Novel Models of Immunotherapy Response

• 6973 · PDF B-NDG hIL15、FcgammaR KO小鼠：一种用于评估T细胞调节性抗体的优化人源化模型 B-NDG hIL15, FcgammaR KO mice: An optimized humanized model for evaluating T cell-modulating antibodies Jiyue Chen, Yanhui Nie, Dexuan Huang, Qingqing Xu, Qiang Liu, Xiaofei Zhou
• 6974 · PDF 用于CD19靶向T细胞衔接器临床前评估的CD3/CD19双人源化小鼠模型 A CD3/CD19 double-humanized mouse model for preclinical evaluation of CD19-targeted T-cell engagers Shuang Li, Lei Ci, Yi Li, Ruilin Sun
• 6975 · PDF 内源性逆转录病毒来源的新抗原实现胶质母细胞瘤的个性化癌症疫苗策略 Endogenous retrovirus-derived neoantigens enable a personalized cancer vaccine strategy for glioblastoma Megan Campbell Benz, Kenan Zhang, David M. Ashley, Christian Garde, Kirit Singh, Ohrt Andersen Rasmus, Birgitte Rønø, Daniela Kleine-Kohlbrecher, Stine Friis Thorsen, Kelly M. Hotchkiss, Jose R. Conejo-Garcia, Mustafa Khasraw
• 6976 · PDF B-CDG小鼠：一种适用于放射治疗和放射性药物评估的新型重度免疫缺陷模型 B-CDG mice: A novel severe immunodeficient model suitable for radiotherapeutic and radiopharmaceutical evaluation Qiurong Wang, Yanhui Nie, Ruili Lv, Chengzhang Shang, Meiqi Zhang, Qingqing Xu
• 6977 · PDF B-NDG MHC I/II DKO小鼠plus：一种用于评估T细胞衔接器疗效和毒性的改良人源化模型 B-NDG MHC I/II DKO mice plus: A refined humanized model for evaluating T cell engager efficacy and toxicity Kelvin Yin, Yanhui Nie, Zhi Zhang, Meiqi Zhang, Yanling Wang, Qiang Liu
• 6978 · PDF 缺乏FcgammaR的HIS模型提供更高的可预测性并有助于免疫肿瘤学治疗药物评估的研究设计 HIS models lacking FcgammaR provide increased predictability and facilitate study design for evaluation of immuno-oncology therapeutics Monika Buczek, Philip Dube, Nicholas Smith, Janell Richardson, Louise Baskin, Esther Andino, Debra Freer, Kathleen Bott
• 6979 · PDF 一种免疫健全、持久的MB49-Luc原位膀胱癌模型展现膀胱特异性肿瘤免疫，用于转化性免疫治疗研究 An immune-competent, durable MB49-Luc orthotopic bladder cancer model demonstrates bladder-specific tumor immunity for translational immunotherapy research Melanie He, Mirian Sifuentes, Neo Wang, Zhigang Peng, Minqi Huang
• 6980 · PDF PDX ovo：以禽类胚胎作为宿主，用于对患者来源异种移植物免疫治疗反应进行快速、定量建模 PDX ovo : Avian embryos as hosts for rapid and quantitative modelling of immunotherapy responses in patient-derived xenografts Olivia R. Grafinger, Kabir A. Khan, Esther Matus, Ping Xu, Sara Mar, Yan Li, David E. Goertz, Wilder Scott, Jean Gariepy, Katarzyna J. Jerzak, Robert S. Kerbel, Hon S. Leong
• 6981 · PDF I型干扰素信号在一种新型人源化NOG-FcgammaR⁻/⁻小鼠模型中抗PD-1诱导的肿瘤排斥中的作用 Involvement of type I interferon signaling in anti-PD-1-induced tumor rejection in a novel humanized NOG-FcgammaR⁻/⁻ mouse model Tatsuhito Ii, Ting-Wei Yu, Katsutoshi Sato, Hirotaka Inoue, Ayumu Tsubosaka, Miwako Kakiuchi, Daisuke Komura, Ikumi Katano, Nao Suzuki, Iyo Ootsuka, Motohito Goto, Misa Mochizuki, Kenji Kawai, Shumpei Ishikawa, Masami Suzuki, Takeshi Takahashi
• 6982 · PDF 患者来源葡萄膜黑色素瘤类器官揭示HLA-I限制性肿瘤抗原和肿瘤反应性T细胞 Patient-derived uveal melanoma organoids reveal HLA-I-restricted tumor antigens and tumor-reactive T cells Alexander Lim, Wei Tian, Zhuoning Li, Mara Monetti, Alexander Noor Shoushtari, James Smithy, Samuel Tischfield, Mark Donoghue, David A. Scheinberg, Chenyang Zhan
• 6983 · PDF 一种用于评估MYC驱动型肝癌靶向治疗和免疫治疗疗效的新型同基因模型 A novel syngeneic model for evaluating the efficacy of MYC-driven liver cancer targeted and immunotherapy Lei Ci, Kai Zhou, Jiangyan Liu, Ruilin Sun
• 6984 · PDF 晚期卵巢癌建模及验证用于转基因表达和肿瘤监测的溶瘤腺病毒工具 Modeling late-stage ovarian cancer and validating oncolytic adenoviral tools for transgene expression and tumor monitoring Lakshmi Kadkol, Eric Gauchat, Maria Jose Godoy Calderon, Manali Patwardhan, VK Gadi
• 6985 · PDF 克服胰腺导管腺癌免疫耐药：微流控预激的类器官相互作用淋巴细胞在患者来源模型中显示出更优的浸润、细胞毒性和肿瘤抑制作用 Overcoming pancreatic ductal adenocarcinoma immunoresistance: Microfluidic-primed organoid interacting lymphocytes demonstrate superior infiltration, cytotoxicity, and tumor suppression in patient-derived models Eleftherios Makris, Damian Hutchins, Tiefu Liu, Adam Hall, Lance Miller, Shay Soker, Konstantinos Votanopoulos

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