PO.IM01.17 · 免疫学
High-Dimensional Immune Profiling and Preclinical Modeling for Cancer Immunotherapy
- 6954 6954 使用经验证的高参数流式细胞术检测进行全面免疫表型分析，以推进实体瘤免疫肿瘤学临床试验的药效学生物标志物发现 Comprehensive immune profiling using a validated high-parameter flow cytometry assay to advance pharmacodynamic biomarker discovery for solid tumor immuno-oncology clinical trials Angelina Bisconte, Vaishali Shinde, Jackie Benko, Jorge Pardo, Samantha Splitt, Rachel Owen, Deborah J. Phippard
- 6955 6955 开发32色光谱流式细胞术抗体组，用于对接受免疫治疗和放疗癌症患者的PBMC进行全面免疫表型分析 Development of a 32-color spectral flow cytometry panel for comprehensive immunophenotyping of PBMCs from cancer patients receiving immunotherapy and radiotherapy Yao-Hui Sun, Logan Vick, Jonathan E. Van Dyke, Andrea L. Gompers, Sohan Dhar, Emanual M. Maverakis, Sean J. Judge, Robert J. Canter, Megan E. daly, William J. Murphy, Arta M. Monjazeb
- 6956 6956 一种61参数CyTOF抗体组，用于全面分析人PBMC以表征免疫活化、检查点表达和细胞因子特征，并应用于癌症免疫学 A 61-parameter CyTOF panel for comprehensive profiling of human PBMC to characterize immune activation, checkpoint expression and cytokine signatures with applications in cancer immunology Michael Cohen, Stephen Li, Lauren Janette Tracey, Katrina Thomson, Christina Loh
- 6957 6957 GAS-Luc2报告基因细胞系可灵敏检测干扰素-γ信号,用于跨2D和3D系统的免疫激活与CAR-T评估 GAS-Luc2 reporter cell lines enable sensitive detection of interferon-gamma signaling for immune activation and CAR-T evaluation across 2D and 3D systems Hyeyoun Chang, John G. Foulke, Luping Chen, Catherine McManus, Meghan Sikes, Fang Tian
- 6958 6958 通过pGen-SHM图可视化的供体来源依赖性B细胞受体谱系模式揭示了造血干细胞移植后适应性免疫重建的差异 Donor source-dependent B cell receptor repertoire patterns visualized by the pGen-SHM plot reveal differences in adaptive immune reconstitution after hematopoietic stem cell transplantation Sakuya Matsumoto, Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Hidetomo Takakura, Yuri Okazoe-Hirakawa, Rina Sakai, Yumiko Inui, Taiji Koyama, Yoshiaki Nagatani, Keiji Kurata, Shiro Kimbara, Shinichiro Kawamoto, Naomi Kiyota, Hironobu Minami
- 6959 6959 使用体外测定对靶向淋巴细胞和髓系细胞的免疫肿瘤学候选药物进行功能评估 Functional evaluation of immuno-oncology drug candidates targeting lymphoid and myeloid cells using in vitro assays Christoph Schifflers, Martijn Vlaming, Sofie Pattyn
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- 6961 6961 患者匹配的类器官-免疫共培养模型作为精准肿瘤学中免疫治疗应答的预测平台 Patient matched organoid-immune co-culture model as a predictive platform for immunotherapy response in precision oncology Maryam Nakhjiri, Sraboni Chaudhury, Youssel Kriko, Mohamad Orabi, Liwei Bao, Mary Horn, Rudnick Avery, Albana Grajqevci, Andrew Chang, David Odell, Udit Singhal, Rishindra M. Reddy, Tudor Borza, Tasha Hughes, Michael Sabel, Lesly Dossett, Joshua Piche, William Aibinder, Sofia Merajver, Nathan Merrill
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- 6964 6964 一种基于NSG-SGM3xIL15xDKO的新型PBMC人源化小鼠模型,用于评估免疫疗法的疗效和细胞因子释放 A novel NSG-SGM3xIL15xDKO-based PBMC humanized mouse model to evaluate efficacy and cytokine release of immunotherapies Xiaoqing (Nancy) Zheng, Guoxiang Yang, Beau Parry, James G. Keck, Li-Chin Yao
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- 6969 6969 在功能基因组学和化合物筛选中对1000种分泌蛋白进行分析，揭示细胞毒性和免疫调节靶点 Analysis of 1000 secreted proteins in functional genomics and compound screens reveals cytotoxic and immunomodulatory targets Nathaniel Robichaud, Amy Johnson, Alistaire Sherman, Eric Miller, Narges Rashidi, Milad Dagher
