Immunotherapies in Pediatric Cancers

• 7798 · PDF Embryonal and alveolar rhabdomyosarcoma immunotherapy treatment benefit prediction by CURE AI Amit Weiss, Ofir Landau, Tzvi Lederer, Gregory Koushnir, Radesh P. Nattamai Malli, Tal Shor, Daniel Khankin, Vitalay Fomin, Neil Pfister
• 7801 · PDF Preclinical efficacy of DLL3 targeted CAR T cells in neuroblastoma Salvatore M. Aspromonte, Tamar Feinberg, Ali Cihan, Samantha Brosius, Armaan H. Siddiquee, Dylan Domenico, Daoqi You, Shakeel Modak, Kevin J. Curran, Andrew L. Kung, Anthony Daniyan, Filemon Dela Cruz
• 7802 · PDF cGAS-STING pathway agonist plus immune checkpoint inhibitor augments chemotherapy effectiveness in murine osteosarcoma models Mayra L. Mendiola, Michele Doucet, Erin E. Resch, Brian H. Ladle
• 7805 · PDF Development of a GFRA2-targeting antibody drug conjugate for neuroblastoma (NB), and Ewing sarcoma (EWS) Amber K. Hamilton, Seungmin Shin, Raphael D. Lopez, Nicholas Hartnett, Alexander B. Radaoui, Maggie Hines, Maria Evancho, Rebecca S. Kaufman, Khushbu Patel, Karina L. Conkrite, Dan Martinez, Brian Mooney, Michelle E. Keyel, Elissa Levine, Alberto D. Guerra, Jarrett Lindsay, Yael P. Mosse, Jennifer Pogoriler, Gregg Morin, Poul H. Sorensen, Patrick J. Grohar, Benjamin A. Garcia, C. Patrick Reynolds, Wei Li, Sharon J. Diskin, John M. Maris
• 7806 · PDF CAR priming lowers TCR activation threshold to enhance recognition of low affinity tumor antigens Chu-Hsuan Chiu, Leo D. Wang
• 7808 · PDF Efficacy of AZD0754, a dominant-negative TGFbetaRII-armored STEAP2 CAR T-cell therapy, in Ewing sarcoma xenograft models Peter Zanvit, Brianna Janocha, Shannon Breen, Christine Fazenbaker, Jessica Pezold, Lihe Zhang, David Clark, Nicolas Giraldo, Ryan Golden, Jonathan Fitzgerald, Mark Cobbold, Gordon Moody, Emily Bosco
• 7809 · PDF Epitope-encoded mRNA-LNP vaccine to enhance anti-tumor potency and persistence of PHOX2B peptide-centric CAR T cells Timothy T. Spear, Nicholas Hartnett, Elisabeth Posthill, David Groff, Dana Al-Halawani, Minu Samanta, Keelan O'Reilly, Richa Kapoor, Muzamil Want, Lingling Liu, Tingting Wang, Ruoning Wang, Richard Madnick, Irina Shkundina, Kristopher R. Bosse, Mohamad-Gabriel Alameh, Drew Weissman, John M. Maris
• 7810 · PDF Engineering macrophages as a novel therapeutic approach for high-risk neuroblastoma Ke-En Tan, Kok Siong Yeo, Cheng Zhang, Caleb Baker, Shyang Hong Tan, Alexis M. Sosic, Yat-Yuen Lim, Choong-Yong Ung, Cristina Correia, Stephanie F. Polites, Yi Lin, William A. Weiss, Hu Li, Shizhen Zhu
• 7811 · PDF Using gammadelta T cells as a potent adoptive cell therapy platform in models of pediatric sarcoma Jessica P. Sanchez, Anne-Katrin Urzynicok, Gabriella Albert, Eduardo Davila, Brian H. Ladle
• 7812 · PDF Preclinical evaluation of a dnTGFbetaR-armored GPC3 CAR-T (AZD5851) in pediatric solid tumor PDX models - A report from the Pediatric Preclinical In Vivo Testing (PIVOT) Consortium Filemon S. Dela Cruz, Glorife Ibanez Sanchez, Samantha Brosius, Kristen Victor, Daoqi You, Armaan H. Siddiquee, Kristina C. Guillan, Michael V. Ortiz, Jee Young Kwon, Emily L. Jocoy, Timothy M. Stearns, Steven B. Neuhauser, Jeffrey H. Chuang, Letizia Giardino, Eric Tu, Carol J. Bult, Beverly A. Teicher, Andrew L. Kung, Malcolm A. Smith
• 7813 · PDF Antitumor activity of a B7-H3 antibody-drug conjugate in osteosarcoma patient-derived and metastatic models Wendong Zhang, Adil Bahadir, Zhongting Zhang, Yianhua Yi, Zhaohui Xu, Simon Olivares, Harjeet Singh, AMER NAJJAR, Caterina Longo, Xin Zhou, Jasbir Kaur, Hiroki Torikai, Chunhua Shi, Jonathan Gill, Michael Roth, Tim Heffernan, Richard Gorlick
• 7814 · PDF Ganglioside targeting: Exerting sweet revenge on neuroblastoma Guillermo Nicolas Dalton, Wonju Kim, Kevin H. Lu, Alessandro Gasparetto, haley Ohlson, Nathaniel W. Mabe, Min Huang, Maria Caterina Rotiroti, Rebekah Kennedy, Susan Ghazarian, Araz Marachelian, SHAHAB ASGHARZADEH, Kimberly Stegmaier, Roberto Chiarle, Robbie G. Majzner
• 7815 · PDF Efficacy of ABBV-706, a SEZ6-targeted topoisomerase 1 inhibitor ADC: A report from the Pediatric Preclinical In Vivo Testing (PIVOT) Program Elizabeth A. Stewart, Michael A. Dyer, Yael P. Mosse, John M. Maris, Xiao-Nan Li, Stefan Atkinson, Chen He, David N. Groff, Alvin Farrel, Yuchen Du, Jinnan Chen, Steven B. Neuhauser, Timothy M. Stearns, Emily L. Jocoy, Jee Young Kwon, Jeffrey H. Chuang, Emily Faivre, Kelly Doyle, Kimberly E. Ellison, Joshua F. Hernandez, Joann P. Palma, Michael Barnes, Pooja Hingorani, Nandini Rudra-Ganguly, Beverly A. Teicher, Carol J. Bult, Malcolm A. Smith
• 7816 · PDF Spatial profiling identifies tumor-associated stroma enrichment and MIF as potential immunotherapy targets in primary Ewing sarcomas Christopher Kuo, Krinio Giannikou, Nuoya Wang, Mikako Warren, Andrew E. Goodspeed, Nick Shillingford, Mas Hayashi, Micha S. Raredon, James Amatruda

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