PO.ET01.05 · 实验与分子治疗
Overcoming Microenvironmental and Delivery Barriers in Cancer Therapy
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- 7144 7144 一种克服抗体类治疗药物结合位点屏障的通用方法 A general method to overcome the binding site barrier in antibody-based therapeutics Yuanzheng Li, Shili Yao, Peng Guo
- 7145 7145 一种空间PK/PD框架通过整合药物递送、靶点结合和微环境就绪状态来预测实体瘤中的ADC反应 A spatial PK/PD framework predicts ADC response in solid tumors by integrating drug delivery, target engagement, and microenvironmental readiness Corinne Ramos, Martha Baydoun, Sandra Delebecq, Amandine Gerstenberg
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- 7148 7148 应激适应决定肉瘤对CDK4/6抑制剂的治疗反应 Stress adaptation defines therapeutic response to CDK4/6 inhibitors in sarcoma Jinfen Xiao, Emily Ko, Ashley Smith, Roberta Piras, Annaliese Fowler, Kristin Ishaya, Jlenia Guarnerio
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- 7151 7151 通过 ICA-1S 和 ζ-Stat 靶向抑制非典型 PKC 亚型 PKC-ι 和 PKC-ζ 可抑制前列腺癌中的致癌信号传导和细胞因子介导的骨转移 Targeted inhibition of atypical PKC isoforms PKC-ι and PKC-ζ by ICA-1S and ζ-Stat suppresses oncogenic signaling and cytokine-mediated bone metastasis in prostate cancer Grazielly Teodoro, Wishrawana Sarathi Ratnayake, Luke Lajmi, Sloan Breedy, Aaron Todman, Shreejana Rimal, Mildred Acevedo-Duncan
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- 7153 7153 选择性非典型蛋白激酶 C 抑制剂降低恶性子宫内膜癌细胞的增殖并促进其凋亡 Selective atypical protein kinase C inhibitor reduces proliferation and promotes apoptosis in malignant endometrial cancer cells Gaurab Raj Khanal, Shreejana Rimal, Grazielly Teodoro, Mildred Acevedo-Duncan
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- 7155 7155 选择性蛋白激酶 C-iota 抑制剂在抑制 PI3K/AKT 驱动的胰腺导管腺癌增殖中的治疗潜力 Therapeutic potential of a selective protein kinase Ciota inhibitor, in suppressing PI3K/AKT driven pancreatic ductal adenocarcinoma proliferation Shreejana Rimal, Grazielly Teodoro, Gaurab Raj Khanal, Abigail Oluwafisayo Olatunji, Abiral Hasib Shourav, Mildred Acevedo-Duncan
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- 7164 7164 新型CLDN18.2靶向ADC TRO-01的临床前表征:强效抗肿瘤疗效及良好的PK和安全性 Preclinical characterization of TRO-01, a novel CLDN18.2-targeting ADC, with potent anti-tumor efficacy and favorable PK and safety Young Hun Lee, Jeongho Kim, Hyun Ju Lee, Sunhwa Lee, Dong Hoon Seo, Myoungki Baek, Sung Ho Woo
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