PO.ET05.03 · 实验与分子治疗
Role of the Microenvironment in Therapeutic Response
- 7169 7169 乳腺肿瘤的纵向单细胞图谱揭示对芳香化酶抑制剂敏感和耐药的免疫及表观遗传机制 Longitudinal single-cell profiling of breast tumors reveals immune and epigenetic mechanisms of sensitivity and resistance to aromatase inhibitors Ilayda Altinönder, Villads Winton, Quy Khang Le, Marie Fongaard, Paal M. Bjornstad, Elin Edda Seland Agustsdottir, Stephanie Geisler, Kamilla Fjermeros, Manouchehr Seyedzadeh, Unn-Cathrin Buvarp, Marianne Lyngra, Arnoldo Frigessi, Diether Lambrechts, Vessela N. Kristensen, Anthony Mathelier, Victor Greiff, Jürgen Geisler, Xavier Tekpli
- 7170 7170 用capivasertib抑制AKT可对抗肿瘤微环境重塑并增强PTEN缺陷型前列腺癌的AR靶向治疗 AKT inhibition with capivasertib counteracts tumor microenvironment remodeling and enhances AR-targeted therapy in PTEN-deficient prostate cancer Marco A. De Velasco, Kazuko Sakai, Daiki Nakatsu, Mamoru Hashimoto, Saizo Fujimoto, Shingo Toyoda, Takafumi Minami, Kazuhiro Yoshimura, Simon T. Barry, Cath Eberlein, Claire Rooney, Kazuto Nishio, Hirotsugu Uemura, Kazutoshi Fujita
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- 7172 7172 B7-H4-TOP1i ADC、PD-1/TIGIT双特异性抗体与PARP抑制的联合在同基因小鼠模型中协调血管生成抑制和干扰素程序激活 Combination of B7-H4-TOP1i ADC, PD-1/TIGIT bispecific antibody, and PARP inhibition orchestrates angiogenesis suppression and interferon-program activation in a syngeneic mouse model Octavio Morante-Palacios, Jon Chesebrough, Yoshimi Johnson, Raymond Rothstein, Varsha Shankarappa, Joseph Boland, Elizabeth Galery, Anna Dominika Staniszewska, Mark R. Albertella, Alex Cazes, Paul Chariou, Bilal Omar
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