PO.MCB07.02 · 分子与细胞生物学
Chromatin Architecture and Regulatory Landscapes
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- 7239 7239 一个基因组缺失变异体控制超级增强子驱动的LINC00636和CD47过表达以促进乳腺癌肿瘤细胞存活 A genomic deletion variant controls super-enhancer-driven overexpression of LINC00636 and CD47 to promote tumor cell survival in breast cancer Carolina Di Benedetto, Amelia Tsark, Alysia Thach, Anmol Singhal, Anthony Rodriguez, Paola Betancur
- 7240 7240 多组学分析确定BACH2转录因子为驱动EGFR突变型肺腺癌对靶向治疗产生药物耐受的关键表观遗传和转录抑制因子 Multi-omic analysis identifies BACH2 transcription factor as key epigenetic and transcriptional repressor driving drug-tolerance to targeted therapy in EGFR-mutant lung adenocarcinoma Yoshimasa Kudo, Althaf Singhawansa, Yong Zeng, Catherine O'Brien, Scott Bratman, Geoffrey Liu
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- 7244 7244 AMPK在染色质上与PRC1.1复合物相互作用,以响应急性淋巴细胞白血病中的代谢应激调控NADK表达 AMPK interacts with PRC1.1 complex on chromatin to regulate NADK expression in response to metabolic stress in acute lymphoblastic leukemia Anna Shvab, Guy J. Leclerc, Julio C. Barredo
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- 7256 7256 增强子重编程使ETS1-RUNX1-FOSL1成为胆囊癌中一种致癌性和免疫抑制性的转录调控回路 Enhancer reprogramming establishes ETS1-RUNX1-FOSL1 as an oncogenic and immunosuppressive transcriptional circuitry in gallbladder carcinoma Jiaxi Sun, Xing He, Yuntan Qiu, Zhenyu Zhou, Daning Lu, Shiru Tang, Wenbin Li, Dong Yin, Lehang Lin
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