PO.TB10.09 · 肿瘤生物学
Functional and Spatial Regulation of Immune Evasion and Anti-Tumor Immunity
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- 7388 7388 单细胞图谱揭示不同的免疫串扰轴定义NSCLC中不同EGFR突变状态的肿瘤微环境 Distinct immune crosstalk axes define the tumor microenvironment across EGFR mutation status in NSCLC by single-cell profiling Yoojin Kim, Hyunsu Kim, Kyungjong Lee, Bo Mi Ku, Hae-Ock Lee, Jinyong Kim, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Sehhoon Park
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- 7392 7392 一个癌细胞内在的PAR1/MALT1/PD-L1信号通路驱动三阴性乳腺癌的免疫逃逸 A cancer cell-intrinsic PAR1/MALT1/PD-L1 signaling pathway drives immune evasion in triple-negative breast cancer Dong Hu, Prasanna Ekambaram, Zheqi Li, Linda Klei, Maria L. Beecher, Yi Liu, Zongyou Cai, John Little, Jeffrey A. Meridew, Jia-Ying Lee, E. Aubrey Thompson, Tullia C. Bruno, Lidija Covic, Seung-Oe Lim, Anushka Dongre, Heide L. Ford, Mien-Chie Hung, Adrian V. Lee, Steffi Oesterreich, Linda McAllister-Lucas, Peter C. Lucas
- 7394 7394 细胞因子驱动的CD38+HLA-DR+CD8+ T细胞定义了一个预测肝细胞癌不良预后的旁观者程序 Cytokine-driven CD38 + HLA-DR + CD8 + T cells define a bystander program predicting poor prognosis in hepatocellular carcinoma Wei-Ting Ku, Chien-Hao Huang, Cheng-Heng Wu, Wei Teng, Po Ting Lin, Tsung-Han Wu, Jian-He Fang, Chan-Keng Yang, Yen-Chun Liu, Wen-Juei Jeng, Yung-Chang Lin, Chun-Yen Lin
- 7396 7396 骨硬化病相关跨膜蛋白1在肝细胞癌免疫治疗中调节CD8+ T细胞应答 Osteopetrosis-associated transmembrane protein1 modulates CD8⁺ T-cell responses during immunotherapy in hepatocellular carcinoma Yixin Chen, Jie Luo, Nanzhou Yu, Yu Zhang, Ming Zhu, Yuma Yang, Lanqi Gong, Xin-Yuan Guan
- 7397 7397 经隧道纳米管的肝细胞癌来源RNA的细胞间转移教育巨噬细胞并增强抗原呈递 Intercellular transfer of hepatocellular carcinoma-derived RNAs via tunneling nanotubes educates macrophages and enhances antigen presentation Yutao He, Lin Wang, Zhitian Shi
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- 7407 7407 NAT10-PBX1 ac4C 轴使 MHC II 类抗原提呈失能，从而促进免疫冷型胆管癌 The NAT10-PBX1 ac4C axis disables MHC Class II antigen presentation to promote immune‑cold cholangiocarcinoma Kai Luo, Yuhan Fang, Yinzhao Chen, Yuting Zhao, Jialin Qu, Dong Shang, Caiming Xu, Guixin Zhang
- 7408 7408 Brca2 缺陷促进前列腺癌中 cGAS-STING 通路活化增强及免疫抑制性肿瘤免疫微环境的形成 Brca2- deficiency promotes increased cGAS-STING pathway activation and an immunosuppressive tumor immune microenvironment in prostate cancer Kimberly A. Rickman, Irena Q. Sun, Ramya Parameswaran, Xuxu Gou, Morgan E. Diolaiti, Harish N. Vasudevan, Alan Ashworth
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- 7410 7410 抗病毒治疗逆转 CMV 诱导的致癌信号并增强 NK 细胞对胶质母细胞瘤的细胞毒性，伴随 PD-L1 上调和免疫调节 Antiviral therapy reverses CMV-induced oncogenic signaling and enhances NK cell cytotoxicity in glioblastoma with associated PD-L1 upregulation and iImmune modulation Vida Tajiknia, Wafik S. El-Deiry, Connor Purcell, Sean E. Lawler
- 7411 7411 乳腺癌 T 细胞状态的蛋白转录组学解析鉴定出与免疫治疗应答相关的 CD103+ Tfh 来源的细胞毒性 CD4+ 细胞 Proteotranscriptomic dissection of breast cancer T cell states identifies CD103+ Tfh-derived cytotoxic CD4+ cells linked to immunotherapy response Ghamdan Al-Eryani, Sophie van der Leij, Etienne Masle-Farquhar, Alma Andersson, Kate Harvey, Sunny Wu, Tony Wang, John Reeves, Cindy Ma, Daniel L. Roden, Charles M. Perou, Nir Hacohen, Aziz Al’Khafaji, Mats Nilsson, Joakim Lundeberg, Marcel Batten, Simon Junankar, Alexander Swarbrick
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