Immune Cell Biology and Tumor-Immune Crosstalk

• 158 · PDF CD4⁺ T细胞中的PI3Kdelta通过IFNgamma诱导的肿瘤衰老抵御肺转移 PI3Kdelta in CD4⁺ T cells protects against lung metastases through IFNgamma-induced tumor senescence Leqi Tang, Grace Cooper, Linsey Porter, Seung joon Kim, Erick Armingol, Oliver Burton, James E. Thaventhiran, Walid T. Khaled, Roser Vento-tormo, Rahul Roychoudhuri, Klaus Okkenhaug
• 159 · PDF 衣康酸通过表观遗传修饰和葡萄糖流重定向促进病毒感染和癌症中记忆性CD8 + T细胞的发育 Itaconate promotes memory CD8 + T cell development by epigenetic modification and glucose flux redirection in viral infection and cancer Xiao Yang, Mengyao Su, Jiacheng Wang, Yue Deng, Lingyi Kong, Kunyu Yang, Chao Wan
• 160 · PDF FGFR3损害膀胱癌中DC1/CD8 + T细胞聚集，阻止PD-1/PD-L1阻断诱导的与免疫治疗疗效相关的CD8 + T细胞表型 FGFR3 impairs DC1s/CD8 + T cell clustering in bladder cancer preventing the PD-1/PD-L1 blockade-induced CD8 + T cell phenotypes associated with immunotherapy efficacy Andrea Ziblat, Ken Hatogai, Anthony A. Fernald, Danny E. Kim, Hyunsik Lee, Alexander T. Pearson, Madeleine S. Torcasso, Randy F. Sweis
• 161 · PDF 腺苷信号在CD8 T细胞淋巴细胞减少的条件下促进双阴性T细胞的抗癌反应 Adenosine signaling promotes double-negative t-cell anticancer responses in conditions of CD8 t-cell lymphopenia Brionna King, Zhi Huang, Laura Naldi, Lucio Miele, Giulia Monticone
• 162 · PDF 早期CD8+ T细胞与NK细胞的相互作用协调先发性免疫监视，以增强能够阻断肿瘤抗原逃逸变异体的最佳细胞毒性 Early CD8 + T and NK cell interactions orchestrate preemptive immunosurveillance to potentiate optimal cytotoxicity that blocks tumor antigen-escape variants Thanigaivelan Kanagasabai, Salvador Gonzalez Ochoa, Roman V. Uzhachenko, Maria Teresa P. de Aquino, Harshana Rajakaruna, Muna A. Mohammed, Jane Tonello, Maria Johnson Irudayam, Alla V. Ivanova, Anil Shanker
• 163 · PDF 同种异体双阴性T细胞在CD8+ T细胞中诱导针对急性髓系白血病的天然样细胞毒性功能 Allogeneic double-negative T cells induce an innate-like cytotoxic function in CD8 + T cells against acute myeloid leukemia Leanne Palichuk, Enoch Tin, Pauline Douglas, Ruzena Filandrova, David Schriemer, Juan Arteaga, Michele Nawata, Sandeep Kaur, Sonia Cerquozzi, Michelle Geddes, Lynn Savoie, Jongbok Lee
• 164 · PDF 恢复TUSC2功能可增强NK细胞细胞毒性以及体内和体外的抗肿瘤免疫 Restoring TUSC2 function boosts NK cell cytotoxicity and antitumor immunity in vivo and in vitro Muna Ahmed Eltayeb A. Mohammed, Salvador Gonzalez Ochoa, Jane Tonello, Thanigaivelan Kanagasabai, Mark S. Berger, Alla Ivanova, Anil Shanker
• 165 · PDF SRC-3在调节性T细胞中作为激活和免疫记忆调节因子的作用 Role of SRC-3 in regulatory T cells as a modulator of activation and immunological memory Davis A. Graham, Yan Xia, Subhashree Pradhan, Amrit Koirala, Xiaobin Yu, Adam M. Dean, Bryan C. Nikolai, Aiden L. Moser, Jianming Xu, Cristian Coarfa, Bert W. O'Malley, David M. Lonard
• 166 · PDF 重构树突状细胞-调节性T细胞轴使前列腺癌对免疫治疗敏感 Rewiring the dendritic cell: Regulatory T cell axis sensitizes prostate cancer to immunotherapy Jessica C. Hill, Kade R. Copple, Collin Jugler, Phuong Nguyen, Nilika Bhattacharya, Jessica N. Lancaster, Casey R. Ager
• 167 · PDF SRC3-KO调节性T细胞在小鼠乳腺癌模型中的临床前研究 Preclinic study of src3-ko regulatory T cells in mouse breast cancer model Yan Xia, Yosef Gilad, Davis Graham, Bert W. O'Malley, David M. Lonard
• 168 · PDF 通过STING和LTbetaR激活利用TLS来源的B细胞揭示了胰腺癌抗体介导免疫治疗的新机遇 Harnessing TLS-derived B cells through STING and LTbetaR activation reveals a novel opportunity to antibody-mediated immunotherapy in pancreatic cancer Maxwell Duah, Yasuhiro Kikuchi, Fumiaki Kanamori, Tomoko Stansel, Gabrielle Brown, Masanobu Komatsu
• 169 · PDF 一种产生TNF的中性粒细胞亚群驱动年龄依赖性肝毒性 A TNF-producing neutrophil subset drives age-dependent hepatotoxicity Jin Lee, Yiming Gao, Yufei Zhang, Aaron Havas, Peter Adams, Gerald S. Shadel, Susan M. Kaech, Gen-Sheng Feng
• 170 170 体内生存与流式细胞术揭示胶质母细胞瘤中双相、时间依赖性的中性粒细胞生物学特征，并经单细胞转录组学佐证 Biphasic, time-dependent neutrophil biology in glioblastoma revealed by in vivo survival and flow cytometry with single-cell transcriptomic corroboration Matthew Alexander Abikenari, John Choi, Justin Liu, Adam Sjoholm, George Nageeb, James Poe, Brandon Hwa-Lin Bergsneider, Andrew Tran, David Bakalov, Ravi Medikonda, Lily Kim, Rohit Verma, Caren Wu, Kwang Bog Cho, Matei Banu, Michael Lim
• 171 171 KEAP1功能缺失通过NRF2-FSP1通路抑制免疫原性铁死亡并限制PD-1阻断疗效 KEAP1 loss-of-function suppresses immunogenic ferroptosis and limits PD-1 blockade efficacy through an NRF2-FSP1 pathway Xinfeng Wang, Yuxin Yao, Tomi Jun, Kuan-lin Huang, Nan Sun, Jie He
• 172 · PDF 探究宿主TLR5信号如何调控FLT3配体治疗卵巢癌的疗效 Investigating how host TLR5 signaling modulates FLT3 ligand therapeutic efficacy for ovarian cancer Cara Hatzinger, Mitchell McGinty, Simona Bajgai, Mika Poblete, Akshita Mirani, Audrey Putelo, Mirna Perusina Lanfranca, Una Miagkov, Melanie Rutkowski
• 173 · PDF 靶向三阴性乳腺癌中肿瘤GLI1：逆转免疫抑制性微环境的新策略 Targeting tumoral GLI1 in triple-negative breast cancer: A novel strategy to reverse the immunosuppressive microenvironment Aidan Gray, Qiang Shen, Wanda Marini, Kiichi Murakami, Pamela Ohashi, Michael Reedijk
• 174 · PDF 从黑色素瘤脑转移灶分离的肿瘤反应性CD8淋巴细胞显示，总群体中的一个亚群在过继转移入异种移植模型后更善于控制肿瘤生长 Tumor-reactive CD8 lymphocyte isolated from melanoma brain metastasis show that a subset of the total population is better at controlling tumor growth after adoptive transfer into a xenograft model Jeffrey Wu, Mike Beymer, Rebekka Duhen, Venkatesh Rajamanickam, Colin Thalhofer, Prakash Ambady, Andrew D. Weinberg
• 176 · PDF NRAS突变型黑色素瘤中免疫激活的内在失败揭示了一种可靶向的检查点耐药机制 Intrinsic failure of immune activation in NRAS -mutant melanoma reveals a targetable mechanism of checkpoint resistance Inyoung Cho, Sung Eun Kim, Joong-Bae Ahn, Sang Joon Shin
• 177 · PDF 体内CRISPR筛选揭示Folr1介导的代谢重塑使结直肠癌对PD-1阻断敏感 In vivo CRISPR screening uncovers Folr1-mediated metabolic remodeling that sensitizes colorectal cancer to PD-1 blockade Boping Jing, Feng Guo, Tadahito Yasuda, Mayu Yasuda, Hudie Li, Fabio Mello, Jay Paul Overholser, Pravin Kaumaya, Yaoqi Alan Wang
• 178 · PDF 探索儿茶酚胺信号在CD8+ T细胞抗神经母细胞瘤免疫中的作用 Exploring the role of catecholamine signaling in CD8+ T cell immunity to neuroblastoma Mark B. Chudnovsky, Daniela Vega-Mendoza, Elinor L. DeCleene, Jose Almeida-Santos, Naomei Lidman, Mingkee Achom, Jared H. Rowe

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