗增强PHOX2B肽中心型CAR-T细胞的抗肿瘤效力和持久性 Epitope-encoded mRNA-LNP vaccine to enhance anti-tumor potency and persistence of PHOX2B peptide-centric CAR T cells Timothy T. Spear, Nicholas Hartnett, Elisabeth Posthill, David Groff, Dana Al-Halawani, Minu Samanta, Keelan O'Reilly, Richa Kapoor, Muzamil Want, Lingling Liu, Tingting Wang, Ruoning Wang, Richard Madnick, Irina Shkundina, Kristopher R. Bosse, Mohamad-Gabriel Alameh, Drew Weissman, John M. Maris
• 7810 · PDF 改造巨噬细胞作为高危神经母细胞瘤的新型治疗方法 Engineering macrophages as a novel therapeutic approach for high-risk neuroblastoma Ke-En Tan, Kok Siong Yeo, Cheng Zhang, Caleb Baker, Shyang Hong Tan, Alexis M. Sosic, Yat-Yuen Lim, Choong-Yong Ung, Cristina Correia, Stephanie F. Polites, Yi Lin, William A. Weiss, Hu Li, Shizhen Zhu
• 7811 · PDF 利用gammadelta T细胞作为一种高效的过继细胞治疗平台用于儿童肉瘤模型 Using gammadelta T cells as a potent adoptive cell therapy platform in models of pediatric sarcoma Jessica P. Sanchez, Anne-Katrin Urzynicok, Gabriella Albert, Eduardo Davila, Brian H. Ladle
• 7812 · PDF dnTGFbetaR装甲型GPC3 CAR-T（AZD5851）在儿童实体瘤PDX模型中的临床前评估——来自儿童临床前体内测试（PIVOT）联盟的报告 Preclinical evaluation of a dnTGFbetaR-armored GPC3 CAR-T (AZD5851) in pediatric solid tumor PDX models - A report from the Pediatric Preclinical In Vivo Testing (PIVOT) Consortium Filemon S. Dela Cruz, Glorife Ibanez Sanchez, Samantha Brosius, Kristen Victor, Daoqi You, Armaan H. Siddiquee, Kristina C. Guillan, Michael V. Ortiz, Jee Young Kwon, Emily L. Jocoy, Timothy M. Stearns, Steven B. Neuhauser, Jeffrey H. Chuang, Letizia Giardino, Eric Tu, Carol J. Bult, Beverly A. Teicher, Andrew L. Kung, Malcolm A. Smith
• 7813 · PDF 一种B7-H3抗体药物偶联物在骨肉瘤患者来源模型和转移模型中的抗肿瘤活性 Antitumor activity of a B7-H3 antibody-drug conjugate in osteosarcoma patient-derived and metastatic models Wendong Zhang, Adil Bahadir, Zhongting Zhang, Yianhua Yi, Zhaohui Xu, Simon Olivares, Harjeet Singh, AMER NAJJAR, Caterina Longo, Xin Zhou, Jasbir Kaur, Hiroki Torikai, Chunhua Shi, Jonathan Gill, Michael Roth, Tim Heffernan, Richard Gorlick
• 7814 · PDF 神经节苷脂靶向：对神经母细胞瘤的甜蜜复仇 Ganglioside targeting: Exerting sweet revenge on neuroblastoma Guillermo Nicolas Dalton, Wonju Kim, Kevin H. Lu, Alessandro Gasparetto, haley Ohlson, Nathaniel W. Mabe, Min Huang, Maria Caterina Rotiroti, Rebekah Kennedy, Susan Ghazarian, Araz Marachelian, SHAHAB ASGHARZADEH, Kimberly Stegmaier, Roberto Chiarle, Robbie G. Majzner
• 7815 · PDF ABBV-706（一种SEZ6靶向的拓扑异构酶1抑制剂ADC）的疗效：来自儿童临床前体内测试（PIVOT）项目的报告 Efficacy of ABBV-706, a SEZ6-targeted topoisomerase 1 inhibitor ADC: A report from the Pediatric Preclinical In Vivo Testing (PIVOT) Program Elizabeth A. Stewart, Michael A. Dyer, Yael P. Mosse, John M. Maris, Xiao-Nan Li, Stefan Atkinson, Chen He, David N. Groff, Alvin Farrel, Yuchen Du, Jinnan Chen, Steven B. Neuhauser, Timothy M. Stearns, Emily L. Jocoy, Jee Young Kwon, Jeffrey H. Chuang, Emily Faivre, Kelly Doyle, Kimberly E. Ellison, Joshua F. Hernandez, Joann P. Palma, Michael Barnes, Pooja Hingorani, Nandini Rudra-Ganguly, Beverly A. Teicher, Carol J. Bult, Malcolm A. Smith
• 7816 · PDF 空间分析确定肿瘤相关基质富集和MIF为原发性尤因肉瘤中潜在的免疫治疗靶点 Spatial profiling identifies tumor-associated stroma enrichment and MIF as potential immunotherapy targets in primary Ewing sarcomas Christopher Kuo, Krinio Giannikou, Nuoya Wang, Mikako Warren, Andrew E. Goodspeed, Nick Shillingford, Mas Hayashi, Micha S. Raredon, James Amatruda

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